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1 kits (10 Vials)
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▎ AOD 9604 Tsarin
Source: PubChem |
Jeri: SALLRSIPAPAGASRLLLLTGEIDLP Tsarin Halitta: C 78H 123N 23O 23S2 Nauyin Kwayoyin: 1815.1g/mol Lambar CAS: 221231-10-3 PubChem CID: 71300630 |
▎ AOD 9604 Bincike
Menene asalin bincike na AOD 9604?
AOD 9604 peptide ne wanda ya ƙunshi guntun C-terminal na hormone girma na mutum (hGH), musamman jerin amino acid 177 - 191, tare da ƙarin ragowar tyrosine a N-terminus na peptide.
Dangantaka tsakanin AOD 9604, hormone girma, da maganin kiba shine kamar haka. Kodayake hormone girma na ɗan adam (hGH) yana da yuwuwar magance kiba, lamuran aminci suna iyakance amfani da shi na dogon lokaci. A matsayin guntun C-terminal na hGH, AOD 9604 ana ɗaukarsa zai iya taka rawa wajen magance kiba ba tare da haifar da mummunan tasirin hGH ba. Nazarin sun gano cewa duka hGH da AOD 9604 na iya haifar da asarar nauyi da kuma ƙara yawan jiyya na lipolytic bayan dogon jiyya a cikin mice. Wata hanya mai yuwuwa ita ce ta hanyar hulɗa tare da hanyar β-adrenergic, musamman tare da beta (3) - masu karɓar adrenergic (β3-AR) [1] .
Dukansu hGH da AOD 9604 na iya rage nauyin jiki da kitsen jikin mice masu kiba, kuma wannan sakamakon yana da alaƙa da haɓaka matakin β3-AR RNA, babban mai karɓar lipolytic a cikin adipocytes. Mahimmanci, duka hGH da AOD 9604 na iya haɓaka matakan β3-AR RNA da aka danne a cikin berayen masu kiba zuwa matakin da ya yi daidai da wancan a cikin berayen raƙuman ruwa [1] .
Duk da haka, a cikin β3-AR knockout mice, amfani da dogon lokaci na hGH da AOD 9604 sun kasa samar da canje-canje masu nauyi da kuma ƙara yawan lipolysis da aka gani a cikin nau'in nau'in nau'in nau'in nau'in daji. Amma a cikin m gwaje-gwaje, AOD 9604 na iya ƙara yawan amfani da makamashi da kuma hadawan abu da iskar shaka a cikin β3-AR knockout mice [1].
Jiyya na osteoarthritis: Intra-articular allura na AOD 9604 ya nuna wasu curative effects a cikin zomo model na osteoarthritis. Binciken da Kwon Dong Rak da Park Gi Young suka yi ya nuna cewa allurar intra-articular ta hanyar duban dan tayi na AOD 9604 yana haɓaka farfadowar guringuntsi, kuma allurar AOD 9604 da hyaluronic acid (HA) ta fi tasiri fiye da amfani da HA ko AOD 9604 kadai [2] .
An ba da rahoton AOD 9604 don yin kwaikwayon kaddarorin lipolytic na hormone girma ba tare da tasiri na haifar da ciwon sukari ba. Don haka, ana iya amfani da shi azaman magani mai haɓaka aiki kuma Hukumar Yaƙi da Doping ta Duniya (WADA) ta hana shi [3].
Asalin bincike na AOD 9604 ya samo asali ne daga sabani tsakanin yuwuwar hormone girma na ɗan adam wajen magance kiba da lamuran lafiyar sa. A lokaci guda, tare da karuwa a cikin cututtuka na rayuwa, rawar da za ta iya takawa wajen inganta lafiyar lafiyar jiki da lafiyarsa ya zama abin da aka mayar da hankali ga bincike.
Menene halaye da fa'idodin tsarin aikin AOD 9604 a cikin asarar nauyi da tsarin rayuwa?
Da farko, dangane da lipolysis, AOD 9604 yana haɓaka haɓakar ji na lipolysis ta hanyar kunna hanyar β3-adrenergic receptor (β3-AR) hanyar adipocytes. Wannan kunnawa yana ba da damar adipocytes don haɓaka yadda ya dace don rushe triglycerides da aka adana a cikin fatty acids da glycerol kyauta, don haka inganta lalata da amfani da mai don samar da kuzari ga jiki. Wannan tsari ba wai kawai yana taimakawa wajen rage tarin kitsen jiki ba, har ma yana inganta rarraba kitse a jiki, yana rage yawan kitsen da ake samu, don haka yana rage hadarin cututtuka daban-daban masu alaka da kiba, kamar cututtukan zuciya da jijiyoyin jini da nau'in ciwon sukari na 2.
Abu na biyu, AOD 9604 kuma yana aiki da kyau wajen hana lipogenesis. Yana iya hana kitse daga abincin da ake ci daga zama mai kitsen jiki ta hanyar daidaita maganganun kwayoyin halittar da ke da alaƙa da lipogenesis. Musamman, AOD 9604 na iya hana ayyukan maɓalli na lipogenic enzymes irin su fatty acid synthase, don haka rage haɗuwa da adana kayan kitse. Wannan sakamako mai hanawa yana taimakawa wajen rage yaduwa da bambance-bambancen adipocytes da kuma hana haɓakar haɓakar ƙwayar adipose mai yawa, don haka samun sakamako na asarar nauyi. A lokaci guda kuma, wannan tasirin hanawa zai iya taimakawa wajen kiyaye ma'auni na kitse na jiki da kuma guje wa rikice-rikice na rayuwa wanda ke haifar da tarin kitse mai yawa.
Dangane da ka'idojin rayuwa, rawar AOD 9604 ya fi rikitarwa kuma cikakke. Yana iya canza tsarin makamashi na jiki daga glucose metabolism zuwa mai mai, kuma wannan motsi yana da mahimmanci ga asarar nauyi da inganta lafiyar jiki. Ta hanyar haɓaka bazuwar oxidative na fatty acid, AOD 9604 yana ba da ƙarin hanyoyin samar da makamashi don jiki kuma yana rage dogaro ga metabolism na glucose. Wannan tsari na rayuwa ba wai kawai yana taimakawa wajen kara yawan basal na rayuwa ba, yana sa jiki ya cinye karin makamashi a hutawa, amma yana inganta haɓakar insulin, yana inganta haɓakawa da amfani da glucose, don haka yana kula da kwanciyar hankali na matakan sukari na jini. Bugu da ƙari, wannan sakamako na tsarin rayuwa yana taimakawa wajen rage yawan kitsen mai a cikin gabobin jiki kamar hanta, hanawa da inganta cututtuka na rayuwa irin su hanta mai kitse.
A ƙarshe, AOD 9604 yana da fa'idodi na musamman don rage juriya na insulin. Idan aka kwatanta da cikakken hormone girma, AOD 9604 yana kawar da illolin da zasu iya haifar da juriya na insulin da ƙara yawan sukarin jini. Wannan haɓakawa yana sa AOD 9604 ya fi aminci yayin aikin jiyya kuma ba zai yi tasiri mai tasiri akan matakan sukari na jini ba. Wannan yana da mahimmancin mahimmancin asibiti ga marasa lafiya masu kiba, musamman waɗanda ke da juriya na insulin ko ƙarancin sukari na jini. AOD 9604 ba kawai zai iya taimaka musu su rasa nauyi ba amma kuma inganta haɓakar insulin, rage haɗarin haɓaka nau'in ciwon sukari na 2, da haɓaka ƙimar lafiyar lafiyar gaba ɗaya.
A ƙarshe, AOD 9604 yana haifar da tasirin sa akan asarar nauyi da tsarin rayuwa ta hanyar hanyoyin aiki da yawa, yana ba da sabon zaɓi da bege don maganin kiba da cututtukan rayuwa.
Tasirin AOD9604 akan tara yawan nauyin jiki na berayen Zucker (fa/fa). An ba da dabbobin gwajin (p) a kowace rana kashi na baki na 500 Ìg na AOD9604 a kowace nauyin jiki na tsawon kwanaki 20, kuma dabbobi masu kulawa (P) sun sami daidaitattun adadin saline a kowace rana a cikin irin wannan hanya. Sakamakon yana nufin B SEM na dabbobi 8. Ana nuna bambance-bambance masu mahimmanci tare da alamar alama.
Source:PubMed [5]
Menene takamaiman hanyoyin haɗin da AOD 9604 ke shafar metabolism na mai?
Yin hulɗa tare da hanyar β-adrenergic: Nazarin ya nuna cewa hGH da gutsuttsuran lipolytic AOD 9604 da aka haɗa daga C-terminal na iya haifar da asarar nauyi da kuma ƙara yawan hankali na lipolytic bayan jiyya na dogon lokaci a cikin mice [4] . Wata hanya mai yuwuwa ita ce ta hanyar hulɗa tare da hanyar β-adrenergic, musamman tare da mai karɓar β₃-adrenergic (β₃-AR). A cikin berayen masu kiba, hGH da AOD 9604 na iya haɓaka matakin magana na β₃-AR RNA kuma suna iya haɓaka matakan β₃-AR RNA da aka danne a cikin ɓeraye masu kiba zuwa matakin kwatankwacin wancan a cikin ƙwanƙwasa mice. Koyaya, dogon lokaci na jiyya na β₃-AR knockout mice tare da hGH da AOD 9604 sun kasa samar da canje-canje masu nauyi da haɓakar lipolysis da aka lura a cikin nau'ikan sarrafa nau'ikan daji. Amma a cikin m gwaje-gwaje, AOD 9604 na iya ƙara yawan amfani da makamashi da kuma hadawan abu da iskar shaka a cikin β₃-AR knockout mice. Wannan yana nuna cewa tasirin lipolytic na hGH da AOD 9604 ba a daidaita su ta hanyar β₃-AR kai tsaye ba, kodayake duka biyun na iya haɓaka maganganun β₃-AR, wanda daga baya zai iya taimakawa haɓaka haɓakar lipolytic hankali.
Ƙara yawan iskar shaka da haɓakar lipolysis: A cikin kiba (ob / ob) da ƙananan C57BL / 6J mice, tasirin haɓakar haɓakar ɗan adam (hGH) da AOD 9604 (ɓangaren C-terminal na hGH) ana iya lura dashi akan nauyin jiki, daidaiton makamashi, da ƙimar iskar shaka. Dukansu hGH da AOD 9604 sun rage girman girman nauyin berayen masu kiba, wanda ke da alaƙa da haɓakar oxidation mai yawa a cikin jiki da haɓaka matakan glycerol na plasma (mai nuna alamar lipolysis). Ba kamar hGH ba, AOD 9604 baya haifar da hyperglycemia ko rage ƙwayar insulin. AOD 9604 ba ya gasa tare da mai karɓar hGH kuma baya haifar da yaduwar kwayar halitta kamar hGH. Wannan yana ƙara tabbatar da manufar hGH a matsayin prohormone, yana nuna cewa guntun hGH na iya yin aiki ta hanyar da ta bambanta da hanyar haɓaka hGH na gargajiya [4] .
Menene tasirin AOD 9604 akan hanta?
Tasirin AOD 9604 akan hanta yana nunawa a cikin tasirin sa na tsari akan metabolism na mai. A matsayin polypeptide na roba wanda ke kwaikwayi yanki na aikin lipolytic na hormone girma na mutum (hGH), AOD 9604 na iya haɓaka lipolysis, hana lipogenesis, da canza ƙarfin kuzarin jiki daga metabolism na glucose zuwa mai mai. Wannan tsarin aikin yana taimakawa wajen rage yawan kitse a cikin hanta, don haka yana ba da wani matakin kariya ga hanta. Don cututtuka na rayuwa irin su hanta mai kitse, asarar nauyi da tasirin ka'idojin rayuwa na AOD 9604 na iya taimakawa inganta yanayin hanta mai mai, rage nauyi akan hanta, don haka inganta aikin hanta. Koyaya, a halin yanzu akwai ƙananan karatun kai tsaye akan tasirin AOD 9604 akan hanta. Abubuwan da ke sama ana yin hasashe galibi dangane da tasirin sa akan metabolism na kitse, kuma ana buƙatar ƙarin binciken kimiyya don tabbatar da takamaiman tasirin kariya na hanta da hanyoyin aiwatarwa.
Menene mahimmancin AOD 9604?
AOD 9604 shine polypeptide na roba wanda ke kwaikwayi yanki na aikin lipolytic na hormone girma na ɗan adam (HGH), kuma ƙimar aikace-aikacen likita yana da mahimmanci. A cikin lura da kiba da cututtuka na rayuwa, AOD 9604 na iya inganta haɓakar lipolysis yadda ya kamata, hana lipogenesis, da daidaita tsarin tsarin rayuwa na jiki, yana taimaka wa marasa lafiya masu kiba su rasa nauyi, haɓaka abubuwan da ke cikin jiki, kuma yana da ƙimar aikace-aikacen da ake buƙata don magance cututtukan rayuwa kamar hanta mai mai. Idan aka kwatanta da cikakken hormone girma, yana kawar da illa masu illa wanda zai iya haifar da juriya na insulin da kuma ƙara yawan sukarin jini, don haka yana da aminci yayin aikin jiyya kuma ya dace da yawancin marasa lafiya.
AOD 9604 yana da mahimmanci a fagen bincike da ci gaba na miyagun ƙwayoyi. A matsayin magani mai asarar nauyi tare da tsarin aiki na musamman, yana ba da sabon zaɓi don maganin kiba, yana nuna yuwuwar magungunan polypeptide a cikin magance cututtuka na rayuwa, kuma yana ba da sabbin ra'ayoyi da kwatancen bincike don ci gaba na gaba na ƙarin aminci da inganci magungunan asarar nauyi. Bugu da ƙari, haɓakawa da bincike na AOD 9604 sun inganta ci gaban fannin magungunan polypeptide, sun tabbatar da yiwuwar magungunan polypeptide a cikin yin kwaikwayon da kuma tsara takamaiman ayyuka na ilimin lissafi a cikin jiki, kuma sun ba da kwarewa mai mahimmanci don ƙira, haɓakawa, da haɓaka magungunan polypeptide.
A cikin haɓaka salon rayuwa mai kyau, AOD 9604 za a iya amfani dashi azaman hanyar taimako don taimakawa mutane sarrafa nauyin su da kuma kula da lafiya. Kiba babbar matsala ce a cikin al'ummar zamani, kuma tasirinsa na asarar nauyi zai iya ba da ƙarin tallafi ga mutanen da ke da wahalar rasa nauyi ta hanyar abinci mai sauƙi da motsa jiki. Har ila yau, ta hanyar daidaita metabolism na kitse, yana taimakawa wajen inganta yanayin lafiyar jiki, rage yawan lipids na jini, rage yawan kitse a cikin jini, rage hadarin cututtuka masu alaka da metabolism kamar cututtukan zuciya, da inganta rayuwa.
AOD 9604 kuma yana taka muhimmiyar rawa wajen haɓaka bincike na asali. Bincikensa yana taimakawa sosai don bincika tsarin aikin hormone girma na ɗan adam, musamman takamaiman rawar da yake takawa da hanyar sigina a cikin ƙa'idar metabolism na mai. Ta hanyar bincike akan AOD 9604, masana kimiyya zasu iya fahimtar yadda hormone girma ke aiwatar da ayyukan ilimin lissafin jiki ta hanyar hulɗar tsakanin takamaiman yanki da masu karɓa, da kuma yadda waɗannan ayyuka ke canzawa a ƙarƙashin yanayi daban-daban na ilimin lissafi da ilimin cututtuka. Bugu da kari, AOD 9604 za a iya amfani da a matsayin bincike kayan aiki ga bincike alaka da mai metabolism, taimaka masana kimiyya nazarin tafiyar matakai na fats bazuwa, tsara, da kuma cell transduction siginar, bayyana da kwayoyin hanyoyin da kayyade hanyoyin sadarwa na mai metabolism, da kuma samar da ka'idar tushe ga ci gaban da magani hanyoyin da kwayoyi don m mai metabolism.
Mawallafin Jarida
Heffernan, MA yana da alaƙa da Jami'ar Limerick kuma yana aiki a fannonin ilimi da yawa. Waɗannan sun haɗa da Endocrinology & Metabolism, inda bincike zai iya mai da hankali kan ayyukan hormonal da tafiyar matakai na rayuwa a cikin jiki. A cikin Kimiyyar Polymer, aikinsu na iya haɗawa da nazarin kayan polymer, haɗarsu, kaddarorinsu, da aikace-aikace. Physiology zai rufe ayyuka da tafiyar matakai na rayayyun halittu, yayin da Nutrition & Dietetics ya shafi kimiyyar abinci, abinci mai gina jiki, da ayyukan abinci.
Game da Marubuci
Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.
Mawallafin Jaridar Kimiyya
Binciken Heffernan na iya bincika mahaɗar waɗannan fagagen, kamar haɓaka tsarin isar da magunguna na tushen polymer don rikice-rikice na rayuwa ko nazarin tasirin ilimin halittar jiki na ayyukan abinci mai gina jiki ta amfani da dabarun kimiyyar kayan haɓaka. Ayyukansu na ba da gudummawa ga zurfin fahimtar hanyoyin nazarin halittu da haɓaka sabbin hanyoyin warware matsalar kiwon lafiya da kimiyyar kayan aiki. Heffernan, MA an jera shi a cikin ambaton ambaton [4].
