Los ntawm Cocer Peptides 
15 hnub dhau los
Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.
Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.
Txheej txheem cej luam ntawm BPC-157
BPC-157 yog ib qho chaw ruaj khov hauv plab hnyuv pentapeptide pib pom rau nws cov khoom tiv thaiv kab mob. Nws tseem nyob ruaj khov nyob rau hauv tib neeg cov kua txiv hmab txiv ntoo rau ntau tshaj 24 teev, ua rau nws ua haujlwm tsis tu ncua ntawm nws cov teebmeem hauv plab hnyuv ib puag ncig thiab tso lub hauv paus rau kev kho lub plab thiab kev puas tsuaj. Nws cov qauv tshuaj
e yog GEPPPGKPADDAGLV, nrog qhov hnyav molecular ntawm 1419. Cov qauv molecular no ua rau nws cuam tshuam nrog ntau yam biomolecules hauv lub cev, yog li ua haujlwm tseem ceeb ntawm lub cev.
Daim duab 1 BPC-157 cuam tshuam rau kev loj hlob thiab lub voj voog ntawm tes ntawm HUVECs.
Kev Kho Cov teebmeem ntawm BPC-157 ntawm kev puas tsuaj rau plab hnyuv
Tiv thaiv lub plab zom mov thiab tswj lub plab zom mov
BPC-157 plays lub luag haujlwm tseem ceeb hauv kev tiv thaiv kab mob plab, tiv thaiv kev phom sij ntawm ntau yam tshuaj ntawm lub plab. Cov tshuaj xws li cawv thiab cov tshuaj uas tsis yog tshuaj steroidal anti-inflammatory (NSAIDs) feem ntau ua rau lub plab zom mov puas tsuaj thiab cuam tshuam rau plab hnyuv. BPC-157 tuaj yeem tiv thaiv lub plab zom mov los ntawm kev puas tsuaj ncaj qha los ntawm cov khoom tsis zoo no los ntawm ntau cov txheej txheem ntawm lub cev. Thaum raug cawv stimulation, BPC-157 tswj cov txheej txheem metabolic nyob rau hauv lub plab zom mov, txhim khu lub hlwb tiv thaiv kab mob antioxidant, thiab txo oxidative puas tsuaj los ntawm cawv metabolites. Rau NSAID-induced gastric mucosal puas tsuaj, BPC-157 cuam tshuam intracellular signaling txoj hauv kev los inhibit qhov kev tso tawm ntawm inflammatory mediators, yog li txo qhov kev puas tsuaj ntawm inflammatory teb nyob rau hauv lub plab mucosa. Qhov no pab tswj kev ncaj ncees ntawm lub plab mucosa thiab ua kom lub cev muaj zog ntawm lub plab.
Daim duab 2 BPC-157 nce qhov txhab reepithelialization thiab collagen cov ntsiab lus ntawm granulation cov ntaub so ntswg.
Stabilizing plab hnyuv permeability
Kev nce ntxiv hauv plab hnyuv permeability yog ib qho tseem ceeb uas ua rau muaj ntau yam kab mob hauv plab. Cov kab mob plab hnyuv, xws li kev ntxhov siab ntawm lub cev lossis kev puas siab puas ntsws, kev siv NSAID, stimulation ntawm cov kua tsib acid surfactant, thiab kev haus dej cawv, tuaj yeem ua rau cov plab hnyuv ntau ntxiv, ua rau cov plab hnyuv plab. BPC-157 tuaj yeem txhim kho txoj hnyuv permeability los ntawm kev tswj cov kab mob sib kis ntawm cov kab mob hauv plab hnyuv, yog li txhim kho kev sib txuas ntawm lub cev. Raws li cov ntaub ntawv, nyob rau hauv cov qauv tsiaj tau nthuav tawm cov kev ntxhov siab uas tau hais tseg, kev siv BPC-157 ua rau muaj kev nthuav qhia ntawm cov proteins nruj nreem ntawm txoj hnyuv epithelial hlwb, nrog cov txheej txheem nruj dua, yog li txo cov plab hnyuv permeability rau cov molecules loj. Qhov no tau zoo txo cov tsos mob ntawm cov plab hnyuv plab, txo qhov kev pheej hmoo ntawm cov khoom tsis zoo nkag mus rau hauv cov hlab ntsha los ntawm cov hnyuv, thiab tswj kev ruaj ntseg ntawm cov hnyuv microenvironment.
Txhawb txoj kev kho mob plab hnyuv
Txawm hais tias nyob rau hauv cov txheej txheem kho mob ntawm ulcers thoob plaws hauv lub plab zom mov los yog sab nraud fistulas (xws li esophageal daim tawv nqaij fistulas, gastric daim tawv nqaij fistulas, duodenal daim tawv nqaij fistulas, thiab colonic daim tawv nqaij fistulas) thiab sab hauv fistulas (xws li colonic zais zis fistulas thiab qhov quav), qhov chaw mos fistulas. BPC-157 qhia txog kev txhawb nqa tseem ceeb. BPC-157 txhawb kev loj hlob thiab tsiv teb tsaws ntawm fibroblasts, accelerates collagen synthesis thiab deposition, yog li muab cov tsim nyog matrix txhawb rau qhov txhab kho. Nws tseem tswj hwm cov lus teb hauv zos, nyiam cov kab mob tiv thaiv kab mob rau lub qhov txhab kom tshem tawm cov kab mob thiab cov ntaub so ntswg necrotic, thiab txhawb nqa angiogenesis, ua kom muaj cov zaub mov txaus thiab cov pa oxygen rau kev kho mob. Hauv kev phais plab hnyuv anastomosis, thaum qhov chaw anastomotic ntsib kev kho mob nyuaj vim muaj yam xws li NSAIDs, cystamine, lossis colectomy, BPC-157 kuj tuaj yeem ua lub luag haujlwm zoo hauv kev txhawb nqa kev kho anastomotic thiab txo cov kev pheej hmoo ntawm cov teeb meem xws li anastomotic fistula.
Kev cuam tshuam rau pancreatic thiab gastrointestinal lesions
Hauv cov qauv nas ntawm tus mob pancreatitis tshwm sim los ntawm cov kab mob sib kis, BPC-157 tau qhia txog kev tiv thaiv ntawm tus txiav txiav txawm tias siv los tiv thaiv lossis kho tus neeg sawv cev. Prophylactic kev tswj hwm ntawm BPC-157 txo qis qhov mob pancreatitis, txo qis pancreatic necrosis, edema, thiab neutrophil infiltration, thaum nce monocyte suav. Hauv kev kho mob ntawm tus mob pancreatitis uas twb tau tshwm sim lawm, cov txiaj ntsig tseem ceeb kuj tau pom, nrog rau kev tswj hwm qib ntawm cov ntshav amylase. BPC-157 kuj muaj kev cuam tshuam zoo rau cov kab mob plab thiab duodenal concurrent, pab tswj kev ncaj ncees ntawm lub plab hnyuv mucosa thiab txo cov kev puas tsuaj rau lub plab thiab duodenum.
Kev Kho Cov teebmeem ntawm BPC-157 ntawm Kev Puas Tsuaj Sib Koom
Kev txhim kho ntawm temporomandibular joint osteoarthritis
Nyob rau hauv cov qauv nas ntawm temporomandibular sib koom ua ke osteoarthritis, kev sib koom ua ke puas tau raug phais, xws li unilateral condylar articular deg puas tsuaj, lateral ligament ntawm articular disc, thiab posterior disc txuas theem incisions, simulate cov txheej txheem pathological ntawm osteoarthritis. Tom qab kev phais, BPC-157 tau siv los ntawm kev txhaj tshuaj intraperitoneal. Ntawm 6-lub hlis tom qab kev soj ntsuam, pawg kho BPC-157 tau nthuav tawm qhov kev nce ntxiv ntawm tag nrho cov pob txha mos thickness piv rau pawg tswj hwm. Tshwj xeeb, qhov no tau tshwm sim raws li qhov tuab ntawm cov pob txha mos thiab thaj chaw sib koom ua ke, txo cov pob txha mos ntawm tes sib sau ua ke, ploj ntawm cov pob txha mos ntsug, thiab kev khaws cia ntawm cov pob txha mos ib txwm muaj. Qhov no qhia tau hais tias BPC-157 tuaj yeem txo cov kev hloov pauv pathological ntawm temporomandibular sib koom tes osteoarthritis thiab txhawb kev kho thiab rov tsim cov pob txha pob txha. Nws cov txheej txheem ntawm kev ua haujlwm yuav cuam tshuam nrog kev cuam tshuam ntawm BPC-157 nrog cov molecules xws li collagen thiab proteoglycans cuam tshuam nrog kev txhim kho pob txha mos. Raws li kev tshawb fawb, ntau yam motifs ntawm BPC-157 yog concentrated nyob rau hauv collagen α-1 (I), collagen α-1 (IX), aggrecan, fibronectin precursor, chondroitin sulfate proteoglycan NG2 precursor, thiab chondroitin oligosaccharide precursor, uas yog ib qho tseem ceeb heev rau kev tswj cov pob txha mos. BPC-157 tuaj yeem txhawb kev kho thiab rov tsim kho cov pob txha mos los ntawm kev tswj cov kev qhia lossis kev ua haujlwm ntawm cov molecules.
Daim duab 3 BPC-157 txhawb kev qhia ntawm VEGF-a hauv cov ntaub so ntswg raug mob.
Kev kho mob ntawm lub hauv caug pob qij txha
Kev mob hauv caug pob qij txha yog ib qho mob tshwm sim los ntawm ntau yam, xws li osteoarthritis, meniscus kua muag, tendon disorders, ligament kua muag, los yog sprains. Ib txoj kev tshawb nrhiav rov qab tau pom 17 tus neeg mob uas mob hauv lub hauv caug, nrog 16 tus neeg mob tau soj ntsuam. Ntawm cov neeg mob no, 12 tau txais kev txhaj tshuaj intra-articular ntawm BPC-157 ib leeg, nrog 11 (91.6%) muaj kev txhim kho tseem ceeb hauv lub hauv caug; 4 tus neeg mob ntxiv tau txais kev txhaj tshuaj sib xyaw ua ke ntawm BPC-157 thiab thymosin-β4, nrog rau 75% ntawm cov neeg mob no tau txais kev mob hnyav. Zuag qhia tag nrho, 87.5% ntawm cov neeg mob tau txais kev kho mob ntawm lub hauv caug tom qab siv BPC-157 los yog nws ua ke nrog thymosin-β4. Qhov no qhia tau hais tias BPC-157 muaj txiaj ntsig zoo hauv kev txo ntau hom mob hauv caug. Kev soj ntsuam ntxiv qhia tias BPC-157 muaj peev xwm kho cov kua muag thiab txhawb kev tsim cov pob txha mos, uas tej zaum yuav yog ib qho laj thawj tseem ceeb rau nws txoj kev ua tau zoo hauv kev kho mob hauv caug. Thaum kho cov txheej txheem ntawm kev sib koom tes, BPC-157 tuaj yeem txhawb kev loj hlob thiab kev sib txawv ntawm chondrocytes, ua kom cov pob txha mos matrix, yog li kho cov pob txha mos. Tsis tas li ntawd, nws kuj tseem tuaj yeem ua rau muaj txiaj ntsig zoo rau cov ligaments puas, leeg, thiab lwm yam ntaub so ntswg, txhim kho kev sib koom ua ke thiab txo qhov mob los ntawm kev sib koom ua ke.
Kho cov leeg-cov leeg pob txha raug mob
Tom qab cov leeg ntawm txoj cai quadriceps cov leeg hauv nas tau muab cais tawm ntawm cov leeg, kev kho mob nrog BPC-157 tau pom tias muaj txiaj ntsig zoo rau kev kho mob. Los ntawm kev ntsuam xyuas macroscopic, pawg tswj tau pom qhov tsis xws luag ntawm quadriceps tendon thiab cov leeg uas txuas ntxiv mus, ua rau tsis zoo. Hauv qhov sib piv, cov nas kho nrog BPC-157 pom kev kho tsis tu ncua, nrog rau qhov tsis xws luag yog qhov me me los ntawm qhov pib, thaum kawg ua rau qhov pib kho dua tshiab ntawm kev sib txuas ntawm cov leeg-cov leeg. Kev tshuaj xyuas microscopic tau qhia tias pawg tswj xyuas pom cov leeg nqaij edema, nruab nrab lymphocytic infiltration, thiab granulation cov ntaub so ntswg tsim los ntawm lub lim tiam thib ob tom qab kev phais, thaum BPC-157 pab pawg kho mob tsuas pom me me lymphocytic infiltration, tsis muaj granulation cov ntaub so ntswg tsim, thiab kho zoo ntawm cov leeg-cov leeg nqaij sib txuas. Kev ntsuam xyuas biomechanical tau pom tias cov leeg lub zog rov qab los tsis zoo hauv pawg tswj hwm, thaum pab pawg kho mob BPC-157 tau ua tiav tiav. Qhov no qhia tau hais tias BPC-157 tsis yog tsuas yog muaj kev kho mob rau cov leeg thiab cov leeg raug mob tab sis kuj qhia txog kev kho thiab kho cov teebmeem ntawm kev puas tsuaj rau cov leeg-cov leeg pob txha, pab txhawb kev rov qab los ntawm kev sib txuas thiab kev ua haujlwm ntawm cov leeg thiab cov leeg thiab ua kom muaj kev sib koom ua ke.
Muaj Peev Xwm thiab Kev Pom Zoo ntawm BPC-157 hauv Kev Siv Tshuaj Kho Mob
Kev kho mob plab kab mob
Muab BPC-157 cov kev tiv thaiv ntawm lub plab zom mov, stabilization ntawm txoj hnyuv permeability, txhawb kev kho mob ntawm plab hnyuv, thiab muaj txiaj ntsig zoo rau cov kab mob pancreatic thiab gastric-duodenal, nws muaj peev xwm tseem ceeb hauv kev kho mob ntawm ntau yam kab mob hauv plab. Hauv kev kho mob plab ulcers thiab duodenal ulcers, BPC-157 tuaj yeem ua kom lub qhov txhab zoo thiab txo qhov kev pheej hmoo ntawm kev rov tshwm sim. Rau cov kab mob inflammatory plob tsis so tswj xws li ulcerative colitis, BPC-157 tuaj yeem txhim kho txoj hnyuv mucosal barrier muaj nuj nqi los ntawm kev tswj cov kab mob hauv plab thiab cov kab mob inflammatory, txo cov tsos mob, thiab txhawb kev tshem tawm kab mob. Tom qab kev phais plab hnyuv, kev siv BPC-157 tuaj yeem pab txhawb kev kho mob anastomotic, txo qhov tshwm sim ntawm cov teeb meem, thiab ua kom tus neeg mob txoj kev rov zoo.
Kev kho cov kab mob sib koom ua ke
Hauv thaj tsam ntawm cov kab mob sib koom ua ke, BPC-157 cov txiaj ntsig rov qab rau ntawm temporomandibular joint osteoarthritis thiab hauv caug raug mob muab kev nkag siab tshiab rau nws cov peev txheej hauv kev kho mob osteoarthritis thiab kev ua kis las. Rau cov neeg mob osteoarthritis, BPC-157 tuaj yeem ua cov tshuaj tiv thaiv kab mob, tsis tsuas yog txo cov tsos mob ntawm tus mob, tab sis kuj ua rau cov pob txha mos degeneration, txhawb kev kho pob txha mos, thiab txhim kho kev sib koom tes. Nyob rau hauv kev kho mob ntawm cov kev ua si raug mob, xws li tendon thiab ligament raug mob nyob rau hauv lub hauv caug thiab pob qij txha pob qij txha feem ntau pom nyob rau hauv cov neeg ncaws pob, BPC-157 tuaj yeem ua kom cov ntaub so ntswg puas, ua kom lub sijhawm rov qab los, thiab txhim kho kev rov qab ceev ntawm cov neeg ncaws pob kev ua kis las.
Xaus
Raws li bioactive peptide nrog ntau txoj haujlwm kho, BPC-157 qhia tau tias muaj kev ua tau zoo hauv kev kho mob plab thiab kev sib koom tes.
Qhov chaw
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Cov khoom muaj rau kev tshawb fawb siv nkaus xwb:
