By Cocer Peptides 
kwanaki 15 da suka gabata
DUKKANIN LABARI DA BAYANIN KYAUTATAWA DA AKE BAYAR A WANNAN SHAFIN KAWAI DOMIN WATSA BAYANI NE DA MANUFOFIN ILIMI.
Kayayyakin da aka bayar akan wannan gidan yanar gizon an yi niyya ne kawai don binciken in vitro. Binciken in vitro (Latin: *a cikin gilashi*, ma'ana a cikin gilashin gilashi) ana gudanar da shi a wajen jikin mutum. Waɗannan samfuran ba magunguna ba ne, Hukumar Abinci da Magunguna ta Amurka (FDA) ba ta amince da su ba, kuma dole ne a yi amfani da su don hanawa, magani, ko warkar da duk wani yanayi na likita, cuta, ko cuta. Doka ta haramta shigar da waɗannan samfuran cikin jikin mutum ko dabba ta kowace hanya.
Bayanan Bayani na BPC-157
BPC-157 wani tsayayyen pentapeptide na ciki ne wanda aka fara gano shi don abubuwan da ke hana ciwon ciki. Yana dawwama a cikin ruwan 'ya'yan ciki na ɗan adam sama da sa'o'i 24, yana ba shi damar ci gaba da yin tasirinsa a cikin yanayin gastrointestinal da aza harsashi don gyara lalacewar gastrointestinal da haɗin gwiwa. Tsarin sinadaransa
e shine GEPPPGKPADDAGLV, tare da nauyin kwayoyin halitta na 1419. Wannan tsarin kwayoyin yana ba shi damar yin hulɗa tare da kwayoyin halitta daban-daban a cikin jiki, don haka yana aiki da muhimman ayyuka na ilimin lissafi.
Hoto na 1 BPC-157 yana rinjayar haɓakawa da kuma rarraba kwayoyin halitta na HUVECs.
Tasirin Gyaran BPC-157 akan Lalacewar Gastrointestinal
Kare Kwayoyin Gastric da Kula da Mutuncin Gastric
BPC-157 yana taka muhimmiyar rawa wajen kare kwayoyin halitta na ciki, ta yadda ya kamata ya kare kariya daga illar magunguna daban-daban akan ciki. Abubuwa irin su barasa da magungunan anti-inflammatory marasa steroidal (NSAIDs) sukan haifar da lalacewa ga ƙwayoyin ciki kuma suna rushe mutuncin ciki. BPC-157 na iya kare ƙwayoyin ciki daga lalacewa kai tsaye ta waɗannan abubuwa masu cutarwa ta hanyar jerin hadaddun hanyoyin ilimin lissafi. Lokacin da aka fallasa shi ga haɓakar barasa, BPC-157 yana daidaita hanyoyin rayuwa a cikin ƙwayoyin ciki, yana haɓaka tsarin garkuwar ƙwayoyin ƙwayoyin cuta, kuma yana rage lalacewar oxidative ta hanyar metabolites na barasa. Don lalacewar ƙwayar ƙwayar cuta ta NSAID, BPC-157 yana tasiri hanyoyin siginar siginar intracellular don hana sakin masu shiga tsakani, ta haka ne ya rage tasirin sakamako mai lalacewa a kan mucosa na ciki. Wannan yana taimakawa kiyaye mutuncin mucosa na ciki da kuma tabbatar da ayyukan al'ada na jiki na ciki.
Hoto 2 BPC-157 ya karu da sake dawowa da rauni da abun ciki na collagen na granulation nama.
Tabbatar da karfin hanji
Rashin haɓakar haɓakar haɓakar hanji wani muhimmin al'amari ne da ke ba da gudummawa ga haɓakar cututtukan hanji da yawa. Abubuwan da ke haifar da hanji, irin su damuwa na jiki ko tunani, amfani da NSAID, motsa jiki na bile acid, da shan barasa, duk na iya haifar da haɓakar ƙwayar hanji na hanji, yana haifar da ciwo na gut. BPC-157 na iya daidaita iyawar hanji ta hanyar daidaita sunadaran haɗin gwiwa tsakanin sel epithelial na hanji, ta haka ne ke haɓaka ƙarfin haɗin kai. Dangane da bayanai, a cikin nau'ikan dabbobin da aka fallasa ga abubuwan damuwa da aka ambata, amfani da BPC-157 ya haifar da haɓaka haɓakar sunadaran haɗin gwiwa tsakanin sel epithelial na hanji, tare da ƙarin tsari mai tsari, don haka rage haɓakar hanji zuwa manyan ƙwayoyin cuta. Wannan ya kawar da bayyanar cututtuka na leaky gut syndrome yadda ya kamata, ya rage haɗarin abubuwa masu cutarwa shiga cikin jini daga hanji, kuma ya kiyaye kwanciyar hankali na microenvironment na hanji.
Inganta raunin ciwon ciki
Ko a cikin tsarin warkarwa na ulcers a ko'ina cikin gastrointestinal fili ko na waje fistulas (irin su esophageal fata fistulas, na ciki fata fistulas, duodenal fata fistulas, da colonic fata fistulas) da kuma ciki fistulas (kamar colonic mafitsara fistulas da rectal farji fistulas) na gastrointestinal fili, BPC-157 ya nuna gagarumin ci gaban gastrointestinal fili. BPC-157 yana haɓaka haɓakawa da ƙaura na fibroblasts, yana haɓaka haɓakar collagen da ƙaddamarwa, ta haka yana ba da tallafin matrix da ake buƙata don warkar da rauni. Har ila yau, yana daidaita martanin kumburi na gida, yana janyo hankalin ƙwayoyin rigakafi zuwa wurin rauni don share ƙwayoyin cuta da ƙwayoyin necrotic, da kuma inganta angiogenesis, tabbatar da isasshen abinci mai gina jiki da iskar oxygen don warkar da raunuka. A cikin tiyata na anastomosis na gastrointestinal, lokacin da shafin anastomotic ya fuskanci matsalolin warkarwa saboda dalilai irin su NSAIDs, cystamine, ko colectomy, BPC-157 kuma zai iya taka muhimmiyar rawa wajen inganta warkarwa na anastomotic da rage haɗarin rikitarwa irin su fistula anastomotic.
Tasiri a kan pancreatic raunuka da gastrointestinal fili
A cikin wani nau'in bera na m pancreatitis wanda aka jawo ta hanyar bile duct ligation, BPC-157 ya nuna tasirin kariya akan pancreas ko ana amfani dashi azaman wakili na rigakafi ko warkewa. Gudanar da prophylactic na BPC-157 ya rage girman girman ƙwayar cuta, raguwar necrosis na pancreatic, edema, da infiltration na neutrophil, yayin da yake ƙara yawan adadin monocyte. A cikin jiyya mai tsanani mai tsanani na pancreatitis wanda ya riga ya faru, an kuma lura da tasiri mai mahimmanci, tare da sarrafa matakan amylase na jini. BPC-157 kuma yana da tasiri mai kyau akan cututtuka na ciki da na duodenal na lokaci guda, yana taimakawa wajen kiyaye mutuncin mucosa na ciki da kuma rage lalacewar ƙwayar cuta ga ciki da duodenum.
Tasirin Gyaran BPC-157 akan Lalacewar Haɗin gwiwa
Inganta haɗin gwiwa na wucin gadi osteoarthritis
A cikin samfurin bera na wucin gadi na haɗin gwiwa osteoarthritis, an haifar da lalacewar haɗin gwiwa ta hanyar tiyata, irin su lalacewa ta hanyar haɗin gwiwa na haɗin gwiwa, ligament na gefe na diski na articular, da ƙananan matakan haɗin diski na baya, don daidaita tsarin pathological na osteoarthritis. Bayan tiyata, an gudanar da BPC-157 ta hanyar allurar intraperitoneal. A cikin kima na watanni 6, ƙungiyar kulawa ta BPC-157 ta nuna karuwa mai yawa a cikin kauri na guringuntsi na haɗin gwiwa idan aka kwatanta da ƙungiyar kulawa. Musamman, wannan ya bayyana a matsayin ƙãra kauri a cikin duka yankin guringuntsi da yankin haɗin gwiwa, rage yawan ƙwayar guringuntsi, bacewar ƙwayar guringuntsi na tsaye, da kuma adana kullun guringuntsi na al'ada. Wannan yana nuna cewa BPC-157 na iya magance sauye-sauyen cututtukan cututtuka na wucin gadi na haɗin gwiwa na osteoarthritis da kuma inganta gyaran gyare-gyare da farfadowa na guringuntsi na articular. Hanyar aikinta na iya kasancewa da alaƙa da hulɗar BPC-157 tare da kwayoyin halitta irin su collagen da proteoglycans da ke hade da ci gaban guringuntsi. Bisa ga bincike, mahara motifs na BPC-157 suna mayar da hankali a cikin collagen α-1 (I), collagen α-1 (IX), aggrecan, fibronectin precursor, chondroitin sulfate proteoglycan NG2 precursor, da chondroitin oligosaccharide precursor, wanda ke da mahimmanci don ci gaba da aiki da tsarin cartilage. BPC-157 na iya inganta gyare-gyare da sake ginawa na guringuntsi na haɗin gwiwa ta hanyar daidaita magana ko aiki na waɗannan kwayoyin.
Hoto 3 BPC-157 ya inganta maganganun VEGF-a a cikin ƙwayoyin fata da suka ji rauni.
Gyara raunin haɗin gwiwa gwiwa
Ciwon gwiwa na haɗin gwiwa wata alama ce ta asibiti ta gama gari da abubuwa daban-daban ke haifar da su, irin su osteoarthritis, hawaye na meniscus, raunin jijiya, hawayen ligament, ko sprains. Wani bincike na baya-bayan nan ya lura da marasa lafiya na 17 tare da ciwon gwiwa na gwiwa, tare da marasa lafiya 16 da ke ci gaba da biyo baya. Daga cikin waɗannan marasa lafiya, 12 sun karbi injections na intra-articular na BPC-157 kadai, tare da 11 (91.6%) suna fuskantar gagarumin ci gaba a cikin ciwon gwiwa; sauran marasa lafiya na 4 sun sami hadadden injections na BPC-157 da thymosin-β4, tare da 75% na waɗannan marasa lafiya suna fama da ciwo mai tsanani. Gabaɗaya, 87.5% na marasa lafiya sun sami jin daɗin jin daɗin gwiwa bayan amfani da BPC-157 ko haɗuwa tare da thymosin-β4. Wannan yana nuna cewa BPC-157 yana da inganci mai kyau don rage nau'in ciwon gwiwa daban-daban. Ƙarin bincike ya nuna cewa BPC-157 yana da damar gyara hawaye da kuma inganta ƙwayar guringuntsi, wanda zai iya zama muhimmiyar dalilin da ya dace don rage ciwon gwiwa. A lokacin aikin gyaran gyare-gyare na haɗin gwiwa na haɗin gwiwa, BPC-157 na iya inganta haɓakawa da bambance-bambancen chondrocytes, ƙara haɓakar matrix na guringuntsi, ta haka ne ya gyara ƙwayar guringuntsi da aka lalata. Bugu da ƙari, yana iya haifar da sakamako mai gyare-gyare akan ligaments da suka lalace, tendons, da sauran kyallen takarda, inganta daidaituwar haɗin gwiwa da kuma rage jin zafi da rashin kwanciyar hankali ya haifar.
Gyaran raunin jijiya da tsoka
Bayan da tsokar tsokar quadriceps na dama a cikin berayen ya rabu da tsoka, jiyya tare da BPC-157 ya nuna tasiri mai mahimmanci na warkewa. Daga ƙididdigar macroscopic, ƙungiyar kulawa ta nuna babban lahani tsakanin jigon quadriceps da tsoka wanda ya ci gaba da ci gaba, wanda ya haifar da rashin lafiya. Sabanin haka, berayen da aka bi da su tare da BPC-157 sun nuna ci gaba da warkaswa, tare da lahani yana da ƙanƙanta sosai daga farko, a ƙarshe yana haifar da ainihin maido da haɗin tsoka da tsoka. Microscopic examination revealed that the control group exhibited tendon edema, moderate lymphocytic infiltration, and granulation tissue formation by the second week post-surgery, whereas the BPC-157 treatment group showed only mild lymphocytic infiltration, no granulation tissue formation, and good restoration of the tendon-muscle connection structure. Ƙididdigar nazarin halittu ya nuna cewa ƙarfin ƙarfin tsoka ya kasance mara kyau a cikin ƙungiyar kulawa, yayin da ƙungiyar kulawa ta BPC-157 ta sami cikakkiyar farfadowa. Wannan yana nuna cewa BPC-157 ba wai kawai yana da tasirin warkewa a kan tsokoki da tendons da suka ji rauni ba amma kuma yana nuna takamaiman gyare-gyare da kuma maganin warkewa akan lalacewar jigon jijiya-tsoka, yana taimakawa wajen dawo da haɗin kai na al'ada da aiki tsakanin tsokoki da tendons da kuma tabbatar da motsi na haɗin gwiwa na al'ada.
Yiwuwa da Haƙƙin BPC-157 a cikin Aikace-aikacen Clinical
Maganin Cututtukan Gastrointestinal
Idan aka ba da tasirin kariya na BPC-157 akan sel na ciki, kwanciyar hankali na hanji, haɓakar warkar da rauni na gastrointestinal, da tasiri mai kyau akan cututtukan pancreatic da na ciki-duodenal raunuka, yana da babban tasiri wajen magance cututtukan gastrointestinal iri-iri. A cikin maganin cututtukan ciki da duodenal ulcers, BPC-157 na iya hanzarta warkar da ciwon ciki da kuma rage haɗarin sake dawowa. Don cututtuka masu kumburi irin su ulcerative colitis, BPC-157 na iya inganta aikin shinge na hanji na hanji ta hanyar daidaita matakan rigakafi na hanji da kumburi, rage alamun bayyanar cututtuka, da inganta maganin cututtuka. Bayan aikin tiyata na gastrointestinal, amfani da BPC-157 na iya taimakawa wajen inganta warkarwa na anastomotic, rage abubuwan da ke faruwa na rikitarwa, da kuma hanzarta tsarin dawo da majiyyaci.
Maganin cututtukan haɗin gwiwa
A fagen cututtuka na haɗin gwiwa, BPC-157's reparative effects on temporomandibular hadin gwiwa osteoarthritis da gwiwa raunin da ya ba da sabon fahimta game da yuwuwar aikace-aikace a cikin maganin osteoarthritis da wasanni raunin da ya faru. Ga marasa lafiya na osteoarthritis, BPC-157 na iya zama magani mai mahimmanci na maganin cututtuka, ba wai kawai rage bayyanar cututtuka ba amma har ma da rage jinkirin lalata guringuntsi, inganta gyaran guringuntsi, da inganta aikin haɗin gwiwa. A cikin maganin raunin wasanni, irin su raunin jijiya da ligament a cikin gwiwa da haɗin gwiwa da aka saba gani a cikin 'yan wasa, BPC-157 na iya hanzarta gyaran gyare-gyaren kyallen takarda, rage lokacin gyarawa, da haɓaka saurin dawowa na wasan motsa jiki na 'yan wasa.
Kammalawa
A matsayin peptide bioactive tare da ayyuka masu yawa na gyare-gyare, BPC-157 yana nuna wasu tasiri a cikin sassan gastrointestinal da haɗin gwiwa na gyaran gyare-gyare.
Sources
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