By Cocer Peptides 
Watanni 1 da suka gabata
DUKKANIN LABARI DA BAYANIN KYAUTATAWA DA AKE BAYAR A WANNAN SHAFIN KAWAI DOMIN WATSA BAYANI NE DA MANUFOFIN ILIMI.
Kayayyakin da aka bayar akan wannan gidan yanar gizon an yi niyya ne kawai don binciken in vitro. Binciken in vitro (Latin: *a cikin gilashi*, ma'ana a cikin gilashin gilashi) ana gudanar da shi a wajen jikin mutum. Waɗannan samfuran ba magunguna ba ne, Hukumar Abinci da Magunguna ta Amurka (FDA) ba ta amince da su ba, kuma dole ne a yi amfani da su don hanawa, magani, ko warkar da kowane yanayi na likita, cuta, ko cuta. Doka ta haramta shigar da waɗannan samfuran cikin jikin mutum ko dabba ta kowace hanya.
A fagen kyau da kuma kula da fata, maganin hana kumburin fuska abu ne mai matukar sha'awa. Snap-8 da botulinum toxin sune sinadarai guda biyu na rigakafin ƙyalli na yau da kullun, kowannensu yana da hanyoyin aiki na musamman da halayen aikace-aikace.
1. Tsarin Aiki
Tsarin aiki na Snap-8: Snap-8 wani takamaiman peptide ne wanda tsarin aikinsa ke da alaƙa da samuwar hadaddun SNARE. Ta hanyar tsoma baki tare da samar da hadaddun SNARE, Snap-8 yana rage sakin masu amfani da kwayoyin halitta, don haka ya hana ƙwayar tsoka da kuma samun sakamako na rage wrinkles. A matakin salula, lokacin da aka watsa siginar jijiyoyi zuwa ƙwayoyin tsoka, suna haifar da jerin amsawar ilimin lissafi, tare da al'ada na al'ada na SNARE shine mataki mai mahimmanci a cikin sakin neurotransmitter. Kasancewar Snap-8 yana hana haɓakar al'ada na hadaddun SNARE, wanda ke haifar da rashin iyawar neurotransmitters don sakin su a cikin ɓangarorin synaptic. A sakamakon haka, ƙwayoyin tsoka ba su karɓar sigina na raguwa, rage yawan mita da ƙarfin ƙwayar tsoka. Yin amfani da dogon lokaci na iya rage zurfin wrinkles a hankali.
Hanyar aikin toxin botulinum: Botulinum toxin da Clostridium botulinum ke samarwa shine neurotoxin. Da farko yana aiki ne a mahaɗin neuromuscular ta musamman manne sunadaran da ke da alaƙa da sakin neurotransmitter, kamar SNAP-25, don haka yana toshe sakin neurotransmitter acetylcholine. Acetylcholine shine mabuɗin neurotransmitter wanda ke watsa siginar jijiya zuwa tsokoki kuma yana haifar da raguwar tsoka. Lokacin da aka katange sakin acetylcholine, tsokoki ba za su iya karɓar sigina na raguwa ba, wanda zai haifar da shakatawa na tsoka. A cikin tsokoki na fuska, toxin botulinum yana raunana tsokar tsoka yayin bayyanar fuska, ta haka yana rage wrinkles da aka samu ta hanyar maimaita tsokawar tsoka, kamar ƙafafun hankaka da layin glabellar.
2. Aikace-aikace
Aikace-aikace a cikin samfuran kula da fata - Snap-8: Snap-8 ana yawan amfani dashi a cikin samfuran kula da fata daban-daban, kamar su creams da serums. Amfaninsa ya ta'allaka ne cikin kasancewa ɗan ƙaramin sinadari na rigakafin wrinkle wanda ya dace da yawancin nau'ikan fata. Ta hanyar yin amfani da samfuran kula da fata akai-akai masu ɗauke da Snap-8 ta hanyar amfani da yau da kullun, ana iya inganta wrinkles na fata a hankali. Tunda yana samuwa a cikin nau'in samfurin kula da fata, ya dace don amfani kuma baya buƙatar ƙwararrun ma'aikatan likita don gudanarwa, rage shingen amfani.
Aikace-aikace a cikin Kayayyakin Kyawawa da Kula da fata - Botulinum Toxin: Botulinum toxin ana amfani dashi da farko a cikin filin kyau ta hanyar allura. Wannan hanyar kai tsaye tana ba da kayan aiki mai aiki zuwa takamaiman ƙwayoyin tsoka, suna niyya ga al'amuran wrinkle. Yawancin lokaci ana amfani da shi don magance tsummoki mai zurfi da tsauri, kamar layin goshi da ƙafafun hankaka. Koyaya, alluran Botox suna buƙatar ƙwararrun ma'aikatan kiwon lafiya don gudanar da su, tare da ƙaƙƙarfan buƙatu don sashi, wuraren allura, da yadudduka. A lokacin da yin gyaran fuska rage wrinkle, likitoci dole ne lissafta da sarrafa Botox sashi daidai dangane da mara lafiya ta wrinkle yanayin da kuma fuskar tsoka rarraba don cimma mafi kyau duka anti-alagammana effects yayin da guje wa illa kamar fuska stiffness.
Aikace-aikace a fannin likitanci - Snap-8: A halin yanzu, akwai ɗan ƙaramin bincike kan aikace-aikacen Snap-8 a fannin likitanci. Koyaya, dangane da tsarin aikin sa, yana iya ƙila a ƙa'idar yana da ƙima a matsayin jiyya na haɗin gwiwa don wasu yanayi masu laushi ko alamun da ke da alaƙa da matsananciyar ƙwayar tsoka. Don rashin jin daɗin fuska mai laushi ko ɓarnar tsoka da tashin hankali na tsoka ke haifarwa, abubuwan da ke ɗauke da Snap-8 na iya ba da ɗan jin daɗi.
Aikace-aikacen Likita - Botulinum Toxin: Botulinum toxin yana da aikace-aikace da yawa a fannin likitanci. Bugu da ƙari, rage ƙuƙumma na kwaskwarima, ana amfani da shi don magance yanayi daban-daban masu alaka da tsoka. A cikin ilimin jijiyoyi, ana amfani da shi don magance dystonia, ciki har da dystonia cranial, dystonia na mahaifa, da dystonia na hannu. Lokacin da aka shigar da toxin botulinum a cikin tsokoki da dystonia ya shafa, yana haifar da gurɓataccen gurɓataccen yanayi, sarrafawa, yana rage yawan tashin hankali na tsoka da inganta alamun. A cikin ilimin ilimin otolaryngology, ana iya amfani da toxin botulinum don magance yanayi irin su Lucia Frey syndrome, fistula salivary, ciwon salivation mai yawa, dystonia laryngeal, rawar murya, muryar murya, granuloma na murya, synkinesis bayan jijiyar fuska, dysphagia, da rhinitis refractory. Bugu da ƙari, a cikin ilimin ophthalmology, ana iya amfani dashi don magance wasu cututtukan ƙwayar ido, kamar blepharospasm.
Sources
[1] Wee SY, Park E S. Immunogenicity na toxin botulinum[J]. Archives of Plastic Surgery-Aps, 2022,49(1):12-18.DOI:10.5999/aps.2021.00766.
[2] Dołomisiewicz D, Lipiec M, Mielniczek K, et al. Botulinum toxin - bayyani na aikace-aikace a cikin otorhinolaryngology[J].Polski Przegląd Otorynolaryngologiczny, 2022. https://api.semanticscholar.org/CorpusID:254297988
