Cocer Peptides ye ŋlɔe 
ŋkeke 24 enye sia
NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.
Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.
1. CJC-1295 ƒe nyatakaka kpui aɖe
CJC-1295, abe tsitsime lãmetsiŋusẽ si wowɔ ene la, kpena ɖe ame ŋu le lolo dzi ɖeɖe kpɔtɔ, lãmekawo ƒe nyonyo, ŋutigbalẽ ƒe ɖekakpuiwɔwɔ, alɔ̃dɔdɔ ƒe nyonyo, kple abi ƒe dɔyɔyɔ me. Ipamorelin nye pentapeptide si wowɔ si le peptide siwo ɖea tsitsi ƒe lãmetsiwo (secretagogues) ƒe hatsotso me. Edoa ŋusẽ tsitsiŋusẽ ƒe dodo eye wòkpɔa ŋusẽ ɖe ŋutilã ƒe dɔwɔwɔ vovovowo dzi, siwo dometɔ aɖewoe nye dɔgbo ƒe ʋuʋu kabakaba, dɔgbo ƒe mɔxexeɖedɔléle ƒe dzesi siwo dzena le dɔwɔwɔ vɔ megbe ƒe nyonyo, insulin ƒe dodo, kple glucocorticoids ƒe catabolic ŋusẽkpɔɖeamedzi ɖe ƒunukpeƒeŋusẽ kple ƒu dzi nutsitsi. Nusɔsrɔ̃ tso atike eve siawo ƒe dɔwɔwɔ ɖekae ŋu ate ŋu ana woakpɔ ŋgɔyiyi yeyewo le lãmesẽnyawo, kamedefefewo ƒe atikewɔwɔ, kple dɔléle siwo do ƒome kplii dada me.
CJC-1295 Dɔwɔwɔ ƒe Mɔnu
CJC-1295 wɔa eƒe ŋusẽkpɔɖeamedziwo koŋ to nuwɔwɔ kple tsitsime lãmetsiŋusẽ si ɖea lãmetsiŋusẽ si xɔa lãmetsiŋusẽ (GHRHR) me. Esrɔ̃a tsitsime lãmetsiŋusẽ (GHRH) ƒe dɔwɔwɔ, si wɔnɛ be ŋgɔgbe lãkusia ɖea tsitsimeŋusẽ (GH) doa goe. Ne wotsɔe sɔ kple dzɔdzɔme GHRH la, CJC-1295 ƒe agbenɔƒe afã didi wu, si wɔnɛ be wòte ŋu doa ŋusẽ tsitsime lãmetsiŋusẽ ƒe dodo le mɔ si anɔ anyi ɖaa. Dzideƒoname sia si nɔa anyi ɖaa kpena ɖe ame ŋu be tsitsi ƒe lãmetsiŋusẽ ƒe agbɔsɔsɔ si li ke vie le ŋutilãa me, si kpɔa ŋusẽ ɖe ŋutilã ƒe dɔwɔwɔ siwo kplɔ wo nɔewo ɖo siwo nɔa te ɖe tsitsi ƒe lãmetsi dzi dzi.
CJC-1295 Ŋusẽkpɔɖeamedziwo
Ami ƒe asitɔtrɔ le lãme na ame dodo ɖe ŋgɔ: Tsitsi ƒe lãmetsi wɔa akpa vevi aɖe le ami ƒe asitɔtrɔ me. CJC-1295 doa ŋusẽ tsitsi ƒe lãmetsi si dona, si naa ami ƒe ʋuʋu le ami lãmenugbagbeviwo me, si mãa ami me wòzua ami kple glycerol. Nusiwo gblẽa nu le ame ŋu siawo dona ɖe ʋukawo me eye lãmenugbagbevi kple ŋutinu bubuwo zãnɛ abe ŋusẽtsoƒe ene, si wɔnɛ be ame ƒe lolo dzi ɖena kpɔtɔna eye ami dzi ɖena kpɔtɔna le ŋutilã me.
Enaa lãmekawo ƒe ŋusẽ kple woƒe lolome dzina ɖe edzi: Tsitsi ƒe lãmetsi kpɔa ŋusẽ ɖe lãmekawo ƒe tsitsi kple wo dzadzraɖo dzi vevie. CJC-1295 doa tsitsi ƒe lãmetsiŋusẽ ƒe dodo ɖe ŋgɔ, si wɔnɛ be satelait lãmenugbagbeviwo—siwo nye lãmenugbagbevi siwo le ƒunukpeƒeŋusẽ me siwo wɔa akpa vevi aɖe le lãmekawo ɖɔɖɔɖo kple tsitsi me—ƒe dzidziɖedzi kple vovototodedeameme. Tsitsi ƒe lãmetsi hã dzia amino acid ƒe xɔxlɔ̃ kple protein ƒe wɔwɔ ɖe edzi esime wòɖea protein ƒe gbagbã dzi kpɔtɔna, si wɔnɛ be wòkpena ɖe lãmekawo ƒe lolome ŋu eye wònaa lãmekawo ƒe ŋusẽ nyona ɖe edzi.
Ŋutilã ƒe nɔnɔme ƒe nyonyo: Tsitsi ƒe lãmetsi kpɔa gome le ŋutigbalẽ ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ me. Ne CJC-1295 do ŋusẽ tsitsime lãmetsiŋusẽ ƒe dodo vɔ la, edoa fibroblasts ƒe dzidziɖedzi kple collagen ƒe wɔwɔ ɖe ŋgɔ. Fibroblasts ye nye lãmenugbagbevi ƒomevi vevitɔ si le ŋutigbalẽ me si ƒe dɔe nye be wòawɔ collagen kple lãmenugbagbeviwo godo ƒe akpa bubu siwo le ŋutigbalẽa me. Collagen ƒe wɔwɔme si dzi ɖe edzi nana ŋutigbalẽa te ŋu nɔa te sesĩe eye wòsẽna ɖe edzi, eɖea ɖa ƒe ƒoƒo dzi kpɔtɔna, eye wònana ŋutigbalẽa dzena ɖekakpui.
Abi ƒe dɔyɔyɔ dodo ɖe ŋgɔ: Tsitsi ƒe lãmetsi wɔa akpa vevi aɖe le lãmenugbagbeviwo ɖɔɖɔɖo me. CJC-1295 nana lãmenugbagbeviwo ƒe dzidziɖedzi kple ʋuʋu kabakaba le lãkusi siwo gblẽ me to tsitsi ƒe lãmetsiŋusẽ ƒe dodo ɖe ŋgɔ me, enaa ʋukawo ƒe wɔwɔme nɔa bɔbɔe, enaa nunyiame kple ɔksidzin geɖe lãmenugbagbevi siwo gblẽ, eye wònaa abi vovovowo abe abi ƒe dɔyɔyɔ kple abi ƒe gbagbã ƒe dɔyɔyɔ ene dzadzraɖo kabakaba.
CJC-1295 Dɔbiagbalẽviwo
Kamedefefewo kple kamedede: Zi geɖe la, kamedefefewɔlawo kple kamedede lɔ̃lawo zãa CJC-1295 tsɔ doa hehexɔxɔ ɖe ŋgɔ, dzia lãmekawo ƒe ŋusẽ ɖe edzi, ɖea ami si le ŋutilã me dzi kpɔtɔna, eye wònaa kamedefefewo ƒe dɔwɔwɔ kple ŋutilã ƒe wɔwɔme nyona ɖe edzi.
Atsyɔ̃ɖoɖo kple tsitsi nutsitsi: Le eƒe ŋutigbalẽ ƒe ɖekakpuiwɔwɔ ta la, woate ŋu azã CJC-1295 atsɔ ana ŋutigbalẽ ƒe ʋuʋu, eƒe ŋeŋe, kple nya bubu siwo do ƒome kple tsitsi nanyo ɖe edzi.
Atikewɔwɔ Ŋuti Numekuku ƒe Akpa: Le atikewɔwɔ ŋuti numekuku me la, CJC-1295 nye dɔwɔnu si wotsɔ srɔ̃a nu tso ŋutilã ƒe dɔwɔwɔ siwo do ƒome kple tsitsi ƒe lãmetsiŋusẽ ŋu, si kpena ɖe numekulawo ŋu be woase akpa si tsitsi ƒe lãmetsiŋusẽ wɔna le amegbetɔ ƒe ŋutilã kple dɔléle ƒe dɔwɔwɔ me gɔme nyuie wu, eye wònaa nukpɔsusu ƒe gɔmeɖoanyi si dzi woato ato atikewɔwɔmɔnu yeyewo kple atike yeyewo vɛ.
2. Ipamorelin ƒe Dɔwɔwɔ ƒe Mɔnu
Mitochondrial Ŋusẽ ƒe Tɔtrɔ ƒe Dɔwɔwɔ ƒe Nyonyome
ADP ƒe Seselelãme ƒe Dzidziɖedzi: Le tsitsi me la, mitochondria ƒe seselelãme ɖe ADP ŋu dzi ɖena kpɔtɔna, si gblẽa nu le ATP ƒe wɔwɔme ƒe ŋutete ŋu. Numekukuwo ɖee fia be SS-31 ate ŋu abla ɖe mitochondrial ADP transporter ANT ŋu tẽ, si ana ANT ƒe ADP ƒe xɔxlɔ̃ nadzi ɖe edzi, si ana mitochondrial ƒe seselelãme ɖe ADP ŋu nadzi ɖe edzi. Le lãmeka ƒe mitochondria tsitsiwo me la, SS-31 dɔdamɔnu dzi ADP ƒe xɔxlɔ̃ ɖe edzi to ANT dzi, si wɔe be mitochondrial gbɔgbɔ le ADP ƒe ʋuʋu te, dzi ATP wɔwɔ ɖe edzi, eye wòna ŋusẽ ƒe asitɔtrɔ le lãmeka ƒe mitochondria tsitsiwo me nyo ɖe edzi.
Mitochondrial gbɔgbɔtsixe ƒe kɔsɔkɔsɔ ƒe ƒuƒoƒo ƒe ɖoɖowɔwɔ: Mitochondrial gbɔgbɔtsixe ƒe kɔsɔkɔsɔ ƒe ƒuƒoƒo nye mitochondrial ƒe ŋusẽ wɔwɔ ƒe akpa veviwo. Le tsitsime la, gbɔgbɔtsixe ƒe kɔsɔkɔsɔ ƒe dɔwɔwɔ dzi ɖena kpɔtɔna zi geɖe. SS-31 ate ŋu alé gbɔgbɔtsixe ƒe kɔsɔkɔsɔ ƒe dɔwɔwɔ ɖe te alo ana woƒe dɔwɔwɔ nanyo ɖe edzi to woƒe wɔwɔme ƒe blibonyenye li ke alo protein siwo do ƒome kplii ƒe ɖeɖefia dzi kpɔkpɔ me. Numekuku siwo wowɔ va yi ɖee fia be le mitochondrial ƒe dɔmawɔmawɔ nyuie ƒe kpɔɖeŋu siwo do ƒome kple tsitsi me la, gbɔgbɔtsixe ƒe kɔsɔkɔsɔ ƒe dɔwɔwɔ gaɖoa wo ɖokui me le SS-31 zazã vɔ megbe, si fia be eƒe ɖoɖowɔwɔ ƒe ŋusẽkpɔɖeamedzi nyui ɖe mitochondrial gbɔgbɔtsixe ƒe kɔsɔkɔsɔa dzi.
Nɔnɔmetata 1 Ipamorelin ƒe ŋusẽkpɔɖeamedzi le POI ƒe kpɔɖeŋu si wowɔ le sisiblisi me.
Dɔgbo ƒe mɔxexeɖedɔléle le dɔwɔwɔ vɔ megbe ƒe dzesiwo ƒe nyonyo: Le dɔgbo ƒe mɔxexe le dɔwɔwɔ vɔ megbe ƒe kpɔɖeŋu si wowɔ le sisiblisi me me la, Ipamorelin ɖe ŋusẽkpɔɖeamedzi nyuiwo fia eɖanye be wodoe zi ɖeka alo wodoe enuenu o. Dodokpɔ ɖeka ɖe ɣeyiɣi si wotsɔ ɖea aɖuɖɔ zi gbãtɔ dzi kpɔtɔ, gake edodo enuenu na aɖuɖɔ si dona le lãme na ame, nuɖuɖu si woɖuna, kple lolo dzi ɖe edzi ŋutɔ. Ipamorelin nana dɔgboa ƒe dɔwɔwɔ gahayana le dɔwɔwɔ vɔ megbe eye wòɖea dzesi siwo do ƒome kple dɔgbo ƒe xexe dzi kpɔtɔna.
Insulin ƒe dodo: Ipamorelin kpɔa ŋusẽ aɖe ɖe dɔgboa ƒe lãkusiwo dzi, si wɔnɛ be insulin dona tso dɔgboa ƒe lãkusi kakɛwo me le sisiblisi siwo sɔ kple suklidɔ siaa me. Numekukuwo ɖee fia be mɔxenu aɖewo siwo xea mɔ na mɔ̃memiwo kple esiwo tsi tre ɖe dɔlékuiwo ƒe dɔwɔwɔ ŋu, abe diltiazem, yohimbine, kple propranolol ene, ate ŋu axe mɔ ɖe insulin ƒe dodo si Ipamorelin hena vɛ nu, si ɖo kpe edzi be eƒe dɔwɔwɔ ƒe mɔnu do ƒome kple mɔ̃ siawo kple mɔ̃ siwo xɔa dɔlékuiwo.
Nɔnɔmetata 2 Fia ŋusẽ si Ipamorelin kpɔna ɖe insulin ƒe dodo tso dɔgbo ƒe lãkusi kakɛ siwo le sisiblisi siwo sɔ kple suklidɔlélawo me dzi.
Tsitretsitsi ɖe glucocorticoids ƒe catabolic ŋusẽkpɔɖeamedziwo ŋu: Le sisiblisi tsitsi ƒe kpɔɖeŋu me la, glucocorticoids (abe methylprednisolone ene) kple Ipamorelin zazã ɖekae na nyitsu ƒe lãmeka ƒe tetanic tension si sɔ gbɔ wu dzi ɖe edzi ŋutɔ ne wotsɔe sɔ kple glucocorticoid ɖeɖeko dodo, eye wòdzi ƒu ƒe wɔwɔme ƒe agbɔsɔsɔme ɖe edzi zi gbɔ zi ene. Esia fia be Ipamorelin ate ŋu atsi glucocorticoids ƒe catabolic ŋusẽkpɔɖeamedzi ɖe ƒunukpeƒeŋusẽ kple ƒu dzi, si ana lãmekawo ƒe ŋusẽ kple ƒu ƒe lolome nanɔ anyi.
Ipamorelin zazã
Nuɖuɖumeŋusẽ ƒe dɔlélewo dada: Ipamorelin ƒe atikewɔwɔ ƒe ŋusẽkpɔɖeamedzi aɖewo le nuɖuɖumeŋusẽ ƒe dɔlélewo dada me. Le dzesiwo abe nuɖuɖu ƒe dɔmawɔmawɔ nyuie kple dɔgbo ƒe ʋuʋu si tsoa dɔgboa ƒe ʋuʋu nyuie gbɔ, kpakple dɔgbo ƒe mɔxexeɖedɔléle ƒe kuxi siwo dona tso ƒodo ƒe dɔwɔwɔ vɔ megbe le dɔwɔwɔ vɔ megbe gome la, Ipamorelin ate ŋu ado abe atikewɔmɔnu yeye ene.
Suklidɔ ŋuti numekuku kple edada: Ipamorelin ate ŋu aʋã insulin ƒe dodo eye wòwɔa akpa aɖe le suklidɔ ŋuti numekuku me. Ate ŋu anye dɔwɔnu si woatsɔ asrɔ̃ nu tso insulin ƒe dodo ƒe mɔnuwo ŋu, si akpe ɖe numekulawo ŋu woase insulin ƒe dodo ƒe ɖoɖowɔwɔ ƒe ɖoɖowo gɔme nyuie wu. Le suklidɔléla ƒomevi aɖewo gome, vevietɔ amesiwo ƒe insulin mesɔ gbɔ o eye womewɔa dɔ nyuie ɖe atike siwo li fifia ŋu o la, Ipamorelin ate ŋu ana atike yeye aɖe.
Kamedefefewo ƒe Atikewɔwɔ Kple Gbugbɔgaɖɔɖo: Le kamedefefewo ƒe atikewɔwɔ kple gbugbɔgaɖɔɖo ƒe akpawo me la, ŋutete si le Ipamorelin ŋu be wòatsi glucocorticoids ƒe catabolic ŋusẽkpɔɖeamedziwo nu kple ŋusẽ nyui si wòkpɔna ɖe lãmekawo kple ƒuwo ƒe lãmesẽ dzi la na wònye amesi ŋugbe wodo be woate ŋu azãe. Le dɔnɔ siwo ƒe lãmekawo vuvu kple ƒumeŋuɖui le glucocorticoids zazã ɣeyiɣi didi hena dɔlélewo dada ta gome la, Ipamorelin zazã le ɣeyiɣi ɖeka me ate ŋu akpe ɖe wo ŋu woaɖe nugbegblẽ le ame ŋu siawo dzi akpɔtɔ eye wòado lãmekawo kple ƒunukpeƒewo ƒe dɔwɔwɔ ƒe hayahaya ɖe ŋgɔ. Le kamedefefewɔla siwo ƒe lãmekawo ƒe ɖeɖi tea wo ŋu eye woxɔa abi le hehexɔxɔ sesẽ megbe gome la, Ipamorelin ate ŋu ana woahaya kabakaba hã to lãmekawo ƒe ɖɔɖɔɖo kple tsitsi dodo ɖe ŋgɔ me.
3. CJC-1295 kple Ipamorelin ƒe dɔwɔwɔ aduadu ƒe ŋusẽkpɔɖeamedziwo me dzodzro
Tsitsi ƒe lãmetsiŋusẽ ƒe dodo ɖe ŋgɔ le nuwɔwɔ aduadu me
CJC-1295 doa ŋusẽ tsitsi ƒe lãmetsi ƒe dodo to kadodo kple GHRHR kple GHRH ƒe dɔwɔwɔ sɔsrɔ̃ me, gake Ipamorelin ya doa tsitsi ƒe lãmetsi ƒe dodo ɖe ŋgɔ tso ŋgɔgbe lãkusi me to ghrelin xɔlawo ƒe dɔwɔwɔ me. Wo ame evea siaa wɔa dɔ ɖe lãmenugbagbevi vovovowo dzi gake mlɔeba la, wodzia tsitsimeŋusẽ ƒe dodo ɖe edzi. Ne wozã CJC-1295 kple Ipamorelin ɖekae la, woate ŋu awɔ dɔ aduadu atsɔ aʋã tsitsi ƒe lãmetsiŋusẽ ƒe dodo to dzesimɔ vovovowo dzi. Tsitsi ƒe lãmetsi ƒe dodo si CJC-1295 hena vɛ ate ŋu ana ŋgɔgbe lãkusi ƒe lãmenugbagbeviwo nase veve ɖe Ipamorelin nu. Dɔwɔwɔ aduadu sia ate ŋu ana tsitsi ƒe lãmetsi ƒe dodo nasɔ gbɔ ŋutɔ ne wotsɔe sɔ kple nu eveawo dometɔ ɖesiaɖe ɖeɖeko zazã, si ana wòaɖɔ ŋutilã ƒe dɔwɔwɔ siwo do ƒome kple tsitsi ƒe lãmetsi, abe ami ƒe asitɔtrɔ, lãmekawo ƒe tsitsi, kple ŋutigbalẽ ɖɔɖɔɖo ene, ɖo nyuie wu.
Dɔwɔwɔ aduadu ƒe ŋusẽkpɔɖeamedzi ɖe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi
Le ami ƒe asitɔtrɔ gome la, CJC-1295 doa ami ƒe ʋuʋu ɖe ŋgɔ, gake Ipamorelin ate ŋu akpɔ ŋusẽ ɖe ŋusẽ si woxɔna kple eƒe xɔxlɔ̃ dzi to dɔgbo ƒe dɔwɔwɔ dzi kpɔkpɔ me. Wo ame evea siaa ƒe dɔwɔwɔ aduadu ate ŋu ana ami ƒe asitɔtrɔ le lãmenugbagbeviwo ŋu me tsonu nadzi ɖe edzi. Ipamorelin nana dɔgbo me tsi ƒuƒlu kabakaba, si wɔnɛ be nuɖuɖu gena ɖe dɔgbo suea me kabakaba wu be wòaxɔe, si ate ŋu akpɔ ŋusẽ ɖe ŋusẽ si ŋutilãa xɔna kple eƒe mama dzi. Woate ŋu azã ŋusẽ si ami ƒe gbagbã si CJC-1295 hena vɛ la ŋudɔ nyuie wu, si ana woaɖe lolo dzi akpɔtɔ nyuie wu eye woaɖe ami si le ŋutilã me dzi akpɔtɔ.
Le sukli ƒe asitɔtrɔ gome la, CJC-1295 ƒe tsitsiŋusẽ ƒe dɔwɔwɔ ate ŋu akpɔ ŋusẽ ɖe insulin ƒe seselelãme dzi le mɔ si mele tẽ o nu, evɔ Ipamorelin ya ate ŋu aʋã insulin ƒe dodo tẽ. Dɔwɔwɔ aduadu ƒe ŋusẽkpɔɖeamedzi ate ŋu ana ɖoɖowɔwɔ ƒe ŋusẽkpɔɖeamedzi si de to wu nasu sukli ƒe asitɔtrɔ le lãmenugbagbeviwo ŋu. Le suklidɔlélawo ƒe lãwo ƒe kpɔɖeŋuwo me la, CJC-1295 kple Ipamorelin zazã ɖekae ate ŋu aɖe sukli ƒe agbɔsɔsɔ dzi akpɔtɔ le ʋu me to insulin ƒe dodo to Ipamorelin dzi dodo ɖe ŋgɔ me, eye wòana insulin ƒe seselelãme hã nanyo ɖe edzi to CJC-1295 dzi, si ana ʋumesukli ƒe ɖoɖowɔwɔ nanyo ɖe edzi be wòanɔ agbɔsɔsɔ si li ke wu me.
Nutata 3 Fia ŋusẽ si cholinergic, adrenergic, kple calcium channel antagonists kpɔna ɖe insulin si ipamorelin (IPA) ʋãna tsoa dɔgbo me le sisiblisi siwo sɔ kple suklidɔlélawo ƒe dɔgbo me dzi.
Dɔwɔwɔ aduadu ƒe ŋusẽkpɔɖeamedzi ɖe lãmeka kple ƒu dzi
Le lãmeka gome la, CJC-1295 doa satelait lãmenugbagbeviwo ƒe dzidziɖedzi, vovototodedeameme, kple protein ƒe wɔwɔ ɖe ŋgɔ, gake Ipamorelin ya tsia tre ɖe glucocorticoids ƒe catabolic ŋusẽkpɔɖeamedziwo ŋu eye ate ŋu ado lãmekawo ɖɔɖɔɖo ɖe ŋgɔ. Ne wozã wo ɖekae la, woate ŋu awɔ dɔ aduadu le lãmekawo ƒe tsitsi kple wo dzadzraɖo me. Le lãmekawo ƒe abi dzadzraɖo me la, CJC-1295 naa satellite cell ƒe dɔwɔwɔ kple dzidziɖedzi kabakaba, si naa lãmenugbagbeviwo ƒe dzɔtsoƒe geɖe wu hena lãmekawo ɖɔɖɔɖo, gake Ipamorelin ya doa ŋusẽ ʋu ƒe sisi kple nunyiame eye wòtsia tre ɖe nusiwo ate ŋu agblẽ nu le lãmekawo ŋu ŋu, si wɔnɛ be nɔnɔme si nyo wu na lãmekawo ɖɔɖɔɖo, si wɔnɛ be wòdoa lãmeka siwo xɔ abi ƒe dzadzraɖo kple lãmekawo ƒe lolome ɖe ŋgɔ nyuie wu.
Dɔwɔwɔ aduadu ƒe ŋusẽkpɔɖeamedzi le lãmekawo dzadzraɖo kple wo gbugbɔgadzɔ me
Le abi ƒe dɔyɔyɔ me la, CJC-1295 doa tsitsi ƒe lãmetsiŋusẽ ƒe dodo ɖe ŋgɔ, enaa lãmenugbagbeviwo ƒe dzidziɖedzi kabakaba, eye wòdoa ŋusẽ ʋukawo ƒe dzɔdzɔ, gake Ipamorelin ate ŋu ana lãmenugbagbeviwo ɖɔɖɔɖo nanɔ bɔbɔe to nutoa me ƒe nuto suewo ƒe ɖoɖowɔwɔ kple nunyiame ƒe agbɔsɔsɔ dodo ɖe ŋgɔ me. Le abi ƒe dɔyɔɣi la, CJC-1295 ate ŋu aʋã fibroblasts be woawɔ collagen kabakaba wu, evɔ Ipamorelin ya ate ŋu ana ʋu nazɔ ɖe abi la ŋu, si ana nunyiame kple oxygen geɖe wu hena abi ƒe dɔyɔyɔ. Nu evea siaa ƒe dɔwɔwɔ aduadu ate ŋu ana abi ƒe hayahaya nawɔ kabakaba eye wòana abi ƒe dɔyɔyɔ nanyo ɖe edzi.
Le ahɔhɔ̃mekawo ɖɔɖɔɖo gome la, tsitsi ƒe lãmetsi wɔa akpa aɖe le ahɔhɔ̃mekawo ƒe tsitsi, agbetsitsi, kple vovototodedeameme me, evɔ Ipamorelin ate ŋu akpɔ ŋusẽ ɖe ahɔhɔ̃mekawo ƒe ɖɔɖɔɖo dzi to ahɔhɔ̃mekawo ƒe dɔwɔwɔ dzi kpɔkpɔ kple nutoa me ƒe nuto suewo ƒe nyonyo me.
Teƒe siwo woate ŋu azãe le hena nuwɔwɔ aduadu ƒe ŋusẽkpɔɖeamedziwo
Kamedefefewo ƒe atikewɔwɔ kple kamedede
Le kamedefefewɔlawo kple kamedede lɔ̃lawo gome la, CJC-1295 kple Ipamorelin ƒe dɔwɔwɔ aduadu ate ŋu ana kamedefefewo ƒe dɔwɔwɔ kple ŋutilã ƒe wɔwɔme nanyo ɖe edzi ŋutɔ. Woƒe lãmekawo ƒe tsitsi kple ami ƒe asitɔtrɔ le ŋutilã me dodo ɖe ŋgɔ ɖekae ate ŋu akpe ɖe kamedefefewɔlawo ŋu woadzi lãmekawo ƒe ŋusẽ kple woƒe lolome ɖe edzi esime woɖea ami si le ŋutilã me dzi kpɔtɔna nyuie wu, si ana kamedefefewo ƒe dzidodo kple bɔmb ƒe ŋusẽ nadzi ɖe edzi. Le kamedefefewo ƒe abixɔxɔ ƒe hayahaya gome la, woƒe dɔwɔwɔ aduadu ate ŋu ana lãmekawo, ƒuwo, kple lãkusi falɛfalɛwo naɖɔ ɖo kabakaba, si ana kamedefefewɔlawo ƒe hayahaya ƒe ɣeyiɣi nanɔ kpuie eye wòana woatrɔ ayi hehexɔxɔ kple hoʋiʋli me kaba wu.
Atsyɔ̃ɖoɖo Kple Tsitretsitsi ƒe Agble
Le atsyɔ̃ɖoɖo kple tsitsi dzi ɖuɖu gome la, CJC-1295 kple Ipamorelin ƒe dɔwɔwɔ aduadu ate ŋu ana tiatia yeyewo na ŋutigbalẽ ƒe ɖekakpui kple ŋutilã ƒe dɔwɔwɔ bliboa ƒe nyonyo. Wo ame evea siaa doa collagen ƒe wɔwɔme kple ŋutigbalẽ ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ɖe ŋgɔ le ɖekawɔwɔ me, si wɔnɛ be ŋutigbalẽ ƒe tete, eƒe sesẽme, kple eƒe keklẽ nyona ɖe edzi ŋutɔ ne wotsɔe sɔ kple wo dometɔ ɖesiaɖe ɖeɖeko zazã, evɔ wòɖea flitete kple tsitsi ƒe teƒeteƒewo ƒe wɔwɔ dzi kpɔtɔna. Woƒe ŋusẽkpɔɖeamedzi ɖekae ɖe ŋutilã ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ kple lãmenugbagbeviwo ɖɔɖɔɖo dzi hã kpena ɖe ame ŋu be lãmesẽ bliboa nanɔ anyi, si wɔnɛ be tsitsi ƒe ɖoɖoa nɔa blewu tso ememe eye wònaa dzedzeme kple ŋutilã ƒe dɔwɔwɔ siaa nyona ɖe edzi.
Atikewɔwɔ ƒe Dɔdamɔnu ƒe Agble
Nuɖuɖumeŋusẽdɔlélewo: Le nuɖuɖumeŋusẽdɔléle aɖewo, abe dɔgbo ƒe ʋuʋu ƒe anyimanɔmanɔ atraɖii kple dɔgbo ƒe mɔxexe le dɔwɔwɔ vɔ megbe ene gome la, CJC-1295 kple Ipamorelin ƒe dɔwɔwɔ aduadu ate ŋu ana woazã atikewɔwɔmɔnu yeyewo. Wowɔa dɔ aduadu tsɔ ɖɔa dɔgbo ƒe dɔwɔwɔ ɖo, nana dɔgboa me ƒuna kabakaba, eye dɔgboa ƒe ʋuʋu nyona ɖe edzi, si ate ŋu aɖe dzesi siwo do ƒome kplii dzi akpɔtɔ nyuie wu eye wòado dɔnɔwo ƒe hayahaya ɖe ŋgɔ. Le dɔnɔ siwo ƒe nunyuimakpɔɖu kple lolo dzi ɖe kpɔtɔ le nuɖuɖumeŋusẽ ƒe dɔlélewo ta gome la, nu eve siawo ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ɖekae ate ŋu akpe ɖe dɔnɔwo ŋu be woƒe nunyiame ƒe nɔnɔme kple woƒe kpekpeme nagaɖo wo ŋu nyuie wu.
Dɔléle Siwo Le Dɔlékuiwo Me Kple Lãmetsiŋusẽ ƒe Dɔlélewo: Le lãmenugbagbeviwo ƒe dɔlélewo abe suklidɔ kple lolo akpa ene dada me la, asixɔxɔ si ate ŋu anɔ CJC-1295 kple Ipamorelin ƒe dɔwɔwɔ aduadu ƒe ŋusẽkpɔɖeamedziwo ŋu. Woƒe ɖoɖowɔwɔ ƒe ŋusẽkpɔɖeamedzi siwo wɔa dɔ aduadu ɖe sukli ƒe asitɔtrɔ kple ami ƒe asitɔtrɔ dzi naa taɖodzinu yeyewo kple mɔnu yeyewo hena dɔléle siawo dada. Ne wotsɔ wo zazã ƒo ƒui la, woate ŋu akpɔ sukli ƒe agbɔsɔsɔ si le ʋu me dzi nyuie wu, insulin ƒe dɔlélenutsiŋutete nanyo ɖe edzi, eye ami si le ŋutilã me dzi naɖe akpɔtɔ, si ana woakpɔ lãmenugbagbeviwo ƒe dɔlélewo kple lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe atikewɔwɔ bliboe.
Lãmetsiŋusẽ ƒe dɔmawɔmawɔ nyuie: Le nɔnɔmewo abe lãmekawo ƒe ʋuʋu kple ƒumeŋuɖui ene gome la, CJC-1295 kple Ipamorelin ƒe dɔwɔwɔ aduadu ate ŋu akpe ɖe lãmekawo ƒe tsitsi kple ƒu ƒe wɔwɔme ŋu, si ana dɔnɔwo ƒe lãmekawo ƒe ŋusẽ kple ƒu ƒe nyonyome nanyo ɖe edzi. Le dɔnɔ siwo ƒe lãmekawo vuvu le aba dzi ɖiɖiɖeme ɣeyiɣi didi alo dɔléle ta gome la, nu eve siawo zazã ɖekae ate ŋu ana lãmekawo nahaya eye woatsi kabakaba, si ana dɔnɔwo ƒe agbenɔnɔ nanyo ɖe edzi. Le dɔnɔ siwo ŋu ƒumeŋuɖui le gome la, woƒe dɔwɔwɔ aduadu ate ŋu ana ƒu ƒe kpekpeme nadzi ɖe edzi eye wòaxe mɔ ɖe kuxiwo abe ƒu ƒe gbagbã ene nu.
Nyanuwuwuw
CJC-1295 kple Ipamorelin doa tsitsi ƒe lãmetsiŋusẽ ƒe dodo ɖe ŋgɔ to mɔ vovovowo dzi wɔa dɔ aduadu, si ɖea dɔwɔwɔ aduadu ƒe ŋusẽkpɔɖeamedzi siwo kpe ɖe wo nɔewo ŋu fiana le nutowo abe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe ɖoɖowɔwɔ (si nana ami ƒe ʋuʋu kabakaba, sukli ƒe asitɔtrɔ nyuie wu), lãmenugbagbeviwo ɖɔɖɔɖo (si naa dɔyɔyɔ kabakaba, lãmekawo ƒe gbugbɔgadzɔ), kple lãmekawo ƒe dɔwɔwɔ (anti-catabolic effects, promoting protein) ene nuƒoƒoƒu).
Dzɔtsoƒewo
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[4] Adeghate E, Ponery AS, Emirates U A. ORIGINALARTICLE Mɔnu si dzi ipamorelin-ʋãna ɖe insulin si dona tso sisiblisi siwo sɔ kple suklidɔlélawo ƒe dɔgbo me, 2004[C].
[5] Adeghate EA, Ponery A S. Mɔnu si ipamorelin-ʋãna ɖe insulin si dona tso dɔgbo me le sisiblisi siwo le lãmesẽ me kple esiwo ŋu suklidɔ le me.[J]. Neuro Endocrinology Lɛtawo, 2004,25 6:403-406. https://api.semanticscholar.org/CorpusID: 7118136. Ƒe 1999 ƒe ɣleti gbãtɔ me.
[6] Andersen N. B., Malmlöf K., Johansen P. B., kple ame bubuwo. Tsitsi ƒe lãmetsi si nye secretagogue ipamorelin tsia tre ɖe ƒu ƒe wɔwɔme dzi ɖeɖe kpɔtɔ si glucocorticoid hena vɛ le sisiblisi tsitsiwo ŋu[J]. Tsitsi ƒe lãmetsi & Igf Numekuku, 2001, 11 (5): 266-272.DOI: 10.1054 / ghir.2001.0239.
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