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1 kits (10 Vials)
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▎ Tsarin Sermorelin
Source: PubChem |
Jeri: YADAXFXNSYRKVLGQLSARKLLQDXMSR Tsarin Halitta: C 149H 246N 44O 42S Nauyin Kwayoyin Halitta: 3357.9 g/mol Lambar CAS: 86168-78-7 PubChem CID: 16129620 Synonyms: Sermorelin (INN) ;CHEBI: 9118 |
▎ Binciken Sermorelin
Menene Sermorelin?
Sermorelin shine analog na roba na haɓakar sakin hormone girma (GHRF). Babban aikinsa shine ɗaure ga masu karɓar hormone mai sakin hormone (GHRH) a cikin glandan pituitary na baya, kunna hanyoyin siginar intracellular (kamar hanyar cAMP / PKA), haɓaka haɓakawa da sakin hormone girma na endogenous (GH), don haka inganta haɓaka da haɓaka yara. An fi amfani dashi don magance rashi na hormone girma na farko (ci gaban girma a cikin yara wanda ya haifar da rashin isasshen aikin pituitary). Ta hanyar maido da ɓoyewar GH, zai iya inganta haɓaka tsayi da aiki na rayuwa. Ba kamar recombinant girma na ɗan adam hormone, wanda kai tsaye kari exogenous GH, Sermorelin dogara da pituitary gland shine yake da ikon mugunyar kansa kuma ya dace da marasa lafiya da al'ada pituitary aiki amma kasa GHRH.
Menene asalin bincike na Sermorelin?
Binciken bincike na Sermorelin ya samo asali ne daga muhimmiyar rawa na hormone girma a cikin ci gaban mutum da ci gaba. Rashin ƙarancin girma na farko na iya haifar da haɓaka girma a cikin yara kuma yana shafar tsayin su na ƙarshe. Sabili da haka, gano ingantattun hanyoyin magani koyaushe ya kasance muhimmin batu a cikin binciken likita. Ko da yake an yi amfani da hormone girma na ɗan adam recombinant shekaru da yawa kuma ya haifar da karuwa mai yawa a cikin tsayin ƙarshe na yara masu ƙarancin haɓakar hormone girma, tare da zurfafa bincike na likita, mutane kuma suna neman ƙarin zaɓuɓɓukan magani da ingantaccen tsarin kulawa. A kan wannan yanayin, Sermorelin, a matsayin sinadari mai sakin hormone girma na ɗan adam, ya fito. Ta hanyar ƙarfafa sakin hormone girma, ya kawo sabon bege don maganin raunin hormone girma kuma ya inganta girma da ci gaban yara.
Tsarin Aiki
Menene takamaiman tsarin Semorelin a cikin kula da ƙarancin girma na farko?
Tushen aikin Semorelin
A matsayin ma'aunin sakin hormone girma, Sermorelin galibi yana aiwatar da tasirin sa ta hanyar ɗaure ga takamaiman masu karɓa. Yana kwaikwayi aikin sinadari mai sakin hormone girma a cikin jikin mutum kuma yana ƙarfafa glandar pituitary na gaba don sakin hormone girma. Wannan tsarin aikin yana kama da na sauran abubuwan haɓaka hormone masu haɓakawa, kamar haɓakar hormone mai sakin peptides (GHRPs).
Ƙarfafa sakin hormone girma
Matsayin tsari na axis hypothalamic-pituitary:
Sermorelin wani abu ne mai sakin hormone girma na ɗan adam. A karkashin yanayi na al'ada, ɓoyewar hormone girma a cikin jikin mutum yana da ƙayyadaddun tsari ta hanyar hypothalamic-pituitary axis. Hypothalamus yana ɓoye hormone mai sakin hormone (GHRH), wanda ke motsa glandar pituitary na gaba don haɗawa da ɓoye hormone girma (GH). Sermorelin yana kwaikwayon aikin GHRH, yana ɗaure ga takamaiman masu karɓa a cikin hypothalamus, kuma yana haɓaka glandar pituitary don sakin hormone girma.
Kunna hanyar sigina :
Bayan ɗaure ga mai karɓa, Sermorelin yana kunna hanyar siginar intracellular. Wannan na iya haɗawa da jerin halayen enzymatic da tsarin manzo na biyu, a ƙarshe yana haifar da karuwa a cikin haɗuwa da sakin hormone girma. Alal misali, yana iya kunna adenylate cyclase, ƙara matakin cAMP na ciki, sannan kunna furotin kinase A, inganta rubutun da fassarar kwayar halittar hormone girma.
Tasiri akan ƙarancin hormone girma
Inganta haɓaka da haɓakawa:
Yaran da ke da ƙarancin girma na hormone yawanci suna nuna jinkirin girma da ɗan gajeren tsayi. Sermorelin yana rama rashi na hormone girma a cikin jiki ta hanyar ƙarfafa sakin hormone girma. Hormone mai girma zai iya yin aiki kai tsaye akan kasusuwa, tsokoki, da sauran kyallen takarda, inganta haɓakar ƙwayoyin cuta da bambance-bambance, don haka inganta haɓaka da haɓaka. Hakanan hormone girma na iya haɓaka gabobin jiki kamar hanta don haɗar insulin-kamar girma factor-1 (IGF-1), kuma IGF-1 yana ƙara yin tasiri mai haɓaka haɓaka.
