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1kits (10Vials) .
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▎ AOD 9604 ƒe Dɔwɔɖoɖo
Dzɔtsoƒe: PubChem |
Nusiwo kplɔ wo nɔewo ɖo: SALLRSIPAPAGASRLLLLTGEIDLP Molekyulãwo ƒe Mɔfiame: C 78H 123N 23O 23S2 Molekyulãwo ƒe Kpekpeme: 1815.1g/mol CAS ƒe xexlẽdzesi: 221231-10-3 PubChem ƒe CID: 71300630 |
▎ AOD 9604 Numekuku
Nukae nye numekuku si wowɔ le AOD 9604 ŋu?
AOD 9604 nye peptide si wowɔ tso amegbetɔ ƒe tsitsi ƒe lãmetsi (hGH) ƒe C-nuwuƒe kakɛ, vevietɔ amino acid ƒe ɖoɖo 177 - 191, si me tyrosine ƒe nugbagbevi bubu aɖe le le peptide la ƒe N-nuwuƒe.
Ƒomedodo si le AOD 9604, tsitsi ƒe lãmetsi, kple lolo akpa ƒe atikewɔwɔ domee nye esi gbɔna. Togbɔ be ŋutete le amegbetɔ ƒe tsitsi ƒe lãmetsi (hGH) ŋu be wòada lolo akpa hã la, dedienɔnɔnyawo xea mɔ na eŋudɔwɔwɔ ɣeyiɣi didi. Abe hGH ƒe C-nuwuƒe kakɛ ene la, wobu AOD 9604 be ate ŋu awɔ akpa aɖe le lolo akpa dada me evɔ mahe hGH ƒe ŋusẽkpɔɖeamedzi gbegblẽwo vɛ o. Numekukuwo ɖee fia be hGH kple AOD 9604 siaa ate ŋu ana ame ƒe lolome naɖiɖi eye wòana lipolytic sensitivity nadzi ɖe edzi le atikewɔwɔ ɣeyiɣi didi le sisiblisiwo me megbe. Mɔnu ɖeka si ate ŋu awɔe nye to kadodo kple β-adrenergic mɔa, vevietɔ kple beta (3)-adrenergic receptors (β3-AR) [1]. .
hGH kple AOD 9604 siaa ate ŋu aɖe mice lolo akpa ƒe ŋutilã ƒe kpekpeme kple ami dzi akpɔtɔ, eye emetsonu sia do ƒome kple β3-AR RNA, si nye lipolytic receptor vevitɔ le adipocytes me ƒe ɖeɖefia ƒe agbɔsɔsɔ si dzi ɖe edzi. Vevietɔ la, hGH kple AOD 9604 siaa ate ŋu ana β3-AR RNA ƒe agbɔsɔsɔ si woxe mɔ na le sisiblisi siwo lolo akpa me nadzi ɖe edzi va ɖo agbɔsɔsɔ si sɔ kple esi le sisiblisi siwo me lãmesẽ mele o me [1]. .
Gake le β3-AR knockout mice me la, hGH kple AOD 9604 zazã ɣeyiɣi didi mete ŋu na kpekpeme ƒe tɔtrɔ kple lipolysis ƒe dzidziɖedzi si wokpɔ le gbemelã ƒomevi siwo wotsɔ ɖua wo dzi me o. Gake le dodokpɔ sesẽwo me la, AOD 9604 ate ŋu ana ŋusẽzazã kple ami ƒe oxidation nadzi ɖe edzi le β3-AR knockout mice me [1]..
Ƒumeŋuɖui dada: AOD 9604 dodo ɖe ƒunukpeƒewo ɖe ƒunukpeƒetetedɔ ƒe dɔdada ƒe ŋusẽkpɔɖeamedzi aɖewo fia le avugbɔ̃e ƒe ƒunukpeƒetetedɔ ƒe kpɔɖeŋu aɖe me. Numekuku si Kwon Dong Rak kple Park Gi Young wɔ ɖee fia be AOD 9604 dodo ɖe ʋuka me to ultrasound dzi doa ŋusẽ ƒunukpeƒetetedɔ ƒe gbugbɔgadzɔ, eye AOD 9604 kple hyaluronic acid (HA) dodo ƒo ƒu wɔa dɔ wu HA alo AOD 9604 ɖeɖeko zazã [2]. .
Woka nya ta be AOD 9604 srɔ̃a tsitsime lãmetsiŋusẽ ƒe lipolytic nɔnɔmewo evɔ suklidɔ hehe vɛ ƒe nugbegblẽ le ame ŋu menɔa eŋu o. Eyata woate ŋu azãe abe atike si doa ŋusẽ ame ƒe dɔwɔwɔ ene eye Xexeame ƒe Dɔwɔha si Tsi Tre Ðe atike muamewo Zazã Ŋu (WADA) de se ɖe enu [3]..
Numekuku si wowɔ tso AOD 9604 ŋu koŋ tso tsitretsitsi ɖe ŋutete si le amegbetɔ ƒe tsitsimeŋusẽ ŋu le lolo akpa dada me kple eƒe dedienɔnɔnyawo dome gbɔ. Le ɣeyiɣi ma ke me la, esi lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔlélewo le dzidzim ɖe edzi ta la, akpa si wòate ŋu awɔ le lãmenugbagbeviwo ƒe lãmesẽ kple eƒe dedienɔnɔ dodo ɖe ŋgɔ me va zu nusi ŋu numekukuwo ku ɖo.
Nukae nye nɔnɔme kple viɖe siwo le AOD 9604 ƒe dɔwɔwɔ ƒe mɔnu ŋu le lolo dzi ɖeɖe kpɔtɔ kple lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe ɖoɖowɔwɔ me?
Gbã la, le lipolysis gome la, AOD 9604 doa lipolysis ƒe seselelãme ɖe ŋgɔ ŋutɔ to β3-adrenergic receptor (β3-AR) mɔ si le adipocytes ƒe dɔwɔwɔ me. Dɔwɔwɔ sia nana ami lãmenugbagbeviwo te ŋu mãa triglyceride siwo wodzra ɖo me nyuie wu zua ami siwo me ami mele o kple glycerol, si wɔnɛ be ami ƒe gbegblẽ kple eŋudɔwɔwɔ be wòana ŋusẽ ŋutilãa. Menye ɖeko nuwɔna sia kpena ɖe ame ŋu be ami ƒe ƒoƒo ɖe ŋutilã me dzi ɖena kpɔtɔna ko o, ke enaa ami si le ŋutilãa me ƒe mama nyona ɖe edzi, eɖea ami si le dɔgboa me ƒe agbɔsɔsɔ dzi kpɔtɔna, eye wòtoa esia me ɖea dɔléle vovovo siwo do ƒome kple lolo akpa, abe dzitodzito me dɔlélewo kple suklidɔ ƒomevi evelia ene, xɔxɔ ƒe afɔkua dzi kpɔtɔna.
Evelia, AOD 9604 hã wɔa dɔ nyuie le mɔxexe ɖe lipogenesis nu me. Ate ŋu axe mɔ na ami si le nuɖuɖu si woɖu me be wòagatrɔ zu ŋutilã me ami o to domenyiŋusẽfianu siwo do ƒome kple ami ƒe wɔwɔme ƒe ɖeɖefia dzi kpɔkpɔ me. Etɔxɛe la, AOD 9604 ate ŋu axe mɔ ɖe ami ƒe dɔwɔwɔ veviwo abe ami si woyɔna be fatty acid synthase ene ƒe dɔwɔwɔ nu, si ana ami ƒe wɔwɔme kple wo dzadzraɖo dzi naɖe akpɔtɔ. Mɔxexeɖedɔ sia kpena ɖe ame ŋu be ami lãmenugbagbeviwo ƒe dzidziɖedzi kple vovototodedeameme dzi ɖena kpɔtɔna eye wòxea mɔ na ami ƒe lãkusiwo ƒe keke fũ akpa, si wɔnɛ be wokpɔa lolo dzi ɖeɖe kpɔtɔ ƒe ŋusẽkpɔɖeamedzi. Le ɣeyiɣi ma ke me la, mɔxexeɖedɔléle nu ƒe ŋusẽkpɔɖeamedzi sia ate ŋu akpe ɖe ŋutilãa ƒe ami ƒe asitɔtrɔ le lãme na ame ŋu hã be wòada asɔ eye wòaƒo asa na lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe kuxi siwo ami ƒe ƒuƒoƒo fũ hena vɛ.
