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▎ Bpc 157 Jatebɔ
Sɔrɔyɔrɔ: PubChem |
A kɛcogo: GEPPPGKPADDAGLV Formula molekilɛri: C 62H 98N 16O22 Molecules girinya: 1419,5g/mol CAS nimɔrɔ: 137525-51-0 PubChem ka CID: 9941957. Bamako, Mali Kɔrɔɲɔgɔnmaw: Bepecin |
▎ Bpc 157 Sɛgɛsɛgɛli
Bpc 157 ka ɲininiw kɛcogo ye mun ye?
Bpc 157 ye pepitiri ye min bɛ kɛ ni asidi aminiki 15 ye, wa a ye farikolo lakanani furakisɛ (Bpc) sigiyɔrɔma dɔ ye min sɔrɔla ka bɔ hadamaden kɔnɔbara ji la. Nin ye ɲininiw kɛcogo ye min ɲɛsinnen bɛ Bpc 157 ma:
Aksidan min bɛ wele ko Brain-Gut Axis ani Bpc 157:
Sugunɛ ni kɔnɔnatumuw ka jɛɲɔgɔnya bɛ pepitiridiji bonya fɛnw de kan. Olu dɔw la, kɔnɔbara basigilen pentadekapɛpɛtidi Bpc 157 ye fɛnɲɛnamafagalan ye min bɛ kirinni kɛlɛ, min farati tɛ ani min bɛ se ka banakɔtaa funu sɛgɛsɛgɛliw kɛ, wa a bɛ ka sɛgɛsɛgɛli kɛ sisan sklerose multiple (sklerosis multiple) kan. A bɛ sɔrɔ hadamaden kɔnɔbara ji la a yɛrɛ la [1] . Bpc 157 bɛ se ka kɛ Robert selilɛri lakanani cɛmancɛ kura ye, ka a sen don kɔnɔbara basigilen dafalen marali la k’a sɔrɔ baga tɛ a la.
A ye ɲɛtaa sɔrɔ kɔnɔbolibanaw furakɛli la, ɲinw dawoloci, sugunɛ ni kɔnɔboli joginda furakɛli la, ka fara farikolo yɔrɔw ni joginda suguya caman kɛnɛyali kan. A bɛ Egr-1 jamu, NAB2, FAK-paxillin, ani JAK-2 siraw fana lawuli [1] .Ni Bpc 157 bɛ kɛ lamini na, cɛmancɛ nafa minnu bɛ bɛn o ma, olu bɛ ye a daminɛ na, kɛrɛnkɛrɛnnenya la, fɛn minnu bɛ yeli kɛ serotonin bɔli la kunsɛmɛ yɔrɔ dɔw la (kɛrɛnkɛrɛnnenya la nigrostriatal yɔrɔ). Bpc 157 bɛ serotonergique ni dopaminergic systems labɛn, a bɛ nɔ ɲuman bila kɛwale jugu suguya caman na minnu bɛ sɔrɔ ka da farikoloɲɛnajɛ kɛrɛnkɛrɛnnenw lawulili/tiɲɛni kan.
Ka fara o kan, Bpc 157 bɛ se ka farikolo tanga, i n’a fɔ ka farikolo yɔrɔw lakana, ka farikolo yɔrɔw labɛn kokura, ka ɲɛtaa taabolo kɛlɛ kunsɛmɛ joginni kɔfɛ, ka axonal ni neuronal necrosis bali, ka demyelination, ani cyst formation bali sosow la minnu ka kɔkolo degun bɛ taa ni caudal paralyse ye, ani ka caudal baara segin [1] . .
Jɔrɔ min bɛ kɔnɔbara basigilenw lakanani ni farikolo yɔrɔw lakanani na:
Bpc 157 nafa ka bon kosɛbɛ i n’a fɔ Robert ka kɔnɔbara basigilen lakanani/adaptive cellule protection ani farikolo yɔrɔw lakanani cɛsiribaa min bɛ se ka kɛ, ani fana Selye ka degun jaabi cɛmancɛlafɛn kura. Bpc 157 bɛ kɔnɔbara basigilenw lakana ani ka kɔnɔbara dafalen mara fɛn jugu suguya caman ma.
A bɛ se ka dɔlɔ ni banakisɛfagalanw nɔ juguw bali kɔnɔbara basigilen ni ɲɛgɛnɛsira wɛrɛw la (i n’a fɔ fari, sugunɛ, kɔnɔboli, dusukun ani kunsɛmɛ), wa a bɛ se ka kɛ joginda kɛnɛyali la. Ka fara o kan, Bpc 157 bɛ se fana ka kɔnɔbara basigilen tiɲɛni kunbɛn, ka joli sira wɛrɛw lakana, ka nɔ ɲuman bila joli siraw la, ka joli bolicogo dafalen labɛn joona, ani ka tumuw ka cachexia, farikolo tiɲɛni, ani ka pro-inflammatory/cachectic cytokines caya .
Furakɛcogo jɔyɔrɔ min bɛ joli siraw datugucogo la:
Sosow ka ɲɛgɛnɛsira sanfɛla ni jolisira datugucogo sɛgɛsɛgɛli la, Bpc 157 bɛ se ka kolajɛ siraw baara teliya la, i n’a fɔ ɲɛgɛnɛsira sanfɛla-kɔnɔna ɲɛfɛla-pankreyasi-duodenal ɲɛfɛla-superior anterior pancreaticoduodenal vein-pyloric vein-portal vein sira, sira wɛrɛw minnu bɛ taa duguma-yɔrɔ la ka tɛmɛ cɛmancɛ-kɔli fɛ jolisira ni ɲɛgɛnɛsira duguma joli, ani fana ɲɛgɛnɛsira ɲɛfɛla duguma ni kɔnɔbara duguma joli.
Bpc 157 bɛ se ka tansiyɔn jiginni kunbɛn, min bɛ se ka kɛ sababu ye ka tansiyɔn jiginni kunbɛn, ka tansiyɔn jiginni kunbɛn, ka tansiyɔn jiginni kunbɛn, ka joli siraw ni joli siraw joli segin ka taa ɲɛ, ka farikolo yɔrɔ caman joginda nɔgɔya, ka joginda nɔgɔya dusukun na, fogonfogon la, sugunɛ na, sugunɛ na, kɔnɔbara la, kɛrɛnkɛrɛnnenya la kunsɛmɛ na, ani ka oksidan degun nɔgɔya farikolo yɔrɔw la [3] ..
Jɔrɔ min bɛ Budd-Chiari Syndrome la : Budd-Chiari syndrome model (occlusion suprahepatique vena cava) kalanni na sosow la, Bpc 157 bɛ se ka teliya ka bypass siraw dilan inferior vena cava-azygos vein (hemiazygos vein)-superior vena cava ani portacaval shunt, ka portal vein ni inferior kɛlɛ vena cava tansiyɔn jiginni, tansiyɔn jiginni min bɛ kɛ joli sira fɛ, ani ka jolisiraci, dusukun tantanni gɛlɛyaw, ani joginda minnu bɛ sugunɛ ni kɔnɔbara la, olu nɔgɔya. Ligasiyɔn waati, ɔkisizɛni azote ni malondialdehyde hakɛ bɛ to sugunɛ na, a hakɛ bɛ to kɛnɛya la, wa joli la, anzimuw caya fana bɛ dɔgɔya kosɛbɛ [4] ..
Furakɛcogo jɔyɔrɔ min bɛ se ka kɛ COVID-19 la:
COVID-19 bɛ jate joli-sira-funu ni joli-sira-funubana ye min bɛ ɲɛsin kosɛbɛ farikolo-ɲɛnajɛ-yɔrɔw ma, o bɛ se ka kɛ sababu ye ka joli-sira-funu cɛmancɛ baarabaliya lase mɔgɔ ma, min bɛ na ni gɛlɛyaw ye ani farikolo yɔrɔ caman ka dɛsɛ. Bpc 157 ye pepitiri ye min bɛ banakisɛfagalanw, sitoprotective ani endothéliale lakanani kɛ farikolo yɔrɔw la minnu tɛ kelen ye suguya wɛrɛw la. A bɛ se ka endothéliale nitric oxyde synthase baara, o min bɛ tali kɛ azote oxide bɔli la, farikolo yɔrɔw dilancogo la, ani joli siraw labɛncogo la, ka joli siraw dafalen ni farikolo tangacogo ɲɛ, ka dɔ bɔ funu dɛmɛcogo la, ani ka bana juguya dɔgɔya. O la, a nafa ka bon ka baro kɛ a seko kan i n’a fɔ furakɛli fɛɛrɛ min bɛ se ka bana kunbɛn ani ka dɔ fara a kan [5] (Deek SA, 2022).
Bpc 157 ka baara kɛcogo kɛrɛnkɛrɛnnen ye mun ye kunsɛmɛ ni kɔnɔbara basigilen na?
Sugunɛ ni kɔnɔbara basigilen ye kumaɲɔgɔnya sira fila ye min ka gɛlɛn, min bɛ tali kɛ farikoloɲɛnajɛ ni kɔnɔbara basigilen cɛ, wa Bpc 157 jɔyɔrɔ ka bon a la, kɛrɛnkɛrɛnnenya la, a fan saba fɛ: A fɔlɔ, i n’a fɔ sitoprotective mediator, Bpc 157 bɛ se ka a sen don kɔnɔnatumuw dafalen sabatili la. I n’a fɔ Robert ka selilɛri lakanani cɛsiribaa kura min tɛ baga nɔ bila a la, a bɛ kɔnɔbara basigilen farikolo baara kɛcogo ɲuman sabati ni kɔnɔbara basigilenw lakanani ye, o la, a bɛ nɔ bila hakili ni kɔnɔbara basigilen balansi la. Filanan, a bɛ farikolo-ɲɛnajɛ-yɔrɔw labɛn. Bpc 157 bɛ se ka serotonergique ni dopaminergique systemes labɛn. Ni Bpc 157 kɛra a lamini na, serotonin bɔli kunsɛmɛ yɔrɔ kɛrɛnkɛrɛnnenw na (kɛrɛnkɛrɛnnenya la nigrostriatal yɔrɔ) bɛna Changé, o bɛ kɛ sababu ye ka cɛmancɛ nɔ nafamaw lase. Ka fara o kan, a bɛ se ka nɔ ɲuman bila kɛwale jugu suguya caman na minnu bɛ sɔrɔ ka a sababu kɛ farikoloɲɛnajɛ kɛrɛnkɛrɛnnenw lawulili/tiɲɛni ye. Misali la, a bɛ serotonɛriji ni dopaminɛrɛjiw labɛn walasa ka kɛwale gɛlɛyaw ɲɛ, minnu bɛ sɔrɔ farikolojidɛsɛbanakisɛw fɛ. Sabanan, a bɛ se ka farikolo tanga. Bpc 157 bɛ se ka somatosensory neurons lakana, ka senfagabana ɲɛnamaya ni baarakɛcogo kɛnɛyali sabati ni farikoloɲɛnajɛ joginna, ka farikolo yɔrɔw labɛncogo kura sabati, ani ka farikolojidɛsɛ baara segin, ka dɔ bɔ hakili joginni jugumanw na. Misali la, ni kɔkolo degun kɛra sosow la ni kɔkolo sɔgɔsɔgɔli, axonal ni neuronal necrosis, demyelination, ani cyst formation ye, Bpc 157 bɛ se ka kɔkolo baara kisi ani ka dɔ bɔ farikolo yɔrɔw tiɲɛni na i n’a fɔ farikolojidɛsɛ ni kɔnɔbara basigilen min bɛ sɔrɔ fura tali caya fɛ walima kunsɛmɛnasumaya fɛ, ka farikolo baarakɛcogo ɲumanw lakana [1] ..
Bpc 157 ka fɛɛrɛ kɛrɛnkɛrɛnnen ye mun ye farikolo cɛmancɛ banaw furakɛli la?
Bpc 157 ye fɛɛrɛ caman jira minnu bɛ se ka kɛ farikolo cɛmancɛ banaw furakɛli la. Kunsɛmɛnasumaya misali la, Bpc 157 bɛ sɔgɔsɔgɔninjɛ min bɛ sɔrɔ bilateral common carotid artery clamping fɛ, o kɛlɛ ka ɲɛ, a kɛtɔ ka senfagabana lakana ani ka jeninida kɛrɛnkɛrɛnnenw jirali dɛmɛ. A bɛ se ka tiɲɛni basigilenw ɲɛnabɔ sosow ka kunsɛmɛnasumaya la, ka sɔrɔ ka hakilijagabɔ, farikoloɲɛnajɛ ani baarakɛɲɔgɔnya seko tiɲɛnenw ɲɛ. A bɛ nɔ tilennen bila senfagabana tiɲɛni na min bɛ sɔrɔ joli-sira-funu fɛ, wa a bɛ dɛmɛ fana ka jamu kɛrɛnkɛrɛnnenw jirali dɛmɛ hipokampus (hippocampe) farikolo yɔrɔw la. A bɛ se ka kɛ sababu ye ka sɔgɔsɔgɔninjɛw ka ɲɛnamaya ni u ka baarakɛcogo ɲɛnabɔ ni a bɛ jeninida kɛrɛnkɛrɛnnenw jiracogo ɲɛnabɔ [6] . .
BPC 157 dicogo ɲɛnabɔcogo ɲumanw misaliw; sira bɛɛ, sigida ni sigida la, a fɔra ko kɛnɛyako ɲuman bɛ u la
Soso:PubMed [7] Ɲɛjirali dɔw.
Ni hakiliɲagami bana don, Bpc 157 bɛ jɛɲɔgɔnya min bɛ ɔkisizɛni azotiki ni dopamine sigida cɛ, o ɲɛnabɔ ani ka dopamine sigida ka fɛn caman kɛlɛ, o la, a bɛ hakiliɲagami taamasiɲɛw ɲɛ. A bɛ se ka jɛɲɔgɔnya gɛlɛn min bɛ ɔkisizɛni azotiki ni anfetamini, apomɔrini, MK-801, ani metilfenidati tali kuntaalajan cɛ, o ɲɛnabɔ, o b’a jira ko a bɛ se ka hakiliɲagami taamasiɲɛw ɲɛ ka ɲɛ ni azote fɛnɲɛnamafagalan ni dopamine sigida baarakɛcogo ɲɛnabɔli ye. A bɛ se fana ka dopamine (dopamine) kɛcogo jugu suguya caman kɛlɛ, i n’a fɔ dopamine (dopamine) sɔrɔcogo balili, a minɛbagaw ka fɛnɲɛnamafagalanw (recepteurs hypersensitivités) sɔrɔli, a minɛbagaw ka baarakɛcogo, a bɔli kojugu, nigrostriatal tiɲɛni, ani vesicular depletion, a ɲɔgɔnnaw . .
Ka fara o kan, i n’a fɔ sitoprotective mediator suguya kura, Bpc 157 bɛ serotonergic ni dopaminergic systems labɛn, a bɛ nɔ ɲuman bila kɛwalew la, ani a ka neuroprotective effect fɛ, a bɛ somatosensory neurons lakana, ka peripheral nerves regeneration (sɔgɔsɔgɔninjɛ laminiw) lasegin, ka kunsɛmɛ joginni jugumanba ka taa ɲɛ, ka caudal baara segin. A bɛ se ka kɛ i n’a fɔ sitoprotective mediator suguya kura, ka a sen don kɔnɔnatumuw dafalen marali la, ani ka furakɛli nɔ tilennen bila cɛmancɛlafanga banaw la. A bɛ se fana ka serotonergic ni dopaminergic systems labɛn, ka nɔ ɲuman bila kɛwale jugu suguya caman na minnu bɛ sɔrɔ ka a sababu kɛ neurotransmitter system lawulili/tiɲɛni kɛrɛnkɛrɛnnen (damatɛmɛ) ye, ani o waati kelen na, a bɛ se ka neuroprotective effects sɔrɔ, i n’a fɔ ka somatosensory neurons lakana, ka peripheral nerves regeneration sabati, ka brain traumatic ka ɲɛtaa kɛlɛ, ka axonal ni neuronal necrosis, demyelination ani cyst formation kɛlɛ sosow la minnu kɔkolo bɛ degun, ani ka kɔkolo baara segin [1] . .
Kalan minnu bɛ tali kɛ Bpc 157 la, olu ye jumɛnw ye?
I n’a fɔ COVID-19 furakɛcogo min bɛ se ka kɛ:
San 2019 laban na, coronavirus bana 2019 (COVID-19) ye banaba lase diɲɛ fan bɛɛ la. Sɛgɛsɛgɛliw y’a jira ko COVID-19 ye joli-sira-funu ni joli-sira-funubana ye kosɛbɛ min bɛ farikolo yɔrɔw laɲini, o bɛ se ka kɛ sababu ye ka joli-sira baara tiɲɛ cɛmancɛ - funu COVID-19 bɛ banabagatɔ minnu na, olu bɛ se ka farikolo yɔrɔ caman dɛsɛ i n’a fɔ ninakilidegun jugumanba, dusukun ni jolisiraw gɛlɛyaw, sugunɛ jogin, ani farikolojidɛsɛ. Ka da baganw ka misali kunnafoniw kan, ɲininikɛlaw ye kuma ta Bpc 157 jɔyɔrɔ kan, n’o ye fura kura ye, COVID-19 furakɛli kɛnɛyaso la. Bpc 157 ye pepitiri ye min bɛ funu kɛlɛli, sitoprotective ani endothéliale lakanani nɔ jira farikolo yɔrɔw la minnu tɛ kelen ye suguya wɛrɛw la. Bpc 157 bɛ endothéliale nitric oxyde synthase (eNOS) baara, o min bɛ tali kɛ nitric oxide (NO) bɔli la, farikolo yɔrɔw dilancogo la, ani joli siraw labɛncogo la, wa a bɛ se ka joli siraw dafalen ni farikolo tangacogo ɲɛ, ka dɔ bɔ funu dɛmɛcogo la, ani ka bana juguya dɔgɔya. O la, a nafa ka bon kosɛbɛ ka baro kɛ a seko kan i n’a fɔ furakɛli fɛɛrɛ min bɛ se ka bana kunbɛn ani ka dɛmɛ don.
Farikolo ni kolotugudaw kɛnɛyali teliya:
Seginkanni kɛra Bpc 157 jɔyɔrɔ kan farikolo yɔrɔ nugulama joginw furakɛli la [7] .Sisan, Bpc 157 kalanni kɔlɔsili bɛɛ y’a jira ko joginda suguya caman na (jogin minnu bɛ kɛ ni bɔnɛ ye ani joginda minnu bɛ sɔrɔ farikolo la ani farikolo yɔrɔ nɔgɔlenw jogin suguya caman), Bpc 157 bɛ kɛnɛya sabatili nɔ ɲuman ni kɛnɛya teliya la tuma bɛɛ. Nka fo ka na se bi ma, kalan fanba kɛra sogo misɛnninw ka misaliw kan, wa Bpc 157 nafa ma dafa hadamadenw na. O bɛɛ n’a ta, a jɛlen don ko sebaayaba bɛ Bpc 157 la, wa a bɛ fɔ ko a bɛna kɛ furakɛli fɛɛrɛ ye min bɛ kɛ ka joli-sira-funu ni farikolo yɔrɔ nɔgɔlenw (i n’a fɔ sɔgɔsɔgɔninjɛ ni sɔgɔsɔgɔninjɛ) joginw furakɛ cogo kɔrɔlen na walima ka kɛ dɛmɛnan ye walasa ka kɛnɛya sɔrɔ yiriwali wɛrɛw kɔfɛ. Ka fara o kan, kolotugudaw jogincogo misali b’a jira ko Bpc 157 tɛ nafa dɔrɔn bila joginw na minnu bɛ sɔrɔ joginda tilennenw fɛ, nka a bɛ se ka kɛ fana farikolo joginw na i n’a fɔ kalisiyɔmu camanba ni magnɛsi caya.
Motɛri baarakɛcogo ɲɛnabɔli kɔkolo jogin kɔfɛ:
Ɲininikɛlaw ye baara kɛ ni sosow ka misali ye min dilannen don ka ɲɛ walasa k’a jira ko kɔnɔbara basigilen pentadekapɛpitiri Bpc 157 bɛ se ka kɔkolo jogincogo ɲɛ [8] . Nin ɲinini tɛmɛnenw y’a jira ko Bpc 157 bɛ se ka farikolo lamini (sciatic nerve) nerve transection/anastomosis kɔlɔlɔw kɛlɛ ani ka nerve kɛnɛya, kunsɛmɛnasumaya, ani kunsɛmɛnasumaya suguya caman ɲɛ. Bpc 157 kɛra kirinni kɛlɛli pepitiri ye banakɔtaa funu sɛgɛsɛgɛliw la ani sklerose multiple sɛgɛsɛgɛliw la. Kalan dɔ la, sosow ye Bpc 157 (200 walima 2μg/kg) walima saline normal (5ml/kg) pikiri kelen kɛ kɔnɔbara la kɔkolo jogin kɔfɛ. Sogo joginlenw bɛɛ ye ɲɛtaa jira ka taa a fɛ Bpc 157 furakɛli kɔfɛ, ni kɛnɛyaso kɔkanna motɛri baara kɛcogo ka ɲi kosɛbɛ ani u yɛrɛ tigɛcogo si ma kɛ; sɔgɔsɔgɔninjɛ gɛlɛya ɲɛnabɔra tile 15nan na; mikroskɔpu kɔrɔ (k’a daminɛ tile 7nan na), vacuoles ni axonal bɔnɛni fɛn finman na, edema min bɛ fɛn jɛman na, ani motor neurons bɔnɛni Bpc 157 wuluw la, ani axons belebele mielinɛtiw hakɛ dɔgɔyali soso kɔda la, olu tun bɛ kɛlɛ kosɛbɛ. Elektɔromiyɔgramu sɛbɛnniw y’a jira ko dɔ bɔra kosɛbɛ motɛri unit seko la kɔkolo fasaw la. Ka fara o kan, ɲininikɛlaw ye kɔrɔbɔli wɛrɛ fana Kɛ. Bpc 157 kɛra tile 4 kɔkolo jogin kɔfɛ, ani Bpc 157 (10μg/kg, 0,16μg/mL, 12ml/rat/day) kɛra ji minta fɛ dɔgɔkun 4 kɔnɔ, ka sɔrɔ kɔlɔsili kulu ye ji minta dɔrɔn de ta. Jateminɛw y’a jira ko wulu minnu furakɛra ni Bpc 157 ye, olu ye ɲɛtaa caman jira, wa u tora ka kɛnɛya fo ka se u kɛnɛya pewu.
Kɔnɔbara basigibaliya kɛlɛli:
Walasa ka kɔkolo basigibaliya bila sosow la, ɲininikɛlaw y’u sinsin ɲɛda fila tigɛli kan ani ka kɔnɔbara basigilen pentadekapɛpɛtidi Bpc 157 furakɛli nafaw sɛgɛsɛgɛ ji minta la [9] .Kalan tɛmɛnenw na, a jirala ko Bpc 157 bɛ kɔkolo jogin, farikolo yɔrɔ jogin, kunsɛmɛ jogin, ani suguya caman ɲɛnabɔ kunsɛmɛnasumaya. Nin ɲinini in na, sosow ye L3-L4 ɲɛda tigɛcogo dafalen kɛ, opereli kɔfɛ, u ye Bpc 157 (10ng/kg, 0,16ng/mL, 12ml/sogo/don) walima ji min dɔrɔn di u ma. Jateminɛw kɛra dɔgɔkun fɔlɔ la ani dɔgɔkun 8. Jateminɛw y’a jira ko dɔgɔkun fɔlɔ la, bɔgɔbɔgɔli jɛlen si ma ye kɔrɔsili kulu ni Bpc 157 kulu sosow la awiyɔn si la, a kɛra i n’a fɔ a ma nɔ bila kɔkolo ni kɔkolo cɛ disiki yɔrɔ la, opereli hakɛ la, sɔgɔsɔgɔninjɛ yɔrɔ bonyalen don dɔɔni, ani Bpc 157 minni kulu kɔnɔ sosow tun bɛ ni a ye kolo bɛɛ lajɛlen hakɛ ka ca. Dɔgɔkun 8nan na, bɔgɔbɔgɔli jɛlen si ma ye kulu fila bɛɛ ka sosow la awiyɔn si la, kɔkolo ni kɔkolo cɛ disiki yɔrɔ ma nɔ bila, farikolojidɛsɛ yɔrɔ min bɛ opereli hakɛ la, o bonyalen don dɔɔni, Bpc 157 kulu kɔnɔ sosow koloci hakɛ tun ka ca kosɛbɛ, wa koloci hakɛ caman ma sɔrɔ cogo la min bɛ ye k’a sɔrɔ a ma kɛ cogo la min bɛ ye kɔrɔsili kulu la. Ka fara o kan, sogo minnu tun bɛ kɔrɔsili kulu la, olu ye farikoloɲɛnajɛ dɛsɛ jɛlen jira joginni daminɛ kɔfɛ dɔrɔn, ka sɔrɔ sogo minnu tun bɛ Bpc 157 minni kulu la, olu ye o farikoloɲɛnajɛ dɛsɛ in kɛlɛ pewu.
Kuncɛli la, Bpc 157 nafa jɔnjɔn bɛ a kɔnɔna ni sigida caman labɛnni jogo la, o bɛ fura kura di funu ma min tɛ se ka furakɛ, farikolo yɔrɔw tiɲɛni, ani hakiliɲagami banaw. Spor joginda siratigɛ la, a bɛ se ka farikolo yɔrɔw dilancogo ni u lasegincogo teliya i n’a fɔ farikolo yɔrɔw, senkɔniw, ani sɔgɔsɔgɔninjɛ, ka kɛnɛya waati surunya, wa a bɛ se ka furakɛli nɔ ɲuman bila joginda jugumanw na. Jeninida furakɛli la, Bpc 157 bɛ se ka endoteliyali farikolokisɛw ka ɲɛnamaya baarakɛcogo ɲɛ kosɛbɛ i n’a fɔ u caya, u jiginni, ani u ka tubabufura, o la, a bɛ jeninida joginda dilan teliya. Ka fara o kan, a bɛ kɔnɔnatumuw tanga, a bɛ se ka kɔnɔbara basigilenw kɛnɛyali sabati, ka kɔnɔboli banaw bali ani ka u nɔgɔya. Bpc 157 fana bɛ seko jira farikoloɲɛnajɛ la, a bɛ farikoloɲɛnajɛ lakana fɛɛrɛw fɛ i n’a fɔ ka funu jaabi dɔgɔya ani ka apoptose bali. A bɛ hadamaden farikolo yɔrɔw fana tanga i n’a fɔ kɔnɔbara, sugunɛ, ani dusukun, o b’a jira ko a bɛ se ka kɛ fɛnɲɛnamaw ye i n’a fɔ pepitiri min bɛ baara caman kɛ.
A sɛbɛnbaga ko la
Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.
Dɔnniya gafe sɛbɛnbaga
Predrag Sikiricis ye dɔnnikɛla ye min ni kalanso caman bɛ ɲɔgɔn na, i n’a fɔ Zagreb Iniwɛrisite, Sarajevo Iniwɛrisite, Sch Med, J. J. Strossmayer Osijek Iniwɛrisite, ani Rudjer Boskovic Iniwɛrisite. A ka ɲininiw bɛ Kɛ dakun caman na i n'a fɔ Farmasi ni Farmasi, Biochimie & Molecular Biology, Gastroenterology & Hepatology, Physiology, ani Cell Biology.
Sikiric ka jɛkulu ye ɲinini caman kɛ BPC157 ka sitoprotective nɔw kan farikolo yɔrɔw ni farikolo yɔrɔ caman na, a jɔyɔrɔ fana bɛ senfagabana joginw ni kɔnɔbara basigilenw na. A ka patenti fana b’a bolo BPC labɛnni na, o ye fura ye min bɛ se ka kɛ furakɛli la, a labɛncogo n’a furakɛli kɛcogo fana sen bɛ o la.Sikiric Pis ye mɔgɔ bonyalen ye kalanko la, wa a ka ɲininiw ye ɲɛtaa caman kɛ a sen bɛ baara minnu na.Sikiric Pis listed in the reference of citation