Inganta aikin metabolism:
Rashin ƙarancin hormone girma ba kawai yana rinjayar girma da haɓaka ba amma yana iya haifar da rashin lafiya na rayuwa. Maganin Semorelin na iya inganta aikin rayuwa, kamar haɓaka haɗin furotin, haɓaka rushewar mai, da haɓaka amfani da glucose. Wadannan canje-canje na rayuwa suna taimakawa wajen kula da ayyukan ilimin lissafi na al'ada na jiki da kuma inganta rayuwar marasa lafiya.
Bambance-bambancen tsayi-SDS a cikin yaran da ke da cututtukan nama da aka yi da su tare da magungunan halitta.
Source:PubMed [1]
Menene aikace-aikacen Semorelin?
Jiyya na raunin hormone girma:
Rashin ƙarancin girma na farko zai iya haifar da jinkirin girma da ci gaba a cikin yara kuma yana shafar tsayin su na ƙarshe. An yi amfani da hormone girma na ɗan adam recombinant a asibiti tsawon shekaru da yawa kuma ya haifar da karuwa mai yawa a tsayin ƙarshe na yara masu ƙarancin girma na hormone. A matsayin ma'aunin sakin hormone girma, Semorelin kuma yana taka muhimmiyar rawa wajen magance rashi hormone girma.
Sermorelin yana haɓaka girma da haɓakar yara ta hanyar ƙarfafa glandar pituitary don ɓoye hormone girma. Yana iya kwaikwayi tsarin sakin hormone girma na jiki, ƙara matakan girma hormone, don haka inganta haɓakar ƙashi da haɓakar jiki. Idan aka kwatanta da recombinant hormone girma na mutum, Semorelin yana da wasu fa'idodi na musamman. Misali, yana iya samun mafi kyawu da juriya da aminci, rage wasu illa masu illa.
Menene tasirin warkewar Sermorelin a cikin yara masu nau'ikan cututtuka daban-daban ko cututtukan ƙwayoyin cuta?
Yara masu fama da cututtuka na kullum
Yaran da ke fama da cututtukan haɗin gwiwa mai kumburi:
Ga yaran da ke fama da cututtukan cututtukan ƙwayar cuta na yau da kullun (CTD), irin su spondyloarthropathy na yara da cututtukan cututtukan ƙwayar cuta na yara (JIA), saboda kumburin tsarin musculoskeletal kai tsaye da jiyya na glucocorticoid, haɓaka ƙimar girma sau da yawa yana faruwa. Jiyya na yau da kullum suna amfani da kwayoyin halitta irin su tumor necrosis factor-α blockers (etanercept, adalimumab, golimumab) da interleukin-6 receptor blockers (tocilizumab), wanda a hankali zai iya haɓaka da kuma daidaita girman girman yara ta hanyar hana kumburi da rage yawan yau da kullum na glucocorticoids. Koyaya, a halin yanzu babu wani karatu akan aikace-aikacen da tasirin warkewar Sermorelin a cikin irin waɗannan yaran [1].
Yara masu fama da ciwon huhu:
Ciwon huhu na yau da kullun ya fi zama ruwan dare a cikin yara maza, ya fi yawa a yankunan karkara fiye da na birane, kuma ba a bayyana shekaru ko bambance-bambancen yanayi ba. Daga cikin yara 'yan kasa da shekaru 3 masu fama da cututtuka, cututtukan cututtuka na tracheobronchopulmonary na ci gaba suna da yawa, yayin da cututtuka na farko na rigakafi sun fi yawa a cikin yara masu shekaru 3 zuwa sama. Cututtukan ƙwayoyin cuta, musamman cututtukan ƙwayoyin cuta na ƙwayoyin cuta na Gram-negative, sune manyan abubuwan da ke haifar da kowane rukunin shekaru [2].
Menene takamaiman tsarin Semorelin a cikin maganin hana girma a cikin yara da ke haifar da ƙarancin girma na farko?
Ƙarfafa sakin hormone girma:
Sermorelin wani abu ne mai sakin hormone girma na ɗan adam. Abubuwan sakin hormone girma na iya ɗaure ga masu karɓar haɓakar hormone girma a cikin glandar pituitary na baya, yana ƙarfafa ƙwayoyin pituitary don haɗawa da sakin hormone girma[3]. Ta wannan hanyar, Semorelin na iya haɓaka matakin haɓakar hormone girma a cikin jiki, ta haka inganta haɓakar yara.
A karkashin yanayi na al'ada, ana sarrafa siginar hormone girma ta hanyar dalilai daban-daban, ciki har da hormone girma hormone sakewa (GHRH), somatostatin, neurotransmitters, da dai sauransu A matsayin exogenous girma hormone sakewa factor, Semorelin iya mimic da mataki na GHRH da kuma inganta mugunya na girma hormone.
Tasirin haɓakar hormone-insulin-kamar girma factor axis:
Bayan fitowar hormone girma ya karu, yana aiki akan kyallen takarda kamar hanta kuma yana ƙarfafa haɓakawa da haɓakar haɓakar haɓakar insulin-kamar (IGF). IGF wani muhimmin mahimmancin tsarin haɓakar haɓakawa wanda zai iya haɓaka haɓakar ƙwayoyin cuta, bambance-bambance, da haɗin furotin, suna taka muhimmiyar rawa wajen haɓaka da haɓaka yara[3].
Sermorelin a kaikaice yana haɓaka haɓakawa da sakin IGF ta hanyar haɓaka haɓakar haɓakar hormone girma, don haka ƙara haɓaka tasirin haɓaka haɓaka. IGF na iya ɗaure ga masu karɓar IGF akan ƙwayoyin da aka yi niyya, kunna hanyoyin siginar ƙasa, da haɓaka haɓakar ƙwayoyin cuta da metabolism.
Tasiri kan haɓakar kashi:
Girman hormone da IGF suna da tasiri mai mahimmanci akan ci gaban kashi. Suna iya haɓaka haɓakawa da bambance-bambancen chondrocytes, haɓaka tsayin kashi da ƙasusuwan kashi[3]. Semorelin yana kula da haɓakar haɓakawa a cikin yara da ke haifar da ƙarancin girma na farko ta hanyar haɓaka matakan girma da kuma IGF, inganta haɓakar kashi da ci gaba.
Bugu da ƙari, hormone girma kuma zai iya daidaita metabolism na ma'adanai irin su calcium da phosphorus, kiyaye tsarin al'ada da aikin ƙasusuwa. Semorelin na iya ƙara haɓaka haɓakar ƙashi ta hanyar tasirin waɗannan hanyoyin rayuwa.
Tasiri kan tsoka da mai metabolism:
Girman hormone da IGF ba wai kawai ya shafi ci gaban kashi ba amma har ma suna da tasiri akan ƙwayar tsoka da mai. Hormone na girma zai iya inganta haɗin furotin, ƙara yawan ƙwayar tsoka, kuma a lokaci guda rage yawan kitsen mai[3]. Maganin Semorelin na iya inganta ƙwayar tsoka da kitse na yara ta hanyar haɓaka matakin hormone girma, haɓaka haɓakar jiki da haɓakawa.
Bugu da ƙari, hormone girma kuma zai iya daidaita tsarin makamashi na makamashi, ƙara yawan adadin kuzari na basal, da ƙara yawan amfani da makamashi. Wannan yana taimakawa kula da nauyin al'ada da tsarin jiki na yara kuma yana inganta haɓaka lafiya.
Menene alaƙar aikace-aikacen Sermorelin?
Ana amfani dashi don maganin hana girma a cikin yara:
Kamar yadda wani roba analog na girma hormone sakewa factor, Semorelin a kaikaice inganta mugunya na endogenous girma hormone ta kunna GHRH rabe a cikin na baya pituitary gland shine yake, muhimmanci inganta tsawo girma da kuma rayuwa aiki na yara da primary girma hormone rashi. Muhimmancin sa ya ta'allaka ne ga samar da zaɓin magani tare da tsarin tsarin ilimin lissafin jiki don marasa lafiya masu aikin pituitary na yau da kullun amma rashin isasshen GHRH, guje wa haɗarin halayen antibody ko rikicewar rayuwa wanda za'a iya haifar da shi ta hanyar maye gurbin hormone girma. Semorelin yana da fa'idodin dogaro da ɓoyewar kansa, rage tasirin hormonal, da kasancewa kusa da yanayin ƙa'idar ilimin lissafi.
Game da Marubuci
Abubuwan da aka ambata a sama duk an bincika su, gyara su kuma Cocer Peptides ne suka haɗa su [4].
Mawallafin Jaridar Kimiyya
Simon TJ mai bincike ne mai alaƙa da ƙungiyoyi masu daraja da yawa. Waɗannan sun haɗa da Zoetis Vet Med Regulatory Affairs, Akili Interact Labs, Jami'ar California Davis, Univ Calif, Dept Psychiat & Behav Sci, UC Davis MIND Inst, Jami'ar Jihar California Sacramento, MIND Inst, UCDHS, Asibitin Yara na Philadelphia, NIH National Institute on Drug Abuse (NIDA), Jami'ar Emory, Cibiyar Fasaha ta Georgia da Cibiyar Fasaha ta Georgia, da Cibiyar Fasaha ta Georgia da Merck. Irin waɗannan bambance-bambancen haɗin kai na cibiyoyi suna nuna faffadan iliminsa da na bincike.
Bukatun bincikensa sun mamaye nau'ikan batutuwa daban-daban kamar Neurosciences & Neurology, Psychiatry, Psychology, Genetics & Heredity, da Gastroenterology & Hepatology. Ayyukansa a waɗannan fagagen suna nuna zurfin iliminsa da gagarumar gudunmawar haɓaka ilimin likitanci da inganta ayyukan kiwon lafiya. An jera Simon TJ a cikin ambaton ambaton [4].
