Amegãkuku nye nusi womate ŋu aƒo asa na godoo, gake ɖe míate ŋu aɖe edzi akpɔtɔa? Numekuku siwo wowɔ nyitsɔ laa ɖee fia be NAD+ kple glutathione ate ŋu akpe ɖe ame ŋu. Molekyul siawo nye nu vevi aɖe le lãmenugbagbeviwo ƒe lãmesẽ kple ŋusẽ wɔwɔ me.
Nyati sia ku alesi NAD+ kple glutathione wɔa dɔ ɖekae tsɔ ɖea tsitsi ƒe ŋusẽkpɔɖeamedzi dzi kpɔtɔnae me. Srɔ̃ alesi wodoa agbenɔƒe didi kple lãmenugbagbeviwo ƒe gbugbɔgadzɔ ɖe ŋgɔe.
Le Cocer Peptides , míetsɔa kpeɖeŋutɔ siwo doa alɔ molecule sesẽ siawo naa amewo. Na wò ŋusẽ nasẽ ne èle tsitsim.
NAD+ (Nicotinamide Adenine Dinucleotide) nye coenzyme si le lãmenugbagbevi gbagbewo katã me eye wòwɔa akpa vevi aɖe le nugbagbewo ƒe dɔwɔwɔ vevi geɖe me. Ele vevie ŋutɔ na lãmenugbagbeviwo ƒe dɔwɔwɔ, ŋusẽdodo, kple lãmenugbagbeviwo ƒe lãmesẽ me léle ɖe asi. Etɔxɛe la, NAD+ doa alɔ mitochondria ƒe dɔwɔwɔ, si ƒe dɔe nye be wòawɔ ŋusẽ le ATP (adenosine triphosphate) ƒe nɔnɔme me. Ne NAD+ mesɔ gbɔ o la, lãmenugbagbeviwo mate ŋu awɔ ŋusẽ si hiã be woatsi agbe nyuie o, si wɔnɛ be lãmenugbagbeviwo ƒe dɔwɔwɔwo gblẽna.
Tsɔ kpe ɖe akpa si wòwɔna le ŋusẽ wɔwɔ me ŋu la, NAD+ le vevie na DNA ɖɔɖɔɖo kple lãmenugbagbeviwo ƒe agbenɔnɔ. NAD+ naa sirtuins, si nye protein ƒe ƒome aɖe si kpɔa gome le tsitsi ƒe ɖoɖoa dzi kpɔkpɔ me, si naa nuteɖeamedzi ƒe tsitretsitsi nyona ɖe edzi, eye wòdoa lãmenugbagbeviwo ɖɔɖɔɖo ɖe ŋgɔ me la wɔa dɔ. Protein siawo kpena ɖe lãmenugbagbeviwo ŋu wokpɔa wo ta tso oxidative stress me eye woɖɔa domenyiŋusẽfianu ƒe ɖeɖefia ɖo be lãmenugbagbeviwo nawɔ dɔ nyuie. Eyata NAD+ do ƒome tẽ kple agbenɔƒe didi kple ŋutilã ƒe ŋutete be wòakpɔ nuteɖeamedzi gbɔ, aɖɔ nusiwo gblẽ ɖo, eye wòanɔ sɔhɛme le lãmenugbagbeviwo ƒe ɖoɖo nu.
Ne míele tsitsim la, NAD+ ƒe agbɔsɔsɔ si le míaƒe ŋutilã me dzi ɖena kpɔtɔna le dzɔdzɔme nu, si kpɔa ŋusẽ ɖe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi le mɔ geɖe nu. Ðeɖe sia dzena le mitochondria me vevietɔ, afisi ŋusẽ wɔwɔ dzea egɔme nɔa blewu le, si wɔnɛ be ŋusẽ ƒe agbɔsɔsɔ dzi ɖena kpɔtɔna. Ŋusẽdodo sia si dzi ɖe kpɔtɔ la gblẽa nu le ŋutilã ƒe dɔwɔwɔ vovovowo ŋu, si wɔnɛ be ɖeɖi tea ame ŋu, ŋusẽ dzi ɖena kpɔtɔna, eye wòhayana blewu tso kamedede me.
NAD+ ƒe vɔvɔ hã nana DNA ɖɔɖɔɖo ƒe mɔnuwo dzi ɖena kpɔtɔna, si wɔnɛ be lãmenugbagbeviwo te ŋu gblẽna bɔbɔe wu le domenyiŋusẽfianu ƒe gbegblẽ kple tɔtrɔwo me. Esia nana ame tsina le lãmenugbagbeviwo ƒe ɖoɖo nu, si hea nɔnɔmewo abe ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie, dzitodzito me kuxiwo, kple lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔmawɔmawɔ nyuie vɛ. NAD+ ƒe anyimanɔmanɔ na lãmenugbagbeviwo mete ŋu kpɔa oxidative stress gbɔ o, si naa tsitsi kabakaba eye wònana dɔléle siwo do ƒome kple tsitsi ƒe afɔkua dzina ɖe edzi. Esia tae NAD+ ƒe agbɔsɔsɔ nyuitɔ me léle ɖe asi le vevie na tsitsi le lãmesẽ me ɖo.
Numekuku siwo wowɔ nyitsɔ laa ɖee fia be NAD+ ƒe agbɔsɔsɔ gbugbɔgaɖo ate ŋu aɖe vi geɖe le tsitsi ŋu. Ne wotsɔ NAD+ ƒe ŋgɔdonuwo abe nicotinamide riboside (NR) kple nicotinamide mononucleotide (NMN) kpe ɖe eŋu me la, woate ŋu ana NAD+ ƒe agbɔsɔsɔ nadzi ɖe edzi le ŋutilã me, le ame tsitsiwo gɔ̃ hã me. Wokpɔe be kpeɖeŋutɔ siawo naa lãmenugbagbeviwo gawɔa ɖekakpui, woƒe mitochondria ƒe dɔwɔwɔ nyona ɖe edzi, eye wodzia ŋusẽ ƒe agbɔsɔsɔ ɖe edzi.
NAD+ dzi ɖeɖe kpɔtɔ ate ŋu akpe ɖe ŋutilãa ƒe dzɔdzɔmenuwo ɖɔɖɔɖomɔnu ŋu, ana sirtuins ƒe dɔwɔwɔ nanyo ɖe edzi, eye wòaɖe oxidative damage dzi akpɔtɔ. Esia kpena ɖe ame ŋu wòɖea tsitsi dzi kpɔtɔna, wònaa ŋutilã ƒe dɔwɔwɔ nyona ɖe edzi, eye wòkpɔa ame ta tso lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe toɖeɖe le tsitsi ta me. Ne ègbugbɔ NAD+ ƒe agbɔsɔsɔ ɖo la, àte ŋu aɖe tsitsi ƒe ŋusẽkpɔɖeamedziwo dzi akpɔtɔ, ado lãmenugbagbeviwo ƒe gbugbɔgadzɔ ɖe ŋgɔ, eye nàdo alɔ lãmesẽ kple ŋusẽ bliboa.
Molekyul |
Dɔ Vevi Siwo Wowɔna |
Ŋusẽkpɔɖeamedzi ɖe Tsitsi Dzi |
Dɔwɔwɔ ƒe Mɔnu |
NAD+ |
Ŋusẽwɔwɔ, DNA dzadzraɖo, sirtuin ƒe dɔwɔwɔ |
Eɖea tsitsi dzi kpɔtɔna to mitochondria ƒe dɔwɔwɔ dzi ɖeɖe kpɔtɔ me |
Doa alɔ lãmenugbagbeviwo ƒe dɔwɔwɔ eye wònaa nuwo ɖɔɖɔɖo ƒe ɖoɖowo wɔa dɔ |
Glutathione si woyɔna be glutathione |
Antioxidant, detoxification, dɔlélenutsiŋutete ƒe kpekpeɖeŋu |
Eɖea oxidative ƒe nugbegblẽ, dɔdzẽ, kple tsitsi dzi kpɔtɔna |
Enaa free radicals mewɔa dɔ o eye wòdoa alɔ aɖi ɖeɖeɖa |
Wobua glutathione be enye atike sesẽ siwo tsia dzoxɔxɔ nu le ŋutilã me la dometɔ ɖeka. Eɖea free radicals kple reactive oxygen species (ROS), siwo nye molecule siwo gblẽa nu le ame ŋu siwo hea oxidative stress vɛ la ɖa. Oxidative stress hea lãmenugbagbeviwo ƒe gbegblẽ vɛ, enaa tsitsi kabakaba, eye wòhea dɔléle vovovowo vɛ, siwo dometɔ aɖewoe nye dzitodzito kple ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie. To redox ƒe dadasɔ me la, glutathione kpena ɖe lãmenugbagbeviwo ŋu wokpɔa wo ta tso oxidative stress ƒe nugbegblẽ le wo ŋu me, si wɔnɛ be woxea mɔ na tsitsi kaba eye wònaa lãmenugbagbeviwo ƒe lãmesẽ bliboa nyona ɖe edzi.
Le eƒe antioxidant ŋutetewo megbe la, glutathione wɔa akpa vevi aɖe le aɖiɖeɖe le ŋutilãa me me. Ekpena ɖe ame ŋu wòɖea aɖi siwo gblẽa nu le ame ŋu kple ga kpekpewo ɖa to woƒe kadodo kple wo ɖeɖeɖa bɔbɔe me. Aɖi ɖeɖeɖa ƒe mɔnu sia le vevie ŋutɔ be ŋutinuwo nawɔ dɔ nyuie, vevietɔ le aklã me. Aklã wɔa dɔ abe ŋutilãa ƒe dzɔdzɔmenu si ɖea aɖi ɖa ene, eye wòɖea aɖinuwo ɖa le ʋukawo me. To asikpekpe ɖe dɔ sia ŋu me la, glutathione kpena ɖe ame ŋu be woɖea nusiwo gblẽa nu le ame ŋu ɖa le ŋutilãa me nyuie, si doa lãmesẽ bliboa ɖe ŋgɔ eye wòɖea dɔléle siwo nɔa anyi didi ƒe afɔkua dzi kpɔtɔna.
Ne míele tsitsim la, glutathione ƒe agbɔsɔsɔ si le ŋutilãa me dzi ɖena kpɔtɔna le dzɔdzɔme nu, si wɔnɛ be lãmenugbagbeviwo te ŋu gblẽa nu le lãmenugbagbeviwo ŋu bɔbɔe wu. Gbɔdzɔgbɔdzɔ sia gbɔdzɔa ŋutilã ƒe ŋutete be wòawɔ avu kple oxidative stress, si nana lãmenugbagbeviwo ƒe gbagbã kabakaba, gblẽa nu le dɔlélenutsiŋutete ƒe dɔwɔwɔ ŋu, eye wònaa dɔléle siwo do ƒome kple tsitsi ƒe afɔkua dzina ɖe edzi. Ŋutete si dzi ɖe kpɔtɔ be wòaɖe free radicals ɖa la wɔnɛ be dɔdzẽ, DNA ƒe gbegblẽ, kple lãmenugbagbeviwo ƒe dɔwɔwɔ veviwo dzi ɖena kpɔtɔna. Glutathione alo nusiwo do ŋgɔ nɛ abe N-acetyl cysteine (NAC) ene tsɔtsɔ kpe ɖe eŋu ate ŋu akpe ɖe ame ŋu wòagaɖo ametakpɔnu siwo tsia dzoxɔxɔ nu eye wòana ŋutilãa ƒe ŋutete be wòawɔ avu kple tsitsi ƒe ɖoɖoa nanyo ɖe edzi.
NAD+ kple glutathione wɔa akpa vovovowo gake wokpena ɖe wo nɔewo ŋu le lãmenugbagbeviwo ƒe lãmesẽ me. NAD+ le vevie na ŋusẽ wɔwɔ, mitochondria ƒe dɔwɔwɔ, kple DNA ɖɔɖɔɖo, evɔ glutathione ya nyea ametakpɔnu si tsia dzoxɔxɔ nu, si kpɔa lãmenugbagbeviwo ta tso oxidative stress me. Wo katã wowɔa dɔ aduadu sẽŋu aɖe si doa ŋusẽ lãmenugbagbeviwo ƒe gbugbɔgadzɔ eye wòdoa lãmenugbagbeviwo ƒe lãmesẽ ɖe ŋgɔ. NAD+ kpena ɖe lãmenugbagbeviwo ɖɔɖɔɖo kple ŋusẽdodo ŋu, gake glutathione ya kpɔa egbɔ be lãmenugbagbeviawo gakpɔtɔ kpɔa ta tso oxidative ƒe nugbegblẽ me. Nusiwo wotsɔ ƒo ƒui sia si me ŋusẽ le la nana ame ƒe hayahaya kabakaba, eɖea tsitsi ƒe ŋusẽkpɔɖeamedziwo dzi kpɔtɔna, eye wòdoa alɔ lãmenugbagbeviwo ƒe dɔwɔwɔ nyuie.
Mitochondria, siwo nye lãmenugbagbevi ƒe ŋusẽtɔwo, ɖoa ŋu ɖe NAD+ kple glutathione siaa ŋu hena dɔwɔwɔ nyuie wu. NAD+ wɔa akpa vevi aɖe le mitochondria biogenesis me, si doa ŋusẽ mitochondria yeyewo wɔwɔ be woakpɔ ŋusẽ si lãmenugbagbeviwo hiã la gbɔ. Le go bubu me la, glutathione kpɔa mitochondria ta tso oxidative damage me, si ate ŋu agblẽ nu le woƒe dɔwɔwɔ ŋu eye wòaɖe woƒe dɔwɔwɔ dzi akpɔtɔ. To dɔwɔwɔ ɖekae me la, NAD+ kple glutathione kpɔa egbɔ be mitochondriawo gakpɔtɔ le lãmesẽ me eye wowɔa dɔ nyuie, wodoa alɔ lãmenugbagbeviwo ƒe ŋusẽ wɔwɔ eye wòkpena ɖe mía ŋu be ŋusẽ nanɔ mía si ne míele tsitsim.
NAD+ le vevie ŋutɔ na DNA dzadzraɖo, vevietɔ to eƒe dɔwɔwɔ na enzymewo abe Poly ADP-Ribose Polymerase (PARP), siwo naa DNA si gblẽ la dzadzraɖo bɔbɔe me. Gake DNA ɖɔɖɔɖo ƒe ɖoɖoa ate ŋu awɔ ROS, si ahe oxidative stress bubuwo vɛ. Afi siae glutathione va gena ɖo. To ROS si dona le DNA ɖɔɖɔɖo me ɖeɖeɖa me la, glutathione kpena ɖe ame ŋu be lãmenugbagbeviwo ƒe nugbegblẽ le ame ŋu geɖe wu. Nuwɔwɔ aduadu sia nana be DNA ɖɔɖɔɖo ƒe ɖoɖoa wɔa dɔ nyuie eye wòwɔa dɔ nyuie, si ɖea DNA ƒe tɔtrɔ ƒe afɔkua dzi kpɔtɔna eye wòdoa alɔ lãmenugbagbeviwo ƒe blibonyenye bliboa. Ne wotsɔ NAD+ kple glutathione ƒo ƒu wɔa akpa vevi aɖe le lãmenugbagbeviwo ƒe lãmesẽ me léle ɖe asi me, woɖea DNA ƒe gbegblẽ si do ƒome kple tsitsi dzi kpɔtɔna, eye wodoa lãmenugbagbeviwo ƒe gbugbɔgadzɔ ɖe ŋgɔ.
Ŋusẽkpɔɖeamedzi Siwo Woƒo Ƒu |
Dɔwɔwɔ ƒe Mɔnu |
Viɖe Siwo Do Tso Eme |
Lãmenugbagbeviwo ƒe ŋusẽ si dzi ɖe edzi |
NAD+ doa ŋusẽ mitochondria ƒe dɔwɔwɔ |
Lãmenugbagbeviwo dzadzraɖo kple wo gbugbɔgadzɔ si nyo wu |
Antioxidant takpɔkpɔ si wodo ɖe ŋgɔ |
Glutathione nana ROS megawɔa dɔ o |
Oxidative ƒe nugbegblẽ kple dɔdzẽ dzi ɖe kpɔtɔ |
DNA dzadzraɖo si nyo wu |
NAD+ naa PARP enzymes wɔa dɔ, glutathione ɖea ROS dzi kpɔtɔna |
DNA dzadzraɖo nyuie wu evɔ womagblẽ nu bubu aɖeke o |
Lãmenugbagbeviwo takpɔkpɔ si wɔa dɔ aduadu |
NAD+ gbugbɔa glutathione wɔa dɔ eye wòdoa alɔ DNA ɖɔɖɔɖo |
Lãmetsiwo ƒe dɔyɔyɔ kple woƒe ɖekakpuiwo gbugbɔgawɔ si sɔ gbɔ wu |
To NAD+ ƒe agbɔsɔsɔ dzi ɖeɖe kpɔtɔ kple glutathione ƒe dɔwɔwɔ nyuie me léle ɖe asi me la, míate ŋu ana tsitsi ƒe ɖoɖoa nagbɔdzɔ eye míaɖe dɔléle siwo do ƒome kple tsitsi ƒe afɔkua dzi akpɔtɔ. NAD+ kple glutathione ƒe dɔwɔwɔ aduadu nana lãmenugbagbeviwo ƒe ɖɔɖɔɖo nyona ɖe edzi, eɖea dɔdzẽ dzi kpɔtɔna, eye wòdoa alɔ mitochondrial ƒe lãmesẽ, eye esiawo katã nana ame tsitsi le lãmesẽ me.
Viɖe gã aɖe le NAD+ kple glutathione hã ŋu na ŋutigbalẽ ƒe lãmesẽ. NAD+ kpena ɖe ame ŋu be collagen wɔwɔ kple ŋutigbalẽ ƒe tete ɖe edzi, gake glutathione ya kpɔa ŋutigbalẽ ƒe lãmenugbagbeviwo ta tso oxidative ƒe nugbegblẽ kple nuteɖeamedzi si UV hena vɛ me. Wo katã wodoa ŋutigbalẽa ƒe ɖekakpui ɖe ŋgɔ, woɖea fli nyuiwo dzi kpɔtɔna, eye wònaa ŋutigbalẽa ƒe lãmesẽ bliboa nyona ɖe edzi, si wɔnɛ be ŋutigbalẽa ƒe dzedzeme nɔa sɔhɛme.
Molekyul |
Viɖe Vevi Siwo Le Ŋutilã Ŋu |
Dɔwɔwɔ ƒe Mɔnu |
Ŋusẽkpɔɖeamedzi si Wokpɔna |
NAD+ |
Enaa collagen wɔwɔ nyona ɖe edzi, enaa ŋutigbalẽ ƒe tete ɖe edzi |
Doa lãmenugbagbeviwo ƒe ŋusẽ ɖe ŋgɔ eye wòdoa alɔ collagen ƒe wɔwɔme |
Fli nyuiwo dzi ɖe kpɔtɔ, ŋutigbalẽ si sesẽ wu |
Glutathione si woyɔna be glutathione |
Eɖea ŋutigbalẽ ƒe amadede dzi kpɔtɔna, edoa aɖi ɖeɖeɖa ɖe ŋgɔ |
Neutralizes free radicals, dzraa oxidative ƒe nugbegblẽ ɖo |
Ŋutilã ƒe amadede gɔ̃ hã, flitete kple teƒeteƒewo dzi ɖe kpɔtɔ |
Nuƒoƒu |
Enaa ŋutigbalẽ ƒe ɖekakpuiwɔwɔ nyona ɖe edzi, enaa ŋutigbalẽ ƒe nɔnɔme nyona ɖe edzi |
Ewɔa dɔ ɖekae tsɔ dzraa ŋutigbalẽ ɖo, doa gbugbɔgadzɔ ɖe ŋgɔ |
Ŋutilã si le lãmesẽ me wu, si dze abe sɔhɛ ene wu |
Ne míele tsitsim la, dɔlélenutsiŋutete ƒe dɔwɔwɔ dzi ɖena kpɔtɔna, eye dɔdzẽ si nɔa anyi didi va bɔ ɖe edzi. NAD+ kple glutathione kpena ɖe ame ŋu wowɔa avu kple nya siawo to dɔlélenutsiŋutete ƒe dɔwɔwɔ nyuie wu kple dɔlélenutsiŋutete ƒe dɔdzẽ dzi ɖeɖe kpɔtɔ me. NAD+ nana dɔlélenutsiŋutete ƒe lãmenugbagbeviwo wɔa dɔ, gake glutathione ya kpɔa wo ta tso oxidative stress me, si wɔnɛ be ŋutilãa ƒe ametakpɔnuawo gakpɔtɔ li ke eye wowɔa dɔ nyuie.
Numekuku siwo wowɔ nyitsɔ laa ɖee fia be nu nyuiwo do tso eme le NAD+ ƒe ŋgɔdonuwo, abe nicotinamide riboside (NR) kple nicotinamide mononucleotide (NMN) ene, siwo wokpɔ be wodzia NAD+ ƒe agbɔsɔsɔ ɖe edzi le ŋutilã me. Kpekpeɖeŋunu siawo ɖe ŋgɔyiyi fia le nɔnɔme siwo do ƒome kple tsitsi abe susu ƒe dɔwɔwɔ ƒe gbɔdzɔgbɔdzɔ, lãmekawo ƒe gbɔdzɔgbɔdzɔ, kple insulin ƒe dɔmawɔmawɔ nyuie ene me. Wole dɔdamɔnu ŋuti numekukuwo wɔm be woaku woƒe ŋutete bliboa me le agbenɔƒe didi ɖe edzi kple lãmesẽ ƒe didime dodo ɖe ŋgɔ me.
Wosrɔ̃ nu tso glutathione ƒe kpeɖeŋutɔ hã ŋu le eƒe viɖe siwo tsia tsitsi nu ŋu. Dɔdamɔnu dodokpɔwo ɖee fia be glutathione ƒe agbɔsɔsɔ gbugbɔgaɖo ate ŋu ana antioxidant ƒe ametakpɔnu nanyo ɖe edzi, aɖe dɔdzẽ dzi akpɔtɔ, eye wòakpɔ ame ta tso oxidative ƒe nugbegblẽ me. Wozãa glutathione zi geɖe le atikewɔwɔ na ŋutigbalẽ ƒe ɖekakpui, dɔlélenutsiŋutete ƒe kpekpeɖeŋu, kple aɖi ɖeɖeɖa me.
Numekuku geɖe ku ɖe NAD+ kple glutathione kpeɖeŋutɔ zazã ɖekae ŋu. Nusiwo ŋu woke ɖo gbã ɖee fia be molecule eve siawo ƒe dɔwɔwɔ aduadu ate ŋu ana ŋutilãa nate ŋu adzra lãmenugbagbevi siwo gblẽ ɖo, aɖe oxidative stress dzi akpɔtɔ, eye wòado lãmesẽ bliboa ɖe ŋgɔ. Ehiã be woagawɔ numekuku geɖe wu be woase viɖe siwo anɔ anyi ɣeyiɣi didi tso nu sia ƒokpli me gɔme bliboe.
Be NAD+ ƒe agbɔsɔsɔ nadzi ɖe edzi la, bu NAD+ ƒe ŋgɔdonuwo abe nicotinamide riboside (NR) alo nicotinamide mononucleotide (NMN) tsɔtsɔ kpe ɖe eŋu ŋu. Agbenɔnɔ ƒe tɔtrɔ, abe nutsitsidɔ ɣeaɖewoɣi kple kamedede edziedzi ene hã ate ŋu aʋã NAD+ ƒe wɔwɔ le dzɔdzɔme nu.
Woate ŋu adzi glutathione ƒe agbɔsɔsɔ ɖe edzi to glutathione alo eƒe ŋgɔdonyawo abe N-acetyl cysteine (NAC) tsɔtsɔ kpe ɖe eŋu me. Nuɖuɖu siwo me sulfur sɔ gbɔ ɖo, abe galik, anyitsi, kple atitsoga amagbewo ene ɖuɖu ate ŋu ado alɔ glutathione ƒe wɔwɔ hã. Tsɔ kpe ɖe eŋu la, agbenɔnɔ nyui si ɖea oxidative stress dzi ɖeɖe kpɔtɔ, abe atamanono kple ahanono fũu akpa ene, me léle ɖe asi ate ŋu akpe ɖe ame ŋu be glutathione ƒe agbɔsɔsɔ nanɔ anyi.
Agbenɔnɔ si me lãmesẽ le si me kamedede edziedzi, nuɖuɖu si da sɔ, kple nuteɖeamedzi dzi ɖuɖu ƒe mɔnuwo zazã ate ŋu ado alɔ NAD+ kple glutathione siaa ƒe dzɔdzɔme wɔwɔ. Alɔ̃dɔdɔ nyuie, tsi ƒe agbɔsɔsɔ, kple nunyiame nyuie le vevie be molecule vevi siawo ƒe agbɔsɔsɔ nyuitɔ nanɔ ame si.
Le nyataƒoƒo me la, NAD+ kple glutathione wɔa dɔ ɖekae tsɔ tsia tsitsi nu, doa lãmenugbagbeviwo ƒe gbugbɔgadzɔ ɖe ŋgɔ, eye wodoa lãmesẽ bliboa ɖe ŋgɔ. Ne míegade molecule vevi siawo me la, míenaa lãmenugbagbeviwo ƒe dɔwɔwɔ nyona ɖe edzi, míeɖea oxidative ƒe nugbegblẽ dzi kpɔtɔna, eye míetsina blewu. Ne numekukua le edzi yim la, wo zazã ɖekae ate ŋu atrɔ asi le atike siwo wozãna tsɔ tsia tsitsi nu ŋu. Cocer Peptides naa atike siwo doa alɔ molecule siawo, si doa agbenɔƒe didi kple agbenɔnɔ ƒe nyonyome ɖe ŋgɔ.
A: NAD+ wɔa akpa vevi aɖe le lãmenugbagbeviwo ƒe ŋusẽ wɔwɔ, DNA dzadzraɖo, kple mitochondrial ƒe lãmesẽ me, siwo le vevie ŋutɔ na avuwɔwɔ kple tsitsi kple agbenɔƒe didi ƒe nyonyo.
A: Glutathione nye antioxidant sẽŋu aɖe si ɖea free radicals ɖa, si ɖea oxidative damage kple inflammation, siwo nye nu vevi siwo nana ame tsitsi dzi kpɔtɔna.
A: Ẽ, NAD + kple glutathione wɔa dɔ aduadu tsɔ doa lãmenugbagbeviwo ƒe dɔwɔwɔ ɖe ŋgɔ, kpɔa ame ta tso oxidative stress me, eye wodoa lãmenugbagbeviwo ƒe gbugbɔgadzɔ ɖe ŋgɔ, si naa atike si tsi tre ɖe tsitsi ŋu si me kɔ nyuie.
A: NAD+ ŋgɔdonuwo abe nicotinamide riboside kple nuɖuɖu alo kpeɖeŋutɔ siwo me glutathione sɔ gbɔ ɖo ene tsɔtsɔ kpe ɖe eŋu ate ŋu akpe ɖe ame ŋu be woagbugbɔ molecule siawo ƒe agbɔsɔsɔ nyuitɔ aɖo anyi ahalé wo me ɖe asi hena tsitsi nyuie wu.
