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SermorelinStructure Imiterere ya
Inkomoko: PubChem |
Urukurikirane: YADAXFXNSYRKVLGQLSARKLLQDXMSR Inzira ya molekulari: C 149H 246N 44O 42S. Uburemere bwa molekuline: 3357.9 g / mol Numero ya CAS: 86168-78-7 PubChem CID: 16129620 Synonyme: Sermorelin (INN) ； CHEBI: 9118 |
Research Ubushakashatsi bwa Sermorelin
Sermorelin ni iki?
Sermorelin ni ikigereranyo cyerekana imisemburo ikura (GHRF). Igikorwa cyacyo nyamukuru ni uguhuza imisemburo ikura irekura imisemburo (GHRH) yakira reseptor ya glande y'imbere ya pitoito, gukora inzira zerekana ibimenyetso (nk'inzira ya cAMP / PKA), bigatera guhuza no gusohora imisemburo ikura ya endogenous (GH), bityo bigatera imbere no gukura kw'abana. Ikoreshwa cyane mukuvura imisemburo yibanze yo gukura (guhagarika imikurire kubana biterwa numurimo udahagije wa pitoito). Mugusubiza ibyuka bya GH, birashobora kunoza imikurire yimikorere nimikorere ya metabolike. Bitandukanye na hormone yo gukura kwabantu, yuzuza byimazeyo GH idasanzwe, Sermorelin yishingikiriza kumitsi ya pitoito ubushobozi bwayo bwo gusohora kandi ibereye abarwayi bafite imikorere isanzwe ya pitoito ariko GHRH idahagije.
Ni ubuhe bushakashatsi bwakozwe na Sermorelin?
Ubushakashatsi bwakozwe na Sermorelin buturuka ku ruhare rukomeye rwa hormone yo gukura mu mikurire y’abantu no mu iterambere. Kubura imisemburo yibanze ya hormone birashobora gutuma abana bakura kandi bikagira ingaruka kuburebure bwabo bwa nyuma. Kubwibyo, gushakisha uburyo bwiza bwo kuvura byahoze ari ingingo yingenzi mubushakashatsi bwubuvuzi. Nubwo imisemburo ikura ya recombinant ikoreshwa mumyaka myinshi kandi yatumye habaho kwiyongera cyane muburebure bwa nyuma bwabana bafite imisemburo ikura, hamwe nubushakashatsi bwimbitse bwubuvuzi, abantu nabo barashaka uburyo bwinshi bwo kuvura hamwe nuburyo bwiza bwo kuvura. Kuruhande rwinyuma, Sermorelin, nkumusemburo ukura wumuntu ukura imisemburo irekura. Mugukangurira gusohora imisemburo ikura, yazanye ibyiringiro bishya byo kuvura kubura imisemburo ikura kandi biteza imbere imikurire niterambere ryabana.
Uburyo bwibikorwa
Ni ubuhe buryo bwihariye bwa Semorelin mu kuvura ibura rya hormone y'ibanze?
Ishingiro ryibikorwa bya Semorelin
Nka misemburo ikura irekura, Sermorelin ikora cyane cyane muguhuza kwakirwa neza. Yigana imikorere yimisemburo ikura yibisanzwe ikura mumubiri wumuntu kandi igatera glande ya pitoito imbere kurekura imisemburo ikura. Ubu buryo bwibikorwa busa nubundi bukangura imisemburo ikura, nka hormone yo gukura irekura peptide (GHRPs).
Gukangurira kurekura imisemburo ikura
Uruhare rwo kugenzura hypothalamic-pitoitar axis:
Sermorelin ni imisemburo ikura yumuntu ikura. Mubihe bisanzwe, gusohora imisemburo ikura mumubiri wumuntu bigengwa cyane na hypothalamic-pituito axis. Hypothalamus isohora imisemburo ikura irekura imisemburo (GHRH), itera glande ya pitoito y'imbere guhuza no gusohora imisemburo ikura (GH). Sermorelin yigana ibikorwa bya GHRH, ihuza reseptor zihariye muri hypothalamus, kandi igatera glande ya pitoito kurekura imisemburo ikura.
Gukora inzira yerekana ibimenyetso :
Nyuma yo guhambira reseptor, Sermorelin ikora inzira yerekana ibimenyetso. Ibi birashobora kuba bikubiyemo urukurikirane rwimikorere hamwe na sisitemu ya kabiri yintumwa, amaherezo biganisha ku kwiyongera kwa synthesis no kurekura imisemburo ikura. Kurugero, irashobora gukora adenylate cyclase, ikongera urwego rwimikorere ya cAMP, hanyuma igakora protein kinase A, igatera kwandukura no guhindura imisemburo ikura.
Ingaruka zo kubura imisemburo ikura
Guteza imbere iterambere n'iterambere:
Abana bafite imisemburo yibanze yo gukura bakunze kwerekana gukura buhoro no kuba muremure. Sermorelin yishyura kubura imisemburo ikura mu mubiri itera gusohora imisemburo ikura. Imisemburo ikura irashobora gukora neza kumagufa, imitsi, nizindi ngingo, bigatera ikwirakwizwa ryingirabuzimafatizo no gutandukana, bityo bigatera imbere no gukura. Imisemburo ikura irashobora kandi gukangura ingingo nkumwijima kugirango ihuze insuline imeze nkikura-1 (IGF-1), kandi IGF-1 irongera igira ingaruka ziterambere.
Kunoza imikorere ya metabolike:
Gukura imisemburo ya hormone ntabwo bigira ingaruka kumikurire niterambere gusa ahubwo birashobora no gutuma habaho ihungabana. Kuvura Semorelin birashobora kunoza imikorere ya metabolike, nko kongera intungamubiri za poroteyine, guteza imbere ibinure, no kongera ikoreshwa rya glucose. Izi mpinduka za metabolike zifasha kugumana imikorere isanzwe yumubiri yumubiri no kuzamura imibereho yabarwayi.
Uburebure-SDS butandukanye kubana bafite indwara zifatika zifata imiti ya biologique.
Inkomoko: Byatangajwe [1]
Ni ubuhe buryo bukoreshwa na Semorelin?
Umuti wo kubura imisemburo ikura:
Kubura imisemburo yibanze ya hormone birashobora gutuma gukura gutinda no gukura mubana kandi bikagira ingaruka kuburebure bwabo bwa nyuma. Imisemburo ikura ya recombinant ikoreshwa mumyaka myinshi kandi yatumye habaho kwiyongera cyane muburebure bwa nyuma bwabana bafite imisemburo ikura. Nka misemburo ikura irekura, Semorelin nayo igira uruhare runini mukuvura kubura imisemburo ikura.
Sermorelin iteza imbere imikurire niterambere ryabana mugukangurira glande ya pitoito gusohora imisemburo ikura. Irashobora kwigana uburyo busanzwe bwo gukura bwimisemburo yumubiri, bikongera imisemburo ikura, bityo bigatera imbere gukura kwamagufwa no gukura kumubiri. Ugereranije na recombinant hormone yo gukura kwabantu, Semorelin ifite ibyiza byihariye. Kurugero, irashobora kugira kwihanganira umutekano n'umutekano, kugabanya ingaruka zimwe zishobora kubaho.
Ni izihe ngaruka zo kuvura Sermorelin ku bana bafite ubwoko butandukanye bw'indwara zidakira cyangwa syndromes?
Abana barwaye indwara zidakira
Abana barwaye indwara zidakira zidakira:
Ku bana barwaye indwara zidakira zifata indwara zidakira (CTD), nka spondyloarthropathie juvenile spondyloarthropathie na arthritis idiopathic arthritis (JIA), bitewe na sisitemu ya musculoskeletal itwika no kuvura glucocorticoid, guhagarika umuvuduko ukabije bikunze kubaho. Ubuvuzi bwa none bukoresha cyane cyane ibinyabuzima nkibibyimba necrosis factor-α blokers (etanercept, adalimumab, golimumab) hamwe na interleukin-6 yakira reseptor (tocilizumab), bishobora kwihuta buhoro buhoro kandi bigahindura umuvuduko witerambere ryabana muguhagarika umuriro no kugabanya ikinini cya buri munsi cya glucocorticoide. Ariko, kuri ubu nta bushakashatsi bwakozwe ku bijyanye n'ingaruka zo kuvura Sermorelin mu bana nk'abo [1].
Abana barwaye umusonga udakira:
Umusonga udakira ukunze kugaragara cyane ku bana b'abahungu, ukunze kugaragara mu cyaro kuruta mu mijyi, kandi nta myaka igaragara cyangwa itandukaniro ry'ibihe. Mu bana bari munsi y’imyaka 3 barwaye indwara zifatika, kuvuka kwa tracheobronchopulmonary kuvuka ni byo bikunze kugaragara, mu gihe indwara z’ibanze z’ubudahangarwa zikunze kugaragara cyane ku bana bafite imyaka 3 nayirenga. Indwara ziterwa na bagiteri, cyane cyane indwara ziterwa na Gram-mbi, nizo ntandaro nyamukuru mu byiciro byose [2].
Ni ubuhe buryo bwihariye bwa Semorelin mu kuvura guhagarika imikurire ku bana biterwa no kubura imisemburo ya mbere yo gukura?
Gukangurira kurekura imisemburo ikura:
Sermorelin ni imisemburo ikura yumuntu ikura. Gukura imisemburo ikura irashobora guhuza imisemburo ikura irekura ibintu byakira muri glande y'imbere ya pitoito, bigatera ingirabuzimafatizo zo guhuza no kurekura imisemburo ikura [3]. Muri ubu buryo, Semorelin irashobora kongera urwego rwimisemburo ikura mumubiri, bityo igatera imbere gukura kwabana.
Mubihe bisanzwe, gusohora imisemburo ikura bigengwa nibintu bitandukanye, harimo imisemburo ikura irekura imisemburo (GHRH), somatostatin, neurotransmitters, nibindi.
Guhindura imisemburo ikura-insuline-imeze nkikintu gikura:
Nyuma yo gusohora imisemburo ikura yiyongera, ikora ku ngingo nk'umwijima kandi igatera synthesis hamwe no gusohora ibintu bikura nka insuline (IGF). IGF ni ikintu gikomeye kigenga imikurire gishobora guteza imbere ikwirakwizwa ry'uturemangingo, gutandukanya, hamwe na sintezamubiri ya poroteyine, bigira uruhare runini mu mikurire no gukura kw'abana [3].
Sermorelin iteza imbere mu buryo butaziguye synthèse no kurekura IGF mu gusohora imisemburo ikura, bityo bikarushaho kuzamura ingaruka ziterambere. IGF irashobora guhuza na reseptor ya IGF kuri selile igenewe, igakora inzira yerekana ibimenyetso byerekana inzira, kandi igatera imbere gukura kwa selile na metabolism.
Ingaruka ku mikurire y'amagufwa:
Gukura imisemburo na IGF bigira ingaruka zikomeye kumikurire yamagufwa. Zishobora guteza imbere ikwirakwizwa rya chondrocytes, kongera uburebure bw'amagufwa n'ubucucike bw'amagufwa [3]. Semorelin ivura guhagarika imikurire ku bana iterwa no kubura imisemburo ya hormone yibanze mu kongera urwego rwimisemburo ikura na IGF, bigatera imikurire niterambere.
Byongeye kandi, imisemburo ikura irashobora kandi kugenga metabolisme yimyunyu ngugu nka calcium na fosifore, igakomeza imiterere n'imikorere y'amagufwa. Semorelin irashobora guteza imbere imikurire yamagufwa muguhindura imikorere.
Ingaruka ku mitsi no guhinduranya ibinure:
Gukura imisemburo na IGF ntabwo bigira ingaruka kumikurire yamagufwa gusa ahubwo binagira ingaruka kumitsi no guhinduranya amavuta. Gukura imisemburo irashobora gutera intungamubiri za poroteyine, kongera imitsi, kandi icyarimwe bikagabanya ibinure [3]. Ubuvuzi bwa Semorelin bushobora guteza imbere imitsi hamwe n’ibinure byabana byongera urwego rwimisemburo ikura, bigatera imikurire niterambere.
Byongeye kandi, imisemburo ikura irashobora kandi kugenga ingufu za metabolisme, kongera umuvuduko wa metabolike, no kongera ingufu. Ibi bifasha kugumana uburemere busanzwe hamwe numubiri wabana kandi bigatera imbere gukura neza.
Ni ubuhe buryo bujyanye na Sermorelin?
Ikoreshwa mukuvura guhagarika gukura mubana:
Nkikigereranyo cyogukwirakwiza imisemburo ikura, Semorelin iteza imbere mu buryo butaziguye imisemburo ikura ya endogenous hormone ikura reseptor ya GHRH muri glande y'imbere ya pitoito, ikazamura cyane imikurire yuburebure n'imikorere ya metabolike y'abana bafite imisemburo ikura ya hormone. Akamaro kayo ni ugutanga uburyo bwo kuvura hamwe nuburyo bwo kugenzura imikorere ya physiologique kubarwayi bafite imikorere isanzwe ya pitoito ariko GHRH idahagije, birinda ingaruka ziterwa na antibody cyangwa indwara ziterwa na metabolike zishobora kuzanwa no kuvura imisemburo ya hormone ikura. Semorelin ifite ibyiza byo kwishingikiriza ku ibanga ryayo, kugabanya ingaruka za hormone, no kuba hafi yuburyo bwo kugenzura umubiri.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides [4].
Umwanditsi w'ikinyamakuru
Simon TJ numushakashatsi ufite aho ahurira nimiryango myinshi ikomeye. Muri byo harimo Zoetis Vet Med Igenzura, Akili Interact Labs, Kaminuza ya Californiya Davis, Univ Calif, Dept Psychiat & Behav Sci, UC Davis MIND Inst, Kaminuza ya Leta ya Kaliforuniya Sacramento, MIND Inst, UCDHS, Ibitaro by’abana ba Philadelphia, Ikigo cy’igihugu cya NIH n’ikigo cy’ikoranabuhanga, NIory, Ikigo cya Jeworujiya. Ihuriro ritandukanye ryinzego zigaragaza amasomo ye yagutse nubushakashatsi.
Inyungu zubushakashatsi bwe zikubiye mubyiciro bitandukanye nka Neurosciences & Neurology, Psychiatrie, Psychology, Genetics & Heredity, na Gastroenterology & Hepatology. Ibikorwa bye muri izi nzego byerekana ubumenyi bwe bwimbitse n’umusanzu ukomeye mu guteza imbere siyanse y’ubuvuzi no kunoza imikorere y’ubuzima. Simon TJ yanditse kurutonde rwerekana [4].