Le lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe ɖoɖowɔwɔ gome la, akpa si AOD 9604 wɔna la sesẽ wu eye wòkeke ta wu. Ate ŋu atrɔ ŋutilã ƒe ŋusẽ ƒe asitɔtrɔ tso sukli ƒe asitɔtrɔ dzi ayi ami ƒe asitɔtrɔ dzi, eye tɔtrɔ sia le vevie ŋutɔ na lolo dzi ɖeɖe kpɔtɔ kple lãmenugbagbeviwo ƒe lãmesẽ dodo ɖe ŋgɔ. To ami ƒe oxidative decomposition dzi ɖeɖe kpɔtɔ me la, AOD 9604 naa ŋusẽtsoƒe geɖe ŋutilãa eye wòɖea ŋuɖoɖo ɖe sukli ƒe asitɔtrɔ ŋu dzi kpɔtɔna. Menye ɖeko lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe ɖoɖo sia kpena ɖe ame ŋu wòdzia basal metabolic rate ɖe edzi, si wɔnɛ be ŋutilãa zãa ŋusẽ geɖe le ɖiɖiɖemeɣi o, ke enaa insulin ƒe seselelãme hã nyona ɖe edzi, edoa sukli ƒe xɔxlɔ̃ kple eŋudɔwɔwɔ ɖe ŋgɔ, eye wòtoa esia me léa sukli ƒe agbɔsɔsɔ si le ʋu me la li ke. Gakpe ɖe eŋu la, lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe ɖoɖowɔwɔ ƒe ŋusẽkpɔɖeamedzi sia hã kpena ɖe ami ƒe tsɔtsɔ ɖe ŋutinuwo abe aklã ene me dzi ɖeɖe kpɔtɔ ŋu, si xea mɔ na lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔlélewo abe aklã si me ami le ene eye wònaa wo nyona ɖe edzi.
Mlɔeba la, viɖe tɔxɛ aɖewo le AOD 9604 ŋu le insulin ƒe dɔlélenutsiŋutete dzi ɖeɖe kpɔtɔ me. Ne wotsɔ AOD 9604 sɔ kple tsitsi ƒe lãmetsi bliboa la, eɖea nugbegblẽ siwo ate ŋu ana insulin ƒe dɔlélenutsiŋutete kple sukli nadzi ɖe edzi le ʋu me la ɖa. Dɔwɔwɔ nyuie sia na AOD 9604 le dedie le atikewɔwɔa me eye makpɔ ŋusẽ gbegblẽ ɖe sukli ƒe agbɔsɔsɔ le ʋu me dzi o. Esia le vevie ŋutɔ le atikewɔwɔ me na dɔnɔ siwo lolo akpa, vevietɔ amesiwo ƒe insulin mete ŋu nɔa te ɖe dɔlékuiwo nu o alo amesiwo ƒe ʋumesukli mesɔ o. Menye ɖeko AOD 9604 ate ŋu akpe ɖe wo ŋu woaɖe woƒe lolo dzi akpɔtɔ ko o, ke ate ŋu ana insulin ƒe dɔwɔwɔ nanyo ɖe edzi, aɖe suklidɔ ƒomevi eve xɔxɔ ƒe afɔkua dzi akpɔtɔ, eye wòana lãmenugbagbeviwo ƒe lãmesẽ bliboa nanyo ɖe edzi.
Le nyataƒoƒo me la, AOD 9604 wɔa eƒe ŋusẽkpɔɖeamedzi ɖe lolo dzi ɖeɖe kpɔtɔ kple lãmenugbagbeviwo ƒe dɔwɔwɔ dzi to dɔwɔwɔ ƒe mɔnu vovovowo dzi, si naa tiatia yeye kple mɔkpɔkpɔ na lolo akpa kple lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔlélewo dada.
Dɔ si AOD9604 wɔna ɖe Zucker (fa/fa) lãwo ƒe kpekpeme dzi ɖeɖe kpɔtɔ dzi. Wona AOD9604 Ìg 500 Ìg le nu me gbesiagbe hena ŋkeke 20 sɔŋ, eye lã siwo wodo kpɔ (P) xɔa dze agbɔsɔsɔme si sɔ gbesiagbe le mɔ ma ke nu. Emetsonuwo nye lã 8 ƒe B SEM ƒe mama dedie. Wotsɔ ɣletividzesi ɖe vovototo ɖedzesiwo fia.
Dzɔtsoƒe:PubMed [5] .
Kadodo tɔxɛ kawo dzie AOD 9604 tona kpɔa ŋusẽ ɖe ami ƒe asitɔtrɔ le lãmenugbagbeviwo ŋu dzi?
Kadodo kple β-adrenergic mɔ: Numekukuwo ɖee fia be hGH kple lipolytic fragment AOD 9604 si wowɔ tso eƒe C-nuwuƒe ateŋu ana lolo dzi naɖe akpɔtɔ eye wòana lipolytic sensitivity nadzi ɖe edzi le atikewɔwɔ ɣeyiɣi didi le mice me megbe [4] . Mɔnu ɖeka si ate ŋu awɔe nye to kadodo kple β-adrenergic mɔa, vevietɔ kple β3-adrenergic receptor (β3-AR). Le mi siwo lolo akpa me la, hGH kple AOD 9604 ate ŋu ana β3-AR RNA ƒe ɖeɖefia ƒe agbɔsɔsɔ nadzi ɖe edzi eye ate ŋu ana β3-AR RNA ƒe agbɔsɔsɔ si wote ɖe anyi le mi siwo lolo akpa me nadzi ɖe edzi va ɖo agbɔsɔsɔ si sɔ kple esi le mi siwo me lã mele o me. Gake atikewɔwɔ na β3-AR knockout mice ɣeyiɣi didi aɖe kple hGH kple AOD 9604 mete ŋu na kpekpeme ƒe tɔtrɔ kple lipolysis ƒe dzidziɖedzi si wokpɔ le gbemelã ƒomevi siwo dzi woɖu me o. Gake le dodokpɔ sesẽwo me la, AOD 9604 ate ŋu ana ŋusẽzazã kple ami ƒe oxidation nadzi ɖe edzi le β3-AR knockout mice me. Esia ɖee fia be hGH kple AOD 9604 ƒe lipolytic ŋusẽkpɔɖeamedziwo metoa β3-AR dzi tẽ o, togbɔ be wo ame evea siaa ate ŋu ana β3-AR ƒe ɖeɖefia nadzi ɖe edzi hã, si ate ŋu akpe ɖe lipolytic ƒe seselelãme ŋu emegbe.
Ami ƒe oxidation ƒe dzidziɖedzi kple lipolysis si doa ŋusẽ ame: Le C57BL/6J mice siwo lolo akpa (ob/ob) kple esiwo me lãmesẽ mele o me la, woate ŋu akpɔ amegbetɔ ƒe tsitsi ƒe lãmetsi (hGH) kple AOD 9604 (hGH ƒe C-nuwuƒe kakɛ) ƒe ŋusẽkpɔɖeamedzi atraɖii le ŋutilã ƒe kpekpeme, ŋusẽ ƒe dadasɔ, kple substrate oxidation ƒe agbɔsɔsɔme dzi. hGH kple AOD 9604 siaa ɖe mice lolo akpa ƒe kpekpeme dzi kpɔtɔ ŋutɔ, si do ƒome kple ami ƒe oxidation ƒe dzidziɖedzi le ŋutilã me kple plasma glycerol ƒe agbɔsɔsɔ si dzi ɖe edzi (si nye ami ƒe ʋuʋu ƒe dzesi). To vovo na hGH la, AOD 9604 mehea suklidɔ ƒe dzidziɖedzi vɛ alo ɖea insulin ƒe dodo dzi kpɔtɔna o. AOD 9604 meʋlia ho kple hGH xɔla o eye meʋãa lãmenugbagbeviwo ƒe dzidziɖedzi abe hGH ene o. Esia gaɖo kpe nukpɔsusu si nye hGH be enye prohormone dzi, si fia be hGH ƒe kakɛ ate ŋu awɔ dɔ le mɔ si to vovo na hGH ƒe ʋuʋu ƒe mɔnu si wozãna tsã la nu [4]. .
Nukae nye ŋusẽ si AOD 9604 kpɔna ɖe aklã dzi?
Dɔ si AOD 9604 wɔna ɖe aklã dzi la dzena le eƒe ɖoɖowɔwɔ ɖe ami ƒe asitɔtrɔ ŋu me. Abe polypeptide si wowɔ si srɔ̃a amegbetɔ ƒe tsitsi ƒe lãmetsi (hGH) ƒe lipolytic functional domain ene la, AOD 9604 ate ŋu ado lipolysis ɖe ŋgɔ, axe mɔ ɖe lipogenesis nu, eye wòatrɔ ŋutilã ƒe ŋusẽ ƒe asitɔtrɔ tso sukli ƒe asitɔtrɔ dzi ayi ami ƒe asitɔtrɔ dzi. Dɔwɔwɔ ƒe mɔnu sia kpena ɖe ame ŋu be ami ƒe ƒuƒoƒo ɖe aklãa me dzi ɖena kpɔtɔna, si wɔnɛ be aklãa kpɔa ta vaseɖe afi aɖe. Le lãmenugbagbeviwo ƒe dɔwɔwɔ abe aklã si me ami le ene gome la, AOD 9604 ƒe lolome dzi ɖeɖe kpɔtɔ kple lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe ɖoɖowɔwɔ ƒe ŋusẽkpɔɖeamedzi ate ŋu akpe ɖe aklã ƒe ami ƒe asitɔtrɔ ƒe nɔnɔme ŋu wòanyo ɖe edzi, aɖe agba si le aklãa dzi dzi akpɔtɔ, eye wòato esia me ana aklã ƒe dɔwɔwɔ nanyo ɖe edzi. Gake fifia la, numekuku ʋɛ aɖewo koe li tẽ tso ŋusẽ si AOD 9604 kpɔna ɖe aklã dzi ŋu. Wonɔ te ɖe ŋusẽ si wòkpɔna ɖe ami ƒe asitɔtrɔ dzi koŋ dzi bua ŋusẽkpɔɖeamedzi siwo le etame, eye egahiã kokoko be woawɔ dzɔdzɔmeŋutinunya me numekuku geɖe wu be woatsɔ aɖo kpe aklã takpɔkpɔ ƒe ŋusẽkpɔɖeamedzi tɔxɛwo kple alesi wòwɔa dɔe dzi.
Nukae nye AOD 9604 ƒe vevienyenye?
AOD 9604 nye polypeptide si wowɔ si srɔ̃a amegbetɔ ƒe tsitsi ƒe lãmetsi (HGH) ƒe lipolytic functional domain, eye asixɔxɔ si le eŋu le atikewɔwɔ me la ɖe dzesi ŋutɔ. Le lolo akpa kple lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔlélewo dada me la, AOD 9604 ate ŋu ado ami ƒe ʋuʋu ɖe ŋgɔ nyuie, axe mɔ ɖe ami ƒe dzɔdzɔ nu, eye wòaɖɔ ŋutilã ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ɖo, akpe ɖe lolo akpa dɔnɔwo ŋu be woaɖe woƒe lolo dzi akpɔtɔ, woana ŋutilã ƒe wɔwɔme nanyo ɖe edzi, eye asixɔxɔ si ate ŋu azãe le lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔlélewo abe aklã si me ami le ene dada me. Ne wotsɔe sɔ kple tsitsi ƒe lãmetsi bliboa la, eɖea nugbegblẽ siwo ate ŋu ana insulin ƒe dɔlélenutsiŋutete kple sukli nadzi ɖe edzi le ʋu me la ɖa, eyata ele dedie wu le atikewɔwɔa me eye wòsɔ na dɔnɔ geɖe wu.
AOD 9604 ƒe vevienyenye le vevie le atikewo ŋuti numekuku kple wo wɔwɔ me. Abe lolo dzi ɖeɖe kpɔtɔ ƒe atike si ƒe dɔwɔwɔ ƒe mɔnu tɔxɛ aɖe le ene la, enaa tiatia yeye aɖe hena lolo akpa dada, eɖea ŋutete si le polypeptide atikewo ŋu le lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔlélewo dada me fiana, eye wònaa susu yeyewo kple numekuku ƒe mɔfiamewo hena lolo dzi ɖeɖe kpɔtɔ ƒe atike siwo le dedie wu eye wowɔa dɔ nyuie wu la toto vɛ emegbe. Tsɔ kpe ɖe eŋu la, AOD 9604 ƒe wɔwɔme kple numekuku do polypeptide atikewo ƒe akpaa ƒe ŋgɔyiyi ɖe ŋgɔ, woɖo kpe polypeptide atikewo ƒe dɔwɔwɔ dzi le ŋutilã ƒe dɔwɔwɔ tɔxɛwo sɔsrɔ̃ kple wo dzi kpɔkpɔ me le ŋutilã me, eye wòna nuteƒekpɔkpɔ vevi aɖe mí le polypeptide atikewo ƒe wɔwɔme, wo wɔwɔ, kple wo zazã nyuie wu me.
Le agbenɔnɔ si me lãmesẽ le dodo ɖe ŋgɔ me la, woate ŋu azã AOD 9604 abe kpekpeɖeŋunu ene atsɔ akpe ɖe amewo ŋu woaɖu woƒe kpekpeme dzi eye woalé nɔnɔme nyui me ɖe asi. Lolo akpa nye kuxi gã aɖe le egbegbe hadomegbenɔnɔ me, eye eƒe lolo dzi ɖeɖe kpɔtɔ ƒe ŋusẽkpɔɖeamedzi ate ŋu ana kpekpeɖeŋu bubu amesiwo ƒe lolo dzi ɖeɖe kpɔtɔ sesẽna to nuɖuɖu bɔbɔe kple kamedede me. Le ɣeyiɣi ma ke me la, to ami ƒe asitɔtrɔ le lãme na ame ŋu me la, ekpena ɖe ame ŋu be ŋutilã ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ nanyo ɖe edzi, eɖea ʋumemi ƒe agbɔsɔsɔ dzi kpɔtɔna, eɖea ami ƒe gege ɖe ʋukawo me dzi kpɔtɔna, eɖea dɔléle siwo do ƒome kple lãmenugbagbeviwo ƒe dɔwɔwɔ abe dzitodzito me dɔlélewo ene xɔxɔ ƒe afɔkua dzi kpɔtɔna, eye wònaa agbenɔnɔ nyona ɖe edzi.
AOD 9604 hã wɔa akpa vevi aɖe le numekuku veviwo dodo ɖe ŋgɔ me. Eƒe numekukuwo kpena ɖe ame ŋu be woaku alesi amegbetɔ ƒe tsitsi ƒe lãmetsiŋusẽ wɔa dɔe me tsitotsito, vevietɔ akpa tɔxɛ si wòwɔna kple dzesimɔ si wòwɔna le ami ƒe asitɔtrɔ le lãme na ame ƒe ɖoɖowɔwɔ me. To numekuku si wowɔ le AOD 9604 ŋu me la, dzɔdzɔmeŋutinunyalawo ate ŋu ase alesi tsitsiŋusẽ wɔa eƒe ŋutilã ƒe dɔwɔwɔwoe to kadodo si le domenyiŋusẽfianu tɔxɛwo kple lãmenugbagbevi siwo xɔa dɔlékuiwo dome, kple alesi dɔwɔwɔ siawo trɔna le ŋutilã kple dɔléle ƒe nɔnɔme vovovowo me gɔme nyuie wu. Tsɔ kpe ɖe eŋu la, woate ŋu azã AOD 9604 abe numekuku dɔwɔnu ene hena numekuku siwo ku ɖe ami ƒe asitɔtrɔ le lãmenugbagbeviwo ŋu, si akpe ɖe dzɔdzɔmeŋutinunyalawo ŋu woasrɔ̃ nu tso ami ƒe gbegblẽ, dzidzi, kple lãmenugbagbeviwo ƒe dzesiwo ƒe tɔtrɔ ƒe ɖoɖowo ŋu, aɖe molecule ƒe mɔnuwo kple ami ƒe asitɔtrɔ ƒe ɖoɖowɔwɔ ƒe kadodowo afia, eye wòana nukpɔsusu ƒe gɔmeɖoanyi na atikewɔwɔmɔnu kple atikewo toto vɛ na ami ƒe asitɔtrɔ si mesɔ o.
Journal ŋlɔla
Heffernan, MA do ƒome kple Limerick Yunivɛsiti eye wòle vevie dom nu le sukunusɔsrɔ̃ geɖe me. Esiawo dometɔ aɖewoe nye Endocrinology & Metabolism, afisi numekuku ate ŋu aku ɖe lãmetsiŋusẽ ƒe dɔwɔwɔ kple lãmenugbagbeviwo ƒe dɔwɔwɔ le ŋutilã me ŋu le. Le Polymer Science me la, woƒe dɔa ate ŋu abia be woasrɔ̃ nu tso polymer-nuawo, woƒe wɔwɔme, woƒe nɔnɔmewo, kple wo zazã ŋu. Dzɔdzɔmeŋusẽŋununya aƒo nu tso nugbagbewo ƒe dɔwɔwɔ kple woƒe dɔwɔwɔ ŋu, gake Nutrition & Dietetics ya ku ɖe nuɖuɖu, nunyiame, kple nuɖuɖu ŋuti dzɔdzɔmeŋutinunya ŋu.
Le Agbalẽŋlɔla La Ŋu
Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.
Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla
Heffernan ƒe numekuku ate ŋu aku nu me le akpa siawo ƒe tsatsam ŋu, abe atikewo nana ƒe ɖoɖo siwo wotu ɖe polymer dzi toto vɛ na lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe kuxiwo alo nusɔsrɔ̃ tso nunyiame ƒe nudede nyawo me ƒe ŋusẽkpɔɖeamedzi ɖe ŋutilã dzi to nuwo ŋuti dzɔdzɔmeŋutinunya ƒe mɔnu deŋgɔwo zazã me ene. Woƒe dɔa kpena ɖe ame ŋu wòsea nugbagbewo ƒe dɔwɔwɔ gɔme nyuie wu eye wòtoa egbɔkpɔnu yeyewo vɛ le lãmesẽnyawo kple ŋutilãmenunya me. Woŋlɔ Heffernan, MA ŋkɔ ɖe nyayɔyɔ ƒe nyatakaka me [4].
