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Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.
Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadoghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.
Nkọwa nke BPC-157
BPC-157 bụ pentapeptide eriri afọ kwụsiri ike nke achọpụtara na mbụ maka ihe mgbochi ọnya ya. Ọ na-anọgide na-eguzosi ike na ihe ọṅụṅụ gastric mmadụ ruo ihe karịrị awa 24, na-enyere ya aka ịnọgide na-arụ ọrụ ya na gburugburu eriri afọ yana ịtọ ntọala maka ịrụzi eriri afọ na nkwonkwo. Ọdịdị kemịkal ya
e bụ GEPPPGKPADDAGLV, nke nwere ihe dị arọ nke 1419. Usoro ihe omimi a na-enyere ya aka ịmekọrịta ihe dị iche iche biomolecules n'ime ahụ, si otú ahụ na-arụ ọrụ dị mkpa physiological.
Ọgụgụ 1 BPC-157 na-emetụta mgbasawanye na nkesa okirikiri cell nke HUVEC.
Mmetụta Ndozi nke BPC-157 na Mmebi Gastrointestinal
Ichekwa Selụ afọ na Idokwa iguzosi ike n'ezi ihe nke afọ
BPC-157 na-arụ ọrụ dị mkpa n'ichekwa mkpụrụ ndụ gastric, na-echebe nke ọma megide mmetụta ọjọọ nke ọgwụ dị iche iche na afọ. Ihe ndị dị ka mmanya na-egbu egbu na ọgwụ ndị na-adịghị steroidal anti-inflammatory (NSAIDs) na-ebutekarị mmebi nke mkpụrụ ndụ gastric ma na-akpaghasị iguzosi ike n'ezi ihe nke afọ. BPC-157 nwere ike ichebe mkpụrụ ndụ gastric ka ọ ghara imebi ozugbo site na ihe ndị a na-emerụ ahụ site n'usoro usoro ihe omimi dị mgbagwoju anya. Mgbe ekpughere ya na mkpali mmanya na-aba n'anya, BPC-157 na-achịkwa ụzọ metabolic na mkpụrụ ndụ gastric, na-eme ka sistemu nchekwa antioxidant nke mkpụrụ ndụ dịkwuo mma, ma belata mmebi oxidative nke metabolites mmanya na-akpata. Maka mmebi nke eriri afọ nke NSAID, BPC-157 na-emetụta ụzọ mgbaàmà intracellular iji gbochie ntọhapụ nke ndị mgbasa ozi mkpali, si otú a na-ebelata mmetụta mbibi nke nzaghachi mkpali na mucosa gastric. Nke a na-enyere aka ịnọgide na-eguzosi ike n'ezi ihe nke mucosa gastric ma hụ na ọrụ physiological nkịtị nke afọ.
Ọgụgụ 2 BPC-157 mụbara ọnya repithelialization na collagen ọdịnaya nke granulation anụ ahụ.
Nkwụsi ike n'ime eriri afọ permeability
Mmụba na-adịghị mma nke nrịba nke eriri afọ bụ ihe dị mkpa na-enye aka na mmepe nke ọtụtụ ọrịa eriri afọ. Ihe mgbakasị ahụ nke eriri afọ, dị ka nchekasị anụ ahụ ma ọ bụ nke uche, iji NSAID, mkpali bile acid surfactant, na ịṅụ mmanya na-aba n'anya, nwere ike iduga ụbara epithelial intestinal permeability, na-ebute ọrịa leaky gut syndrome. BPC-157 nwere ike ime ka eriri afọ kwụsie ike site na ịhazi protein njikọ siri ike n'etiti sel epithelial intestinal, si otú a na-eme ka ike njikọ intercellular dịkwuo elu. Dị ka data si kwuo, n'ụdị anụmanụ ndị ekpughere n'ihe ndị a kpọtụrụ aha n'elu, ojiji nke BPC-157 mere ka mmụba nke protein njikọ dị n'etiti sel epithelial intestinal, na-enwekwa usoro a haziri nke ọma, si otú ahụ na-ebelata ikike nke eriri afọ na nnukwu ụmụ irighiri ihe. Nke a na-ebelata ihe mgbaàmà nke ọrịa leaky gut syndrome nke ọma, belata ihe ize ndụ nke ihe ndị na-emerụ ahụ na-abanye n'ọbara site na eriri afọ, ma nọgide na-enwe nkwụsi ike nke microenvironment intestinal.
Na-akwalite ọgwụgwọ ọnya eriri afọ
Ma na usoro ọgwụgwọ ọnya n'ime akụkụ eriri afọ ma ọ bụ fistulas dị n'èzí (dị ka fistulas anụ ahụ nke esophageal, fistulas akpụkpọ anụ, duodenal akpụkpọ fistulas, na colonic skin fistulas) na fistulas dị n'ime (dị ka colonic bladder fistulas na rectal vaginal fistulas) nke eriri afọ tract, mmetụta BPC-157 na-egosi ọganihu dị ịrịba ama. BPC-157 na-akwalite mmụba na mbugharị nke fibroblasts, na-eme ka njikọ nke collagen na ntinye aka, si otú a na-enye nkwado matrix dị mkpa maka ọgwụgwọ ọnya. Ọ na-achịkwa nzaghachi mkpali nke mpaghara, na-adọta mkpụrụ ndụ na-adịghị ahụkebe na saịtị ọnya iji kpochapụ pathogens na anụ ahụ necrotic, ma na-akwalite angiogenesis, na-eme ka ihe oriri na-edozi ahụ zuru oke na ikuku oxygen maka ọgwụgwọ ọnya. N'ime ịwa ahụ anastomosis nke eriri afọ, mgbe saịtị anastomotic na-eche nsogbu ọgwụgwọ ihu n'ihi ihe ndị dị ka NSAIDs, cystamine, ma ọ bụ colectomy, BPC-157 nwekwara ike rụọ ọrụ dị mma n'ịkwalite ọgwụgwọ anastomotic na ibelata ihe ize ndụ nke nsogbu dị ka fistula anastomotic.
Mmetụta na ọnya pancreatic na eriri afọ
N'ụdị oke oke nke nnukwu pancreatitis kpatara site na bile duct ligation, BPC-157 gosipụtara mmetụta nchebe na pancreas ma ejiri ya dị ka ihe mgbochi ma ọ bụ ọgwụgwọ. Nlekọta prophylactic nke BPC-157 na-ebelata oke nke pancreatitis, mbelata necrosis pancreatic, edema na neutrophil infiltration, ebe na-abawanye ọnụ ọgụgụ monocyte. N'ịgwọ ọrịa pancreatitis siri ike nke merelarị, a hụkwara mmetụta bara uru dị ukwuu, na-achịkwa ọkwa amylase serum. BPC-157 na-enwekwa mmetụta dị mma na ọnya afọ na duodenal na-ejikọta ọnụ, na-enyere aka ịnọgide na-eguzosi ike n'ezi ihe nke mucosa eriri afọ ma belata mmebi mmebi nke afọ na duodenum.
Mmetụta Mmezi nke BPC-157 na mmebi nkwonkwo
Mmelite nke nkwonkwo osteoarthritis temporomandibular
N'ihe atụ nke oke osteoarthritis temporomandibular nkwonkwo, a na-ebute mmebi nkwonkwo site na ịwa ahụ, dị ka mmebi condylar articular elu nke otu akụkụ, ligament mpụta nke diski articular, na nrịba nke mgbakwụnye diski azụ, iji mee ka usoro pathological nke ọrịa ogbu na nkwonkwo. Mgbe ịwachara ahụ, a na-enye BPC-157 site na ntụtụ intraperitoneal. Na nyocha nyocha nke ọnwa 6, ndị otu BPC-157 na-ahụ maka ọgwụgwọ gosipụtara mmụba dị ukwuu na oke nkwonkwo cartilage n'ozuzu ya ma e jiri ya tụnyere otu njikwa. Kpọmkwem, nke a gosipụtara dị ka ụbara ọkpụrụkpụ na mpaghara cartilage na mpaghara nkwonkwo, mbelata mkpokọta mkpụrụ ndụ cartilage, mwepu nke mgbawa nke cartilage kwụ ọtọ, na ichekwa n'ịkwadebe cartilage nkịtị. Nke a na-enye echiche na BPC-157 nwere ike belata ngbanwe nke ọrịa ogbu na nkwonkwo nke oge na-adịghị anya ma kwalite nrụzi na mmeghari nke cartilage articular. Usoro ya nwere ike jikọta na mmekọrịta nke BPC-157 na ụmụ irighiri ihe dị ka collagen na proteoglycans jikọtara ya na mmepe nke cartilage articular. Dị ka nchọpụta si kwuo, ọtụtụ motifs nke BPC-157 na-etinye uche na collagen α-1 (I), collagen α-1 (IX), aggrecan, fibronectin precursor, chondroitin sulfate proteoglycan NG2 precursor, na chondroitin oligosaccharide precursor, nke dị oké mkpa maka ịnọgide na-arụ ọrụ na cartilage. BPC-157 nwere ike ịkwalite nrụzi na nwughari nke cartilage nkwonkwo site na ịhazi okwu ma ọ bụ ọrụ nke ụmụ irighiri ihe ndị a.
