Cocer Peptides fɛ 
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BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.
Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.
Kuma bɛɛ lajɛlen
Sidabanakisɛ ni banakisɛfagalanw tali (ART) bɛ tulumafɛnw sɛnɛcogo jugumanba lase sidabanabagatɔw ka kɛnɛya ni u ka ɲɛnamaya kɛcogo ɲuman ma. O fɛnɲɛnamafagalanw bɛ ye cogo caman na, i n’a fɔ farikolojidɛsɛ ani farikolojidɛsɛ, ni kɔnɔnatumuw (VAT) dalajɛli kojugu bɛ ye kɛrɛnkɛrɛnnenya la. PIB caya tɛ nɔ bila banabagatɔw farikolo cogoya dɔrɔn na, nka a bɛ tali kɛ farikoloɲɛnajɛ gɛlɛya jugu caman fana na, i n’a fɔ dusukunnabana, inisɔndiya, ani sugunɛbilenni min tɛ dɔlɔ ye (NAFLD), o bɛ faratiba lase banabagatɔw ka ɲɛnamaya kuntaalajan ni u ka kɛnɛyako ma.
Tesamoreli, n’o ye bonya hormone releasing hormone synthétique (GHRH) ɲɔgɔnna ye, o bɛ jigiya kura di tulumafɛnw furakɛli la sidabanabagatɔw la. A bɛ siri kɛrɛnkɛrɛnnenya la GHRH minɛbagaw la ɲɛgɛnɛsira ɲɛfɛla la, o bɛ kɛ sababu ye ka kɔnɔnatumuw (GH) sɔrɔli ni a bɔli lawuli kosɛbɛ. GH jɔyɔrɔ ka bon kosɛbɛ tulumafɛnw falenfalenni labɛnni na hadamaden farikolo la, ka tulumafɛnw falenfalen sabati, ka asidi tulumafɛnw oksidan caya, ani ka jamu jiracogo ɲɛnabɔ minnu bɛ tali kɛ tulumafɛnw sɛnɛcogo la, o la, a bɛ nɔ ɲuman bila tulumafɛnw sɛnɛcogo la. Nin walekɛcogo kɛrɛnkɛrɛnnen in bɛ Tesamoreli dɛmɛ ka tulumafɛnw falenfalenbaliya ɲɛ sidabanabagatɔw la.
Jaa 1 Sɛgɛsɛgɛli kɛcogo. joli-sira-funu-poroteyini 9 bɛɛ lajɛlen sɛgɛsɛgɛra, minnu bɛ bɛn sanfɛla ɲɛfɛla jamu ma sugunɛ jamu siraw kɔnɔ minnu bɛ ɲɔgɔn sɛgɛsɛgɛ tesamɔrilini fɛ.
Tesamoreli ka baara kɛcogo tulumafɛnw falenfalenni kan sidabanakisɛ la
Banabagatɔw
Bonya-hormone-insuline-like Growth Factor Axis (Kɔrɔya-hormone-Insuline-like Growth Factor Axis) labɛnni
Tesamoreli bɛ siri GHRH minɛbaga la ɲɛgɛnɛsira ɲɛfɛla selilɛri kan, ka taamasiɲɛw siraw baara minnu bɛ tali kɛ minɛbagaw la i n’a fɔ JAK-STAT taamasiɲɛw sira. O baarakɛcogo in bɛ bonya hormone (GH) sɔrɔli ni a bɔli sabati ɲɛgɛnɛsira ɲɛfɛla fɛ. Ni a donna joli la, a bɛ se farikolo yɔrɔ laɲinitaw ma i n’a fɔ sugunɛ, o bɛ sugunɛ bila ka inisɔndiya-like growth factor-1 (IGF-1) labɛn ani k’a bɔ. IGF-1 bɛ kɛ GH ka farikoloɲɛnajɛ nɔw cɛmancɛlafɛnba ye, wa a jɔyɔrɔ ka bon tulumafɛnw falenni na. IGF-1 bɛ se ka PI3K-AKT taamasiɲɛw sira baara, ka farikolo tulumafɛnw ka apoptose bali, ani ka tulumafɛnw ka baara kɛcogo ɲuman sabati. A bɛ asidi tulumaw tali ni u oksidan fana sabati farikolokisɛw fɛ, o bɛ tulumafɛnw dalajɛli dɔgɔya farikolokisɛw kɔnɔ. Sidabanabagatɔw la, a ka ca a la, bonya furakisɛ min bɛ i n’a fɔ insuline, o baara bɛ tiɲɛ ka a sababu kɛ bana yɛrɛ ye ani banakisɛfagalanw (ART) nɔw. Tesamoreli bɛ se ka nin aksidan in baara walasa k’a ka tulumafɛnw sɛnɛcogo ɲɛnabɔcogo ɲuman segin a cogo kɔrɔ la.
A bɛ nɔ tilennen bila farikolojidɛsɛbanakisɛw ka farikoloɲɛnajɛ la
Lipolyse (lipolyse) sabatili : Tesamoreli bɛ se ka lipase hormone-sensitive (HSL) jiracogo ni a baaracogo kɔrɔta farikolojidɛsɛbanakisɛw la. HSL ye anzimu jɔnjɔn ye lipolyse la, a bɛ triglycérides hydrolyse kɛ ka kɛ glycérol ni asidi tulumaw ye, o bɛ tulumafɛnw ka kataboliki sɛnɛcogo sabati. In vitro, ni aw ye Tesamoreli fara tulumafɛnw kan minnu falen don, o bɛ HSL baara caya kosɛbɛ ani ka dɔ fara asidi tuluma bɔli kan kosɛbɛ. Tesamoreli fana bɛ se ka HSL baara cogo la min tɛ ɲɛ, a kɛtɔ ka AMP (cAMP)-protéine kinase A (PKA) taamasiɲɛw sira cyclique labɛn, o bɛ lipolyse sabati ka taa a fɛ. Sidabanabagatɔw la, o nɔ min bɛ tulumafɛnw bɔli sabati, o bɛ dɛmɛ ka tulumafɛnw dalajɛ kojugu dɔgɔya, kɛrɛnkɛrɛnnenya la, farikolo yɔrɔw tulu dɔgɔyali, o la, tulumafɛnw tilatilali cogoya jugu bɛ banabagatɔw la.
Asidi fatɔw ka oksidan ɲɛnabɔli : Tesamoreli bɛ anzimu kolomaw baara bonya minnu bɛ asidi fatɔw ka oksidan sɔrɔli la farikolojidɛsɛbanakisɛw kɔnɔ, i n’a fɔ carnitine palmitoyltransferase 1 (CPT1). CPT1 ye anzimu ye min bɛ dan sigi asidi fatɔw doncogo la mitokondriyaw la walasa ka β-oxydation sɔrɔ, wa a ka baara min bɛ bonya, o bɛ asidi tulumaw tiɲɛni oksidan fɛ mitokondriyaw kɔnɔ, ka fanga di farikolokisɛw ma. Tesamoreli bɛ se fana ka anzimu wɛrɛw ni tabaga wɛrɛw jirali wuli ka taa a fɛ minnu bɛ asidi tuluma β-oksidan na, i n’a fɔ asetili-CoA karɔkisilazi 2 (ACC2) ani asidi tuluma tabaga 1 (FATP1), o bɛ asidi tuluma oksidan farikoloɲɛnajɛ kɛcogo ɲɛ ka taa a fɛ. Ni a bɛ asidi fatɔw ka oksidan sabati, Tesamoreli bɛ se ka tulumafɛnw marali dɔgɔya farikolokisɛw kɔnɔ ani ka tulumafɛnw falenfalenbaliya ɲɛ sidabanabagatɔw la.
Lipid metabolism-relatif jeninida jirali
Fasa sɔrɔcogo bɛ se ka nɔ bila farikolojidɛsɛ la : Tesamoreli bɛ se ka tulumafɛnw jirali bali, i n’a fɔ peroxisome proliferator-activated receptor γ (PPARγ) ani CCAAT/enhancer-binding protein α (C/EBPα). PPARγ ye sɛbɛnnikɛlan jɔnjɔn ye farikolo tulumafɛnw danfara ni tulumafɛnw bɔli la, a bɛ fiɲɛbanakisɛw danfara sabati ka kɛ tulumafɛnw ye minnu kɔgɔlen don, wa a bɛ tulumafɛnw bɔli daminɛ ni jamu caman jirali ye, i n’a fɔ asidi fatɔ sirili poroteyini 4 (FABP4) ani asidi fatɔ sintazi (FAS). C/EBPα fana jɔyɔrɔ ka bon farikolo tulumafɛnw danfara ni fasa bɔli la. Ni Tesamoreli bɛ PPARγ ni C/EBPα jirali bali, a bɛ dɔ bɔ farikolo tulumafɛnw danfara ni fasa bɔli la, o la, a bɛ dɔ bɔ tulumafɛnw dalajɛli la farikolo la. Sidabanabagatɔw la, o sariyasunba nɔ min bɛ sɔrɔ farikolojidɛsɛbanakisɛw la, o bɛ dɛmɛ ka tulumafɛnw bɔli damatɛmɛni latilen, o min bɛ sɔrɔ tulumafɛnw sɛnɛcogo jugu fɛ.
Jaa 2 Jɛɲɔgɔnya min bɛ joli la VEGFA ni CSF1 yeli ni NAS jate caman yeli ye Tesamoreli furakɛli kɛbagaw la.
Lipidiw tali ni farikolojɔli jɛnɛya labɛnni : Tesamoreli bɛ se ka jɛnɛya jiracogo ɲɛnabɔ min bɛ tali kɛ tulumafɛnw tacogo ni farikolojɔli la, i n’a fɔ apolipoprotéine (Apo) denbaya kɔnɔmɔgɔw. ApoB ye apolipoprotéine fɔlɔ ye min bɛ sɔrɔ lipoprotéine très low-density (VLDL) ni low-density lipoprotéine (LDL) la, wa a jiracogo hakɛ bɛ tali kɛ kosɛbɛ VLDL ni LDL hakɛ la joli la. Tesamoreli bɛ se ka ApoB jirali dɔgɔya, ka VLDL ni LDL sɔrɔli ni u bɔli dɔgɔya, o la, a bɛ joli segin furakisɛw hakɛ dɔgɔya joli la. Ka fara o kan, Tesamoreli bɛ se ka ApoA-I jiracogo kɔrɔta, o min ye lipoprotéine haute densité (HDL) ka apolipoprotéine fɔlɔ ye. ApoA-I jirali caya bɛ dɛmɛ ka HDL hakɛ kɔrɔta, ka kolosinsinnanw tacogo kɔsegin, ani ka dusukunnabana farati dɔgɔya. Sidabanabagatɔw la, yɔrɔ minnu na tulumafɛnw falenni gɛlɛyaw bɛ taa ni tulumafɛnw falenfalenbaliya ye tuma caman na, Tesamoreli ka sariyataama nɔ minnu bɛ tulumafɛnw tacogo ni farikolojɔli jamu kan, olu bɛ se ka dɛmɛ don ka banabagatɔw ka tulumafɛnw cogoya ɲɛ.
Tesamoreli nɔ kɛrɛnkɛrɛnnenw farikolojɔli la sidabanabagatɔw la
Ka farikolojidɛsɛbanakisɛw dɔgɔya (VAT) .
Tesamoreli bɛ dɔ bɔ kosɛbɛ PIB la sidabanabagatɔw la. Fasa III kɛnɛyaso sɛgɛsɛgɛli dɔ la, min kɛra sidabanabagatɔw kan, u bilala ka Tesamoreli miligaramu 2 ta don o don walima ka furakisɛ ta dɔgɔkun 26 kɔnɔ. Tesamoreli furakɛli kulu la, banabagatɔw ye PIB dɔgɔyaliba jira, wa o dɔgɔyali kɔlɔsira banabagatɔw bɛɛ la minnu ka daminɛcogo tɛ kelen ye (misali la, kɔkolo tulu sɔrɔli walima a sɔrɔbaliya). Tesamoreli jaabibagaw fɛ (a ɲɛfɔlen don ko banabagatɔ minnu ka PIB dɔgɔyara ni 8% ye a dɔgɔyalenba la ani minnu tugura furakɛli kɔ), PIB dɔgɔyara kosɛbɛ k’a sɔrɔ kɔ ni kɔ tulu bɛ yen, wa danfara si ma sɔrɔ jateminɛ na kulu fila ninnu cɛ (P = 0,657). O b’a jira ko Tesamoreli bɛ se ka PIB dɔgɔya sidabanabagatɔw la, a tɛ kɛ ni kɔ tulu sɔrɔli ye. PIB dɔgɔyali tɛ banabagatɔw farikolo cogoya dɔrɔn ɲɛ, nka min nafa ka bon kosɛbɛ, o bɛ dɔ bɔ farikoloɲɛnajɛ gɛlɛyaw la minnu bɛ sɔrɔ PIB fɛ, i n’a fɔ dusukunnabana ani inisɔndiya.
Sugunɛ tulumafɛnw falen-falencogo ɲɛnabɔli
Sugunɛbilenni hakɛ dɔgɔyali : Sidabanabagatɔw la, sugunɛbilenni min tɛ dɔlɔ ye (NAFLD) hakɛ ka ca, wa a ni tulumafɛnw falencogo juguman bɛ tali kɛ ɲɔgɔn na kosɛbɛ. Tesamoreli bɛ furakɛli nɔ ɲuman bila NAFLD la min bɛ sɔrɔ sidabanakisɛ fɛ. Sɛgɛsɛgɛli dɔ la min kɛra ni mɔgɔw ye, fiyentɔ fila, santiri caman kɔnɔ, sidabanakisɛ bɛ banabagatɔ minnu na, ni sugunɛ tuluma hakɛ (HFF) ≥5%, olu bilala tesamɔrilini kulu la walima furakisɛ kulu la k’u furakɛ kalo 12 kɔnɔ. Jateminɛw y’a jira ko banabagatɔ minnu bɛ Tesamoreli kulu la, olu ka HFF dɔgɔyara kosɛbɛ, ni nɔ dafalen hakɛ ye -4,1% ye (95% CI -7,6 ka se -0,7 ma, P = 0,018) ani ka dɔgɔya ni 37% ye ka bɔ a daminɛ na (95% CI -67 ka se -7 ma, P = 0,016). Kalo 12 furakɛli kɔfɛ, Tesamoreli kulu banabagatɔ 35% ka HFF hakɛ tun bɛ 5% duguma, ni i ye a suma ni furakisɛ tabaga 4% dɔrɔn ye (P = 0,0069). O b’a jira ko Tesamoreli bɛ sugunɛ tulu hakɛ dɔgɔya kosɛbɛ ani ka sugunɛ tulu sɛnɛcogo ɲɛ sidabanabagatɔw la.
Kɔnɔnafili minnu bɛ se ka sɔrɔ sugunɛbilenni na : Sugunɛ jamu jiracogo sɛgɛsɛgɛli sidabanakisɛbanabagatɔw la, o y’a jira ko Tesamoreli ye jamu kuluw dɔgɔya minnu bɛ tali kɛ funu, farikolo yɔrɔw dilancogo ani farikolokisɛw tilali la sugunɛ na. Protéomique sɛgɛsɛgɛli wɛrɛw y’a jira ko Tesamoreli kɛra sababu ye ka joli-sira-funu-kɔnɔ-fɛnw hakɛ dɔgɔya kosɛbɛ joli-sira-funu-kɔnɔ-fɛnw hakɛ la, minnu bɛ sɔrɔ joli-sira-funu-kɔnɔ-fɛnw falen-falen A (VEGFA), jiginni-facteur β1 (TGFB1), ani makɔrɔfaga koloni-stimulant facteur 1 (CSF1) la, olu minnu ni sugunɛbilenni ni funu bɛ tali kɛ ɲɔgɔn na kosɛbɛ. Banabagatɔ minnu furakɛra ni Tesamoreli ye, joli la VEGFA ni CSF1 dɔgɔyali bɛ tali kɛ NAFLD baarakɛcogo hakɛ dɔgɔyali la, ka sɔrɔ TGFB1 ni CSF1 dɔgɔyali bɛ tali kɛ fibrose hakɛ dɔgɔyali la jeninida hakɛ la. O b’a jira ko Tesamoreli bɛ se ka nɔ ɲuman bila sugunɛ na ni a bɛ funu ni fiɲɛbana siraw labɛn sugunɛ na.
Jaa 3 Jɛɲɔgɔnya min bɛ joli la TGFB1 ni CSF1 yeli ni fɛn caman yeli ye jeninida hakɛ la fibrose hakɛ la Tesamoreli furakɛli kɛbagaw la.
Farikolo bɛɛ tulu tilatilali ni farikolo labɛncogo ɲɛnabɔli
Kɔnɔnatumuw dɔgɔyali : Ka fara PIB dɔgɔyali kan, Tesamoreli bɛ se ka sariyaw sigi sen kan fana kɔkolo tulu kan sidabanabagatɔw la. Dɔgɔtɔrɔso ka sɛgɛsɛgɛliw la, banabagatɔ minnu furakɛra ni Tesamoreli ye, olu ye dɔ bɔ dɔɔni dɔɔni u ka jiribolo tulu hakɛ la, o bɛ dɛmɛ ka farikolo cogoya ɲɛ ani ka dɔ bɔ ko dɔw la i n’a fɔ kɔnɔbara bɔli min bɛ sɔrɔ tulumafɛnw tilatilali cogo la. Bagan tulu dɔgɔyali bɛ tali kɛ ɲɔgɔn na ni PIB dɔgɔyali ye, o bɛɛ lajɛlen bɛ farikolo labɛncogo ɲɛ.
Cɛsirilan laminicogo ɲɛnabɔli : Cɛsirilan ye kɔnɔbara tulu dalajɛli taamasiɲɛ nafama ye. Tesamoreli furakɛli bɛ cɛya lamini ɲɛ kosɛbɛ sidabanabagatɔw la. Kɛnɛyaso sɛgɛsɛgɛliw la minnu bɛ tali kɛ o la, Tesamoreli jaabibaga minnu kɔkili tulu bɛ u la ani minnu tɛ u la, olu fila bɛɛ y’a jira ko dɔ bɔra kosɛbɛ u cɛmancɛ lamini na furakɛli dɔgɔkun 26 kɔfɛ. Cɛsiri lamini ɲɛtaa tɛ kɔnɔbara tulu dɔgɔyali dɔrɔn jira, nka a ni farikoloɲɛnajɛ faratiw dɔgɔyali fana bɛ tali kɛ ɲɔgɔn na kosɛbɛ i n’a fɔ dusukunnabana.
A bɛ nɔ bila farikolo labɛncogo wɛrɛw la : Tesamoreli fana bɛ se ka sariyaw sigi farikolo labɛncogo wɛrɛw la sidabanabagatɔw la. Misali la, sɛgɛsɛgɛli dɔw la, hali ni farikolo girinya hakɛ (IMC) ma fɛn caman jira, farikolo tulu hakɛ cayara. Tesamoreli bɛ se ka farikolo tulu tilatilali ɲɛ ka sɔrɔ a ma nɔ bila mɔgɔ girinya bɛɛ la, ka tulu dalajɛli kojugu dɔgɔya, ka farikolo yɔrɔ nɔgɔlenw caya i n’a fɔ farikolo, ani ka banabagatɔw farikolo cogoya ɲɛ.
Tesamoreli tali tulumafɛnw falenni na sidabanabagatɔw la
Jamanadenw ka laɲini
Sidabanabagatɔ minnu ka tulumafɛnw tɛ ɲɔgɔn ta : Tesamoreli bɛ jira fɔlɔ sidabanabagatɔw ma minnu ka tulumafɛnw tɛ ɲɔgɔn ta, kɛrɛnkɛrɛnnenya la minnu ka tulu ka ca u kɔnɔbara la (misali la, i n’a fɔ a bɛ dɔn ni kɔnɔbara CT walima MRI sɛgɛsɛgɛliw ye minnu b’a jira ko kɔnɔnatumuw [VAT] bɛ tɛmɛ a hakɛ kan). A ka ca a la, o banabagatɔ ninnu bɛ kɔnɔbara fasa jira, u cɛmancɛ lamini bɛ caya, wa u bɛ se ka kɛ fana ni farikoloɲɛnajɛ taamasiɲɛ wɛrɛw ye, i n’a fɔ inisɔndiyabaliya ani farikolojidɛsɛ.
Kuncɛli
I n’a fɔ furakɛli fɛɛrɛ ɲuman min bɛ tulumafɛnw sɛnɛcogo jugu la sidabanabagatɔw la, Tesamoreli bɛ tulumafɛnw sɛnɛcogo ɲɛnabɔ fɛɛrɛ caman fɛ, a jɔyɔrɔ ka bon PIB dɔgɔyali la, ka sugunɛ tulumafɛnw sɛnɛcogo ɲɛ, ka farikolo bɛɛ tulumafɛnw tilatilali ɲɛnabɔ, ani ka farikolo labɛncogo ɲuman ɲɛnabɔ.
Sosow (Sɔrɔyɔrɔw).
[1] Rahman F, de Chantal M, Mesquita P, ani a ɲɔgɔnnaw. 935. Tesamoreli nɔ min bɛ sidabanakisɛ bɛ mɔgɔ minnu na, ni kɔkolo tulu bɛ u la ani ni u tɛ u la: Post Hoc Analysis of Phase III Double Blind Placebo Control Trial[J]. Foro da wulilen banakisɛw, 2020,7(Supplement_1):S500-S501.DOI:10.1093/ofid/ofaa439.1121.
[2] Dɔgɔtɔrɔso lajɛ rapɔɔri: Tesamoreli (Egrifta)[M]. Ottawa (ON): Kanada ka furako ni fɛɛrɛbɔ baarada kɛnɛyako la, san 2016.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Sɔrɔ&db=pubmed&dopt=Abstract&list_uids=30920787&query_hl=
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