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1kits （10Ibikoresho）
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▎ Imiterere ya TB4
Inkomoko: PubChem |
Urukurikirane: LKKTETQ Inzira ya molekulari: C 38H 68N 10O.14 Uburemere bwa molekuline: 889.0 g / mol Numero ya CAS: 885340-08-9 PubChem CID: 62707662 Synonyme: QHK6Z47GTG |
▎ TB4 Ubushakashatsi
Ni ubuhe bushakashatsi bwakozwe na TB4?
TB4 ni peptide ntoya itunganijwe kuva kurubuga rukora rwa thymosine β4. Thymosine β4 ifite ubushobozi bwo kuvugurura ingirabuzimafatizo, kurwanya umuriro, no gusana byihuse, kandi TB4 yarazwe iyi mitungo. Ku ikubitiro, mu bushakashatsi bwakozwe kuri thymosine β4, wasangaga bufite ibikorwa byinshi by’ibinyabuzima, bigira uruhare runini nko kwimuka kw ingirabuzimafatizo, gusana ingirabuzimafatizo, no kugenzura umuriro. TB4 nigice gikora cya thymosine β4. Abashakashatsi bizeye ko binyuze mu bushakashatsi bwakozwe na TB4, bashobora kurushaho gusobanukirwa n’uburyo bukoreshwa kandi bakanareba niba bushobora gukorerwa imiti igamije kuvura.
Mu rwego rwo gusana ibikomere no kwangirika kwinyama ziterwa nindwara zidakira, uburyo bwo kuvura gakondo bufite aho bugarukira. Bitewe nubushobozi bwayo bushobora guteza imbere kwimuka kw ingirabuzimafatizo no gusana ingirabuzima fatizo, TB4 yahindutse ahantu h’ubushakashatsi, kandi abantu biteze ko izatanga ibitekerezo nuburyo bushya bwo kuvura izo ndwara. Kurugero, mubushakashatsi bwindwara nka myocardial infarction no gukomeretsa imitsi, ubushakashatsi burakorwa kugirango harebwe niba TB4 ishobora guteza imbere gusana imyenda yangiritse no kugarura imikorere yabo.
Abakinnyi bakunze gukomereka mu gihe cy'imyitozo n'amarushanwa, harimo imitsi n'imvune. TB4 ikekwa ko ishobora gufasha kwihutisha gusana imvune no kuzamura umuvuduko wo gukira imvune za siporo, bityo ikaba yarakwegereye abantu mubuvuzi bwa siporo. Ubushakashatsi bumwe bugerageza kumenya ubushobozi bwa TB4 mugusubiza mu buzima busanzwe imvune zabakinnyi. Ariko, icyarimwe, byateje kandi impaka zo kumenya niba ishobora gukoreshwa nabi nka doping. Hamwe niterambere ryubuvuzi, ibyifuzo byimiti mishya bigenda byiyongera. Nka peptide ifite uburyo bwihariye bwibikorwa, TB4 ifite ubushobozi bwo gutezimbere muburyo bushya bwibiyobyabwenge, bitanga ubundi buryo bwo kuvura amavuriro.
Ni ubuhe buryo bwo gukora bwa TB4?
Guteza imbere kuvugurura ingirangingo:
TB4 ni peptide ntoya yatunganijwe kurubuga rukora rwa thymosine β4. Thymosine β4 ifite ubushobozi bwo guteza imbere ingirabuzima fatizo, kandi TB4 yarazwe uyu mutungo. Irashobora guteza imbere kuvugurura ingirabuzimafatizo muburyo bukurikira:
Gukora selile yerekana inzira:
Irashobora gukora selile yihariye yerekana inzira yo guteza imbere ikwirakwizwa ryimikorere no gutandukana. Kurugero, irashobora gukora inzira yerekana inzira zijyanye no gukura kwakagari no gusana, nka PI3K / Akt yerekana inzira, nibindi, bityo bigatera ikwirakwizwa ryingirabuzimafatizo no gutandukana no guteza imbere ingirabuzimafatizo [1].
Kugenga matrise idasanzwe:
Matrisa idasanzwe igira uruhare runini mu kuvugurura ingirangingo. TB4 irashobora kugenga synthesis no gutesha agaciro matrice idasanzwe, igatera ingirabuzimafatizo, kwimuka, hamwe no kuvugurura ingirangingo. Kurugero, irashobora kongera synthesis ya kolagen na elastine, igateza imbere imikorere nimikorere yinyama [1].
Ingaruka zo kurwanya inflammatory:
Gutwika ni igisubizo kirinda umubiri gukomeretsa no kwandura, ariko gutwika cyane bishobora gutera kwangirika kwinyama. TB4 igira ingaruka zo kurwanya inflammatory kandi irashobora kubuza umusaruro wabunzi. Abunzi batwika nka cytokine na chemokine bafite uruhare runini mugusubiza umuriro. TB4 irashobora kubuza umusaruro abo bahuza batera, bityo bikagabanya igisubizo. Kurugero, irashobora kubuza kubyara ibintu bitera umuriro nkibibyimba bya niyosezi-α (TNF-α) na interleukin-1β (IL-1β) [1].
Kugenga imikorere yingirabuzimafatizo:
Ingirabuzimafatizo zigira uruhare runini mugusubiza umuriro. TB4 irashobora kugenga imikorere ya selile yumubiri, nko kugenzura ibikorwa bya macrophage na lymphocytes, bityo bikagabanya ibisubizo byumuriro. Kurugero, irashobora guteza imbere ihinduka rya macrophage muri fenotipike irwanya inflammatory kandi ikabuza gukora no gukwirakwiza lymphocytes [1].
Kwihutisha ikwirakwizwa ry'utugari no gutandukana:
Mugukoresha inzira yerekana inzira ya selile no kugenzura matrice idasanzwe, TB4 irashobora kwihutisha ikwirakwizwa ryingirabuzimafatizo no gutandukanya, bigatera gusana ingirangingo zangiritse [1].
Kugabanya igisubizo kibabaza:
Igisubizo cyo gutwika kizadindiza gusana ingirangingo, kandi ingaruka zo kurwanya indwara ya TB4 zirashobora kugabanya igisubizo cyakongeje, bigatuma habaho ibidukikije byiza byo gusana ingirangingo [1].
Guteza imbere angiogenez:
Angiogenezi ningirakamaro mugusana ingirangingo. TB4 irashobora guteza angiogenez, kongera amaraso kumubiri wangiritse, gutanga intungamubiri na ogisijeni mu ngirabuzimafatizo, no guteza imbere gusana ingirangingo ..
Amabwiriza ya MMP / TIMP kuri fibrosis ya hepatike.
Inkomoko: Byatangajwe [3]
Nigute TB4 igenga synthesis no gutesha agaciro matrix idasanzwe?
Impirimbanyi hagati ya synthesis no gutesha agaciro matrice idasanzwe (ECM) ningirakamaro mugukomeza imiterere n'imikorere isanzwe. TB-500 irashobora kugira ingaruka kuri synthesis ya matrice idasanzwe muburyo bukurikira:
Guteza imbere ububiko bwa kolagen:
TB-500 bemeza ko ishobora guteza imbere imyanda ya kolagen, kandi kolagen ni ikintu cyingenzi cya matrice idasanzwe. Uburyo bwihariye bwibikorwa bushobora kuba bukubiyemo amabwiriza yinzira yerekana inzira igira uruhare muri synthesis ya kolagen. Kurugero, irashobora guteza imbere imvugo ya genagen ikora ibintu bimwe na bimwe bikura cyangwa ibintu byandikirwa, bityo bikongerera synthesis ya kolagen [2].
Guteza imbere gutandukanya selile ya endoteliyale na angiogenez:
Utugingo ngengabuzima twa endothelia dusohora ibintu bitandukanye bigize matrice idasanzwe mugihe cyo gukora imiyoboro y'amaraso. TB-500 iteza imbere ingirabuzimafatizo ya endoteliyale hamwe na angiogenezi mu ngingo za dermal, zishobora guteza imbere mu buryo butaziguye synthesis ya matrice idasanzwe. Imiyoboro y'amaraso imaze kuvuka isaba inkunga ya matrice idasanzwe, ishobora gutera ingirabuzimafatizo guhuza ibice byinshi bya matrice idasanzwe [2].
Ingaruka zo gutesha agaciro matrix idasanzwe:
Irashobora kugenga ibikorwa bya matrix metalloproteinase (MMPs) hamwe na inhibitor zabo (TIMPs):
Iyangirika rya matrice idasanzwe igengwa ahanini na matrix metalloproteinase na inhibitor zabo. Nubwo kuri ubu nta bimenyetso simusiga byerekana ko TB-500 igenga ibikorwa bya MMPs na TIMPs, urebye ko TB-500 igira ingaruka zo kwimuka kwimuka no gukira ibikomere, kandi inzira yo kwimuka kwakagari no gukira ibikomere ubusanzwe iherekejwe no kuvugurura matrice idasanzwe, ibi bishobora kuba bikubiyemo amabwiriza ya MMPs na TIMPs. Kurugero, mubushakashatsi bwa fibrosis yumwijima, matrix metalloproteinase na inhibitor zihariye (urugero, ingirabuzimafatizo za metalloproteinase, TIMPs) zigira uruhare runini muguhindura hamwe no gusesa. Mugusubizaho uburinganire hagati ya MMPs na TIMPs, kwirundanya kwa matrise idasanzwe birashobora guhagarikwa, bityo bikagabanya fiboside yumwijima [3].
Kugenzura mu buryo butaziguye iyangirika rya matrice idasanzwe bigira ingaruka ku myitwarire ya selile:
TB-500 irashobora guteza imbere kwimuka kwa keratinocyte. Mugihe cyo kwimuka kwakagari, selile zigomba kugenzura iyangirika rya matrice idasanzwe kugirango isibe inzira. Ibi birashobora kuba birimo gusohora imisemburo runaka cyangwa ibintu na selile kugirango bigabanye kwangirika kwa matrix idasanzwe. Kurugero, mubikorwa bimwe na bimwe bya physiologique na patologique, selile zirekura matrix metalloproteinase kugirango itesha agaciro matrice idasanzwe yo kwimuka [2].
Ni mu buhe buryo TB4 ikorana na biomaterial kugirango iteze imitsi kuvugurura?
Kurekura molekile ya bioactive:
Ibinyabuzima birashobora gukora nk'abatwara kandi bigakorana na TB4 kurekura molekile ya bioaktike, bigatera imitsi kuvugurura imitsi. Kurugero, bimwe mubinyabuzima bishobora kurekura ibintu bifatika nkibintu bikura. Ibi bintu bifatanya na TB4 kugirango bikwirakwize no gutandukanya ingirangingo. TB4 ubwayo ifite ingaruka zo guteza imbere kwimuka kwa selile na angiogenez. Ufatanije na molekile ikora irekurwa na biomaterial, irashobora kurushaho guteza imbere imitsi kuvugurura imitsi [4, 5].
Uruhare rwibikoresho bya biomimetike:
Ibikoresho bya biomimetike bigana imiterere karemano n'imikorere y'inyama z'imitsi, bitanga ibidukikije bikwiye kuri TB4. Ibikoresho nkibi bya biomimetike birashobora guhuzwa neza nuduce twimitsi, bigateza imbere ibikorwa bya TB4 ahangiritse. Kurugero, ibikoresho bya biomimetike bifite imiterere yihariye irashobora gutanga inkunga yo gukura kwakagari, kandi mugihe kimwe, kwemerera TB4 gukwirakwira no gukora neza [4].
Ingaruka zo gukingira:
Ibinyabuzima birashobora guteza imbere imitsi kuvugurura imitegekere yubudahangarwa, bihujwe na TB4. Ubushakashatsi bwerekanye ko ibinyabuzima bishobora kugenga polarike ya macrophage, bityo bikagenzura ubudahangarwa bw'umubiri kandi bigatera ahantu heza ho kuvugurura imitsi. TB4 irashobora kongera imbaraga zo gukingira indwara bigira ingaruka kumikorere ya selile. Kurugero, binyuze muri immunomodulation yunganirwa na biomaterial, polarisiyasi ya macrophage irashobora gutegekwa kugirango habeho kuvugurura ingirabuzimafatizo zoroheje za sisitemu ya musculoskeletal, kandi TB4 irashobora kugira uruhare runini muriki gikorwa [5].
Guhuriza hamwe ingirabuzimafatizo n'ibinyabuzima:
Ingirabuzimafatizo zigira uruhare runini mu kuvugurura imitsi. Gukomatanya na biomaterial na TB4 birashobora gutanga ingamba nziza zo kuvura. Benshi mubaturage b'ingirabuzimafatizo, nka mesenchymal stem selile na adipose-stem selile stem selile, bagira uruhare muguhindura imitsi. Ibinyabuzima bishobora gutanga ubufasha nubuyobozi bwingirabuzimafatizo, mugihe TB4 ishobora guteza imbere kwimuka, kubaho, no gutandukanya ingirabuzimafatizo. Guhuza bitatu birashobora gutsinda imbogamizi zo kubikoresha wenyine kandi bigatera imitsi kuvugurura.
Guteza imbere imitsi mishya:
Kuvugurura imitsi ya periferique nabyo bigira uruhare runini mu kuvugurura imitsi. Ibinyabuzima birashobora gutanga ikiraro cyubaka kugirango gitezimbere imitsi, kandi TB4 irashobora kurushaho guteza imbere imitsi no gukira kwimitsi imitsi bigira ingaruka kumagambo ya gene ajyanye na neurogenezi. Kurugero, ubushakashatsi bumwe bwerekanye ko imiterere ya gene ijyanye na neurogenezi itunganijwe neza, byerekana uruhare rwo kuvugurura imitsi ya periferique muguhuza imbaraga zimitsi, kandi biomaterial na TB4 bishobora gufatanya guteza imbere iki gikorwa [6].
Gukoresha ibinyabuzima byifashishwa mu buryo bwa magneti:
Ibinyabuzima bishya byifashishwa mu buryo bwa magneti birashobora kongera imitsi kuvugurura imiti no kubyara. TB4 irashobora gukoreshwa ifatanije nibi binyabuzima kugirango tunoze ingaruka zo gusana imitsi yangiritse. Kurugero, biphasic fer gel scaffold irashobora gukoreshwa mugutanga ingirabuzimafatizo nibintu bikura, neza na neza muri vivo kugirango imitsi ikore neza mugihe cyo gutwika. TB4 irashobora gukorana hamwe niyi biomaterial kugirango irusheho guteza imbere imitsi [7].
Muri rusange, nka peptide ntoya yatunganijwe kuva kurubuga rwa thymosine β4, TB4 yerekanye imbaraga zidasanzwe muguhindura ingirabuzimafatizo, kurwanya umuriro, no gusana byihuse. Ubushakashatsi bwerekanye ko bushobora guteza imbere gutandukanya ingirabuzimafatizo, angiogenezi, hamwe no kwimuka kwa keratinocyte, kandi bishobora no kugenga synthesis no gutesha agaciro matrix idasanzwe. Mu rwego rwo gusana imitsi, TB4 irashobora kuzana ibyiringiro bishya byo gusana ibikomere bya siporo biteza imbere gukwirakwiza no gutandukanya ingirangingo fatizo z'imitsi, kugenga igisubizo cy’umuriro, no gukorana na biomaterial. TB4 ifite ubushobozi bwo kuba imiti ifatika yo kuvura ibyangiritse nindwara zifitanye isano.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Ye J ni umushakashatsi muri kaminuza ya Zhejiang akaba n'umwe mu bagize itsinda ry’ubuvuzi bw’imyororokere mu Bushinwa (CORMed). Mubushakashatsi bwe harimo ubwubatsi, ibikoresho siyanse, sisitemu yo kugenzura no kugenzura, ubucuruzi nubukungu, nuburyo bwimibare mubumenyi rusange. Ye J yagiye mu bigo bitandukanye n’amasomo n’amasomo, nka Opt Clearing Corp, CTC Holdings, Kaminuza ya Illinois Chicago, n’Ishuri Rikuru ry’Ubugenge rya Dalian, CAS. Ye J yashyizwe ku rutonde rw'ibitekerezo [5].