Ọgụgụ 3 BPC-157 kwalitere ngosipụta nke VEGF-a na anụ ahụ merụrụ ahụ.
Ndozi mmerụ nkwonkwo ikpere
Mgbu nkwonkwo ikpere bụ ihe mgbaàmà na-ahụkarị nke ụlọ ọgwụ na-akpata site na ihe dị iche iche, dị ka ọrịa ogbu na nkwonkwo, anya mmiri meniscus, nsogbu akwara, anya mmiri ligament, ma ọ bụ sprains. Nnyocha a na-atụgharị anya na-ahụ ndị ọrịa 17 na-enwe mgbu nkwonkwo ikpere, na ndị ọrịa 16 na-aga n'ihu. N'ime ndị ọrịa a, 12 natara intra-articular injections nke BPC-157 naanị, na 11 (91.6%) na-enwe ọganihu dị ukwuu na mgbu ikpere; Ndị ọrịa 4 fọdụrụnụ natara ngwakọta nke BPC-157 na thymosin-β4, yana 75% nke ndị ọrịa a na-enweta enyemaka mgbu dị ukwuu. N'ozuzu, 87.5% nke ndị ọrịa nwetara enyemaka nke mgbu ikpere mgbe ha jiri BPC-157 ma ọ bụ ngwakọta ya na thymosin-β4. Nke a na-egosi na BPC-157 nwere ezigbo nrụpụta n'ibelata ụdị mgbu ikpere dị iche iche. Nnyocha ndị ọzọ na-egosi na BPC-157 nwere ikike imezi anya mmiri na ịkwalite ọgbọ cartilage, nke nwere ike ịbụ ihe dị mkpa maka ịdị irè ya n'ibelata mgbu ikpere. N'oge usoro nrụzi nke mmerụ ahụ, BPC-157 nwere ike ịkwalite mmụba na ọdịiche nke chondrocytes, mee ka njikọ nke cartilage matrix dịkwuo elu, si otú ahụ na-edozi anụ ahụ nke cartilage mebiri emebi. Tụkwasị na nke ahụ, ọ nwekwara ike ịkpata mmetụta na-emezigharị na ligaments mebiri emebi, akwara, na anụ ahụ ndị ọzọ, na-eme ka nkwụsi ike nkwonkwo dịkwuo mma ma na-ebelata ihe mgbu nke nkwonkwo nkwonkwo kpatara.
Ndozi mmerụ ahụ nkwonkwo akwara na akwara
Mgbe akwara nke akwara quadriceps ziri ezi na oke kewapụrụ na akwara ahụ, ọgwụgwọ na BPC-157 gosipụtara mmetụta ọgwụgwọ dị ịrịba ama. Site na nyocha nke macroscopic, ndị na-ahụ maka njikwa gosipụtara nnukwu ntụpọ n'etiti akwara quadriceps na ahụ ike nke nọgidere na-aga n'ihu, na-akpata ọgwụgwọ na-adịghị mma. N'ụzọ dị iche, oke a na-emeso ya na BPC-157 gosipụtara ọgwụgwọ na-aga n'ihu, na ntụpọ ahụ dị ntakịrị ntakịrị site na mmalite, n'ikpeazụ na-eduga na isi mweghachi nke njikọ akwara na akwara. Nnyocha nke microscopic gosiri na ndị na-ahụ maka njikwa ahụ gosipụtara edema akwara, ntinye lymphocytic na-agafeghị oke, na nhazi anụ ahụ site na izu nke abụọ ka a gachara ịwa ahụ, ebe otu ọgwụgwọ BPC-157 gosipụtara nanị ntinye lymphocytic dị nro, ọ dịghị nhazi anụ ahụ granulation, na ezigbo mweghachi nke njikọ njikọ akwara na akwara. Nyocha biomechanical gosipụtara na mgbake ike ahụ adịghị mma na otu njikwa, ebe otu ọgwụgwọ BPC-157 nwetara mgbake zuru oke. Nke a na-egosi na BPC-157 ọ bụghị nanị na ọ nwere mmetụta ọgwụgwọ na akwara na akwara ndị merụrụ ahụ kamakwa ọ na-egosipụtakwa mmetụ na ọgwụgwọ kpọmkwem na mmebi nke nkwonkwo akwara-muscle, na-enyere aka na mweghachi nke njikọ nkịtị na ọrụ n'etiti akwara na akwara na ịhụ na nkwonkwo nkịtị.
