Cocer Peptides fɛ 
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BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.
Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.
Kuma bɛɛ lajɛlen
Kolotugudaw (OA) ye kolotugudaw bana basigilen ye min ka teli ka sɔrɔ, a bɛ sɔrɔ kolotugudaw tiɲɛni fɛ, kolotugudaw la kolotuguda la, ani kolotugudaw funu jaabiw, o bɛ banabagatɔw ka ɲɛnamaya kɛcogo tiɲɛ kosɛbɛ. Jamanadenw kɔrɔbayali teliya fɛ, OA sɔrɔli bɛ ka caya, o bɛ doni da jamana ni denbayaw kan.
Jaa 1 Ɲɛgɛnɛsiraw ni kolotugudaw ka bana taamasiɲɛw sumalen. Sɔgɔsɔgɔninjɛ bɛ sɔrɔ funu kɛcogo fɛ min bɛ sɔrɔ farikolo tangalanw ka jaabi bangenenw fɛ, minnu bɛ se ka ladamu ani minnu bɛ kɛ ni sɔgɔsɔgɔninjɛ ye.
Cartilage tiɲɛni ye fɛɛrɛ nafamaba ye OA ka taa ɲɛ. K’a sababu kɛ kolotugudaw yɛrɛdilan seko danma ye, tiɲɛni ka gɛlɛn ka kɛnɛya a yɛrɛ ma, o bɛ na ni bana ka taa ɲɛ dɔɔni dɔɔni. O la, fɛɛrɛ ɲumanw sɔrɔli ka ɲɛsin kolotugudaw tiɲɛni dilancogo ma, o kɛra ɲininiw ɲɛsinnen ye OA furakɛli la.
Cartalax ye biyofarmasi ye min dabɔra kɛrɛnkɛrɛnnenya la walasa ka kolotugudaw tiɲɛni dilancogo sabati. A dacogo kɛrɛnkɛrɛnnen bɛ danfara ka kɛɲɛ ni ɲininiw ni a dilanni taabolo danfaralenw ye, nka a ka c’a la, fɛn caman bɛ sɔrɔ a kɔnɔ minnu bɛ baara kɛ ni fɛnɲɛnamaw ye, fɛn minnu bɛ bɔ selilu kɔkan, ani fɛnw ta minnu bɛ taa ni a ye. Olu cɛma, fɛn minnu bɛ baara kɛ ni fɛnɲɛnamaw ye i n’a fɔ fɛn caman tigɛli-β (TGF-β) ani inisɔn-like growth factor-1 (IGF-1) jɔyɔrɔ ka bon kosɛbɛ kolotugudaw ka caya, u danfara ani u ka matiriyali kɔkanna labɛnni na. Kɔnɔnatumuw kɔkanfɛnw i n’a fɔ kolajɛ ni asidi hyaluronic bɛ farikolo dɛmɛ di kondrositɛriw ma ani u bɛ u sen don selilu nɔrɔli, u jiginni ani taamasiɲɛw cili labɛnni na. Fɛn minnu bɛ taa ni fɛnw ye, olu bɛ kɛ ka biyoaktivi yɔrɔw datugu ani ka u bɔli sabati, o bɛ a to u ka to ka baara kɛ joginda yɔrɔ la.
Cartalax jɔyɔrɔ kolotugudaw joginw dilancogo la
(1) Ka Kɔndrositɛriw caya ni u danfara sabati
Bioactive factors minnu bɛ Cartalax kɔnɔ, i n’a fɔ TGF-β ani IGF-1, olu bɛ taamasiɲɛw siraw baara kondrositɛriw kɔnɔ, ka selilɛriw ka ɲɛtaa sabati ani ka se ka kɔndɔrositɛriw dɛmɛ u ka bɔ lafiya waati la ka taa caya waati la. TGF-β bɛ siri selilu sanfɛla minɛbagaw la walasa ka Smad taamasiɲɛw sira baara, ka selilu sɛrɛkili ni farikolojɔli dumuniw jiracogo ɲɛnabɔ, o la, a bɛ ADN sɔrɔli ni selilɛri tilali sabati kondrositɛriw kɔnɔ. Faan wɛrɛ fɛ, IGF-1 bɛ kondrositɛriw ka apoptose bali PI3K-Akt ni MAPK taamasiɲɛw siraw fɛ ka sɔrɔ ka selilɛriw caya, ka dɔ fara kondrositɛriw hakɛ kan, ani ka selilɛri sɔrɔyɔrɔ bɛnnen di kolotugudaw dilancogo ma.
Kolociw ka taa ɲɛ, kolotugudaw ka fɛnɲɛnamafagalanw ka teli ka Changé, o bɛ sɔrɔ kolosinsinnanw ka matiriyali yɔrɔw labɛnni dɔgɔyali fɛ i n’a fɔ kolajɛ suguya II ni protéoglycans, ani ka dɔ fara kolajɛ suguya fɔlɔ ni matrix metalloprotéinases (MMPs) sɔrɔli kan, o bɛ na ni kolotugudaw tiɲɛni ye. Cartalax bɛ se ka kondrositɛriw ka fɛnɲɛnamafagalanw cogoya ɲuman mara ni a bɛ selilu kɔnɔ taamasiɲɛw cili ni jeninida jirali ɲɛnabɔ, a bɛ kɔndɔrositɛriw ka fɛnɲɛnamafagalanw cogoya ɲuman mara. TGF-β bɛ se ka SOX9 jamu jiracogo kɔrɔta, o min ye sɛbɛnnikɛlan jɔnjɔn ye min bɛ kolajɛ suguya II ni protéoglycans jamu sɛbɛnni sabati, o la, kondrositɛriw ka se ka matiriyali yɔrɔw labɛn minnu bɛ kɛ kariti kɛrɛnkɛrɛnnenw na. Cartalax kɔnɔfɛn dɔw fana bɛ se ka MMPw jirali bali, ka dɔ bɔ farikolo kɔkanna matirili tiɲɛni na, ani ka kolotugudaw dafalen lakana.
(2) Selilu kɔkan matiriyali farikoloɲɛnajɛw labɛnni
Kɔnɔnatumu kɔkanna matirili ye kolotugudaw yɔrɔ nafamaba ye, a bɛ kɛ fɔlɔ ni kolajɛ, protéoglycanes ani fibres élastiques ye. Cartalax bɛ nin farikolo kɔkanna matiriyali yɔrɔw labɛnni sabati ni anaboliki taamasiɲɛw siraw baara ye kondrositɛriw kɔnɔ. Ka fara TGF-β-mediated promotion of the type II collagen and proteoglycan synthesis kan, min kofɔlen don ka tɛmɛ, Cartalax kɔnɔ bonyafɛn wɛrɛw, i n’a fɔ fibroblaste growth factor (FGF), olu fana bɛ se ka baara kɛ ɲɔgɔn fɛ walasa ka kondrositɛriw lawuli walasa u ka se ka extracellular matrix caman dilan. FGF bɛ farikolojɔli seko bonya kondrositɛriw kɔnɔ, ka fɛnɲɛnamafagalan belebelebaw dilanni n’u bɔli sabati i n’a fɔ kolajɛ ni poroteyogilikanw, o bɛ dɔ fara farikolo kɔkanna matirizi kɔnɔfɛnw kan ani ka kolotugudaw ka biyomekaniki cogoyaw ɲɛ.
Kɔnɔbara joginni dilan waati, farikolo kɔkanna matirili labɛncogo kura ye wale ye min bɛ se ka kɛ. Cartalax tɛ dan farikolo kɔkanna matiriyali sɔrɔli dɔrɔn ma, nka a bɛ a labɛncogo kura fana labɛn. A bɛ o sɔrɔ ni balansi labɛnni ye matrix metalloprotéinases (MMPs) ni u tissue inhibiteurs (TIMPs) cɛ. Cartalax bɛ MMPw ka baara bali, ka dɔ bɔ farikolo kɔkanna matiriyali tiɲɛni kojugu la; a bɛ TIMPw jirali sabati, ka dɔ fara u balili nɔ kan MMPw kan, o la, balansi bɛ to selilu kɔkanna matiriyali labɛnni ni a tiɲɛni cɛ, o min bɛ kɛ sababu ye ka kolotugudaw dilancogo ni u labɛncogo kura kɛ cogo labɛnnen na.
(3) A bɛ banakisɛfagalanw kɛlɛ
Funu jaabiw jɔyɔrɔ ka bon OA daminɛni ni a taabolo la. Cartalax bɛ ni funu kɛlɛli fɛɛrɛ dɔw ye, wa a bɛ se ka funubana sitokiniw jiracogo ɲɛnabɔ. Funubana lamini na, Cartalax bɛ se ka funu dɛmɛni sitokiniw bɔli bali i n’a fɔ tumor necrosis factor-α (TNF-α) ani interleukin-1β (IL-1β), ka sɔrɔ ka funu kɛlɛli sitokiniw jirali kɔrɔta i n’a fɔ interleukin-10 (IL-10), o la, a bɛ sigida kolotugudaw funu nɔgɔya ani ka microenvironnement ɲuman dilan kolotugudaw dilancogo.
Cartalax tali kolotugudaw furakɛli la
(1) Baganw ka kɔrɔbɔli kalanw
Baganw ka kɔrɔbɔliw la, ɲininikɛlaw ye OA baganw ka misali suguya caman sigi sen kan, i n’a fɔ sosow ka OA misali min bɛ sɔrɔ ɲɛfɛla kurukuruw tigɛcogo fɛ (ACLT) ani laɲɔ OA misali min bɛ lawuli papayi fɛ, walasa ka Cartalax nafa jateminɛ kolotugudaw tiɲɛni dilancogo la. Kɔrɔbɔliw jaabiw y’a jira ko Cartalax ka baara kɛlen kɔfɛ, farikolo yɔrɔw sɛgɛsɛgɛli y’a jira ko ɲɛtaa caman kɛra kolotugudaw ɲɛda nɔgɔyali la, selilɛriw jɔcogo la, ani selilu kɔkan matiriyali yɔrɔw la. Kɔrɔbɔli kulu kɔnɔ, kolotugudaw tiɲɛni hakɛ dɔgɔyara kosɛbɛ, o b’a jira ko Cartalax bɛ dɔ bɔ kosɛbɛ kolotugudaw tiɲɛni juguya la.
Immunohistochimique ani molecular biologique analyses y’a jira ko cartilage kɛrɛnkɛrɛnnen taamasiɲɛw jiracogo hakɛ cayara ani ka dɔ bɔ anzimu tiɲɛnifɛnw jirali hakɛ la i n’a fɔ MMPs Cartalax furakɛli kulu la, o ye a jɔyɔrɔ sinsin ka t’a fɛ kolotugudaw dilancogo sabatili la ani ka extracellular matrix metabolism labɛn.
(2) Dɔgɔtɔrɔso baarakɛcogo ɲinini
Hali ni Cartalax bɛ ɲinini senfɛ hali bi walasa ka furakɛli kɛ, kɛnɛyaso ka sɛgɛsɛgɛli fɔlɔ dɔw fɔra. Kartalakisi ka kan ka kɛ fɔlɔ banabagatɔw ma minnu kolotugudaw ka jugu fo ka se a danma ma, kɛrɛnkɛrɛnnenya la minnu ka kolotugudaw tiɲɛna. Ni koloci daminɛ na, ni kolotugudaw tiɲɛni bɛ se ka kɔsegin hali bi, Cartalax bɛ se ka bana taabolo sumaya ka ɲɛ ani ka kolotugudaw tiɲɛni dilan ka ɲɛ, a kɛtɔ ka kolotugudaw caya, ka farikolo kɔkanna matiriyali farikoloɲɛnajɛ labɛn, ani ka funu jaabiw dɔgɔya. Cartalax bɛ se ka kɛ fana opereli furakɛli dɛmɛnan ye, a bɛ kɛ jolilabanaw opereli kɔfɛ walima kolotugudaw dilan opereli kɔfɛ walasa ka kolotugudaw kɛnɛyali ni u dilancogo sabati.
Kuncɛli
Kuma surun na, Cartalax bɛ sebaayaba jira kolotugudaw tiɲɛni na kolotugudaw furakɛli la. Ni an bɛ baara kɛcogo jateminɛ, a bɛ kolotugudaw caya ani ka u danfara sabati, ka farikolo kɔkanna matiriyali farikoloɲɛnajɛ labɛn, ani ka banakisɛfagalanw kɛ, o la, a bɛ kolotuguda tiɲɛnenw dilan ani k’u lakana ka bɔ yɔrɔ caman na.
Sosow (Sɔrɔyɔrɔw).
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Fɛn min bɛ sɔrɔ ɲininiw dɔrɔn kama:
