Bya Cocer Peptides 
ennaku 24 eziyise
EBINTU BYONNNA N’AMAWULIRE GW’EBINTU EBIweereddwa KU MUTINDO GUNO BIKOZESEBWA KU KUSASANYA AMAWULIRE N’EBIKOLWA BY’OKUSOMESA.
Ebintu ebiweereddwa ku mukutu guno bigendereddwamu kunoonyereza mu kisenge (in vitro research) byokka. Okunoonyereza mu vitro (Olulattini: *mu ndabirwamu*, ekitegeeza mu bikozesebwa mu ndabirwamu) kukolebwa ebweru w’omubiri gw’omuntu. Ebintu bino si bya ddagala, tebikkiriziddwa kitongole kya Amerika ekivunaanyizibwa ku by’emmere n’eddagala (FDA), era tebirina kukozesebwa kuziyiza, kujjanjaba oba kuwonya mbeera yonna ya bujjanjabi, bulwadde oba bulwadde. Kikugirwa nnyo mu mateeka okuyingiza ebintu bino mu mubiri gw’omuntu oba ebisolo mu ngeri yonna.
1. Okulaba ebikwata ku CJC-1295
CJC-1295, nga synthetic growth hormone analog, eyamba mu kugejja, okutumbula ebinywa, okuzza obuggya olususu, okulongoosa otulo, n’okuwona ebiwundu. Ipamorelin ye pentapeptide ekoleddwa mu kika kya peptides ezifulumya obusimu bw’okukula (secretagogues). Kisitula okufulumya obusimu bw’okukula era kikwata ku nkola ez’enjawulo ez’omubiri, omuli okwanguya okufulumya amazzi mu lubuto, okulongoosa obubonero bw’okuzibikira ekyenda oluvannyuma lw’okulongoosebwa, okusitula okufulumya insulini, n’okuziyiza ebikolwa bya catabolic ebya glucocorticoids ku binywa by’amagumba n’amagumba. Okunoonyereza ku ngeri ebirungo bino ebibiri gye bikwataganamu kiyinza okuvaamu okukulaakulana okupya mu by’obulamu, eddagala ly’emizannyo, n’obujjanjabi bw’endwadde ezikwatagana nabyo.
CJC-1295 Enkola y’okukola
CJC-1295 okusinga ekola ebikolwa byayo nga ekwatagana n’ekirungo ekikwata obusimu obufulumya obusimu bw’okukula (GHRHR). Kikoppa enkola y’obusimu obufulumya obusimu bw’okukula (GHRH), ekireetera endwadde y’omu lubuto (anterior pituitary gland) okufulumya obusimu obukula (GH). Bw’ogeraageranya ne GHRH ey’obutonde, CJC-1295 erina ekitundu ky’obulamu ekiwanvu, ekigisobozesa okusitula mu ngeri ey’olubeerera okufulumya obusimu bw’okukula. Okusikirizibwa kuno okuwangaala kuyamba okukuuma emiwendo gy’obusimu bw’okukula nga teginywevu mu mubiri, okukwata ku nkola z’omubiri eziddiriŋŋana ezisinziira ku busimu bw’okukula.
CJC-1295 Ebivaamu
Okutumbula enkyukakyuka y’amasavu: Obusimu obukula bukola kinene mu nkyukakyuka y’amasavu. CJC-1295 eyamba okufulumya obusimu obukula, n’eyongera ku lipolysis mu butoffaali bw’amasavu, ekimenya amasavu ne gafuuka asidi z’amasavu ne glycerol. Ebintu bino ebimenya bifulumizibwa mu musaayi ne bikozesebwa ebitundu ebirala n’ebitundu by’omubiri ng’ensibuko y’amaanyi ekivaako okugejja n’okukendeeza amasavu mu mubiri.
Ayongera amaanyi g’ebinywa n’obuzito: Obusimu obukula bukwata nnyo ku nkula y’ebinywa n’okuddaabiriza. CJC-1295 etumbula okufulumya obusimu obukula, bwe kityo n’esitula okukula n’okwawukana kw’obutoffaali bwa setilayiti —obutoffaali obusibuka mu binywa by’amagumba obukola kinene mu kuddaabiriza n’okukula kw’ebinywa. Obusimu bw’okukula era bwongera okuyingiza amino asidi n’okukola puloteyina ate nga bukendeeza ku kumenya kwa puloteyina, bwe kityo ne kiyamba okwongera ku buzito bw’ebinywa n’okutumbula amaanyi g’ebinywa.
Okulongoosa embeera y’olususu: Obusimu bw’okukula bwetaba mu nkola z’enkyukakyuka y’olususu. Oluvannyuma lw’okusitula okufulumya obusimu obukula, CJC-1295 etumbula okukula kw’obusimu obuyitibwa fibroblasts n’okukola kolagini. Fibroblasts kye kika ky’obutoffaali ekisookerwako mu lususu ekivunaanyizibwa ku kukola kolagini n’ebitundu ebirala eby’ebweru w’obutoffaali (extracellular matrix components). Okwongera okukola kolagini kiyamba olususu okunyirira n’okunyweza, kikendeeza ku kuzimba enviiri, era kifuula olususu okulabika ng’oluto.
Okutumbula okuwona kw’ebiwundu: Obusimu obukula bukola kinene mu kuddaabiriza ebitundu by’omubiri. CJC-1295 eyanguya okukula kw’obutoffaali n’okusenguka mu bitundu ebyonooneddwa ng’etumbula okufulumya obusimu bw’okukula, eyamba okukola emisuwa, egaba ebiriisa bingi ne omukka gwa oxygen eri ebitundu ebyonooneddwa, n’okwanguya okuddaabiriza obuvune obw’enjawulo ng’okuwona ebiwundu n’okuwona kw’okumenya.
CJC-1295 Okusaba
Emizannyo n’okubeera omulamu obulungi: Abazannyi n’abawagizi ba fitness batera okukozesa CJC-1295 okutumbula okutendekebwa, okwongera amaanyi mu binywa, okukendeeza amasavu mu mubiri, n’okulongoosa omutindo gw’emizannyo n’ensengeka y’omubiri.
Obulungi n’okulwanyisa okukaddiwa: Olw’okuzza obuggya olususu, CJC-1295 esobola okukozesebwa okulongoosa enviiri z’olususu, okugwa, n’ensonga endala ezikwata ku kukaddiwa.
Ekitundu ky’okunoonyereza ku by’obusawo: Mu kunoonyereza ku by’obusawo, CJC-1295 ekola ng’ekintu eky’okunoonyereza ku nkola z’omubiri ezikwatagana n’obusimu bw’okukula, okuyamba abanoonyereza okutegeera obulungi omulimu gw’obusimu bw’okukula mu nkola z’omubiri n’endwadde z’omuntu, n’okuwa omusingi gw’enzikiriziganya ogw’okukola enkola empya ez’obujjanjabi n’eddagala.
2. Enkola y’Ekikolwa kya Ipamorelin
Okulongoosa mu nkyukakyuka y’amasoboza ga Mitochondrial
Okwongera ku ADP Sensitivity: Mu kiseera ky’okukaddiwa, mitochondrial sensitivity eri ADP ekendeera, ekikosa obulungi bw’okusengejja ATP. Okunoonyereza kulaga nti SS-31 esobola okwesiba butereevu ku mitochondrial ADP transporter ANT, okwongera ku ANT okutwala ADP, bwe kityo n’eyongera ku mitochondrial sensitivity eri ADP. Mu mitochondria z’ebinywa ezikaddiye, obujjanjabi bwa SS-31 bwayongera okutwala ADP nga buyita mu ANT, bwe kityo ne kyongera okussa kw’emitochondria wansi w’okusikirizibwa kwa ADP, okwongera okukola ATP, n’okulongoosa enkyukakyuka y’amasoboza mu mitochondria z’ebinywa ezikaddiye.
Okulungamya ebizibu by’olujegere lw’okussa mu mitochondrial: Ebizibu by’olujegere lw’okussa mu mitochondrial bye bitundu ebikulu mu kukola amaanyi ga mitochondria. Mu kiseera ky’okukaddiwa, emirimu gy’ebizibu by’enjegere z’okussa gitera okukendeera. SS-31 eyinza okukuuma oba okutumbula emirimu gy’ebizibu by’enjegere z’okussa nga etebenkeza obulungi bw’enzimba yaabyo oba okulungamya okwolesebwa kwa puloteyina ezikwatagana. Okunoonyereza okwakolebwa emabegako kwalaba nti mu bikolwa by’obutakola bulungi bwa mitochondrial ebikwatagana n’okukaddiwa, emirimu gy’ebizibu by’olujegere lw’okussa gikomezebwawo oluvannyuma lw’okujjanjabwa SS-31, ekiraga nti ekikola obulungi mu kulungamya ku lujegere lw’okussa olw’emitochondria.
Ekifaananyi 1 Enkola ya Ipamorelin mu nkola y’envunza eya POI.
Okulongoosa obubonero bw’okuzibikira ekyenda oluvannyuma lw’okulongoosebwa: Mu nkola y’envunza ey’okuzibikira ekyenda oluvannyuma lw’okulongoosebwa, Ipamorelin yalaga ebirungi awatali kulowooza oba yaweebwa nga ddoozi emu oba enfunda eziwera. Dozi emu yakendeeza ku budde okutuuka ku kusooka okufulumya omusulo, ate okugiwa enfunda eziwera yayongera nnyo ku musulo ogukuŋŋaanyiziddwa, emmere gye balya, n’okugejja. Ipamorelin alongoosa okuddamu okukola kw’ekyenda oluvannyuma lw’okulongoosebwa n’okukendeeza ku bubonero obukwatagana n’okuzibikira kw’ekyenda.
Okusitula okufulumya insulini: Ipamorelin erina akakwate akalala ku bitundu by’olubuto, okusitula okufulumya insulini okuva mu bitundutundu by’ebitundu by’olubuto mu nvunza eza bulijjo n’eza ssukaali. Okunoonyereza kuzudde nti ebimu ku biziyiza emikutu n’ebiziyiza ebikwata ku bikwata, nga diltiazem, yohimbine, ne propranolol, bisobola okuziyiza okufulumya insulini okuleetebwa Ipamorelin, okukakasa nti enkola yaayo ey’okukola ekwatagana n’emikutu gino n’ebikwata.
Ekifaananyi 2 Kiraga enkola ya Ipamorelin ku kufulumya insulini okuva mu bitundutundu by’ebitundu by’olubuto eby’envunza eza bulijjo n’eza ssukaali.
Antagonizing the catabolic effects of glucocorticoids: Mu model y’envunza enkuze, okukozesa awamu glucocorticoids (nga methylprednisolone) ne Ipamorelin kwayongera nnyo ku maximum tetanic tension y’ebinywa by’ennyana bw’ogeraageranya n’okuweebwa glucocorticoid yokka, era ne kikubisaamu emirundi ena omutindo gw’okutondebwa kw’amagumba g’omu lubuto. Kino kiraga nti Ipamorelin esobola okuziyiza ebikolwa bya catabolic ebya glucocorticoids ku binywa by’amagumba n’amagumba, bwe kityo n’akuuma amaanyi g’ebinywa n’obunene bw’amagumba.
Okukozesa eddagala lya Ipamorelin
Okujjanjaba endwadde z’enkola y’okugaaya emmere: Ipamorelin erina ebimu ku bikozesebwa mu kujjanjaba endwadde z’enkola y’okugaaya emmere. Ku bubonero ng’obutagaaya mmere n’okuzimba ebiva ku butatambula bulungi mu lubuto, awamu n’ebizibu by’okuzibikira ekyenda oluvannyuma lw’okulongoosebwa oluvannyuma lw’okulongoosebwa olubuto, Ipamorelin eyinza okuvaayo ng’enkola empya ey’obujjanjabi.
Okunoonyereza n’okujjanjaba ssukaali: Ipamorelin asobola okusitula okufulumya insulini era alina kinene mu kunoonyereza ku ssukaali. Kiyinza okukola ng’ekintu eky’okunoonyereza ku nkola y’okufulumya insulini, okuyamba abanoonyereza okutegeera obulungi enkola z’okulungamya okufulumya insulini. Ku bika by’abalwadde ba ssukaali ebimu naddala abo abatalina insulini emala era nga tebakola bulungi bujjanjabi obuliwo, Ipamorelin eyinza okuwa obujjanjabi obupya.
Eddagala ly’emizannyo n’okuddaabiriza: Mu by’obusawo bw’emizannyo n’okuddaabiriza, obusobozi bwa Ipamorelin okulwanyisa ebikolwa bya katabolic ebiva mu glucocorticoids n’engeri ennungi gye yakwata ku bulamu bw’ebinywa n’amagumba bigifuula omuntu asuubiza okukozesebwa. Ku balwadde abafunye okuzimba ebinywa n’okuzimba amagumba olw’okukozesa eddagala lya glucocorticoids okumala ebbanga eddene okujjanjaba endwadde, okukozesa Ipamorelin mu kiseera kye kimu kiyinza okuyamba okukendeeza ku buzibu buno n’okutumbula okuddamu okukola kw’ebinywa n’amagumba. Ku bannabyamizannyo abafuna obukoowu bw’ebinywa n’obuvune oluvannyuma lw’okutendekebwa okw’amaanyi, Ipamorelin era eyinza okwanguya okuwona ng’etumbula okuddaabiriza n’okukula kw’ebinywa.
3. Okwekenenya ebikolwa eby’okukwatagana ebya CJC-1295 ne Ipamorelin
Okutumbula okukwatagana kw’okufulumya obusimu bw’okukula
CJC-1295 esitula okufulumya obusimu bw’okukula nga yesiba ku GHRHR n’okukoppa enkola ya GHRH, ate Ipamorelin etumbula okufulumya obusimu bw’okukula okuva mu nseke y’omu maaso ng’ekola ku bikwata ghrelin. Zombi zikola ku bikwata eby’enjawulo naye okukkakkana nga zongera ku kufulumya obusimu obukula. CJC-1295 ne Ipamorelin bwe zikozesebwa wamu, ziyinza okusitula mu ngeri ey’okukwatagana okufulumya obusimu bw’okukula okuyita mu makubo ag’enjawulo agalaga obubonero. Okufuluma kw’obusimu bw’okukula okuleetebwa CJC-1295 kuyinza okutumbula okuwuliziganya kw’obutoffaali bw’omu lubuto obw’omu maaso eri Ipamorelin. Kino ekikolwa eky’okukwatagana kiyinza okuvaamu emitendera egy’okufuluma ennyo egy’obusimu bw’okukula bw’ogeraageranya n’okukozesa ekintu kyonna kyokka, bwe kityo ne kitereeza obulungi enkola z’omubiri ezikwata ku busimu bw’okukula, gamba ng’okukyusakyusa amasavu, okukula kw’ebinywa, n’okuddaabiriza olususu.
Ebikosa okukwatagana ku kulungamya enkyukakyuka mu mubiri
Mu nsonga z’okukyusakyusa amasavu, CJC-1295 etumbula lipolysis, ate Ipamorelin eyinza okukosa amaanyi agayingira n’okunyiga ng’etereeza enkola y’olubuto n’ekyenda. Ebiva mu kukwatagana kwa byombi biyinza okwongera okutumbula ebiva mu nkyukakyuka y’amasavu. Ipamorelin ayanguya okufulumya amazzi mu lubuto, n’asobozesa emmere okuyingira amangu mu kyenda ekitono okusobola okuginyiga, ekiyinza okukosa amaanyi omubiri gwe guyingiza n’okugagabanyaamu. Amaanyi agakolebwa okumenya amasavu okuva mu CJC-1295 gasobola okukozesebwa obulungi, ekivaako okugejja obulungi n’okukendeeza amasavu mu mubiri.
Mu nsonga z’okukyusakyusa glucose, okusikirizibwa kwa CJC-1295 kw’obusimu bw’okukula kuyinza okukosa obutatereevu okuwuliziganya kwa insulin, ate Ipamorelin esobola okusitula butereevu okufulumya insulini. Enkola y’okukwatagana eya byombi eyinza okuwa ekikolwa eky’okulungamya ekisingawo ku nkyukakyuka ya glucose. Mu bikolwa by’ebisolo ebirina ssukaali, okukozesa awamu CJC-1295 ne Ipamorelin kuyinza okukendeeza ku mutindo gwa glucose mu musaayi nga kisitula okufulumya insulini okuyita mu Ipamorelin, era n’okulongoosa okuwuliziganya kwa insulini okuyita mu CJC-1295, okwongera okulongoosa enkola ya glucose mu musaayi okugikuuma ku mutindo ogutebenkedde.
Ekifaananyi 3 Kiraga enkola y’ebiziyiza emikutu gya cholinergic, adrenergic, ne calcium channel ku ipamorelin (IPA)-evoked insulin release okuva mu pancreas y’envunza eza bulijjo ne ssukaali.
Ebikosa ebikwatagana ku binywa n’amagumba
Mu nsonga z’ebinywa, CJC-1295 etumbula okukula kw’obutoffaali bwa satellite, okwawukana, n’okukola puloteyina, ate Ipamorelin eziyiza ebikolwa bya catabolic ebya glucocorticoids era eyinza okutumbula okuddaabiriza ebinywa. Bwe zikozesebwa awamu, ziyinza okukola ebikolwa eby’okukwatagana mu kukula n’okuddaabiriza ebinywa. Mu kiseera ky’okuddaabiriza obuvune bw’ebinywa, CJC-1295 eyanguya okukola n’okukula kw’obutoffaali bwa satellite, n’ewa ensibuko z’obutoffaali ezisingawo okuddaabiriza ebinywa, ate Ipamorelin ayongera okutambula kw’omusaayi n’okugabibwa kw’ebiriisa era n’eziyiza ensonga eziyinza okubaawo mu katabolic, n’etondawo embeera ennungi ennyo okuddaabiriza ebinywa, bwe kityo n’etumbula obulungi okuddaabiriza ebinywa n’okweyongera kw’ebinywa.
Ebikosa okukwatagana mu kuddaabiriza ebitundu by’omubiri n’okuzza obuggya
Mu nkola y’okuwona ebiwundu, CJC-1295 etumbula okufulumya obusimu obukula, eyanguya okukula kw’obutoffaali, n’okusitula okukola emisuwa, ate Ipamorelin eyinza okwanguyiza okuddaabiriza ebitundu by’omubiri ng’etereeza obutonde obutono obw’omu kitundu n’okutumbula okugabibwa kw’ebiriisa. Mu kiseera ky’okuwona ebiwundu, CJC-1295 esobola okusitula fibroblasts okukola collagen mu bwangu, ate Ipamorelin esobola okutereeza entambula y’omusaayi okwetoloola ekiwundu, n’ewa ebiriisa bingi ne oxygen okuwona ebiwundu. Ebiva mu kukwatagana kwa byombi biyinza okwanguya enkola y’okuwona ebiwundu n’okulongoosa omutindo gw’okuwona.
Mu nsonga y’okuddaabiriza ebitundu by’obusimu, obusimu bw’okukula bukola kinene mu kukula, okuwangaala, n’okwawukana kw’obutoffaali bw’obusimu, ate Ipamorelin eyinza okukwata ku kuddaabiriza obusimu ng’etereeza obusimu obutambuza obusimu n’okulongoosa obutonde obutono obw’omu kitundu.
Ebitundu ebiyinza okukozesebwa ku bikolwa ebikwatagana
Eddagala ly’emizannyo n’okubeera omulamu obulungi
Ku bannabyamizannyo n’abawagizi ba fitness, ebikolwa eby’okukwatagana ebya CJC-1295 ne Ipamorelin biyinza okuvaako okulongoosa okw’amaanyi mu mutindo gw’emizannyo n’ensengeka y’omubiri. Okutumbula kwazo okukwatagana okukula kw’ebinywa n’okukyusakyusa amasavu kuyinza okuyamba bannabyamizannyo okwongera ku maanyi g’ebinywa n’obuzito ate mu ngeri ennungi ne bakendeeza amasavu mu mubiri, bwe batyo ne bongera okugumiikiriza mu mizannyo n’amaanyi g’okubwatuka. Mu nsonga y’okuwona obuvune mu mizannyo, ebikolwa byabwe eby’okukwatagana bisobola okwanguya okuddaabiriza ebinywa, amagumba n’ebitundu ebigonvu, ne kikendeeza ku budde bw’abazannyi okuwona n’okubasobozesa okudda amangu mu kutendekebwa n’okuvuganya.
Ennimiro y'obulungi n'okulwanyisa okukaddiwa
Mu by’okwewunda n’okulwanyisa okukaddiwa, ebikolwa ebikwatagana ebya CJC-1295 ne Ipamorelin biyinza okuwa eby’okulonda ebipya eby’okuzza obuggya olususu n’okulongoosa enkola y’omubiri okutwalira awamu. Zombi zitumbula okukola kolagini n’okukyusakyusa obutoffaali bw’olususu mu ngeri ey’okukwatagana, ne zilongoosa nnyo okunyirira kw’olususu, okunyweza, n’okumasamasa bw’ogeraageranya n’okukozesa emu yokka, ate nga zikendeeza ku kutondebwa kw’enviiri n’amabala g’emyaka. Ebikolwa byabwe ebikwatagana ku nkyukakyuka y’omubiri n’okuddaabiriza ebitundu by’omubiri nabyo biyamba okukuuma obulamu okutwalira awamu, okukendeeza ku nkola y’okukaddiwa okuva munda n’okutumbula endabika n’enkola y’omubiri.
Ennimiro y'obujjanjabi bw'abasawo
Endwadde z’enkola y’okugaaya emmere: Ku ndwadde ezimu ez’enkola y’okugaaya emmere, gamba ng’obutatambula bulungi mu lubuto n’okuzibikira kw’ekyenda oluvannyuma lw’okulongoosebwa, ebikolwa ebikwatagana ebya CJC-1295 ne Ipamorelin biyinza okuwa enkola empya ez’obujjanjabi. Zitereeza enkola y’olubuto n’ekyenda mu ngeri ey’okukwatagana, okwanguya okufulumya amazzi mu lubuto, n’okulongoosa entambula y’ekyenda, ekiyinza okukendeeza obulungi obubonero obukwatagana n’okutumbula omulwadde okuwona. Ku balwadde abalina endya embi n’okugejja olw’endwadde z’enkola y’okugaaya emmere, enkola y’okukyusakyusa emmere mu mubiri (synergistic metabolic regulation) ey’ebirungo bino ebibiri esobola okuyamba abalwadde okuzzaawo obulungi embeera y’emmere yaabwe n’obuzito bwabwe.
Endwadde z’endwadde z’omu lubuto n’enkyukakyuka mu mubiri: Mu kujjanjaba endwadde z’omubiri n’enkyukakyuka mu mubiri nga ssukaali n’omugejjo, ebikolwa eby’okukwatagana ebya CJC-1295 ne Ipamorelin biyinza okukwata omugaso oguyinza okubaawo. Ebikolwa byabwe eby’okulungamya ebikwatagana ku nkyukakyuka ya glucose n’okukyusakyusa amasavu biwa ebigendererwa ebipya n’enkola ez’okujjanjaba endwadde zino. Nga zigatta enkozesa yazo, emiwendo gya glucose mu musaayi gisobola okufugibwa obulungi, okuziyiza insulini okulongooka, n’amasavu mu mubiri ne gakendeera, bwe kityo ne kiweebwa obujjanjabi obw’enjawulo eri endwadde z’endwadde z’omubiri n’enkyukakyuka mu mubiri.
Obuzibu bw’ebinywa n’amagumba: Ku mbeera ng’okuzimba ebinywa n’okuzimba amagumba, ekikolwa eky’okukwatagana ekya CJC-1295 ne Ipamorelin kiyinza okuyamba okutumbula okukula kw’ebinywa n’okutondebwa kw’amagumba, bwe kityo ne kilongoosa amaanyi g’ebinywa by’abalwadde n’omutindo gw’amagumba. Mu balwadde abalina okuzimba ebinywa nga kiva ku kuwummula ku kitanda okumala ebbanga oba obulwadde, okukozesa ebintu bino ebibiri byonna awamu kiyinza okwanguya ebinywa okudda engulu n’okukula, bwe kityo ne kilongoosa omutindo gw’obulamu bw’abalwadde. Mu balwadde abalina obulwadde bw’amagumba, ebikolwa byabwe eby’okukwatagana biyinza okwongera ku density y’amagumba n’okuziyiza ebizibu ng’okumenya.
Mu bufunzi
CJC-1295 ne Ipamorelin mu ngeri ey’okukolagana zitumbula okufulumya obusimu bw’okukula nga ziyita mu makubo ag’enjawulo, nga ziraga ebikolwa eby’okukwatagana ebijjuliza mu bitundu nga okulungamya enkyukakyuka mu mubiri (okwanguya okusasika kw’amasavu, okulongoosa enkyukakyuka ya glucose), okuddaabiriza ebitundu by’omubiri (okwanguyiza okuwona, okuddamu okukola ebinywa), n’okulabirira ebinywa n’amagumba (ebikolwa ebiziyiza-catabolic, okutumbula puloteyina okugatta ebintu).
Ensonda
[1] Van Hout MC, Hearne E. Netnography of Female Enkozesa y’ekirungo ky’okukula eky’obutonde CJC-1295: Pulses and Potions[J]. Okukozesa ebiragalalagala & Okukozesa obubi, 2016,51 (1): 73-84.DOI: 10.3109/10826084.2015.1082595.
[2] Papak M. Ipamorelin - okuzimba omubiri gwe, 2016[C]. https://api.semanticscholar.org/CorpusID:78470780. Enkola y’okukuuma obutonde bw’ensi.
[3] Greenwood-Van MB, Tyler K, Mohammadi E, n’abalala. Efficacy ya ipamorelin, ghrelin mimetic, ku gastric dysmotility mu model y’ebiwuka ey’oluvannyuma lw’okulongoosebwa ileus[J]. J Exp Pharmacol, 2012, 4:149-155.DOI:10.2147/JEP.S35396.
[4] Adeghate E, Ponery AS, Emirates U A. ORIGINALARTICLE Enkola y’okufulumya insulini ereetebwa ipamorelin okuva mu kyenda ky’envunza eza bulijjo ne ssukaali, 2004[C].
[5] Adeghate EA, Ponery A S. Enkola y’okufulumya insulini evudde ku ipamorelin okuva mu kyenda ky’envunza eza bulijjo ne ssukaali.[J]. Ebbaluwa z’obusimu bw’omubiri, 2004,25 6:403-406. https://api.semanticscholar.org/CorpusID:7118136. Enkola y’okukuuma obutonde bw’ensi.
[6] Andersen NB, Malmlöf K, Johansen PB, n’abalala. Obusimu obukula obuyitibwa secretagogue ipamorelin buziyiza okukendeera kw’amagumba g’envunza enkuze okuva ku glucocorticoid[J]. Okunoonyereza ku busimu bw’okukula & Igf, 2001, 11 (5): 266-272.DOI: 10.1054 / ghir.2001.0239.
Ekintu ekiriwo okukozesebwa mu kunoonyereza kwokka:
