Cocer Peptides ye 
ŋlɔe ɣleti 1 enye sia
NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.
Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.
Kpɔɖeŋu bliboa
TB 500, si wogayɔna be Thymosin Beta-4, nye peptide si me amino acid 43 le. Ewɔa akpa vevi aɖe le ŋutilã ƒe dɔwɔwɔ vovovowo me le amegbetɔ ƒe ŋutilã me, vevietɔ le lãmekawo ƒe hayahaya me. Woɖe TB 500 ɖe vovo tso thymus ƒe lãkusi me gbã, eye numekukuwo ɖee fia be ɖoɖowɔwɔ ƒe dɔ veviwo le esi le lãmenugbagbeviwo ƒe ʋuʋu, ʋukawo ƒe dzɔdzɔ, kple lãmenugbagbeviwo ɖɔɖɔɖo me.
Le molecule ƒe wɔwɔme ƒe nukpɔsusu nu la, TB 500 ƒe amino acid ƒe ɖoɖo tɔxɛa naa nugbagbewo ƒe dɔwɔwɔ tɔxɛ aɖe. Eƒe wɔwɔme ƒe liƒo na wòte ŋu léa dɔwɔwɔ me ɖe asi le ŋutilã ƒe nɔnɔme vovovowo me, si ɖoa gɔmeɖoanyi na akpa si wòwɔna le lãmekawo ƒe hayahaya me. Peptide sia kaka ɖe ŋutilã bliboa me, eye agbɔsɔsɔ gã aɖe le lãmekawo me, si fia be kadodo le wo kple lãmekawo ƒe dɔwɔwɔwo dome.
Nɔnɔmetata 1 TB4 ƒe atikewɔwɔ le dzitodzito me ƒoƒo vɔ megbe nana dzitodzito ƒe dɔwɔwɔ nyona ɖe edzi le agbe me. Miameʋuka ƒe akpa si le kpuie (FS) ƒe mama.
Mɔnu siwo dzi TB 500 tona doa lãmekawo ƒe hayahaya ɖe ŋgɔ
(1)Lãmenugbagbeviwo ƒe ʋuʋu kple wo gbugbɔgadzɔ ƒe mɔnuwo
Myoblast ƒe ʋuʋu dodo ɖe ŋgɔ
Le lãmekawo ƒe abixɔxɔ megbe la, myoblast ƒe ʋuʋu le vevie ŋutɔ na teƒe si gblẽ la dzadzraɖo. TB 500 ate ŋu abla ɖe lãmenugbagbevi ƒe lãkusi tɔxɛ aɖewo ŋu, ana lãmenugbagbeviwo me dzesimɔwo nawɔ dɔ, eye wòado myoblast ƒe ʋuʋu ayi teƒe si woxɔ abi la ɖe ŋgɔ. Numekukuwo ɖee fia be lãmenugbagbeviwo dodokpɔ le vitro, TB 500 tsɔtsɔ kpe ɖe eŋu nana myoblast ƒe ʋuʋu kabakaba ŋutɔ eye wòdzia ʋuʋu ƒe didime ɖe edzi. Dɔ sia bia be woagbugbɔ atrɔ asi le lãmenugbagbeviwo ƒe ƒunukpeƒewo ŋu, eye TB 500 ate ŋu aɖɔ actin ƒe polymerization kple depolymerization ɖo, si ana myoblasts nate ŋu aʋu nyuie wu ayi lãmeka ƒe akpa si gblẽ eye wòana lãmenugbagbeviwo ƒe dzɔtsoƒe si hiã na lãmekawo ƒe gbugbɔgadzɔ.
Satellite Cell ƒe Dɔwɔwɔ Kple Vovototodedeameme
Satellite cells nye lãmenugbagbevi siwo le lãmekawo me siwo woate ŋu awɔ dɔ eye woato vovo azu myoblasts ne lãmekawo xɔ abi, eye emegbe woaƒo ƒu awɔ lãmeka ƒe ka yeyewo. TB 500 doa ŋusẽ satelait lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dzesiwo, si doa woƒe tɔtrɔ tso nɔnɔme si me ɖoɖoezizi le me yi nɔnɔme si me wodzina ɖe edzi me ɖe ŋgɔ. Eɖɔa nuŋɔŋlɔ ƒe nusiwo sɔ, abe MyoD kple Myf5 ene, ƒe ɖeɖefia ɖo be wòafia mɔ satelait lãmenugbagbeviwo ayi myoblast ƒe vovototodedeameme gbɔ. Le dodokpɔ siwo wowɔ le lãwo ŋu me la, yɔmekpe 500 dodo ɖe lãmeka si xɔ abi me le teƒea na satelait lãmenugbagbevi siwo wɔ dɔ ƒe xexlẽme dzi ɖe edzi ŋutɔ, eye lãmeka ƒe ka yeye siwo wowɔ ƒe agbɔsɔsɔ kple nyonyome hã nyo ɖe edzi, si ɖee fia be yɔmekpe 500 wɔa akpa vevi aɖe le lãmekawo ƒe gbugbɔgadzɔ si satelait lãmenugbagbeviwo tona dodo ɖe ŋgɔ me.
(2)Ʋuwo ƒe Dzɔdzɔmeŋusẽ ƒe Mɔnu
Ʋukawo ƒe Tsitsi ƒe Nuwɔna (VEGF) ƒe Nyagbɔgblɔ ƒe Dɔwɔwɔ
Angiogenesis le vevie ŋutɔ na lãmekawo ƒe hayahaya, elabena enaa oxygen kple nunyiame lãmeka siwo xɔ abi esime wòɖea lãmenugbagbeviwo ƒe gbeɖuɖɔwo ɖa. TB 500 ate ŋu aʋã lãmeka me lãmenugbagbeviwo kple mesenchymal lãmenugbagbevi siwo ƒo xlãe be woaɖe ʋukawo ƒe lãmenugbagbeviwo ƒe tsitsi ƒe nuwɔna (VEGF) afia. VEGF nye ʋukawo ƒe dzɔdzɔ ƒe ɖoɖowɔla vevi aɖe, si doa ʋuka me lãmenugbagbeviwo ƒe dzidziɖedzi, ʋuʋu, kple ʋukawo ƒe wɔwɔme ɖe ŋgɔ. Numekukuwo ɖee fia be le lãmeka siwo wotsɔ TB 500 da dɔe me la, VEGF ƒe mRNA kple protein ƒe ɖeɖefia siaa dzina ɖe edzi ŋutɔ. Wokpɔa induction sia to lãmenugbagbeviwo me dzesimɔ tɔxɛwo abe PI3K-Akt kple MAPK dzesimɔwo ene, ƒe dɔwɔwɔ me. Mɔ siawo ƒe dɔwɔwɔ doa VEGF domenyiŋusẽfianu ƒe nuŋɔŋlɔ kple egɔmeɖeɖe ɖe ŋgɔ, si wɔnɛ be VEGF ƒe dodo dzina ɖe edzi eye wònaa ʋuka yeyewo wɔwɔ nɔa bɔbɔe, si wɔnɛ be ʋu ƒe sisi na lãmeka si xɔ abi la nyona ɖe edzi.
Nɔnɔmetata 2 Tɔtrɔ siwo vaa fugboe ƒe domenyiŋusẽfianu ƒe ɖeɖefia ƒe ɖoɖoa me, tsɔ kpe ɖe gotagome kple ememe nuteɖeamedzi ƒe nuteɖeamedzi enuenu ŋu, dzea dɔléle ƒe tɔtrɔ vovovowo gɔme le ame tsitsi ƒe dzi me le míaƒe vidzidzi megbe agbemeŋkekewo katã me.
Ʋuka yeyewo ƒe wɔwɔme ƒe liƒolili
Tsɔ kpe ɖe ʋukawo ƒe dzɔdzɔ ŋu la, yɔmekpe 500 wɔa akpa vevi aɖe le ʋuka yeyewo ƒe wɔwɔme ƒe liƒolili me. Ewɔa ɖoɖo ɖe lãmenugbagbeviwo godo ƒe ƒuƒoƒo (ECM) ƒe wɔwɔme kple eƒe tɔtrɔ yeye ŋu, si wɔnɛ be ʋuka yeyewo te ŋu wɔa ɖeka kple lãkusi siwo ƒo xlãe nyuie wu. TB 500 doa ECM ƒe akpa siwo nye collagen kple fibronectin ƒe wɔwɔ ɖe ŋgɔ esime wòdaa asɔ le matrix metalloproteinases (MMPs) kple woƒe tissue inhibitors (TIMPs) me, si xea mɔ na ʋuka yeyewo be woagagblẽ nu le wo ŋu ne wogblẽ akpa o. Le ʋukawo ƒe dzɔdzɔ ƒe akpa mamlɛawo me la, TB 500 ƒe dɔwɔwɔ sia kpena ɖe ʋuka yeyewo ƒe blibonyenye kple dɔwɔwɔ ŋu, si wɔnɛ be lãmeka siwo xɔ abi la yia edzi xɔa nunyiame si sɔ eye wòdoa lãmekawo ƒe hayahaya ɖe ŋgɔ.
(3) Dɔlékuiwutikewo Kple Dɔlélenutsiŋutete Ŋuti Ðoɖowɔhawo
Mɔxexe Ðe Dɔlékuiwo ƒe Nyaɖeɖefia Nu
Lãmetsi ƒe abixɔxɔ hea dɔdzẽ ƒe ŋuɖoɖo vɛ, eye dɔdzẽ si gbɔ eme ate ŋu agblẽ nu le lãmekawo ŋu geɖe wu. Dɔlékuiwutikewo le TB 500 si, si xea mɔ na dɔdzẽ ƒe nu vovovowo abe tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), kple interleukin-6 (IL-6) ƒe ɖeɖefia. Le dɔdzẽɣi la, TB 500 ate ŋu abla ɖe dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe anyime xɔlawo ŋu, ana lãmenugbagbeviwo me dzesimɔ siwo tsia dɔdzẽ nu nawɔ dɔ, eye wòaxe mɔ ɖe dɔdzẽ ƒe cytokine domenyiŋusẽfianuwo ƒe nuŋɔŋlɔ kple wo gɔmeɖeɖe nu. Le lãwo ƒe dɔdzẽ ƒe kpɔɖeŋuwo me la, le TB 500 zazã vɔ megbe la, TNF-α, IL-1β, kple IL-6 ƒe agbɔsɔsɔ le lãmekawo me dzi ɖe kpɔtɔ ŋutɔ, eye dɔdzẽ ƒe lãmenugbagbeviwo ƒe gege ɖe lãme hã dzi ɖe kpɔtɔ. Esia ɖee fia be TB 500 ɖea dɔdzẽ ƒe ŋuɖoɖo dzi kpɔtɔna le lãmeka ƒe abixɔxɔ megbe to mɔxexe ɖe dɔdzẽ ƒe nusiwo woɖena fiana nu, si wɔnɛ be lãmekawo ƒe hayahaya doa ŋgɔ.
Dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi kpɔkpɔ
TB 500 ate ŋu aɖɔ dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ hã ɖo, si ado dɔlélenutsiŋutete ƒe ŋuɖoɖo siwo doa dzidzɔ na lãmenugbagbeviwo ɖɔɖɔɖo ɖe ŋgɔ. Ate ŋu akpɔ ŋusẽ ɖe macrophages ƒe polarization dzi, si ana woatrɔ tso pro-inflammatory M1 ƒomevi dzi ayi anti-inflammatory kple pro-repair M2 ƒomevi dzi. M2-ƒomevi ƒe macrophages ate ŋu aɖe tsitsinu vovovowo kple cytokines, abe insulin-like growth factor-1 (IGF-1) kple transforming growth factor-β (TGF-β) ene, siwo kpena ɖe lãmekawo ƒe lãmenugbagbeviwo ƒe dzidziɖedzi kple wo dzadzraɖo ŋu. Tsɔ kpe ɖe eŋu la, TB 500 ate ŋu aɖɔ T lymphocyte ƒe dɔwɔwɔ ɖo, si axe mɔ ɖe dɔlélenutsiŋutete ƒe dɔwɔwɔ si gbɔ eme nu be wòaxe mɔ ɖe nusiwo gblẽ le ŋutilãa ŋutɔ ƒe lãmekawo ŋu nu. To dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ tɔtrɔ me la, TB 500 wɔa ɖoɖo ɖe dɔlélenutsiŋutete ƒe dɔwɔwɔ ŋu le lãmekawo ƒe abixɔxɔ megbe, si wɔnɛ be lãmekawo ƒe ɖɔɖɔɖo kple hayahaya doa ŋgɔ.
Akpa si TB 500 Wɔna le Lãmetsiwo ƒe Gbugbɔgadzɔ Me
(1) Lãmetsiwo ƒe Abi Dzadzraɖo Kabakaba
Dzadzraɖo Ɣeyiɣi Kpuie
Eɖanye lãmekawo ƒe tete kpata alo lãmekawo ƒe ɖeɖiteameŋu atraɖii o, TB 500 ate ŋu aɖe ɣeyiɣi si woatsɔ adzra lãmekawo ƒe gbegblẽ ɖo la dzi akpɔtɔ ŋutɔ. Le lãwo ƒe dodokpɔwo me la, esi wogblẽ lãmekawo me vɔ la, dodokpɔha si wotsɔ yɔmekpe 500 da dɔe la ɖee fia be dɔyɔyɔ kabakaba ŋutɔ le afisi lãmekawo gblẽ le. Lãmetsiŋutinunya me dzodzro ɖee fia be dodokpɔ ƒe ƒuƒoƒoa ɖe lãmeka ƒe ka kple ʋuka yeye geɖe fia le ɣeyiɣi kpui aɖe me, eye lãmenugbagbevi siwo naa dɔdzẽ ƒe gege ɖe lãme hã dzi ɖe kpɔtɔ kabakaba wu. Le amegbetɔwo ŋuti numekukuwo me la, le kamedefefewɔla siwo ƒe lãmekawo ƒe tete le hehexɔxɔ sesẽ ta gome la, le yɔmekpe 500 dodo ɖe teƒea alo dodo ɖe ɖoɖo nu megbe la, dɔnɔwo gblɔ be lãmekawo ƒe vevesese dzi ɖe kpɔtɔ do ŋgɔ eye ɣeyiɣi si wòxɔna hafi lãmekawo ƒe dɔwɔwɔ nahaya dzi ɖe kpɔtɔ ŋutɔ, si wɔnɛ be wote ŋu trɔna yia hehexɔxɔ kple hoʋiʋli me kaba wu.
Dzadzraɖo ƒe nyonyome dzi ɖeɖe kpɔtɔ
Menye ɖeko TB 500 nana lãmekawo ƒe abixɔxɔ ƒe nuwo ɖɔɖɔɖo kabakaba ko o, ke enaa nuwo ɖɔɖɔɖo ƒe nyonyome hã nyona ɖe edzi. To mɔnuwo abe myoblast ƒe ʋuʋu dodo ɖe ŋgɔ, satellite cell ƒe dɔwɔwɔ kple vovototodedeameme, kple angiogenesis dzi la, TB 500 nana lãmeka ƒe lãkusi si wodzra ɖo la te ɖe lãmeka si sɔ ŋu le eƒe wɔwɔme kple dɔwɔwɔ gome. Woɖoa lãmeka siwo wodzra ɖo la ɖe ɖoɖo nu wu, eye lãmekawo ƒe tete ƒe ŋusẽ kple dzidodo gaɖoa wo me nyuie wu. Ne wozã TB 500 tsɔ dzra lãmeka siwo xɔ abi ɖo vɔ la, vovototo siwo le lãmeka siwo wodzra ɖo kple esiwo mexɔ abi o dome ƒe ŋusẽ si sɔ gbɔ wu si woate ŋu aƒo kple ɖeɖiteameŋu dzi ɖuɖu me la le sue wu, si ɖee fia be TB 500 nana lãmeka siwo xɔ abi ɖɔɖɔɖo ƒe nyonyome nyona ɖe edzi nyuie eye wòɖea ŋusẽ si lãmekawo ƒe abixɔxɔ kpɔna ɖe lãmekawo ƒe dɔwɔwɔ dzi ɣeyiɣi didi dzi kpɔtɔna.
(2) Lãmetsiwo ƒe Ðeɖiteameŋu Dzi Ðeɖe Akpɔtɔ
Ŋusẽ ƒe Tɔtrɔ ƒe Ðoɖowɔɖi
Lãmetsiwo ƒe ɖeɖiteameŋu do ƒome kplikplikpli kple ŋusẽ ƒe asitɔtrɔ le lãme na ame ƒe dɔlélewo. TB 500 ate ŋu aɖɔ ŋusẽ ƒe asitɔtrɔ le lãmekawo ƒe lãmenugbagbeviwo me ɖo, si ana ŋusẽ nana nyuie wu eye wòato esia me aɖe lãmekawo ƒe ɖeɖiteameŋu dzi akpɔtɔ. Edoa mitochondrial biogenesis kple dɔwɔwɔ ɖe ŋgɔ, dzia mitochondria ƒe xexlẽme kple dɔwɔwɔ ɖe edzi, si wɔnɛ be lãmekawo te ŋu wɔa yagbɔgbɔ nyuie wu eye wowɔa adenosine triphosphate (ATP) geɖe wu. Tsɔ kpe ɖe eŋu la, TB 500 ate ŋu aɖɔ enzyme siwo kpɔa gome le sukli ƒe asitɔtrɔ kple ami ƒe asitɔtrɔ me ƒe dɔwɔwɔ dzi, si ana ŋusẽnu siwo wotsɔ wɔa dɔe la zazã nyuie wu. Le kamedede me la, TB 500 ate ŋu ado ami ƒe gbagbã le oxidative me ɖe ŋgɔ, ana ŋusẽ geɖe lãmekawo, aɖe lactic acid ƒe ƒuƒoƒo dzi akpɔtɔ, eye wòahe lãmekawo ƒe ɖeɖiteameŋu ƒe gɔmedzedze ɖe megbe.
Oxidative Nuteɖeamedzi Ŋuti Ðoɖowɔwɔ
Le kamedede me la, wowɔa oxygen ƒomevi siwo wɔa dɔ (ROS) gbogbo aɖe, si wɔnɛ be oxidative stress, si nye nu vevi siwo hea lãmekawo ƒe ɖeɖiteameŋu vɛ la dometɔ ɖeka vɛ. TB 500 ƒe antioxidant ŋutetewo le esi, enaa lãmenugbagbeviwo me antioxidant enzymes abe superoxide dismutase (SOD) kple glutathione peroxidase (GPx) ƒe dɔwɔwɔ dzina ɖe edzi, eɖea ROS ƒe ƒuƒoƒo dzi kpɔtɔna, eye wòɖea nusiwo oxidative stress hena vɛ na lãmekawo ƒe lãmenugbagbeviwo dzi kpɔtɔna. Le lãwo ƒe dodokpɔwo me la, lã siwo wotsɔ TB 500 da dɔe do ŋgɔ la ɖe oxidative stress markers siwo ɖiɖi ŋutɔ fia le lãmekawo me eye lãmekawo ƒe ɖeɖiteameŋu fafɛ wu ne wotsɔe sɔ kple ƒuƒoƒo si me wokpɔa wo gbɔ le le kamedede didi megbe. Numekuku sia ɖee fia be TB 500 ɖea lãmekawo ƒe lãmenugbagbeviwo ƒe gbegblẽ dzi kpɔtɔna eye wòɖea lãmekawo ƒe ɖeɖiteameŋu dzi kpɔtɔna to oxidative stress ƒe ŋuɖoɖowo dzi kpɔkpɔ me, si wɔnɛ be lãmekawo ƒe dɔwɔwɔ nyuie nɔa anyi.
(3) Lãmetsiwo ƒe Tsitsi Kple Tsitsi Dodo Ðe Ŋgɔ
Lãmetsiwo ƒe Protein ƒe Dɔwɔwɔ si Doa Ŋusẽ
TB 500 doa lãmeka me protein ƒe wɔwɔ ɖe ŋgɔ to mTOR ƒe dzesimɔ si le lãmenugbagbeviwo me ƒe dɔwɔwɔ me. mTOR nye molecule vevi aɖe si kpɔa protein ƒe wɔwɔme dzi, si doa ribosomal biosynthesis kple protein gɔmeɖeɖe gɔmedzenuwo ƒe dɔwɔwɔ ɖe ŋgɔ, si wɔnɛ be lãmeka me protein ƒe wɔwɔme dzina ɖe edzi. TB 500 hã kpɔa nuŋɔŋlɔmenuwo ƒe ɖeɖefia dzi, siwo dometɔ aɖewoe nye NF-κB, si kpɔa ŋusẽ ɖe lãmeka me protein ƒe wɔwɔme dzi le mɔ si mele tẽ o nu. Lãmenugbagbeviwo ƒe agbledede dodokpɔ siwo wowɔ le vitro ɖee fia be TB 500 tsɔtsɔ kpe ɖe eŋu na protein ƒe wɔwɔme dzi ɖe edzi ŋutɔ le lãmekawo me. Le dodokpɔ siwo wowɔ le lãwo ŋu me la, lã siwo wotsɔ TB 500 da dɔ na le ɣeyiɣi didi aɖe me la ɖe lãmekawo ƒe lolome kple ŋusẽ ƒe dzidziɖedzi gã aɖe fia. TB 500 doa lãmekawo ƒe tsitsi kple tsitsi ɖe ŋgɔ to lãmekawo me protein ƒe wɔwɔme dodo ɖe ŋgɔ me.
Lãmetsiŋusẽ ƒe ka ƒomevi ƒe tɔtrɔ dzi kpɔkpɔ
Woma lãmeka ƒe ka ƒomeviwo ɖe ka siwo ʋuʋuna kabakaba kple esiwo ʋuʋuna blewu me, siwo to vovo le kamedede ƒe dɔwɔwɔ kple lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe nɔnɔmewo gome. TB 500 ate ŋu aɖɔ lãmeka ƒe ka ƒomevi ƒe tɔtrɔ ɖo, si akplɔe ayi mɔ si anyo wu be wòana kamedefefewo nanyo ɖe edzi. Numekukuwo ɖee fia be TB 500 doa domenyiŋusẽfianu siwo do ƒome kple ka siwo ʋuʋuna blewu, abe domenyiŋusẽfianu si nye myosin heavy chain (MyHC) ene, ƒe ɖeɖefia ɖe ŋgɔ, evɔ wòxea mɔ na domenyiŋusẽfianu siwo do ƒome kple ka siwo ʋuʋuna kabakaba ƒe ɖeɖefia.
TB 500 zazã le lãmekawo ƒe hayahaya me
(1) Dɔwɔwɔ le Kamedefefewo me
Kamedefefewɔlawo ƒe Nuveviwɔame Mɔxexe Kple Wo Haya
Le hoʋiʋli ƒe kamedefefewo me la, kamedefefewɔlawo dzea ŋgɔ hehexɔxɔ kple hoʋiʋli sesẽwo, si wɔnɛ be lãmekawo xɔa abi geɖe. Ne wodo TB 500 nyuie hafi na hehe ame la, woate ŋu ana lãmekawo nate ŋu anɔ te ɖe abixɔxɔ nu, si aɖe abixɔxɔ abe lãmekawo ƒe tete kple lãmekawo ƒe tete ene ƒe afɔkua dzi akpɔtɔ. Ne kamedefefewɔlawo xɔ abi le lãmekawo me la, TB 500 zazã ɖe ɣeyiɣi nyuitɔ dzi hena atikewɔwɔ ate ŋu ana abiawo ɖɔɖɔɖo kabakaba, ana ɣeyiɣi si woatsɔ ahaya la nanɔ kpuie, eye wòana kamedefefewɔlawo natrɔ ayi hoʋiʋli me kaba wu. Le duɖimekeke kple bɔlƒoƒo ƒe hoʋiʋli aɖewo me la, kamedefefewɔlawo te yɔmekpe 500 dodo kpɔ be woatsɔ ado lãmekawo ƒe abixɔxɔ ƒe hayahaya ɖe ŋgɔ eye wokpɔ nu nyuiwo.
Kamedefefewo ƒe Dɔwɔwɔ Dzi Ðeɖe Akpɔtɔ
TB 500 ate ŋu ana kamedefefewo nanyo ɖe edzi hã to lãmekawo ƒe ɖeɖiteameŋu dzi ɖeɖe kpɔtɔ kple lãmekawo ƒe tsitsi kple tsitsi dodo ɖe ŋgɔ me. Le dzidodo ƒe kamedefefewo me la, TB 500 ƒe ɖoɖowɔwɔ ƒe ŋusẽkpɔɖeamedzi ɖe ŋusẽ ƒe asitɔtrɔ kple oxidative stress dzi ate ŋu ahe lãmekawo ƒe ɖeɖiteameŋu ƒe gɔmedzedze ɖe megbe, si ana kamedefefewɔlawo ƒe dzidodo ƒe agbɔsɔsɔme nanyo ɖe edzi. Le ŋusẽdodo kamedefefewo me la, TB 500 ƒe lãmeka me protein ƒe wɔwɔme ƒe ʋuʋu kple lãmeka ƒe ka ƒomevi ƒe tɔtrɔ ƒe ɖoɖowɔwɔ ate ŋu ana lãmeka ƒe ŋusẽ kple bɔmb ƒe ŋusẽ nadzi ɖe edzi.
(2) Dɔwɔwɔ le Atikewɔwɔ na Amewo ƒe Gbugbɔgaɖɔɖo me
Lãmetsiwo ƒe Abixɔxɔ Gbugbɔgaɖɔɖo ƒe Atikewɔwɔ
Le ɖɔɖɔɖodɔdamɔnu me la, woate ŋu azã yɔmekpe 500 abe atike kpeɖeŋutɔ ene na lãmekawo ƒe abixɔxɔ ƒe ɖɔɖɔɖo. Le dɔnɔ siwo ƒe lãmekawo xɔ abi le nuveviwɔame, amekoko, alo nu bubuwo ta gome la, ɖɔɖɔɖodɔ si wozãna ɖaa kple yɔmekpe 500 zazã tsɔtsɔ tsaka ate ŋu ana ɖɔɖɔɖo me tsonu nanyo ɖe edzi. Le dɔnɔ siwo ƒe lãmekawo xɔ abi le lãmekawo ƒe gbagbã megbe gome la, yɔmekpe 500 dodo ɖe teƒea alo dodo ɖe ɖoɖo nu kpe ɖe kamedede kple gbugbɔgaɖɔɖo ƒe hehexɔxɔ ŋu ate ŋu ana lãmekawo ƒe ŋusẽ kple dɔwɔwɔ nahaya kabakaba, si ana ɣeyiɣi si woatsɔ aɖɔ lãmekawo ɖo la nanɔ kpuie. Atikewɔla siwo naa yɔmekpe ate ŋu atrɔ asi le TB 500 ƒe atikewɔwɔ ƒe ɖoɖowo ŋu le dɔnɔa ƒe nɔnɔme tɔxɛa nu, siwo dometɔ aɖewoe nye agbɔsɔsɔme si woazã, zi nenie, kple mɔ si dzi woato anae, be woakpɔ ɖɔɖɔɖodɔ nyuitɔ kekeake.
Nɔnɔmetata 3: Nukpɔsusu si nye be woazã molecule siwo woɖena do ŋgɔ siwo wɔa dɔ do ŋgɔ na vidzidzi atsɔ agbugbɔ ŋutinuwo awɔ dɔ le ame tsitsiwo me.
Lãmetsiŋusẽ ƒe gbagbã si do ƒome kple ahɔhɔ̃mekawo ƒe dɔlélewo dada
Ahɔhɔ̃medɔléle aɖewo, abe aklã ƒe abixɔxɔ kple amyotrophic lateral sclerosis (ALS) ene, ate ŋu ana lãmekawo natsi. TB 500 ate ŋu awɔ atikewɔwɔ ƒe ŋusẽkpɔɖeamedzi ɖe lãmekawo ƒe tsɔtsrɔ̃ si do ƒome kple ahɔhɔ̃medɔlélewo dzi to lãmekawo ƒe dzidziɖedzi dodo ɖe ŋgɔ kple lãmekawo ƒe lãmenugbagbeviwo ƒe tsɔtsrɔ̃ nu me. Le dodokpɔ siwo wowɔ le lãwo ŋu me la, le lãmekawo ƒe tsɔtsrɔ̃ si tso aklã ƒe abixɔxɔ gbɔ ƒe kpɔɖeŋuwo gome la, TB 500 zazã na lãmekawo ƒe tsɔtsɔme nyo ɖe edzi ŋutɔ, eye lãmekawo ƒe lolome kple ŋusẽ gaɖo eƒe akpa aɖe.
Nyanuwuwuw
TB 500 ate ŋu ado lãmekawo ƒe hayahaya ɖe ŋgɔ. To mɔnuwo abe lãmenugbagbeviwo ƒe ʋuʋu kple wo gbugbɔgadzɔ, ʋukawo ƒe dzɔdzɔ, kple dɔlékuiwutikewo kple dɔlélenutsiŋutete ƒe ɖoɖowɔwɔ dzi la, ewɔa akpa vevi aɖe le lãmekawo ƒe abixɔxɔ ɖɔɖɔɖo, ɖeɖiteameŋu dzi ɖeɖe kpɔtɔ, kple tsitsi kple tsitsi me. Le kamedefefewo gome la, ate ŋu akpe ɖe kamedefefewɔlawo ŋu woaxe mɔ ɖe lãmekawo ƒe abixɔxɔ nu ahada wo eye wòana kamedefefewo nanyo ɖe edzi; le atikewɔwɔ si wotsɔ ɖɔa ame ɖo me la, woate ŋu azãe atsɔ ada lãmekawo ƒe abi gbugbɔgaɖɔɖo kple lãmekawo ƒe gbagbã si do ƒome kple ahɔhɔ̃medɔlélewo dada.
Dzɔtsoƒewo
[1] Bo Z, Mingjun L. Hayahaya tso lãmekawo ƒe abixɔxɔ me le hehexɔxɔ sesẽ le kplɔ̃dzitennis me megbe[J]. Revista Brasileira De Atikewɔwɔ Do Esporte, 2023,29.DOI: 10.1590/1517-8692202329012022_0550.
[2] Zhang D, Fan G. Nusiwo wotsɔ ƒo ƒui zazã le lãmekawo ƒe ʋuʋu ƒe hayahaya ƒe ɖoɖo me[J]. Liƒowo le Dzɔdzɔmeŋusẽŋununya me, 2023, 11: 1246926.DOI: 10.3389 / fchem.2023.1246926.
[3] Roveratti M. C., Jacinto J. L., Oliveira D. B., kple ame bubuwo. Dɔ si beta-alanine ƒe kpeɖeŋutɔ nana kpɔna ɖe lãmekawo ƒe dɔwɔwɔ dzi le hayahaya tso tsitretsitsi ƒe kamedede me le sɔhɛ tsitsiwo me[J]. Amino Acids, 2019, 51 (4): 589-597.DOI: 10.1007 / s00726-018-02686- ƒe.
[4] Ferreira D. V., Gentil P., Soares S., kple ame bubuwo. Pectoralis major kple triceps brachii ƒe hayahaya le bench press kamedede megbe[J]. Lãmetsi & Lãmetsi, 2017, 56 (5): 963-967.DOI: 10.1002 / mus.25541.
[5] Markos F, Campion D. P., Carey M, kple ame bubuwo. Numekuku aɖe le alesi almitrine wɔa dɔe le sisiblisi ƒe lãkusi ƒe lãmeka ƒe ɖeɖiteameŋu si woɖe ɖe aga ŋu[J]. Yagbɔgbɔ, 2002, 69 (4): 339-343.DOI: 10.1159 / 000063267.
[6] Noda K. Mɔnu si dzi woato agbugbɔ lãmenugbagbeviwo me cation ƒe agbɔsɔsɔ aɖo lãmeka si nyrɔ ɖe sucrose solution me[J]. Kurume ƒe Atikewɔwɔ Ŋuti Nyatakakagbalẽ, 1965,12:119-129.
[7] Bock-Marquette I, Maar K, Maar S, kple ame bubuwo. Thymosin beta-4 fia mɔfiame yeye siwo dzi woato ato tsitsi ƒe gbugbɔgadzɔ ƒe atikewɔwɔ siwo me nu dze edzi na vɛ[J]. Dukɔwo Dome Dɔlélenutsiŋutete ƒe Atikeŋutinunya, 2023,116:109741.DOI: https://doi.org/10.1016/j.intimp.2023.109741.
Adzɔnu si li na numekuku zazã ɖeɖeko:
