Na Cocer Peptides 
ukwezi gushize
INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
Mu rwego rwubwiza no kwita ku ruhu, imiti igabanya ubukana ni ingingo ishimishije cyane. Snap-8 hamwe nuburozi bwa botuline nibintu bibiri bisanzwe birwanya kurwanya inkari, buri kimwe gifite uburyo bwihariye bwibikorwa nibiranga porogaramu.
1. Uburyo bwibikorwa
Uburyo bwa Snap-8 bwibikorwa: Snap-8 ni peptide yihariye uburyo bwibikorwa bifitanye isano no gushinga SNARE. Mu kubangamira ishingwa rya SNARE, Snap-8 igabanya irekurwa rya neurotransmitter, bityo bikabuza kugabanuka kwimitsi no kugera ku ngaruka zo kugabanya iminkanyari. Kurwego rwa selile, iyo ibimenyetso byubwonko byandujwe mumitsi, bitera urukurikirane rwibisubizo byumubiri, hamwe no guterana bisanzwe kwikigo cya SNARE nintambwe ikomeye mukurekura neurotransmitter. Kubaho kwa Snap-8 birinda ishingwa risanzwe rya SNARE, biganisha ku kuba neurotransmitter idashobora kurekurwa muri synaptic. Nkigisubizo, ingirangingo z'imitsi ntizakira ibimenyetso byo kugabanuka, bigabanya inshuro nuburemere bwimitsi. Gukoresha igihe kirekire birashobora kugabanya buhoro buhoro ubujyakuzimu.
Uburyo bwibikorwa byuburozi bwa botuline: Uburozi bwa Botuline bwakozwe na Clostridium botulinum ni neurotoxine. Irakora cyane cyane ihuriro rya neuromuscular ihuza poroteyine zijyanye no kurekura neurotransmitter, nka SNAP-25, bityo bikabuza irekurwa rya neurotransmitter acetylcholine. Acetylcholine nurufunguzo rwingenzi rwa neurotransmitter yohereza ibimenyetso byimitsi mumitsi kandi bigatera kwikuramo imitsi. Iyo irekurwa rya acetyloline ihagaritswe, imitsi ntishobora kwakira ibimenyetso byo kugabanuka, biganisha ku kuruhura imitsi. Mu mitsi yo mu maso, uburozi bwa botuline bugabanya kugabanuka kwimitsi mugihe cyo mumaso, bityo bikagabanya iminkanyari iterwa no kwikuramo imitsi inshuro nyinshi, nkibirenge byinkona n'imirongo ya glabellar.
2. Porogaramu
Gushyira mubikorwa byo kuvura uruhu - Snap-8: Snap-8 ikoreshwa mubicuruzwa bitandukanye byita ku ruhu, nka cream na serumu. Ibyiza byayo biri mubintu byoroheje birwanya anti-wrinkle bikwiranye nubwoko bwinshi bwuruhu. Mugukomeza gukoresha ibicuruzwa bivura uruhu birimo Snap-8 ukoresheje buri munsi, inkari zuruhu zirashobora kunozwa buhoro buhoro. Kubera ko iboneka muburyo bwibicuruzwa byuruhu, biroroshye gukoresha kandi ntibisaba abaganga babigize umwuga kuyobora, kugabanya inzitizi yo gukoresha.
Gushyira mu Bwiza no Kuvura Uruhu - Uburozi bwa Botuline: Uburozi bwa Botuline bukoreshwa cyane cyane mu bwiza bw’ubwiza binyuze mu gutera inshinge. Ubu buryo butanga mu buryo butaziguye ibintu bifatika byimitsi yihariye, bigamije ibibazo byiminkanyari. Ubusanzwe ikoreshwa mu kuvura iminkanyari yimbitse kandi ifite imbaraga, nk'imirongo yo mu ruhanga n'ibirenge by'inkona. Nyamara, inshinge za Botox zisaba abaganga babigize umwuga kubayobora, hamwe nibisabwa cyane kubijyanye na dosiye, aho batera inshinge, hamwe. Mugihe cyo kugabanya inkari zo mumaso, abaganga bagomba kubara no kugenzura dosiye ya Botox neza bashingiye kumiterere yiminkanyari yumurwayi no gukwirakwiza imitsi yo mumaso kugirango bagere ku ngaruka nziza zo kurwanya inkari mu gihe birinda ingaruka mbi nko kunangira imitsi yo mu maso.
Gusaba mubuvuzi - Snap-8: Kugeza ubu, hari ubushakashatsi buke ugereranije no gukoresha Snap-8 mubijyanye n'ubuvuzi. Nyamara, ukurikije uburyo bwibikorwa byayo, irashobora kuba ifite agaciro nkigikorwa cyo kuvura ibintu byoroheje cyangwa ibimenyetso bifitanye isano no kugabanuka kwimitsi ikabije. Kuburyo bworoshye bwo mumaso cyangwa spasms yimitsi iterwa no guhagarika imitsi, ibintu byingenzi birimo Snap-8 birashobora gutanga agahengwe.
Gusaba Ubuvuzi - Uburozi bwa Botuline: Uburozi bwa Botuline bukoreshwa cyane mubuvuzi. Usibye kugabanya amavuta yo kwisiga, akoreshwa mukuvura ibintu bitandukanye bijyanye n'imitsi. Muri neurologiya, ikoreshwa mu kuvura dystoniya, harimo na dystonie ya cranial, dystonie cervical, na dystonie. Iyo uburozi bwa botuline bwatewe mu mitsi yibasiwe na dystonie, butanga ubumuga bwaho, bugenzurwa na pariferique, bigabanya imitsi ikabije kandi bikanonosora ibimenyetso. Muri otolaryngologiya, uburozi bwa botulineum burashobora gukoreshwa mu kuvura indwara nka syndrome ya Lucia Frey, fistula salivary, syndrome de salivation ikabije, dystonie yo mu kanwa, guhinda umushyitsi, amajwi ya granuloma, synkinesis nyuma yo kunanirwa mu maso, dysphagia, na rhinite yanga. Byongeye kandi, mubuvuzi bw'amaso, burashobora gukoreshwa mu kuvura indwara zimwe na zimwe zifata imitsi y'amaso, nka blepharospasm.
Inkomoko
Wee SY, Parike E S. Immunogenicity yuburozi bwa botuline [J]. Ububiko bwo Kubaga Plastike-Aps, 2022.49 (1): 12-18.DOI: 10.5999 / aps.2021.00766.
[2] Dołomisiewicz D, Lipiec M, Mielniczek K, n'abandi. Uburozi bwa Botulineum - incamake y'ibisabwa muri otorhinolaryngology [J] .Polski Przegląd Otorynolaryngologiczny, 2022.
