Cocer Peptides fɛ       a bɛ tile 15 bɔ

BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.  

Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *in glass*, o kɔrɔ ye gilasi minɛnw na) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.

BPC-157 ka ɲɛfɔli kunbaba

BPC-157 ye kɔnɔbara basigilen pentapɛtidi ye min sɔrɔla a daminɛ na a ka kirinni kɛlɛli fɛɛrɛw kosɔn. A bɛ to hadamadenw ka kɔnɔbaraji la fo lɛri 24 ni kɔ, o b’a to a bɛ to k’a nɔw kɛ kɔnɔbara lamini na ani ka kɔnɔbara ni kolotugudaw tiɲɛniw dilan jusigilan sigi. A ka kemikaliya jɔcogo

e ye GEPPPGKPADDAGLV ye, a girinya ye 1419. O molekiyɔmu jɔcogo b’a to a bɛ se ka jɛɲɔgɔnya kɛ ni biyomolekuli suguya caman ye farikolo la, o la, a bɛ farikoloɲɛnajɛ baara nafamaw kɛ.

Jaa 1 BPC-157 bɛ nɔ bila HUVECw caya ni u ka selilɛriw tilatilali la.

BPC-157 ka dilancogo nɔ minnu bɛ kɔnɔbara tiɲɛni na

Kɔnɔbara basigilenw lakanani ani kɔnɔbara dafalen marali

BPC-157 jɔyɔrɔ ka bon kɔnɔbara basigilenw lakanani na, a bɛ a yɛrɛ tanga kosɛbɛ fura suguya caman nɔ juguw ma kɔnɔbara la. Fɛn minnu bɛ kɛ i n’a fɔ dɔlɔ ni fura minnu tɛ stɛroyi ye (AINE) olu ka teli ka kɔnɔbara basigilenw tiɲɛ ani ka kɔnɔbara dafalen tiɲɛ. BPC-157 bɛ se ka kɔnɔbara basigilenw tanga tiɲɛni tilennen ma o fɛn jugu ninnu fɛ, farikoloɲɛnajɛ fɛɛrɛ gɛlɛnw fɛ. Ni a bɛ dɔlɔ lawulili la, BPC-157 bɛ farikoloɲɛnajɛ siraw labɛn kɔnɔbara basigilenw na, ka farikolokisɛw ka farikolo tangacogo ɲɛ, ani ka dɔlɔ fɛnɲɛnamafagalanw ka oksidan tiɲɛni dɔgɔya. Ni ANS bɛ sɔrɔ kɔnɔbara basigilen tiɲɛni na, BPC-157 bɛ nɔ bila selilu kɔnɔ taamasiɲɛw siraw la walasa ka funu cɛmancɛfɛnw bɔli bali, o la, funu jaabiw tiɲɛni nɔw bɛ nɔgɔya kɔnɔbara la. O bɛ dɛmɛ ka kɔnɔbara basigilen mara ani ka kɔnɔbara farikolo baara kɛcogo ɲuman sabati.

Jaa 2 BPC-157 ye joginda seginni ni kolajɛ hakɛ caya granulasiyɔn farikolo la.

Banakɔtaa doncogo sabatili

Banakɔtaa doncogo cayalenba ye fɛn nafamaba ye min bɛ kɛ sababu ye ka banakɔtaa bana caman sɔrɔ. Kɔnɔnatumuw, i n’a fɔ farikolo walima hakili degun, AINE tali, asidi bile surfactantw lawulili, ani dɔlɔmin, olu bɛɛ bɛ se ka kɛ sababu ye ka banakɔtaa ɲɛgɛnɛsiraw doncogo caya, ka kɔnɔnatumuw bila mɔgɔ la. BPC-157 bɛ se ka banakɔtaa doncogo sabati ni a bɛ banakɔtaa ɲɛgɛnɛsiraw ni ɲɔgɔn cɛ jɛɲɔgɔnya sirilenw labɛn, o bɛ kɛ sababu ye ka seliluw ni ɲɔgɔn cɛ jɛɲɔgɔnya fanga bonya. Ka kɛɲɛ ni kunnafoniw ye, baganw ka misaliw la, minnu kɛra degunko kofɔlenw na, BPC-157 tali kɛra sababu ye ka dɔ fara ɲɔgɔndan poroteyini sirilenw jirali kan banakɔtaa ɲɛgɛnɛsiraw ni ɲɔgɔn cɛ, ni u jɔcogo labɛnna ka ɲɛ, o la, banakɔtaa doncogo dɔgɔyara ka se fɛnɲɛnamafagalanbaw ma. O ye kɔnɔbara basigilen taamasiɲɛw nɔgɔya kosɛbɛ, ka dɔ bɔ fɛn juguw ka don joli la ka bɔ banakɔtaa la, ani ka banakɔtaa sigida fitinin sabatili sabati.

Kɔnɔbara basigilen joginda kɛnɛyali sabatili

A kɛra banakɔtaa bɛɛ la kirinni kɛnɛyali ye wo, a kɛra kɛnɛma fiɲɛbɔlanw (i n’a fɔ dumunikɛminɛnw farikolojidɛsɛw, kɔnɔbara basigilenw, kɔnɔbara basigilenw, ani kɔnɔbara basigilenw) ani kɔnɔnatumuw (i n’a fɔ kɔnɔbara basigilenw ni musoyabanakisɛw) minnu bɛ kɔnɔbara la, BPC-157 b’o jira nɔba minnu bɛ sɔrɔ yiriwali la. BPC-157 bɛ fiɲɛbanakisɛw caya ni u jiginni sabati, ka kolajɛni sɔrɔli ni u bilali teliya, o la, a bɛ matiriyali dɛmɛ wajibiyalen di joginda kɛnɛyali ma. A bɛ sigida funu jaabiw fana labɛn, ka farikolo tangalanw sama ka taa joginda yɔrɔ la walasa ka banakisɛw ni farikolo yɔrɔw jɛya, ani ka joli-sira-funu sabatili sabati, ka balo ni oksizɛni bɛrɛbɛrɛ sɔrɔ joginda kɛnɛyali kama. Kɔnɔbara basigilen opereli la, ni anastomosi yɔrɔ bɛ kɛnɛya gɛlɛyaw sɔrɔ ka a sababu kɛ fɛnw ye i n’a fɔ AINE, sistamine, walima colectomy, BPC-157 fana bɛ se ka jɔyɔrɔ ɲuman ta anastomozi kɛnɛya sabatili la ani ka gɛlɛyaw dɔgɔya i n’a fɔ anastomotique fistula.

A bɛ nɔ bila kɔnɔboli ni kɔnɔbara joginda la

Pankreyasi jugumanba min bɛ sɔrɔ sosow ka misali la min bɛ sɔrɔ bile sira sirili fɛ, BPC-157 ye lakanani nɔ jira kɔnɔboli la hali ni a kɛra banakunbɛn walima furakɛlifɛn ye. BPC-157 tali kunbɛncogo la, o ye dɔ bɔ kosɛbɛ kɔnɔboli juguya la, ka dɔ bɔ kɔnɔboli la, ka sɔgɔsɔgɔninjɛ, ani ka neutrophils doncogo dɔgɔya, ka sɔrɔ ka dɔ fara monositɛri hakɛ kan. Pankreyasi jugumanba furakɛli la min kɛra kaban, nafa caman fana kɔlɔsira, ni amilazi hakɛ ye joli la. BPC-157 fana bɛ nɔ ɲuman bila kɔnɔbara ni kɔnɔbara joginda la minnu bɛ kɛ ɲɔgɔn fɛ, o bɛ dɛmɛ don ka kɔnɔbara basigilen dafalen mara ani ka dɔ bɔ funu tiɲɛni na kɔnɔbara ni kɔnɔbara la.

BPC-157 ka dilancogo nɔ minnu bɛ joli tiɲɛni na

Jolilabanaw (temporomandibular joint osteoarthritis) ɲɛnabɔli

Sogow ka misali dɔ la, kolotugudaw la, kolotugudaw tiɲɛni kɛra opereli fɛ, i n’a fɔ kolotugudaw ɲɛda tiɲɛni fan kelen fɛ, kolotuguda disiki kɛrɛfɛla ligament, ani disiki kɔfɛla nɔrɔli hakɛ tigɛcogo, walasa ka kolotugudaw ka bana taabolo ladege. Opereli kɔfɛ, BPC-157 kɛra kɔnɔbara basigilen pikiri fɛ. Kalo 6 tuguni jateminɛ na, BPC-157 furakɛli kulu ye dɔ fara kosɛbɛ kolotugudaw bɛɛ lajɛlen girinya kan ni a ni kɔrɔsili kulu ta kɛra ɲɔgɔn fɛ. Kɛrɛnkɛrɛnnenya la, o y’a jira ni kolotuguda yɔrɔ ni kolotuguda yɔrɔ fila bɛɛ ka bonya caya ye, kolotugudaw selilɛriw farali dɔgɔyali, kolotugudaw jɔlenw tununni, ani kolotugudaw laminicogo nɔgɔman marali. O b’a jira ko BPC-157 bɛ se ka kolotugudaw sɔgɔsɔgɔninjɛ bana caman yeli nɔgɔya kosɛbɛ ani ka kolotugudaw dilancogo ni a lasegincogo sabati. A baarakɛcogo bɛ se ka kɛ sababu ye ka BPC-157 ni fɛnɲɛnamafagalanw i n’a fɔ kolajɛ ni poroteyogilikan minnu bɛ tali kɛ joli-sira-funu yiriwali la. Sɛgɛsɛgɛliw y’a jira ko BPC-157 motif caman bɛ sɔrɔ kolajɛ α-1 (I), kolajɛ α-1 (IX), aggrecan, fibronectin ɲɛbila, kondroitin sulfate proteoglycan NG2 ɲɛbila, ani kondroitin oligosaccharide ɲɛbila, minnu nafa ka bon kosɛbɛ kolotugudaw jɔcogo n’a baara sabatili la. BPC-157 bɛ se ka kolotugudaw dilancogo ni u jɔcogo kura sabati ni a bɛ o fɛnɲɛnamafagalanw jiracogo walima u baaracogo ɲɛnabɔ.

Jaa 3 BPC-157 ye VEGF-a jirali sabati farikolo yɔrɔ joginlenw na.

Gɛnɛgɛnɛ joginw dilancogo

Gɛnɛgɛnɛdimi ye kɛnɛyaso taamasiɲɛ ye min bɛ sɔrɔ fɛn caman fɛ, i n’a fɔ kolotugudaw, ɲɛgɛnɛsiralabanaw, ɲɛgɛnɛsiralabanaw, sɔgɔsɔgɔninjɛ, walima sɔgɔsɔgɔninjɛ. Sɛgɛsɛgɛli min kɛra kɔfɛ, o ye banabagatɔ 17 kɔlɔsi minnu gɛnɛgɛnɛdimi bɛ u la, banabagatɔ 16 tun bɛ tugu ɲɔgɔn kɔ. Nin banabagatɔ ninnu cɛma, 12 ye BPC-157 dɔrɔn pikiri kɛ joli la, ni 11 (91,6%) ye ɲɛtaa caman sɔrɔ gɛnɛgɛnɛ dimi na; banabagatɔ 4 tɔw ye BPC-157 ni timosini-β4 pikiri faralen ɲɔgɔn kan, o banabagatɔ 75% ye dimi mada kosɛbɛ. Kuma bɛɛ la, banabagatɔ 87,5% ye gɛnɛgɛnɛ dimi nɔgɔya u kɛlen kɔ ka BPC-157 walima a ni timosini-β4 faralen ɲɔgɔn kan. O b’a jira ko BPC-157 bɛ se ka gɛnɛgɛnɛ dimi suguya caman nɔgɔya. Sɛgɛsɛgɛli wɛrɛw y’a jira ko BPC-157 bɛ se ka ɲɛji dilan ani ka kolotugudaw bɔli sabati, o bɛ se ka kɛ sababu nafama ye a ka baarakɛcogo ɲuman na gɛnɛgɛnɛ dimi nɔgɔyali la. Jogindaw dilancogo senfɛ, BPC-157 bɛ se ka kolotugudaw caya ani ka u danfara sabati, ka dɔ fara kolotugudaw dilanni kan, o la, kolotugudaw tiɲɛnenw bɛ dilan. Ka fara o kan, a bɛ se ka kɛ sababu ye fana ka ɲɛgɛnɛsira tiɲɛnenw, senkɔniw ani farikolo yɔrɔ wɛrɛw labɛn, ka kolotugudaw sabatili ɲɛ ani ka dimi nɔgɔya min bɛ sɔrɔ kolotugudaw basigibaliya fɛ.

Tendon ni farikolo yɔrɔ joginw dilancogo

Sogow ka kinibolo fan naani farikolo senkɔni faralen kɔ farikolo la, furakɛli ni BPC-157 ye furakɛli nɔba jira. Ka bɔ jateminɛ makɔrɔskɔpi la, kɔrɔsili kulu ye fiɲɛba jira senkɔni naani ni farikolo cɛ min tora ka taa ɲɛ, o kɛra sababu ye ka kɛnɛyabaliya sɔrɔ. O ni soso minnu furakɛra ni BPC-157 ye, olu ni kɛnɛya sabatili jirala, ni fiɲɛ in ka dɔgɔn kosɛbɛ kabini a daminɛ na, o laban na, o kɛra sababu ye ka sɔgɔsɔgɔninjɛ ni farikolo jɛɲɔgɔnya jɔnjɔn segin. Sɛgɛsɛgɛli min kɛra ni mikroskɔpi ye, o y’a jira ko kɔrɔsili kulu ye senkɔniw sɔgɔsɔgɔ, farikolojidɛsɛ hakɛ danmadɔ, ani sɔgɔsɔgɔninjɛ sɔgɔsɔgɔninjɛ jira dɔgɔkun filanan opereli kɔfɛ, k’a sɔrɔ BPC-157 furakɛli kulu ye sɔgɔsɔgɔninjɛ sɔgɔsɔgɔninjɛ nɔgɔman dɔrɔn jira, sɔgɔsɔgɔninjɛ sɔgɔsɔgɔninjɛ si ma sɔrɔ, ani senkɔniw ni farikolo jɛɲɔgɔnya sigicogo seginni ɲuman. Biomekanikini jateminɛ y’a jira ko farikolo fanga seginni tun man ɲi kɔrɔsili kulu la, ka sɔrɔ BPC-157 furakɛli kulu ye kɛnɛya dafalen sɔrɔ. O b’a jira ko BPC-157 tɛ furakɛli nɔ kɛ farikolo ni senkɔniw joginlenw dɔrɔn na, nka a bɛ se ka furakɛli ni furakɛli nɔ kɛrɛnkɛrɛnnenw fana jira sɔgɔsɔgɔninjɛ ni farikolo yɔrɔ tiɲɛni na, o bɛ dɛmɛ don ka jɛɲɔgɔnya ni baara kɛcogo ɲuman segin farikolo ni senkɔniw cɛ ani ka kolotugudaw lamagacogo ɲuman sabati.

BPC-157 seko ni a jiracogo kɛnɛyaso baarakɛcogo la

Kɔnɔnatumuw furakɛli

Ni an y’a jateminɛ ko BPC-157 bɛ se ka kɔnɔbara basigilenw tanga, ka banakɔtaa doncogo sabati, ka kɔnɔbara joginda kɛnɛyali sabati, ani ka nɔ ɲuman bila kɔnɔbara ni kɔnɔbara basigilen joginda la, a bɛ se ka kɛ kosɛbɛ kɔnɔbara bana suguya caman furakɛli la. Kɔnɔboli ni kɔnɔbara basigilen furakɛli la, BPC-157 bɛ se ka kirinni kɛnɛyali teliya ani ka dɔ bɔ a seginni farati la. Banakɔtaa funubanaw la i n’a fɔ kɔnɔboli, BPC-157 bɛ se ka banakɔtaa ɲɛgɛnɛsiralabanaw ka baara ɲɛ ka taa a fɛ ni banakɔtaa farikolo tangacogo ni funu jaabiw labɛnni ye, ka bana taamasiɲɛw nɔgɔya, ani ka banaw yafa sabati. Kɔnɔnatumu opereli kɔfɛ, BPC-157 tali bɛ se ka dɛmɛ don ka kɛnɛya sabati anastomotique fɛ, ka gɛlɛyaw dɔgɔya, ani ka banabagatɔ ka kɛnɛya teliya.

Jolibanaw furakɛli

Jolibanaw siratigɛ la, BPC-157 ka furakɛli nɔ minnu bɛ jolilabanaw ni gɛnɛgɛnɛ joginw na, olu bɛ hakilina kuraw di a kɛcogo kan kolotugudaw ni farikoloɲɛnajɛ joginw furakɛli la. Kolotugudaw banabagatɔw fɛ, BPC-157 bɛ se ka kɛ fura ye min bɛ se ka bana caman sɛmɛntiya, a tɛ dimi taamasiɲɛw nɔgɔya dɔrɔn, nka a bɛ kolotugudaw tiɲɛni fana sumaya, ka kolotugudaw dilancogo sabati, ani ka kolotugudaw baara ɲɛ. Spor joginw furakɛli la, i n’a fɔ gɛnɛgɛnɛ ni senkɔniw joginni minnu bɛ sɔrɔ gɛnɛgɛnɛ ni senkɔniw na, minnu bɛ ye farikoloɲɛnajɛlamɔgɔw la, BPC-157 bɛ se ka farikolo yɔrɔ tiɲɛnenw dilan teliya, ka kɛnɛya waati surunya, ani ka farikoloɲɛnajɛlamɔgɔw ka farikoloɲɛnajɛ kɛcogo kɛnɛya teliya bonya.

Kuncɛli

I n’a fɔ pepitiri biyoaktivi min bɛ dilan baara caman kɛ, BPC-157 bɛ nafa dɔw jira kɔnɔbara ni kolotugudaw joginw dilancogo la.

Sosow (Sɔrɔyɔrɔw).

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[3] Sikirikɛ P, Hahm K. B., Blagaic A. B., ani a ɲɔgɔnnaw. Stable Gastric Pentadecapeptide BPC 157, Robert ka kɔnɔbara lakanani/Adaptive Cytoprotection/Organoprotection, ani Selye ka degun kunbɛnni jaabi: Ɲɛtaa, seko ni dɔnko ani sini[J Kɔnɔnatumu ni sugunɛ, 2020,14(2):153-167.DOI:10.5009/gnl18490.

[4] Huang T, Zhang K, Sun L, ani mɔgɔ wɛrɛw. Farikolo tangalan-157 bɛ joginda kɛnɛyali sabati ni alkali ye in vivo ani ka a caya, ka taa yɔrɔ wɛrɛ, ani ka joli-sira-funu-bana sabati in vitro[J]. Fura Des Devel Ther, 2015,9:2485-2499.DOI:10.2147/DDDT.S82030. Bamako : DNAFLA, 2015.

[5] Kokic N, Sikiric P, Seiwerth S, ani a ɲɔgɔnnaw. Pentadecapeptide BPC-157 ani sosow ka kolotugudaw temporomandibular osteoarthrosis[M]. 2001.https://www.researchgate.net/publication/266736896_Pentadecapeptide_BPC-157_ani_sogo_kɔnɔnafili.

[6] Sikirić P, Seiwerth S, Grabarević Z, ani a ɲɔgɔnnaw. Pentadecapeptide BPC 157 ka kɛnɛya ni a kunbɛncogo nɔ min bɛ pankreyasi jugumanba ni kɔnɔbara basigilen joginda minnu bɛ taa ɲɔgɔn fɛ sosow la[J]. Dumunikɛcogo banaw ni dɔnniyaw, 1996,41(7):1518-1526.DOI:10.1007/BF02088582.

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