Amino acids yog cov organic tebchaw uas muaj α-amino pawg (α-NH₂) thiab α-carboxyl pawg (α-COOH), nrog rau cov qauv dav dav RCH (NH₂)COOH. Lub α-carbon atom yog txuas mus rau ib qho tshwj xeeb sab-chain pawg (R pab pawg), tsim cov qauv tsim qauv ntawm cov macromolecules lom. Nyeem ntxiv

Peptide purification yog cov txheej txheem ntawm kev sib cais thiab ua kom cov khoom siv peptide sib xyaw ua ke tau los ntawm kev sib txuas lossis kev qhia siv lub cev, tshuaj, lossis cov txheej txheem lom neeg kom tau txais lub hom phiaj peptides siab purity. Nyeem ntxiv

Peptide solubility yog hais txog qhov siab tshaj plaws ntawm peptide uas tuaj yeem yaj hauv ib chav ntim ntawm cov kuab tshuaj nyob rau hauv qhov kub thiab txias thiab pH, feem ntau yog tus cwj pwm los ntawm huab hwm coj concentration (g / L) lossis molar concentration (mol / L). Raws li cov cuab yeej physicochemical tseem ceeb, nws ncaj qha cuam tshuam rau kev nqus, faib, metabolism, thiab tso tawm (ADME) cov txheej txheem ntawm peptides hauv vivo, thiab tseem txiav txim siab txog kev npaj thev naus laus zis, kev cia ruaj khov, thiab kev soj ntsuam kev ua haujlwm ntawm peptide-based tshuaj. Nyeem ntxiv

Peptide tebchaw, vim lawv qhov tshwj xeeb amino acid sequences thiab spatial cov qauv, muaj cov yam ntxwv uas lawv cov kev ua ub no lom neeg muaj feem cuam tshuam rau sab nraud ib puag ncig. Lub hauv paus ntsiab lus tseem ceeb rau kev khaws cia peptide yog los tiv thaiv cov tshuaj tiv thaiv xws li degradation, oxidation, thiab kev sib sau ua ke, yog li tswj hwm lawv cov qauv kev ntseeg siab thiab kev ua haujlwm lom neeg. Nyeem ntxiv

Dermorphin feem ntau siv nws cov teebmeem analgesic los ntawm kev cuam tshuam nrog μ-opioid receptor (MOP). Lub μ-opioid receptor yog tus tswv cuab tseem ceeb ntawm tsev neeg opioid receptor thiab ua lub luag haujlwm tseem ceeb hauv kev kho mob. Nyeem ntxiv