Los ntawm Cocer Peptides 
1 month ago
Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.
Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.
Txheej txheem cej luam
TB 500, tseem hu ua Thymosin Beta-4, yog peptide muaj li ntawm 43 amino acids. Nws plays lub luag haujlwm tseem ceeb hauv ntau yam txheej txheem physiological hauv tib neeg lub cev, tshwj xeeb tshaj yog nyob rau hauv cov leeg nqaij. TB 500 tau pib cais tawm ntawm cov ntaub so ntswg thymus, thiab kev tshawb fawb tau pom tias nws muaj kev tswj hwm tseem ceeb hauv kev tsiv teb tsaws ntawm tes, angiogenesis, thiab kho cov ntaub so ntswg.
Los ntawm qhov kev xav ntawm cov qauv molecular, TB 500 qhov tshwj xeeb amino acid ib ntus qhia txog kev ua haujlwm lom neeg. Nws cov qauv kev ruaj ntseg ua rau nws muaj peev xwm tswj tau kev ua haujlwm thoob plaws ntau qhov chaw physiological, tso lub hauv paus rau nws lub luag haujlwm hauv cov leeg nqaij. Cov peptide no tau nthuav dav thoob plaws hauv lub cev, nrog cov nyiaj tseem ceeb hauv cov leeg nqaij, qhia txog kev sib txuas rau cov leeg nqaij physiological.
Daim duab 1 TB4 kev kho mob tom qab coronary ligation txhim kho myocardial muaj nuj nqi hauv vivo. Kev faib tawm ntawm sab laug ventricular fractional shortening (FS).
Mechanisms uas TB 500 txhawb nqa cov leeg zoo
(1) Cell migration thiab regeneration mechanisms
Kev txhawb nqa ntawm myoblast migration
Tom qab cov leeg raug mob, myoblast tsiv teb tsaws yog qhov tseem ceeb rau kev kho qhov chaw puas. TB 500 tuaj yeem khi rau cov receptors tshwj xeeb ntawm cov cell membrane, qhib txoj hauv kev hauv lub cev, thiab txhawb nqa myoblast tsiv teb tsaws mus rau qhov chaw raug mob. Cov kev tshawb fawb tau pom tias nyob rau hauv vitro cell thwmsim, ntxiv TB 500 ho accelerate myoblast migration speed thiab tsub kom migration nrug. Cov txheej txheem no suav nrog kev hloov kho ntawm cytoskeleton, thiab TB 500 tuaj yeem tswj cov polymerization thiab depolymerization ntawm actin, ua kom cov myoblasts txav tau zoo dua mus rau thaj tsam cov leeg puas thiab muab cov cellular tsim nyog rau cov leeg nqaij.
Satellite Cell Ua kom muaj zog thiab sib txawv
Satellite cells yog cov qia hlwb hauv cov leeg nqaij uas tuaj yeem qhib tau thiab sib txawv rau hauv myoblasts thaum cov leeg raug mob, tom qab sib txuas los tsim cov leeg nqaij tshiab. TB 500 txhim kho cov teeb liab ua haujlwm ntawm cov xov tooj cua satellite, txhawb lawv txoj kev hloov pauv ntawm lub xeev quiescent mus rau lub xeev proliferative. Nws tswj cov kev qhia ntawm cov xwm txheej cuam tshuam, xws li MyoD thiab Myf5, coj cov cell satellite mus rau qhov sib txawv ntawm myoblast. Hauv kev sim tsiaj, kev txhaj tshuaj hauv zos ntawm TB 500 rau hauv cov leeg raug mob ua rau muaj qhov nce ntxiv ntawm cov xov tooj cua satellite hlwb, nrog rau kev txhim kho kom muaj nuj nqis thiab zoo ntawm cov leeg nqaij tshiab, qhia tias TB 500 plays lub luag haujlwm tseem ceeb hauv kev txhawb nqa satellite cell-mediated leeg nqaij.
(2) Angiogenesis Mechanism
Induction ntawm Vascular Endothelial Growth Factor (VEGF) Qhia
Angiogenesis yog qhov tseem ceeb rau cov leeg nqaij, vim nws muab cov pa oxygen thiab cov as-ham rau cov ntaub so ntswg raug mob thaum tshem tawm cov khib nyiab metabolic. TB 500 tuaj yeem txhawb nqa cov leeg nqaij thiab cov hlwb nyob ib puag ncig mesenchymal los qhia txog vascular endothelial kev loj hlob zoo (VEGF). VEGF yog qhov tseem ceeb ntawm kev tswj hwm ntawm angiogenesis, txhawb kev loj hlob, kev tsiv teb tsaws, thiab tubule tsim ntawm vascular endothelial hlwb. Kev tshawb fawb qhia tau hais tias nyob rau hauv cov leeg nqaij kho nrog TB 500, ob qho tib si mRNA thiab protein qhia theem ntawm VEGF tau nce siab. Qhov induction no tau ua tiav los ntawm kev ua kom muaj kev qhia tshwj xeeb hauv lub cev, xws li PI3K-Akt thiab MAPK signaling pathways. Kev ua kom txoj hauv kev no txhawb nqa cov ntawv sau thiab txhais lus ntawm VEGF noob, yog li ua kom VEGF tso tawm thiab ua kom yooj yim rau cov hlab ntsha tshiab, txhim kho cov ntshav rau cov leeg raug mob.
Daim duab 2 Kev hloov pauv hauv cov txheej txheem embryonic gene nthuav qhia, ua ke nrog nquag raug rau sab nraud thiab sab hauv kev ntxhov siab, pib ntau yam kev hloov pauv hauv cov neeg laus lub siab thoob plaws hauv peb lub neej tom qab yug menyuam.
Stabilizing cov qauv ntawm cov hlab ntsha tshiab
Ntxiv nrog rau inducing angiogenesis, TB 500 plays lub luag haujlwm tseem ceeb hauv kev txhim kho cov qauv ntawm cov hlab ntsha tshiab. Nws tswj cov muaj pes tsawg leeg thiab kev hloov kho ntawm extracellular matrix (ECM), ua kom cov hlab ntsha tshiab tuaj yeem ua ke zoo dua rau hauv cov ntaub so ntswg. TB 500 txhawb nqa cov synthesis ntawm ECM cov khoom xws li collagen thiab fibronectin thaum ntsuas matrix metalloproteinases (MMPs) thiab lawv cov ntaub so ntswg inhibitors (TIMPs), tiv thaiv cov hlab ntsha tshiab los ntawm kev puas tsuaj los ntawm kev degradation ntau dhau. Hauv cov theem tom qab ntawm angiogenesis, qhov kev ua ntawm TB 500 no pab tswj kev ncaj ncees thiab kev ua haujlwm ntawm cov hlab ntsha tshiab, ua kom cov leeg raug mob txuas ntxiv tau txais cov khoom noj txaus thiab txhawb cov leeg nqaij.
(3) Anti-inflammatory thiab Immune Regulatory Mechanisms
Inhibition ntawm Inflammatory Factor Expression
Kev raug mob ntawm cov nqaij ntshiv ua rau cov lus teb inflammatory, thiab kev mob ntau dhau tuaj yeem ua rau muaj kev puas tsuaj ntxiv rau cov leeg nqaij. TB 500 muaj cov tshuaj tiv thaiv kab mob, inhibiting kev qhia ntawm ntau yam inflammatory yam xws li qog necrosis factor-α (TNF-α), interleukin-1β (IL-1β), thiab interleukin-6 (IL-6). Thaum mob, TB 500 tuaj yeem khi rau cov receptors ntawm lub cev tiv thaiv kab mob, ua kom cov kab mob hauv lub cev tiv thaiv kab mob, thiab inhibit qhov kev hloov pauv thiab kev txhais lus ntawm inflammatory cytokine noob. Hauv cov tsiaj mob ua qauv, tom qab siv TB 500, qib TNF-α, IL-1β, thiab IL-6 hauv cov leeg nqaij tau txo qis, thiab kev nkag mus ntawm cov hlwb inflammatory kuj txo. Qhov no qhia tau hais tias TB 500 alleviates inflammatory teb tom qab cov leeg raug mob los ntawm inhibiting qhov kev qhia ntawm inflammatory yam, li no txhawb cov leeg nqaij.
Tswj lub cev tiv thaiv kab mob ua haujlwm
TB 500 tseem tuaj yeem tswj hwm kev ua haujlwm ntawm lub cev tiv thaiv kab mob, txhawb kev tiv thaiv kab mob uas nyiam kho cov ntaub so ntswg. Nws tuaj yeem cuam tshuam cov polarization ntawm macrophages, ua rau lawv hloov los ntawm pro-inflammatory M1 hom mus rau kev tiv thaiv thiab kho M2 hom. M2-hom macrophages tuaj yeem tso tawm ntau yam kev loj hlob thiab cytokines, xws li insulin-zoo li kev loj hlob factor-1 (IGF-1) thiab hloov pauv kev loj hlob-β (TGF-β), uas pab txhawb kev loj hlob ntawm cov leeg nqaij thiab kho. Tsis tas li ntawd, TB 500 tuaj yeem tswj hwm T lymphocyte muaj nuj nqi, tiv thaiv kev tiv thaiv kab mob ntau dhau los tiv thaiv kev puas tsuaj rau lub cev nqaij daim tawv nqaij. Los ntawm kev hloov kho lub cev tiv thaiv kab mob ua haujlwm, TB 500 tswj cov kev tiv thaiv kab mob tom qab cov leeg raug mob, yog li txhawb cov leeg kho thiab rov zoo.
Lub luag haujlwm ntawm TB 500 hauv Muscle Recovery
(1) Kev kho cov leeg mob nrawm
Shortening Repair Time
Txawm hais tias nws yog mob hnyav los yog mob ntev ntawm cov leeg nqaij, TB 500 tuaj yeem txo lub sijhawm kho cov leeg nqaij. Hauv kev sim tsiaj, tom qab ua rau cov nqaij puas tsuaj, pab pawg sim kho nrog TB 500 tau pom tias muaj kev kho mob sai sai ntawm qhov chaw ntawm cov leeg nqaij. Kev tshawb fawb histological tau qhia tias cov pab pawg sim tau nthuav tawm ntau cov leeg nqaij tshiab thiab cov hlab ntsha hauv lub sijhawm luv dua, thiab cov kab mob ntawm tes infiltration kuj tseem sai dua. Hauv tib neeg cov kev tshawb fawb, rau cov neeg ncaws pob uas muaj cov leeg nqaij mob tshwm sim los ntawm kev siv zog siab, tom qab kev txhaj tshuaj hauv zos lossis kev tswj hwm ntawm TB 500, cov neeg mob tau tshaj tawm ua ntej kev kho mob ntawm cov leeg nqaij thiab txo qhov tseem ceeb ntawm lub sijhawm xav tau rau cov leeg nqaij rov ua haujlwm, ua rau lawv rov qab mus rau kev cob qhia thiab kev sib tw sai dua.
Txhim kho kev kho kom zoo
TB 500 tsis yog tsuas yog ua kom nrawm nrawm ntawm cov leeg nqaij, tab sis kuj tseem txhim kho kev kho kom zoo. Los ntawm cov txheej txheem xws li kev txhawb nqa myoblast migration, satellite cell activation thiab kev sib txawv, thiab angiogenesis, TB 500 ua rau cov leeg kho cov nqaij ntshiv thiab ua haujlwm ze rau cov leeg nqaij. Kho cov nqaij fibers yog npaj ntau uniformly, thiab nqaij contractile quab yuam thiab endurance yog zoo dua rov qab. Tom qab siv TB 500 los kho cov nqaij ntshiv raug mob, qhov sib txawv ntawm qhov siab tshaj plaws contractile quab yuam thiab lub sij hawm ua rau qaug zog ntawm cov leeg kho thiab cov leeg tsis muaj mob yog me me, qhia tau hais tias TB 500 zoo txhim kho cov leeg mob zoo thiab txo qhov cuam tshuam ntev ntawm cov leeg nqaij ntawm lub cev muaj zog.
(2) Alleviating Muscle Fatigue
Lub zog Metabolism Regulation
Cov leeg nqaij qaug zog muaj feem cuam tshuam nrog lub zog metabolism tsis zoo. TB 500 tuaj yeem tswj cov txheej txheem metabolism hauv lub zog hauv cov leeg nqaij, txhim kho kev siv hluav taws xob thiab ua kom cov leeg qaug zog. Nws txhawb nqa mitochondrial biogenesis thiab kev ua haujlwm, nce mitochondrial tus naj npawb thiab kev ua haujlwm, ua rau cov leeg nqaij ua pa ua pa ua pa zoo dua thiab tsim cov adenosine triphosphate (ATP). Tsis tas li ntawd, TB 500 tuaj yeem tswj hwm cov haujlwm ntawm cov enzymes koom nrog hauv cov piam thaj metabolism thiab fatty acid metabolism, optimizing kev siv lub zog substrates. Thaum lub sijhawm ua haujlwm, TB 500 tuaj yeem txhawb nqa oxidative kev puas tsuaj ntawm fatty acids, muab cov nqaij ntshiv ntau zog, txo cov lactic acid tsub zuj zuj, thiab ncua qhov pib ntawm cov leeg nqaij.
Oxidative Stress Regulation
Thaum lub sij hawm ib ce, ib tug loj npaum li cas ntawm reactive oxygen hom (ROS) yog tsim, ua rau oxidative kev nyuaj siab, uas yog ib qho ntawm feem ua rau cov leeg nqaij qaug zog. TB 500 muaj cov khoom antioxidant, txhim kho kev ua haujlwm ntawm intracellular antioxidant enzymes xws li superoxide dismutase (SOD) thiab glutathione peroxidase (GPx), txo ROS tsub zuj zuj, thiab txo oxidative kev ntxhov siab vim kev puas tsuaj rau cov leeg hlwb. Hauv kev sim tsiaj, tsiaj ua ntej nrog TB 500 tau nthuav tawm cov cim oxidative kev ntxhov siab hauv cov leeg nqaij thiab cov leeg mob hnyav dua piv rau pawg tswj xyuas tom qab kev tawm dag zog ntev. Txoj kev tshawb no qhia tau hais tias TB 500 alleviates nqaij cell puas thiab txo cov nqaij ntshiv los ntawm kev tswj oxidative kev nyuaj siab, yog li tswj cov leeg nqaij ua haujlwm.
(3) Txhawb nqa cov leeg nqaij thiab kev loj hlob
Stimulating Muscle Protein Synthesis
TB 500 txhawb nqa cov leeg nqaij protein synthesis los ntawm kev ua kom lub mTOR signaling txoj hauv cov hlwb. mTOR yog ib qho tseem ceeb molecule regulating protein synthesis, txhawb ribosomal biosynthesis thiab cov kev ua ntawm protein txhais lus pib yam, yog li nce tus nqi ntawm cov nqaijrog protein synthesis. TB 500 kuj tseem tswj cov kev qhia ntawm kev hloov pauv, suav nrog NF-κB, uas cuam tshuam ncaj qha rau cov leeg nqaij protein synthesis. Hauv vitro cell kab lis kev cai thwmsim tau pom tias ntxiv TB 500 ua kom muaj protein ntau ntxiv hauv cov leeg hlwb. Hauv kev sim tsiaj, tsiaj kho nrog TB 500 nyob rau lub sijhawm ntev tau nthuav tawm qhov kev nce ntxiv hauv cov leeg nqaij thiab lub zog. TB 500 txhawb nqa cov nqaij ntshiv thiab kev loj hlob los ntawm kev txhawb cov leeg nqaij protein synthesis.
Kev tswj cov leeg nqaij fiber ntau hloov pauv
Cov leeg nqaij fiber ntau tau muab faib ua ceev-twitch thiab qeeb-twitch fibers, uas txawv hauv kev ua tau zoo thiab cov yam ntxwv metabolic. TB 500 tuaj yeem tswj cov leeg nqaij fiber ntau hloov pauv, coj nws mus rau kev coj ua kom muaj txiaj ntsig zoo rau kev ua kis las. Kev tshawb fawb tau pom tias TB 500 txhawb nqa qhov kev qhia ntawm qeeb-twitch fiber ntau cov noob, xws li qeeb-type myosin heavy chain (MyHC) gene, thaum inhibiting kev qhia ntawm cov noob ceev-twitch fiber ntau.
Daim ntawv thov TB 500 hauv Cov Muscle Rov Qab
(1) Daim ntawv thov hauv Kev Ua Si
Athlete Injury Prevention and Recovery
Hauv kev sib tw kis las, cov neeg ncaws pob ntsib kev siv zog siab thiab kev sib tw, ua rau muaj qhov tshwm sim ntau ntawm cov leeg nqaij. Los ntawm kev tswj hwm tus kab mob TB 500 kom tsim nyog ua ntej kev cob qhia, cov leeg nqaij tiv thaiv kev raug mob tuaj yeem txhim kho, txo qhov kev pheej hmoo ntawm kev raug mob xws li cov leeg nqaij thiab pob txha. Thaum cov neeg ncaws pob txhawb nqa kev raug mob ntawm cov leeg nqaij, kev siv TB 500 raws sijhawm rau kev kho mob tuaj yeem txhim kho kev raug mob, txo lub sijhawm rov qab los, thiab pab cov neeg ncaws pob rov qab mus rau kev sib tw sai dua. Hauv qee qhov kev sib tw thiab kev sib tw thiab kev ncaws pob, cov neeg ncaws pob tau pib sim nrog TB 500 los txhawb cov leeg mob rov qab thiab tau ua tiav cov txiaj ntsig zoo.
Txhim khu kev ua kis las
TB 500 kuj tseem tuaj yeem txhim kho kev ua kis las los ntawm kev txo cov leeg nqaij qaug zog thiab txhawb cov leeg nqaij thiab kev loj hlob. Hauv kev ua kis las, TB 500 cov kev tswj xyuas cov teebmeem ntawm lub zog metabolism thiab oxidative kev nyuaj siab tuaj yeem ncua qhov pib ntawm cov leeg nqaij qaug zog, yog li txhim kho cov neeg ncaws pob 's endurance qib. Hauv kev ua kis las muaj zog, TB 500 qhov kev txhawb nqa ntawm cov leeg nqaij protein synthesis thiab kev tswj hwm ntawm cov nqaij fiber ntau hloov pauv tuaj yeem ua rau cov leeg muaj zog thiab tawg lub zog.
(2) Cov ntawv thov hauv Kev Kho Mob Kho Mob
Muscle Injury Rehabilitation Treatment
Hauv cov tshuaj kho kom rov zoo, TB 500 tuaj yeem siv los ua kev kho mob ntxiv rau kev kho cov leeg nqaij. Rau cov neeg mob uas raug mob los ntawm kev raug mob, kev phais, lossis lwm yam, kev sib koom ua ke nrog kev kho kom rov zoo li qub nrog TB 500 tuaj yeem txhim kho cov txiaj ntsig zoo. Hauv cov neeg mob uas raug mob ntawm cov leeg tom qab pob txha, kev txhaj tshuaj hauv zos lossis kev tswj hwm ntawm TB 500 nrog rau kev kho lub cev thiab kev cob qhia rov qab tuaj yeem ua kom rov qab muaj zog ntawm cov leeg nqaij thiab ua haujlwm, yog li txo lub sijhawm rov ua haujlwm. Cov kws kho mob kho mob tuaj yeem kho TB 500 cov phiaj xwm kho mob raws li tus neeg mob tus mob tshwj xeeb, suav nrog ntau npaum li cas, zaus, thiab txoj kev tswj hwm, kom ua tiav cov txiaj ntsig kev kho kom zoo.
Daim duab 3: Lub tswv yim ntawm kev siv prenatally active secreted molecules los kho lub cev ua haujlwm hauv cov neeg laus.
Kev kho mob ntawm cov leeg atrophy cuam tshuam nrog cov kab mob neurological
Qee cov kab mob neurological, xws li txha caj qaum raug mob thiab amyotrophic lateral sclerosis (ALS), tuaj yeem ua rau cov leeg nqaij atrophy. TB 500 tuaj yeem siv tshuaj kho mob rau cov leeg nqaij atrophy cuam tshuam nrog cov kab mob hauv lub paj hlwb los ntawm kev txhawb nqa cov leeg hlwb thiab inhibiting leeg hlwb apoptosis. Hauv kev sim tsiaj, rau tus txha caj qaum raug mob-vim cov leeg nqaij atrophy, kev siv TB 500 ua rau muaj kev txhim kho tseem ceeb ntawm cov leeg nqaij atrophy, nrog rau cov leeg nqaij thiab lub zog ib nrab rov qab los.
Xaus
TB 500 tuaj yeem txhawb nqa cov leeg pob txha. Los ntawm cov txheej txheem xws li cell migration thiab regeneration, angiogenesis, thiab kev tiv thaiv kab mob thiab kev tiv thaiv kab mob, nws ua lub luag haujlwm tseem ceeb hauv kev kho cov leeg nqaij, kev qaug zog, thiab kev loj hlob thiab kev loj hlob. Hauv kev ua kis las, nws tuaj yeem pab cov neeg ncaws pob tiv thaiv thiab kho cov leeg nqaij thiab txhim kho kev ua kis las; nyob rau hauv thaj chaw ntawm kev kho mob kho mob, nws tuaj yeem siv rau kev kho mob ntawm cov leeg nqaij thiab kev kho mob ntawm cov leeg nqaij atrophy txuam nrog cov kab mob neurological.
Qhov chaw
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Cov khoom muaj rau kev tshawb fawb siv nkaus xwb:
