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▎ TB4 Ọdịdị
Isi mmalite: PubChem |
Usoro: LKKTETQ Ụdị mkpụrụ ndụ: C 38H 68N 10O14 Ibu ibu: 889.0 g/mol Nọmba CAS: 885340-08-9 PubChem CID: 62707662 Ndị otu: QHK6Z47GTG |
▎ Nchọpụta TB4
Kedu ihe ndabere nyocha nke TB4?
TB4 bụ obere peptide emebere site na saịtị thymosin β4 na-arụ ọrụ. Thymosin β4 nwere ikike nke imeghari anụ ahụ, mgbochi mbufụt, na nrụzi ngwa ngwa, TB4 ketarakwa ihe ndị a. Na mbu, na nyocha nke thymosin β4, achọpụtara na ọ nwere ọtụtụ ihe omume ndụ, na-arụ ọrụ dị mkpa n'akụkụ ndị dị ka mbugharị cell, nrụzi anụ ahụ, na iwu mbufụt. TB4 bụ akụkụ na-arụ ọrụ nke thymosin β4. Ndị na-eme nchọpụta na-atụ anya na site n'ọmụmụ nke TB4, ha nwere ike nweta nghọta miri emi banyere usoro ọrụ ya ma chọpụta ma enwere ike ịmepụta ya n'ime ọgwụ nwere ebumnuche ọgwụgwọ kpọmkwem.
N'ebe a na-edozi ọnya na mmebi anụ ahụ nke ọrịa na-adịghị ala ala kpatara, usoro ọgwụgwọ ọdịnala nwere ụfọdụ njedebe. N'ihi ikike o nwere n'ịkwalite ịkwaga cell na nrụzi anụ ahụ, TB4 aghọwo ebe nyocha, ndị mmadụ na-atụkwa anya na ọ ga-enye echiche na ụzọ ọhụrụ maka ịgwọ ọrịa ndị a. Dịka ọmụmaatụ, na nyocha nke ọrịa ndị dị ka myocardial infarction na nhụjuanya akwara, a na-eme nnyocha iji chọpụta ma TB4 nwere ike ịkwalite nrụzi nke anụ ahụ mebiri emebi na mweghachi nke ọrụ ha.
Ndị na-eme egwuregwu na-enwekarị mmerụ ahụ dị iche iche n'oge ọzụzụ na asọmpi, gụnyere eriri anụ ahụ na mmerụ ahụ ligament. Ekwenyere na TB4 nwere ike inye aka mee ka nrụzi mmerụ ahụ dịkwuo elu ma melite ọsọ mgbake nke mmerụ egwuregwu, ya mere ọ dọtara uche na ngalaba ọgwụ egwuregwu. Ụfọdụ ọmụmụ na-anwa ịchọpụta ike ngwa nke TB4 na nhazigharị nke mmerụ ahụ ndị egwuregwu. Agbanyeghị, n'otu oge ahụ, ọ kpalitekwara arụmụka banyere ma enwere ike iji ya mee ihe n'ụzọ na-ezighị ezi dị ka doping. Site na mmepe nke ọgwụ, ọchịchọ maka ọgwụ ọhụrụ na-abawanye mgbe niile. Dị ka ihe peptide nwere usoro ọrụ pụrụ iche, TB4 nwere ike ịmepụta ya ka ọ bụrụ ụdị ọgwụ ọhụrụ, na-enye ọtụtụ nhọrọ maka ọgwụgwọ ụlọ ọgwụ.
Gịnị bụ usoro omume nke TB4?
Na-akwalite mmụgharị anụ ahụ:
TB4 bụ obere peptide emebere site na saịtị thymosin β4 na-arụ ọrụ. Thymosin β4 nwere ikike ịkwalite mmegharị anụ ahụ, yana TB4 ketara ihe onwunwe a. Ọ nwere ike ịkwalite mmegharị anụ ahụ n'ụzọ ndị a:
Ụzọ mgbama cell na-arụ ọrụ:
Ọ nwere ike mee ka ụfọdụ ụzọ mgbama cell dị iche iche iji kwalite mmụba cell na ọdịiche. Dịka ọmụmaatụ, ọ nwere ike ịgbalite ụzọ mgbaama metụtara uto na nrụzi cell, dị ka ụzọ akara ngosi PI3K/Akt, wdg, si otú ahụ na-akpali mmụba cell na ọdịiche na ịkwalite mmeghari anụ ahụ [1]..
Na-ahazi matrix extracellular:
Matrix extracellular na-arụ ọrụ dị mkpa n'imeghachi anụ ahụ. TB4 nwere ike ịhazi njikọ na mmebi nke matriks extracellular, na-akwalite nrapanye cell, mbugharị, na nhazigharị anụ ahụ. Dịka ọmụmaatụ, ọ nwere ike ịbawanye njikọ nke collagen na elastin, meziwanye nhazi na ọrụ nke anụ ahụ [1]..
Mmetụta mgbochi mkpali:
Mbufụt bụ nzaghachi nchebe nke ahụ na mmerụ ahụ na ọrịa, ma oke mbufụt nwere ike ibute mmebi anụ ahụ. TB4 nwere mmetụta mgbochi mkpali ma nwee ike igbochi mmepụta nke ndị mgbasa ozi mkpali. Ndị mgbasa ozi na-egbuke egbuke dị ka cytokines na chemokines na-ekere òkè dị mkpa na nzaghachi mkpali. TB4 nwere ike igbochi mmepụta nke ndị mgbasa ozi mkpali a, si otú ahụ belata nzaghachi mkpali. Dịka ọmụmaatụ, ọ nwere ike igbochi mmepụta ihe ndị na-egbuke egbuke dị ka tumor necrosis factor-α (TNF-α) na interleukin-1β (IL-1β) [1]..
Na-ahazi ọrụ nke sel ndị na-alụso ọrịa ọgụ:
Mkpụrụ ndụ mgbochi na-arụ ọrụ dị mkpa na nzaghachi mkpali. TB4 nwere ike ịhazi ọrụ nke mkpụrụ ndụ na-alụso ọrịa ọgụ, dị ka ịhazi ọrụ nke macrophages na lymphocytes, si otú ahụ belata nzaghachi mkpali. Dịka ọmụmaatụ, ọ nwere ike ịkwalite mgbanwe nke macrophages ka ọ bụrụ phenotype na-egbochi mkpali ma gbochie mmalite na mmụba nke lymphocytes [1]..
Na-emewanye mmụba cell na ọdịiche:
Site n'ịgbalite ụzọ mgbaama cell na ịhazi matriks extracellular, TB4 nwere ike mee ka mmụba cell na ọdịiche dị ngwa, na-akwalite nrụzi anụ ahụ mebiri emebi [1].
Na-ebelata nzaghachi mkpali:
Nzaghachi nke mkpasu iwe ga-egbu oge nrụzi anụ ahụ, na mmetụta mgbochi mkpali nke TB4 nwere ike ibelata nzaghachi mkpali, na-emepụta ebe dị mma maka nrụzi anụ ahụ [1]..
Na-akwalite angiogenesis:
Angiogenesis dị oké mkpa maka ịrụzi anụ ahụ. TB4 nwere ike ịkwalite angiogenesis, ịba ụba ọbara nye anụ ahụ mebiri emebi, na-enye nri na oxygen maka mkpụrụ ndụ, na ịkwalite nrụzi anụ ahụ [1].
Iwu nke MMP/TIMP na imeju fibrosis.
Isi mmalite: PubMed [3]
Kedu ka TB4 si ahazi nhazi na nbibi nke matriks extracellular?
Ntuzi n'etiti njikọ na mmebi nke matriks extracellular (ECM) dị mkpa maka idowe nhazi na ọrụ nkịtị nke anụ ahụ. TB4 nwere ike imetụta njikọ nke matrix extracellular n'ụzọ ndị a:
Na-akwalite ntinye nke collagen:
Ekwenyere na TB4 nwere ike ịkwalite ntinye nke collagen, na collagen bụ akụkụ dị mkpa nke matrix extracellular. Usoro a kapịrị ọnụ nke omume nwere ike ịgụnye nhazi nke ụzọ mgbaàmà cell na-etinye aka na njikọ collagen. Dịka ọmụmaatụ, ọ nwere ike ịkwalite nkwupụta nke mkpụrụ ndụ ihe nketa collagen site n'ịgbalite ihe ụfọdụ na-eto eto ma ọ bụ ihe odide ederede, si otú ahụ na-amụba njikọ nke collagen [2]..
Na-akwalite ọdịiche nke cell endothelial na angiogenesis:
Mkpụrụ ndụ endothelial na-ezobe ihe dị iche iche nke matrix extracellular n'oge usoro nhazi arịa ọbara. TB4 na-akwalite ọdịiche nke mkpụrụ ndụ endothelial na angiogenesis na anụ ahụ dermal, nke nwere ike na-akwalite njikọ nke matrix extracellular n'ezoghị ọnụ. Ọbara ọbara ndị e hiwere ọhụrụ chọrọ nkwado nke matriks extracellular, nke nwere ike ịkpali mkpụrụ ndụ ka ha mejupụta akụkụ matrix extracellular ndị ọzọ [2].
Mmetụta na mmebi nke matrix extracellular:
Ọ nwere ike ịhazi ọrụ nke matrix metalloproteinases (MMPs) na ndị na-egbochi ha (TIMPs):
A na-ahazi mmebi nke matrix extracellular site na matrix metalloproteinases na ndị na-egbochi ha. Ọ bụ ezie na ọ dịghị ugbu a ọ dịghị ihe àmà kpọmkwem na TB4 na-achịkwa ọrụ nke MMPs na TIMPs, na-atụle na TB4 nwere mmetụta nke ịkwalite mbugharị cell na ọgwụgwọ ọnya, na usoro nke ịkwaga cell na ọgwụgwọ ọnya na-esonyere ya na nhazigharị nke matrix extracellular, nke a nwere ike ịgụnye nhazi nke MMPs na TIMPs. Dịka ọmụmaatụ, n'ọmụmụ ihe gbasara fibrosis imeju, matrix metalloproteinases na ndị na-egbochi ha kpọmkwem (ya bụ, anụ ahụ inhibitors nke metalloproteinases, TIMPs) na-ekere òkè dị mkpa na nhazi na mgbasa nke collagen. Site na iweghachi nguzozi n'etiti MMPs na TIMPs, enwere ike igbochi nchịkọta nke matriks extracellular, si otú ahụ belata fibrosis imeju [3].
Na-achịkwa nbibi nke matriks extracellular na-apụtaghị ìhè site na imetụta omume cell:
TB4 nwere ike ịkwalite ịkwaga keratinocyte. N'oge usoro mbugharị cell, mkpụrụ ndụ kwesịrị ịhazi mmebi nke matrix extracellular iji kpochapụ ụzọ. Nke a nwere ike ịgụnye nzuzo nke ụfọdụ enzymes ma ọ bụ ihe site na mkpụrụ ndụ iji mezie mmebi nke matrix extracellular. Dịka ọmụmaatụ, n'ụfọdụ usoro ihe ọmụmụ physiological na pathological, mkpụrụ ndụ na-ezobe matrix metalloproteinases iji mebie matrix extracellular maka mbugharị [2].
Kedu ụzọ TB4 si emekọrịta ihe na biomaterials iji kwalite mmụba anụ ahụ?
Mwepụta nke ụmụ irighiri ihe na-eme bioactive:
Biomaterials nwere ike ije ozi dị ka ndị na-ebu ma na-emekọ ihe ọnụ na TB4 iji wepụta ụmụ irighiri ihe ndị na-eme ndụ ndụ, na-akwalite mmụba anụ ahụ. Dịka ọmụmaatụ, ụfọdụ biomaterials nwere ike ịhapụ ihe ndị na-arụ ọrụ dị ka ihe na-eto eto. Ihe ndị a na-arụkọ ọrụ ọnụ na TB4 iji kpalite mmụba na ọdịiche nke mkpụrụ ndụ akwara. TB4 n'onwe ya nwere mmetụta nke ịkwalite mbugharị cell na angiogenesis. Ejikọtara ya na ụmụ irighiri ihe ndị na-arụ ọrụ nke biomaterials wepụtara, ọ nwere ike ịkwalite nkwalite ahụ ike nke ọma [4, 5].
Ọrụ nke ihe ndị biomimetic:
Ngwa biomimetic na-eṅomi usoro okike na ọrụ nke anụ ahụ, na-enye microenvironment kwesịrị ekwesị maka TB4. Ihe ndị dị otú ahụ biomimetic nwere ike ịkwado nke ọma na anụ ahụ akwara, na-akwalite omume TB4 na saịtị mebiri emebi. Dịka ọmụmaatụ, ihe ndị biomimetic nwere usoro pore a kapịrị ọnụ nwere ike inye nkwado maka uto cell, ma n'otu oge ahụ, kwe ka TB4 gbasaa ma rụọ ọrụ nke ọma [4].
Mmetụta immunomodulatory:
Biomaterials nwere ike ịkwalite mmụba anụ ahụ site na ịhazi usoro ahụ ji alụso ọrịa ọgụ, na nhazi na TB4. Nnyocha e mere egosiwo na biomaterials nwere ike ịhazi polarization nke macrophages, si otú ahụ na-achịkwa nzaghachi mgbochi ahụ na ịmepụta ebe dị mma maka ịmaliteghachi anụ ahụ. TB4 nwere ike ịkwalite mmetụta immunomodulatory a site na imetụta ọrụ nke mkpụrụ ndụ na-alụso ọrịa ọgụ. Dịka ọmụmaatụ, site na immunomodulation nke ndị na-ahụ maka ihe ndị na-emepụta ihe na-edozi, enwere ike ịhazi polarization nke macrophages iji kwalite mmegharị anụ ahụ dị nro nke usoro musculoskeletal, na TB4 nwere ike rụọ ọrụ synergistic na usoro a [5]..
Nchikota nke sel stem na biomaterials:
Mkpụrụ ndụ azuokokoosisi na-ekere òkè dị mkpa n'ịmụghachi anụ ahụ. Ijikọta na biomaterials na TB4 nwere ike inye usoro ọgwụgwọ dị irè karị. Ọtụtụ mkpụrụ ndụ stem, dị ka mkpụrụ ndụ sel mesenchymal na mkpụrụ ndụ sel adipose enwetara, na-etinye aka na mgbake ahụ. Biomaterials nwere ike inye nkwado na nduzi maka mkpụrụ ndụ steepụ, ebe TB4 nwere ike ịkwalite mbugharị, nlanarị, na ọdịiche nke mkpụrụ ndụ stem. Nchikota nke atọ nwere ike imeri njedebe nke iji ha naanị ya ma kwalite ịmaliteghachi anụ ahụ.
Nkwalite mmeghari akwara:
Mweghachi akwara dị n'akụkụ na-arụkwa ọrụ dị mkpa na mmụgharị akwara. Biomaterials nwere ike inye nhazi nhazi iji kwalite mmeghari akwara, na TB4 nwere ike ịkwalite mmeghari akwara na mgbake na-arụ ọrụ akwara site na imetụta mkpụrụ ndụ ihe nketa metụtara neurogenesis. Dịka ọmụmaatụ, ụfọdụ nchọpụta achọpụtala na a na-edozi usoro mkpụrụ ndụ ihe nketa metụtara neurogenesis, na-atụ aro ọrụ nke imegharị akwara dị n'akụkụ n'ịgbado mgbake nke ike ahụ ike, na biomaterials na TB4 nwere ike ijikọ aka kwalite usoro a [6]..
Ngwa nke biomaterials na-anabata magnetik:
Ihe ọhụrụ ndị na-anabata magnetik nwere ike ime ka anụ ahụ dị ọhụrụ site na ịkpalite ọgwụ na nnyefe cell. Enwere ike iji TB4 jikọtara ya na ihe ndị dị otú ahụ biomaterials iji meziwanye mmetụta nrụzi nke uru ahụ mebiri emebi. Dịka ọmụmaatụ, enwere ike iji scaffold ígwè biphasic na-ebuga mkpụrụ ndụ na ihe ndị na-eto eto, kpọmkwem oge na vivo iji welie uru ahụ na-arụ ọrụ n'oge mbufụt. TB4 nwere ike na-emekọrịta ihe na biomaterial a iji kwalite nkwalite ahụ ike [7].
N'ozuzu, dị ka obere peptide a na-esi na saịtị na-arụ ọrụ nke thymosin β4, TB4 egosila ike dị ịrịba ama na mmeghari anụ ahụ, mgbochi mkpali, na nrụzi ngwa ngwa. Nnyocha achọpụtala na ọ nwere ike ịkwalite ọdịiche dị n'etiti mkpụrụ ndụ endothelial, angiogenesis, na njem keratinocyte, ma nwee ike ịhazi nhazi na mmebi nke matrix extracellular. N'ebe a na-edozi ahụ ike, TB4 nwere ike iweta olileanya ọhụrụ maka nrụzi nke mmerụ egwuregwu site n'ịkwalite mmụba na ọdịiche nke mkpụrụ ndụ sel anụ ahụ, na-achịkwa nzaghachi mkpali, na imekọrịta ihe na biomaterials. TB4 nwere ike ịghọ ọgwụ dị irè maka ọgwụgwọ adjuvant nke mmebi anụ ahụ na ọrịa ndị metụtara ya.
Banyere Onye dere ya
Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.
Onye ode akwụkwọ akụkọ sayensị
Ye J bụ onye nyocha na Mahadum Zhejiang na onye so na Orthopedic Regenerative Medicine Group (CORMed). Mpaghara nyocha ya gụnyere injinia, sayensị ihe, sistemu akpaaka na njikwa, azụmahịa na akụnụba, na usoro mgbakọ na mwepụ na sayensị mmekọrịta. Ye J etinyela aka na ụlọ ọrụ agụmakwụkwọ dị iche iche na otu, dị ka Opt Clearing Corp, CTC Holdings, Mahadum Illinois Chicago, na Dalian Institute of Chemical Physics, CAS. Edepụtara Ye J n'akwụkwọ ntụaka [5].