Enwere ike na atụmanya nke BPC-157 na ngwa ụlọ ọgwụ
Ọgwụgwọ Ọrịa Gastrointestinal
Nyere mmetụta nchebe nke BPC-157 na mkpụrụ ndụ gastric, nkwụsi ike nke intestinal permeability, nkwalite ọgwụgwọ ọnya afọ, na mmetụta dị mma na ọnya pancreatic na gastric-duodenal ọnya, ọ nwere ikike dị ukwuu n'ịgwọ ọrịa dị iche iche nke eriri afọ. N'ịgwọ ọnya afọ na ọnya duodenal, BPC-157 nwere ike mee ka ọgwụgwọ ọnyá dịkwuo ngwa ngwa ma belata ihe ize ndụ nke nlọghachi. Maka ọrịa eriri afọ na-egbuke egbuke dị ka ulcerative colitis, BPC-157 nwere ike imeziwanye ọrụ mgbochi eriri afọ nke eriri afọ site n'ịhazi ihe mgbochi nke eriri afọ na nzaghachi mkpali, belata mgbaàmà, ma kwalite nkwụsị ọrịa. Na-esochi ịwa ahụ eriri afọ, iji BPC-157 nwere ike inye aka kwalite ọgwụgwọ anastomotic, belata nsogbu nke nsogbu, ma mee ka usoro mgbake onye ọrịa dịkwuo ngwa.
Ọgwụgwọ ọrịa nkwonkwo
N'ihe gbasara ọrịa nkwonkwo, BPC-157's reparative effects on temporomandibular joint osteoarthritis na ikpere mmerụ na-enye nghọta ọhụrụ na ngwa ya nwere ike na ọgwụgwọ ọrịa ogbu na nkwonkwo na egwuregwu. Maka ndị ọrịa ogbu na nkwonkwo, BPC-157 nwere ike ịbụ ọgwụ nwere ike imezi ọrịa, ọ bụghị nanị na-ebelata mgbaàmà mgbu kamakwa na-ebelata mmebi nke cartilage, na-akwalite mmezi nke cartilage, na imeziwanye ọrụ nkwonkwo. N'ịgwọ mmerụ ahụ nke egwuregwu, dị ka ọkpụkpụ aka na nkwonkwo ụkwụ na ikpere na nkwonkwo ụkwụ a na-ahụkarị na ndị na-eme egwuregwu, BPC-157 nwere ike mee ka nrụzi nke anụ ahụ mebiri emebi, belata oge nhazigharị, ma welie ọsọ ọsọ mgbake nke egwuregwu ndị na-eme egwuregwu.
Mmechi
Dị ka peptide bioactive nwere ọtụtụ ọrụ nrụzi, BPC-157 na-egosiputa arụmọrụ ụfọdụ na mpaghara nke nrụzi eriri afọ na nkwonkwo.
Isi mmalite
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[3] Sikiric P, Hahm KB, Blagaic AB, et al. Stable Gastric Pentadecapeptide BPC 157, Robert's Stomach Cytoprotection/Adaptive Cytoprotection/Organoprotection, na Selye's Stress Coping Response: Ọganihu, Mmezu, na Ọdịnihu [J]. Gut na imeju, 2020,14 (2):153-167.DOI:10.5009/gnl18490.
[4] Huang T, Zhang K, Sun L, et al. Ngwakọta nchekwa ahụ-157 na-eme ka ọgwụgwọ ọnya alkali na-ere ọkụ na vivo ma na-akwalite mmụba, ọpụpụ, na angiogenesis na vitro [J]. Drug Des Devel Ther, 2015,9:2485-2499.DOI:10.2147/DDDT.S82030.
[5] Kokic N, Sikiric P, Seiwerth S, et al. Pentadecapeptide BPC-157 na oke temporomandibular nkwonkwo osteoarthrosis[M]. 2001.https://www.researchgate.net/publication/266736896_Pentadecapeptide_BPC-157_and_rat_temporomandibular_joint_osteoarthrosis.
[6] Sikirić P, Seiwerth S, Grabarević Z, et al. Mmetụta salutary na prophylactic nke pentadecapeptide BPC 157 na nnukwu pancreatitis na ọnya gastroduodenal concomitant na oke[J]. Ọrịa Digestive na Sayensị, 1996,41 (7): 1518-1526.DOI: 10.1007/BF02088582.
Ngwaahịa dị maka naanị nyocha:
