Cocer Peptides ye ŋlɔe 
ŋkeke 27 enye sia
NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.
Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.
Kpɔɖeŋu bliboa
HIV dɔlékuiwo xɔxɔ kple ami ƒe asitɔtrɔ le lãme na ame ƒe dɔlékuiwutikewo ƒe dɔlékuiwutikewo (ART) hea kuxi gãwo vɛ na HIV dɔnɔwo ƒe lãmesẽ kple agbenɔnɔ ƒe nyonyome. Nusiwo mesɔ o siawo dzena le mɔ vovovowo nu, abe lipoatrophy kple lipohypertrophy ene, eye visceral adipose tissue (VAT) ƒe ƒuƒoƒo fũ akpa ye dzena ŋutɔ. Menye ɖeko VAT ƒe dzidziɖedzi kpɔa ŋusẽ ɖe dɔnɔwo ƒe ŋutilã ƒe dzedzeme dzi ko o, ke edo ƒome kplikplikpli kple lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe kuxi sesẽ vovovowo hã, siwo dometɔ aɖewoe nye dzitodzito me dɔléle, insulin ƒe dɔmawɔmawɔ nyuie, kple aklãdɔ si me ami mele o (NAFLD), si nye afɔku gã aɖe na dɔnɔwo ƒe agbetsitsi ɣeyiɣi didi kple woƒe lãmesẽ.
Tesamoreli, si nye lãmetsi si wotsɔ wɔa tsitsimeŋusẽ (GHRH) si sɔ kple wo nɔewo, na mɔkpɔkpɔ yeye be woatsɔ ada ami ƒe asitɔtrɔ le lãme na ame ƒe dɔmawɔmawɔ nyuie le HIV dɔnɔwo ŋu. Ebla ɖe GHRH xɔla siwo le ŋgɔgbe lãkusi me ŋu koŋ, si doa ŋusẽ lãmetsi si le lãmenugbagbeviwo me (GH) ƒe wɔwɔme kple eƒe dodo nyuie. GH wɔa akpa vevi aɖe le ami ƒe asitɔtrɔ le amegbetɔ ƒe ŋutilã me dzi kpɔkpɔ me, doa ami ƒe ʋuʋu ɖe ŋgɔ, doa ami ƒe oxidation ɖe ŋgɔ, kple domenyiŋusẽfianu siwo do ƒome kple ami ƒe asitɔtrɔ ƒe ɖeɖefia dzi kpɔkpɔ me, si wɔnɛ be ekpɔa ŋusẽ nyui ɖe ami ƒe asitɔtrɔ dzi. Dɔwɔwɔ ƒe mɔnu tɔxɛ sia wɔnɛ be Tesamoreli te ŋu kpena ɖe ami ƒe asitɔtrɔ le lãme na ame ƒe dɔlélewo ŋu wònyona ɖe edzi le HIV dɔnɔwo me.
Nɔnɔmetata 1 Kukuɖenuŋu ƒe Ðoɖowɔɖi. Wodo plasma protein 9 katã kpɔ, si sɔ kple domenyiŋusẽfianu siwo le ŋgɔ wu le aklã ƒe domenyiŋusẽfianu ƒe mɔ siwo tesamorelin trɔ asi le le mɔ vovovowo nu la me.
Mɔnu si Tesamoreli wɔna ɖe Ami ƒe asitɔtrɔ le HIV dɔlékui me ŋu
Dɔnɔwo
Tsitsi ƒe Lãmetsiŋusẽ-Insulin-Abe Tsitsi ƒe Nuwɔna ƒe Axis ƒe Ðoɖowɔwɔ
Tesamoreli blana ɖe GHRH xɔla si le lãmenugbagbevi ƒe lãkusi si le ŋgɔgbe lãkusi me, si wɔnɛ be dzesimɔ siwo do ƒome kple xɔla abe JAK-STAT dzesimɔ ene wɔa dɔ. Dɔwɔwɔ ƒe ɖoɖo sia doa tsitsi ƒe lãmetsi (GH) ƒe wɔwɔme kple eƒe dodo ɖe ŋgɔ to ŋgɔgbe lãkusi me. Ne ege ɖe ʋukawo me vɔ la, eɖoa ŋutinu siwo woɖo taɖodzinu na abe aklã ene gbɔ, si ʋãa aklãa be wòawɔ tsitsinu si le abe insulin ene (IGF-1) eye wòaɖee ɖa. IGF-1 nye domenɔla vevi aɖe le GH ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ me eye wòwɔa akpa vevi aɖe le ami ƒe asitɔtrɔ me. IGF-1 ate ŋu ana PI3K-AKT ƒe dzesimɔa nawɔ dɔ, axe mɔ ɖe adipocyte apoptosis nu, eye wòalé adipocyte ƒe dɔwɔwɔ nyuie me ɖe asi. Edoa ami ƒe lãmenugbagbeviwo ƒe xɔxlɔ̃ kple woƒe oxidation hã ɖe ŋgɔ, si wɔnɛ be ami ƒe ƒoƒo ɖe lãmenugbagbeviwo me dzi ɖena kpɔtɔna. Le HIV dɔnɔwo gome la, zi geɖe la, tsitsi ƒe lãmetsi si le abe insulin ene ƒe dɔwɔwɔ me gblẽna le dɔlélea ŋutɔ kple dɔlékuiwutike (ART) ƒe ŋusẽkpɔɖeamedzi ta. Tesamoreli ate ŋu ana axis sia nawɔ dɔ be wòagbugbɔ ami ƒe asitɔtrɔ le lãmenugbagbeviwo ŋu ƒe ɖoɖowɔwɔ ƒe dɔwɔwɔ si sɔ la aɖo anyi.
Ŋusẽkpɔɖeamedzi tẽ ɖe adipocyte ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi
Lipolysis dodo ɖe ŋgɔ: Tesamoreli ate ŋu adzi hormone-sensitive lipase (HSL) ƒe ɖeɖefia kple dɔwɔwɔ ɖe adipocytes me ɖe edzi. HSL nye enzyme vevi aɖe le lipolysis me, si naa triglycerides ƒe hydrolysis va zua glycerol kple fatty acids, si wɔnɛ be ami ƒe catabolic metabolism doa ŋgɔ. Le vitro me la, Tesamoreli tsɔtsɔ kpe ɖe amimenugbagbevi siwo wode agble me ŋu doa HSL ƒe dɔwɔwɔ ɖe ŋgɔ ŋutɔ eye wòdzia ami ƒe dodo ɖe ŋgɔ ŋutɔ. Tesamoreli ate ŋu ana HSL nawɔ dɔ le mɔ si mele tẽ o nu hã to AMP (cAMP)-protein kinase A (PKA) ƒe dzesimɔ si le tsatsam la dzi kpɔkpɔ me, si ana ami ƒe ʋuʋu ɖe ŋgɔ geɖe wu. Le HIV dɔnɔwo gome la, ŋusẽ sia si doa ami ƒe ʋuʋu ɖe ŋgɔ kpena ɖe ami ƒe ƒuƒoƒo fũ ŋu dzi ɖeɖe kpɔtɔ, vevietɔ ami si le lãkusi me dzi ɖeɖe kpɔtɔ, si wɔnɛ be ami ƒe mama si mesɔ o nyona ɖe edzi le dɔnɔwo me.
Ami ƒe oxidation ƒe ɖoɖowɔwɔ: Tesamoreli doa ŋusẽ enzyme vevi siwo kpɔa gome le ami ƒe oxidation me le adipocytes me, abe carnitine palmitoyltransferase 1 (CPT1) ene, ƒe dɔwɔwɔ. CPT1 nye enzyme si ɖoa seɖoƒe na ami ƒe gege ɖe mitochondria me hena β-oxidation, eye eƒe dɔwɔwɔ si dzi ɖe edzi doa ami siwo le mitochondria me ƒe oxidative gbagbã ɖe ŋgɔ, si naa ŋusẽ lãmenugbagbeviwo. Tesamoreli ateŋu adzi enzyme bubu kple mɔzɔla siwo kpɔa gome le ami ƒe β-oxidation me, abe acetyl-CoA carboxylase 2 (ACC2) kple fatty acid transporter 1 (FATP1) ƒe ɖeɖefia hã ɖe dzi, si ana ami ƒe oxidation ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ nanyo ɖe edzi. To ami ƒe oxidation dodo ɖe ŋgɔ me la, Tesamoreli ate ŋu aɖe ami ƒe dzadzraɖo ɖe lãmenugbagbeviwo me dzi akpɔtɔ eye wòana ami ƒe asitɔtrɔ ƒe kuxiwo nanyo ɖe edzi le HIV dɔnɔwo me.
Domenyiŋusẽfianu ƒe ɖeɖefia si do ƒome kple lipid metabolism ƒe ɖoɖowɔwɔ
Domenyiŋusẽfianu siwo do ƒome kple ami ƒe dzɔdzɔ dzi kpɔkpɔ: Tesamoreli ate ŋu axe mɔ ɖe domenyiŋusẽfianu siwo do ƒome kple ami ƒe dzɔdzɔ ƒe ɖeɖefia nu, abe peroxisome proliferator-activated receptor γ (PPARγ) kple CCAAT/enhancer-binding protein α (C/EBPα) ene. PPARγ nye nuŋɔŋlɔ ƒe akpa vevi aɖe le ami ƒe vovototodedeameme kple ami ƒe dzɔdzɔ me, si doa fibroblasts ƒe vovototodedeameme ɖe ŋgɔ wòzua ami tsitsi, eye wònaa domenyiŋusẽfianu siwo do ƒome kple ami ƒe dzɔdzɔ ɖe wo nɔewo yome, abe fatty acid-binding protein 4 (FABP4) kple fatty acid synthase (FAS) ene, ƒe ɖeɖefia. C/EBPα hã wɔa akpa vevi aɖe le ami ƒe vovototodedeameme kple ami ƒe dzɔdzɔ me. To mɔxexe ɖe PPARγ kple C/EBPα ƒe ɖeɖefia nu me la, Tesamoreli ɖea ami ƒe vovototodedeameme kple ami ƒe dzɔdzɔ dzi kpɔtɔna, si wɔnɛ be ami ƒe ƒoƒo ɖe ŋutilã me dzi ɖena kpɔtɔna. Le HIV dɔnɔwo gome la, ɖoɖowɔwɔ ƒe ŋusẽkpɔɖeamedzi sia ɖe domenyiŋusẽfianu siwo do ƒome kple ami ƒe dzɔdzɔ dzi kpena ɖe ame ŋu wòɖɔa ami ƒe dzidziɖedzi fũ si ami ƒe asitɔtrɔ si mesɔ o hena vɛ la ɖo.
Figure 2 Ƒomedodo si le Tɔtrɔ siwo le Plasma VEGFA kple CSF1 me kple Tɔtrɔ le NAS ƒe Dzesi me le Gomenɔla siwo wotsɔ Tesamoreli da dɔe me.
Lãmetsi ƒe ʋuʋu kple lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe domenyiŋusẽfianuwo dzi kpɔkpɔ: Tesamoreli ate ŋu aɖɔ domenyiŋusẽfianu siwo do ƒome kple ami ƒe ʋuʋu kple lãmenugbagbeviwo ƒe dɔwɔwɔ, abe apolipoprotein (Apo) ƒomea me tɔwo ene, ƒe ɖeɖefia dzi. ApoB ye nye apolipoprotein vevitɔ si le lipoprotein si ƒe kpekpeme le sue ŋutɔ (VLDL) kple lipoprotein si ƒe kpekpeme le sue ŋutɔ (LDL) me, eye eƒe ɖeɖefia ƒe agbɔsɔsɔme do ƒome kplikplikpli kple VLDL kple LDL ƒe agbɔsɔsɔ le ʋumenugbagbevi dzĩ me. Tesamoreli ate ŋu aɖe ApoB ƒe ɖeɖefia dzi akpɔtɔ, aɖe VLDL kple LDL ƒe wɔwɔme kple woƒe dodo dzi akpɔtɔ, si ana atherogenic lipoproteins ƒe agbɔsɔsɔ naɖiɖi le ʋumenugbagbevi dzĩ me. Tsɔ kpe ɖe eŋu la, Tesamoreli ate ŋu ana ApoA-I, si nye apolipoprotein vevitɔ si le high-density lipoprotein (HDL) me la ƒe ɖeɖefia nadzi ɖe edzi. ApoA-I ƒe dzidziɖedzi kpena ɖe HDL ƒe agbɔsɔsɔ ŋu, edoa ʋumemi ƒe tɔtrɔ ɖe megbe ƒe ʋuʋu ɖe ŋgɔ, eye wòɖea dzitodzito me dɔléle ƒe afɔkua dzi kpɔtɔna. Le HIV dɔnɔwo gome, afisi ami ƒe asitɔtrɔ ƒe kuxiwo kpena ɖe ami ƒe asitɔtrɔ ƒe dɔmawɔmawɔ nyuie ŋu zi geɖe la, Tesamoreli ƒe ɖoɖowɔwɔ ƒe ŋusẽkpɔɖeamedzi ɖe ami ƒe tsɔtsɔ yi teƒe bubu kple lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe domenyiŋusẽfianuwo dzi ate ŋu akpe ɖe dɔnɔwo ƒe ami ƒe nɔnɔme ŋu wòanyo ɖe edzi.
Tesamoreli ƒe Ŋusẽkpɔɖeamedzi Tɔxɛwo Ðe Lipid Metabolism Dzi le HIV Dɔnɔwo Me
Visceral Adipose Tissue (VAT) Dzi Ðeɖe Akpɔtɔ .
Tesamoreli ɖea VAT dzi kpɔtɔna ŋutɔ le HIV dɔnɔwo me. Le Akpa III ƒe dɔdamɔnu dodokpɔ aɖe si me HIV dɔnɔwo kpɔ gome le me la, woɖo gomekpɔlawo le vome be woaxɔ Tesamoreli mg 2 gbesiagbe alo atike si wotsɔ ɖɔa amee hena kwasiɖa 26. Le Tesamoreli dɔdamɔnu ƒe ƒuƒoƒoa me la, dɔnɔwo ɖe VAT dzi ɖeɖe kpɔtɔ ŋutɔ fia, eye wokpɔ ɖiɖi sia le dɔnɔ siwo ƒe gɔmedzedze ƒe nɔnɔmewo to vovo (le kpɔɖeŋu me, akɔta ƒe ami ƒe anyinɔnɔ alo manɔmanɔ) dome. Le Tesamoreli-dɔdalawo gome (siwo woɖe fia be wonye dɔnɔ siwo ƒe VAT dzi ɖe kpɔtɔ 8% ya teti eye wowɔ ɖe atikewɔwɔ dzi) gome la, VAT dzi ɖe kpɔtɔ ŋutɔ metsɔ le kɔ kple akɔta ami ƒe anyinɔnɔ me o, eye vovototo aɖeke menɔ ƒuƒoƒo eveawo dome le akɔntabubu nu o (P = 0.657). Esia fia be Tesamoreli wɔa dɔ geɖe le VAT dzi ɖeɖe kpɔtɔ me le HIV dɔnɔwo me, le eɖokui si le akɔta ƒe ami ƒe anyinɔnɔ me. Menye ɖeko VAT dzi ɖeɖe kpɔtɔ nana dɔnɔwo ƒe ŋutilã ƒe dzedzeme nyona ɖe edzi ko o, ke vevietɔ wu la, eɖea afɔku si le lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe kuxi siwo do ƒome kple VAT, abe dzitodzito me dɔléle kple insulin ƒe dɔmawɔmawɔ nyuie ene, me dzi kpɔtɔna.
Aklã me ami ƒe asitɔtrɔ le lãmenugbagbeviwo ŋu ƒe nyonyo
Aklã me ami dzi ɖeɖe kpɔtɔ: Le HIV dɔnɔwo gome la, aklãdɔ si me ami mele o (NAFLD) ƒe dzɔdzɔ sɔ gbɔ eye wòdo ƒome kplikplikpli kple ami ƒe asitɔtrɔ si mesɔ o. Tesamoreli kpɔa ŋusẽ nyui ɖe NAFLD si do ƒome kple HIV dzi le atikewɔwɔ me. Le numekuku aɖe si wowɔ le vome, si me wozã ŋku eve le, le dɔwɔƒe geɖe me la, wotsɔ dɔnɔ siwo ŋu HIV dɔlékuia le siwo ƒe aklã me ami ƒe akpa sue aɖe (HFF) ≥5% de tesamorelin ƒuƒoƒoa alo placebo ƒuƒoƒoa me le vome eye woda dɔ na wo ɣleti 12. Nusiwo do tso eme ɖee fia be dɔnɔ siwo le Tesamoreli ƒuƒoƒoa me ƒe HFF dzi ɖe kpɔtɔ ŋutɔ, eye ŋusẽkpɔɖeamedzi bliboa ƒe lolome nye -4.1% (95% CI -7.6 va ɖo -0.7, P = 0.018) eye wòɖiɖi 37% tso gɔmedzedzea me (95% CI -67 va ɖo -7, P = 0.016). Le ɣleti 12 ƒe atikewɔwɔ megbe la, dɔnɔ siwo le Tesamoreli ƒuƒoƒoa me ƒe 35% ƒe HFF ƒe agbɔsɔsɔme mede 5% o, ne wotsɔe sɔ kple 4% ko le placebo ƒuƒoƒoa me (P = 0.0069). Esia ɖee fia be Tesamoreli ɖea aklã me ami dzi kpɔtɔna nyuie eye wònaa aklã me ami ƒe asitɔtrɔ le HIV dɔnɔwo ŋu nyona ɖe edzi.
Dɔ si wòate ŋu akpɔ ɖe aklã ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi: Aklã ƒe domenyiŋusẽfianu ƒe ɖeɖefia ŋuti numekuku le HIV-NAFLD dɔnɔwo me ɖee fia be Tesamoreli ɖe domenyiŋusẽfianu siwo do ƒome kple dɔdzẽ, lãmenugbagbeviwo ɖɔɖɔɖo, kple lãmenugbagbeviwo ƒe mama le aklã me dzi kpɔtɔ. Proteomics ŋuti numekuku bubuwo ɖee fia be Tesamoreli na be ʋukawo me protein ƒe agbɔsɔsɔ si le ʋukawo me lãmenugbagbeviwo ƒe tsitsi ƒe akpa A (VEGFA), tsitsi ƒe tɔtrɔ β1 (TGFB1), kple macrophage colony-stimulating factor 1 (CSF1), siwo do ƒome kplikplikpli kple aklã ƒe fibrosis kple dɔdzẽ, dzi ɖe kpɔtɔ ŋutɔ. Le dɔnɔ siwo wotsɔ Tesamoreli da dɔe gome la, plasma VEGFA kple CSF1 ƒe ɖiɖi do ƒome kple NAFLD ƒe dɔwɔwɔ ƒe dzesiwo dzi ɖeɖe kpɔtɔ, gake TGFB1 kple CSF1 ƒe ɖiɖi do ƒome kple domenyiŋusẽfianu ƒe dzidzenu ƒe fibrosis ƒe dzesiwo dzi ɖeɖe kpɔtɔ. Esia fia be Tesamoreli ate ŋu akpɔ ŋusẽ nyui ɖe aklã ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi to dɔdzẽ kple mɔ siwo do ƒome kple fibrosis le aklã me la dzi kpɔkpɔ me.
Figure 3 Ƒomedodo si le Tɔtrɔ siwo le Plasma TGFB1 kple CSF1 me kple Tɔtrɔ le Gene-Level Fibrosis Score me le Gomenɔla siwo wotsɔ Tesamoreli Da dɔe Me.
Ŋutilã Bliboa ƒe Ami ƒe Mama Kple Ŋutilã ƒe Nɔnɔme Ŋuti Ðoɖowɔwɔ
Ami si le ʋuka me dzi ɖeɖe kpɔtɔ: Tsɔ kpe ɖe VAT dzi ɖeɖe kpɔtɔ ŋu la, Tesamoreli kpɔa ŋusẽ gã aɖe ɖe ami si le akɔta me dzi le HIV dɔnɔwo me hã le ɖoɖowɔwɔ me. Le dɔdamɔnu ŋuti numekukuwo me la, dɔnɔ siwo wotsɔ Tesamoreli da dɔe ɖee fia be ami si le akɔta me dzi ɖena kpɔtɔna vivivi, si kpena ɖe ame ƒe ŋutilã ƒe nɔnɔme ŋu wònyona ɖe edzi eye wòɖea nyawo abe ƒodo ƒe dodo si ami ƒe mama si mesɔ o hena vɛ ene dzi kpɔtɔna. Ami si le ʋuka me dzi ɖeɖe kpɔtɔ do ƒome kple VAT dzi ɖeɖe kpɔtɔ, si le wo katã me la, enaa ŋutilã ƒe wɔwɔme nyona ɖe edzi.
Akɔta ƒe gotagome ƒe nyonyo: Akɔta ƒe gotagome nye nu vevi aɖe si fia be ami ƒoa ƒu ɖe ƒodo me. Tesamoreli zazã nana akɔta ƒe gotagome nyona ɖe edzi ŋutɔ le HIV dɔnɔwo me. Le dɔdamɔnu dodokpɔ siwo sɔ me la, Tesamoreli ƒe dɔlékuiwutike siwo ŋu akɔtami le kple esiwo me ami mele o siaa ɖee fia be akɔta ƒe gotagome dzi ɖe kpɔtɔ ŋutɔ le kwasiɖa 26 ƒe atikewɔwɔ megbe. Menye ɖeko akɔta ƒe gotagome ƒe nyonyo ɖea ƒodo me ami dzi ɖeɖe kpɔtɔ fiana ko o, ke edo ƒome kplikplikpli kple lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe afɔkuwo abe dzitodzito me dɔléle ene dzi ɖeɖe kpɔtɔ hã.
Ŋusẽkpɔɖeamedzi ɖe ŋutilã ƒe wɔwɔme ƒe nɔnɔme bubuwo dzi: Tesamoreli kpɔa ŋusẽ ɖe ŋutilã ƒe wɔwɔme ƒe nɔnɔme bubuwo dzi hã le ɖoɖowɔwɔ me le HIV dɔnɔwo me. Le kpɔɖeŋu me, le numekuku aɖewo me la, togbɔ be ŋutilã ƒe lolome ƒe dzesi (BMI) meɖe tɔtrɔ ɖedzesi aɖeke fia o hã la, ami si le ŋutilã me ya nyo ɖe edzi. Tesamoreli ate ŋu ana ami ƒe mama nanyo ɖe edzi evɔ makpɔ ŋusẽ ɖe kpekpeme bliboa dzi o, aɖe ami ƒe ƒuƒoƒo fũ dzi akpɔtɔ, ana ŋutilã ƒe akpa siwo me ami mele o abe lãmeka ene nadzi ɖe edzi, eye wòana dɔnɔwo ƒe ŋutilã ƒe nyonyome nanyo ɖe edzi.
Tesamoreli zazã le Ami ƒe asitɔtrɔ le HIV dɔnɔwo me
Amewo ƒe Agbɔsɔsɔ si Woɖo Tae
HIV dɔnɔ siwo ƒe ami ƒe asitɔtrɔ mesɔ o: Wofiaa tesamoreli koŋ na HIV dɔnɔ siwo ƒe ami ƒe asitɔtrɔ mesɔ o, vevietɔ amesiwo ƒe ami sɔ gbɔ ɖe dɔgboa me (le kpɔɖeŋu me, abe alesi wokpɔe to ƒodo ƒe CT alo MRI foto siwo ɖee fia be ami ƒe lãkusi [VAT] wu alesi wòle ene). Zi geɖe la, dɔnɔ siawo ɖea ƒodo lolo akpa, akɔta ƒe gotagome dzina ɖe edzi, eye woate ŋu adze kple lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔléle ƒe dzesi bubuwo hã, abe insulin ƒe dɔmawɔmawɔ nyuie kple ʋumemi ƒe agbɔsɔsɔ si mede ame dzi o ene.
Nyanuwuwuw
Abe atike nyui aɖe na ami ƒe asitɔtrɔ si mesɔ o le HIV dɔnɔwo me ene la, Tesamoreli ɖɔa ami ƒe asitɔtrɔ ɖo to mɔnu vovovowo dzi, ewɔa akpa vevi aɖe le VAT dzi ɖeɖe kpɔtɔ, aklã me ami ƒe asitɔtrɔ nyuie, ami ƒe mama le ŋutilã bliboa me dzi kpɔkpɔ, kple ŋutilã ƒe wɔwɔme nyuitɔ me.
Dzɔtsoƒewo
[1] Rahman F, de Chantal M, Mesquita P, kple ame bubuwo. 935. Tesamoreli ƒe ŋusẽkpɔɖeamedzi ɖe Ame siwo ŋu HIV le siwo si Dorsocervical Fat le kple esiwo mele wo ŋu o dzi: Post Hoc Analysis of Phase III Double Blind Placebo Control Trial[J]. Open Forum Dɔléle siwo xɔa ame me, 2020,7 (Supplement_1): S500-S501.DOI: 10.1093 / ofid / ofaa439.1121.
[2] Dɔdaƒe ƒe Numekuku Ŋuti Nyatakaka: Tesamoreli (Egrifta)[M]. Ottawa (ON): Canada ƒe Dɔwɔƒe si Kpɔa Atikewo Kple Mɔ̃ɖaŋununyawo Gbɔ le Lãmesẽnyawo Me, 2016.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Xɔ&db=pubmed&dopt=Abstract&list_uids=30920787&biabia_hl=1.
Adzɔnu si li na numekuku zazã ɖeɖeko:
