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1kits (Ebipipa 10) .
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▎ Enzimba ya Sermorelin
Ensibuko: PubChem |
Omutendera: YADAXFXNSYRKVLGQLSARKLLQDXMSR Ensengekera ya molekyu: C 149H 246N 44O 42S Obuzito bwa molekyu: 3357.9 g/mol Ennamba ya CAS: 86168-78-7 PubChem CID: 16129620. Enkola y’okukuuma eddagala lino Ebigambo ebifaanagana: Sermorelin (INN);CHEBI: 9118 |
▎ Okunoonyereza ku Sermorelin
Sermorelin kye ki?
Sermorelin ye analog ya synthetic analog y’ekirungo ekifulumya obusimu bw’okukula (GHRF). Omulimu gwayo omukulu kwe kwesiba ku bikwata obusimu obufulumya obusimu obukula (GHRH) mu nseke y’omu maaso (anterior pituitary gland), okukola amakubo g’obubonero mu butoffaali (nga ekkubo lya cAMP/PKA), okusitula okusengejja n’okufulumya obusimu bw’okukula obw’omunda (GH), era bwe kityo okutumbula enkula n’enkula y’abaana. Kisinga kukozesebwa kujjanjaba bbula ly’obusimu obusookerwako (primary growth hormone deficiency) (okuziyiza okukula mu baana okuva ku butakola bulungi bwa pituitary). Nga ezzaawo okufulumya GH, esobola okulongoosa enkula y’obuwanvu n’enkola y’enkyukakyuka y’emmere. Okwawukanako ne recombinant human growth hormone, eyongera butereevu exogenous GH, Sermorelin yeesigamye ku pituitary gland yennyini obusobozi bw’okufulumya era esaanira abalwadde abalina enkola ya pituitary eya bulijjo naye nga GHRH temala.
Sermorelin y’akola mu kunoonyereza kutya?
Ensibuko y’okunoonyereza ku Sermorelin eva ku mulimu omukulu ogw’obusimu obukula mu kukula n’enkula y’omuntu. Obutabeera na busimu obusookerwako mu kukula kiyinza okuvaako okuziyiza okukula mu baana ne kikosa obuwanvu bwabwe obusembayo. N’olwekyo, okuzuula enkola ennungi ez’obujjanjabi bulijjo gubadde mulamwa mukulu mu kunoonyereza ku by’obujjanjabi. Wadde ng’obusimu bw’okukula bw’omuntu obuyitibwa recombinant human growth hormone bubadde bukozesebwa okumala emyaka mingi era nga buvuddeko okweyongera ennyo mu buwanvu obusembayo obw’abaana abalina obuzibu bw’obusimu bw’okukula, olw’okunoonyereza kw’abasawo okweyongera, abantu era banoonya obujjanjabi obusingawo n’enkola y’obujjanjabi ennungi. Mu mbeera eno, Sermorelin, ng’ekintu ekifulumya obusimu bw’okukula kw’omuntu ekikoleddwa mu butonde, yavaayo. Olw’okusitula okufulumya obusimu bw’okukula, ereese essuubi eppya mu kujjanjaba obuzibu bw’obusimu obukula era kitumbula okukula n’okukula kw’abaana.
Enkola y’Ekikolwa
Enkola ki entongole eya Semorelin mu kujjanjaba obutaba na busimu obusookerwako obw’okukula?
Omusingi gw’ekikolwa kya Semorelin
Ng’ekintu ekifulumya obusimu bw’okukula, Sermorelin okusinga ekola ebikolwa byayo ng’esiba ku bikwata ebitongole. Kikoppa enkola y’ekirungo ekifulumya obusimu bw’okukula mu butonde mu mubiri gw’omuntu era kisitula enseke y’omu maaso (anterior pituitary gland) okufulumya obusimu bw’okukula. Enkola eno ey’okukola efaananako n’ey’ebirungo ebirala ebizimba obusimu bw’okukula, gamba nga peptides ezifulumya obusimu bw’okukula (GHRPs).
Okusitula okufulumya obusimu bw’okukula
Omulimu gw’okulungamya ogw’ekisiki kya hypothalamic-pituitary:
Sermorelin kirungo kya butonde ekifulumya obusimu bw’okukula kw’omuntu. Mu mbeera eya bulijjo, okufulumya obusimu bw’okukula mu mubiri gw’omuntu kufugibwa nnyo ekitundu ekiyitibwa hypothalamic-pituitary axis. Hypothalamus efulumya obusimu obufulumya obusimu obukula (GHRH), obusitula endwadde z’omu lubuto (anterior pituitary gland) okukola n’okufulumya obusimu obukula (GH). Sermorelin ekoppa ekikolwa kya GHRH, yeekwata ku bikwata ebitongole mu hypothalamus, era n’etumbula enseke okufulumya obusimu obukula.
Okukola kw'ekkubo ly'obubonero :
Oluvannyuma lw’okusiba ku kisengejja, Sermorelin ekola ekkubo ly’obubonero mu butoffaali. Kino kiyinza okuzingiramu enkola z’enziyiza eziddiriŋŋana n’enkola y’omubaka ey’okubiri, okukkakkana nga kivuddeko okweyongera mu kusengejja n’okufulumya obusimu obukula. Okugeza, kiyinza okukola adenylate cyclase, okwongera ku ddaala lya cAMP mu butoffaali, n’oluvannyuma okukola protein kinase A, okutumbula okuwandiika n’okuvvuunula ensengekera y’obusimu obukula.
Ebikosa obutaba na busimu bw’okukula
Okutumbula enkulaakulana n'enkulaakulana:
Abaana abalina obuzibu bw’obusimu obusookerwako obw’okukula batera okulaga nti bakula mpola ate nga bampi. Sermorelin asasula ebbula ly’obusimu obukula mu mubiri ng’asitula okufulumya obusimu obukula. Obusimu obukula busobola okukola butereevu ku magumba, ebinywa, n’ebitundu ebirala, ne butumbula okukula n’okwawukana kw’obutoffaali, era bwe kityo ne kitumbula okukula n’okukula. Obusimu obukula era busobola okusitula ebitundu by’omubiri ng’ekibumba okukola ekirungo ekikula ekiringa insulini-1 (IGF-1), ate IGF-1 eyongera okukola ekikolwa ekitumbula okukula.
Okulongoosa enkola y’enkyukakyuka mu mubiri:
Obutabeera na busimu bw’okukula tekikoma ku kukosa kukula na nkula wabula kiyinza n’okuleeta obuzibu mu nkyukakyuka y’emmere. Obujjanjabi bwa semorelin busobola okulongoosa enkola y’enkyukakyuka mu mubiri, gamba ng’okwongera ku kukola puloteyina, okutumbula okumenya amasavu, n’okutumbula enkozesa ya glucose. Enkyukakyuka zino mu nkyukakyuka mu mubiri ziyamba okukuuma emirimu gy’omubiri egya bulijjo egy’omubiri n’okutumbula omutindo gw’obulamu bw’abalwadde.
Enkyukakyuka mu buwanvu-SDS mu baana abalina endwadde z’ebitundu ebiyunga abajjanjabwa n’ebirungo ebiramu.
Ensibuko:PubMed [1] .
Ebikozesebwa bya Semorelin bye biruwa?
Obujjanjabi bw’obutaba na busimu bw’okukula:
Obutabeera na busimu obusookerwako mu kukula kiyinza okuvaako okulwawo okukula n’okukula mu baana ne kikosa obuwanvu bwabwe obusembayo. Recombinant human growth hormone ebadde ekozesebwa mu bujjanjabi okumala emyaka mingi era evuddeko okweyongera ennyo mu buwanvu obusembayo obw’abaana abalina obuzibu bw’obusimu bw’okukula. Ng’ekintu ekifulumya obusimu bw’okukula, Semorelin era akola kinene mu kujjanjaba obutaba na busimu bw’okukula.
Sermorelin atumbula okukula n’okukula kw’abaana ng’asitula enseke okufulumya obusimu bw’okukula. Kiyinza okukoppa enkola y’obutonde ey’okufulumya obusimu bw’okukula, okwongera ku busimu bw’okukula, era bwe kityo ne kitumbula okukula kw’amagumba n’okukula kw’omubiri. Bw’ogeraageranya n’obusimu bw’okukula kw’omuntu obuyitibwa recombinant human growth hormone, Semorelin alina ebirungi eby’enjawulo. Ng’ekyokulabirako, kiyinza okuba n’okugumira obulungi n’obukuumi, ekikendeeza ku bimu ku biyinza okuvaamu.
Sermorelin akola ki mu kujjanjaba abaana abalina ebika by’endwadde ez’enjawulo ezitawona oba obulwadde bw’obuzaale?
Abaana abalina endwadde ezitawona
Abaana abalina endwadde z’ebitundu ebiyunga okuzimba ezitawona:
Ku baana abalina endwadde z’ebitundu ebiyungo ebizimba (CTD), gamba ng’obulwadde bw’enkizi obuyitibwa juvenile spondyloarthropathy ne juvenile idiopathic arthritis (JIA), olw’okuzimba obutereevu mu nkola y’ebinywa n’amagumba n’obujjanjabi bwa glucocorticoid, okunyigirizibwa kw’omutindo gw’okukula kutera okubaawo. Obujjanjabi obuliwo kati okusinga bukozesa ebirungo ebiramu nga tumor necrosis factor-α blockers (etanercept, adalimumab, golimumab) ne interleukin-6 receptor blockers (tocilizumab), ebiyinza okwanguya mpolampola n’okuzza omutindo gw’okukula kw’abaana mu mbeera eya bulijjo nga biziyiza okuzimba n’okukendeeza ku ddoozi ya glucocorticoids buli lunaku. Wabula mu kiseera kino tewali kunoonyereza ku ngeri Sermorelin gy’ekozesebwamu n’okujjanjaba mu baana ng’abo [1]..
Abaana abalina ekifuba ekitawona:
Obulwadde bw’ekifuba obutawona businga kubeera mu baana abasajja, businga mu byalo okusinga mu bibuga, era tewali njawulo yeeyoleka mu myaka oba sizoni. Mu baana abali wansi w’emyaka 3 abalina endwadde ezisibukako, obuzibu bw’enkula y’omukka (congenital tracheobronchopulmonary developmental malformations) butera okubaawo, ate endwadde z’obusimu obuziyiza endwadde ezisookerwako zisinga kubeera mu baana ab’emyaka 3 n’okudda waggulu. Yinfekisoni za bakitiriya naddala Gram-negative bacterial infections ze zisinga okuvaako mu bibinja by’emyaka byonna [2] ..
Enkola ki entongole eya Semorelin mu kujjanjaba okuziyiza okukula mu baana okuva ku bbula ly’obusimu obusookerwako obw’okukula?
Okusitula okufulumya obusimu bw’okukula:
Sermorelin kirungo kya butonde ekifulumya obusimu bw’okukula kw’omuntu. Ensonga ezifulumya obusimu bw’okukula zisobola okwesiba ku bikwata ensonga ezifulumya obusimu bw’okukula mu nseke y’omu maaso, ne zisitula obutoffaali bwa pituitary okukola n’okufulumya obusimu bw’okukula[3]. Mu ngeri eno, Semorelin asobola okwongera ku busimu bw’okukula mu mubiri, bw’atyo n’atumbula okukula kw’abaana.
Mu mbeera eya bulijjo, okufulumya obusimu bw’okukula kufugibwa ensonga ez’enjawulo, omuli obusimu obufulumya obusimu obukula (GHRH), somatostatin, neurotransmitters, n’ebirala Ng’ensonga efulumya obusimu bw’okukula obw’ebweru, Semorelin esobola okukoppa ekikolwa kya GHRH n’okutumbula okufulumya obusimu bw’okukula.
Okufuga ekisiki ky’ensonga y’okukula eringa obusimu bw’okukula-insulin:
Oluvannyuma lw’okufulumya obusimu bw’okukula okweyongera, bukola ku bitundu by’omubiri ng’ekibumba ne busitula okukola n’okufulumya ekirungo ekikula ekiringa insulini (IGF). IGF nsonga nkulu etereeza enkula esobola okutumbula okukula kw’obutoffaali, okwawukana, n’okusengejja obutoffaali, nga ekola kinene mu kukula n’enkula y’abaana[3].
Sermorelin mu ngeri etali butereevu etumbula okukola n’okufulumya IGF ng’esitula okufulumya obusimu bw’okukula, bwe kityo n’ayongera okutumbula ekikolwa ekitumbula okukula. IGF esobola okwesiba ku bikwata IGF ku butoffaali obugendererwa, okukola amakubo g’obubonero wansi, n’okutumbula okukula kw’obutoffaali n’okukyusakyusa mu mubiri.
Enkola y’okukula kw’amagumba:
Obusimu bw’okukula ne IGF birina kinene kye bikola ku kukula kw’amagumba. Ziyinza okutumbula okukula n’okwawukana kwa chondrocytes, okwongera ku buwanvu bw’amagumba n’obugumu bw’amagumba[3]. Semorelin ajjanjaba okuziyiza okukula kw’abaana okuva ku bbula ly’obusimu obusookerwako obw’okukula ng’ayongera ku miwendo gy’obusimu bw’okukula ne IGF, okutumbula okukula n’okukula kw’amagumba.
Okugatta ku ekyo, obusimu obukula era busobola okulung’amya enkyukakyuka y’eby’obuggagga eby’omu ttaka nga calcium ne phosphorus, okukuuma ensengekera n’enkola y’amagumba eya bulijjo. Semorelin ayinza okwongera okutumbula okukula kw’amagumba ng’akwata ku nkola zino ez’okukyusakyusa ebiriisa.
Ebikosa enkyukakyuka y’ebinywa n’amasavu:
Obusimu bw’okukula ne IGF tebukoma ku kukosa nkula ya magumba wabula era bikola ku nkyukakyuka y’ebinywa n’amasavu. Obusimu bw’okukula busobola okutumbula okukola puloteyina, okwongera ku binywa, ate mu kiseera kye kimu okukendeeza ku kukuŋŋaanyizibwa kw’amasavu[3]. Obujjanjabi bwa semorelin buyinza okulongoosa enkyukakyuka y’ebinywa n’amasavu mu baana nga byongera ku mutindo gw’obusimu obukula, okutumbula okukula n’okukula kw’omubiri.
Okugatta ku ekyo, obusimu obukula era busobola okulung’amya enkyukakyuka y’amaanyi, okwongera ku mutindo gw’enkyukakyuka mu mubiri (basal metabolic rate), n’okwongera ku nkozesa y’amaanyi. Kino kiyamba okukuuma obuzito n’omubiri gw’abaana ogwa bulijjo n’okutumbula okukula obulungi.
Biki ebikwatagana n’okukozesa Sermorelin?
Ekozesebwa mu kujjanjaba okuziyiza okukula kw’abaana:
Nga synthetic analog of growth hormone releasing factor, Semorelin indirectly etumbula okufulumya endogenous growth hormone nga ekola GHRH receptors mu anterior pituitary gland, okulongoosa ennyo okukula kw’obuwanvu n’enkola y’okukyusakyusa emmere y’abaana abalina obuzibu bw’obusimu obusookerwako obw’okukula. Amakulu gaayo gali mu kuwa eky’okulonda eky’obujjanjabi n’enkola y’okulungamya omubiri eri abalwadde abalina enkola ya pituitary eya bulijjo naye nga GHRH temala, okwewala obulabe bw’okuddamu kw’obusimu obuziyiza endwadde oba obuzibu mu nkyukakyuka y’emmere obuyinza okuleetebwa obujjanjabi obw’okukyusa obusimu bw’okukula obw’ebweru. Semorelin erina ebirungi eby’okwesigamira ku nfulumya yaayo, okukendeeza ku busimu obukosa, n’okubeera okumpi n’engeri y’okulungamya omubiri.
Ebikwata ku Muwandiisi
Ebintu ebyogeddwako waggulu byonna byanoonyezebwa, birongooseddwa era ne bikunganyizibwa Cocer Peptides [4]..
Omuwandiisi wa Scientific Journal
Simon TJ munoonyereza alina akakwate ku bibiina eby’amaanyi ebiwerako. Mu bino mulimu Zoetis Vet Med Regulatory Affairs, Akili Interact Labs, Yunivasite y’e California Davis, Univ Calif, Dept Psychiat & Behav Sci, UC Davis MIND Inst, California State University Sacramento, MIND Inst, UCDHS, eddwaliro ly’abaana erya Philadelphia, NIH National Institute on Drug Abuse (NIDA), Yunivasite ya Emory, Georgia Institute of Technology, ne Merck & Company. Enkolagana ng’eyo ey’ebitongole ey’enjawulo eraga obumanyirivu bwe obw’enjawulo mu by’ensoma n’okunoonyereza.
Okunoonyereza kwe kukwata ku masomo ag’enjawulo nga Neurosciences & Neurology, Psychiatry, Psychology, Genetics & Heredity, ne Gastroenterology & Hepatology. Omulimu gwe mu bintu bino gulaga okumanya kwe okw’obwegendereza n’ebintu ebikulu by’akola mu kutumbula ssaayansi w’obusawo n’okutumbula enkola z’ebyobulamu. Simon TJ awandiikiddwa mu kiwandiiko ekijuliziddwa mu kiwandiiko ekijuliziddwa [4].
