Na Cocer Peptides rayt 
am 15 dez bifo
ƆL DI ATIKUL ƐN PRODƆKT INFƆMƐSHƆN WE DƐN GI NA DIS WƐBSAYT NA FƆ ƆL FƆ DI INFƆMƐSHƆN ƐN FƆ EDYUKESHƆN.
Di prɔdak dɛn we dɛn gi na dis wɛbsayt na fɔ in vitro risach nɔmɔ. in vitro risach (Latin: *in glas*, we min insay glas) dεn de du am ausayd mכtalman bכdi. Dɛn prɔdak ya nɔto mɛrɛsin, dɛn nɔ gɛt di aprɔval frɔm di US Food and Drug Administration (FDA), ɛn dɛn nɔ fɔ yuz dɛn fɔ protɛkt, trit, ɔ mɛn ɛni mɛrɛsin, sik, ɔ sik. Di lɔ nɔ gri fɔ mek dɛn put dɛn tin ya insay mɔtalman ɔ animal bɔdi ɛni we.
Ovaviu fɔ BPC-157
BPC-157 na stebul gεstrointestinal pεntapεptida we dεn bin fכs fכs fכ in anti-ulsa prכpati dεm. i de stebul insay mכtalman gεstrik jus fכ pas 24 awa, we de mek i kכntinyu fכ du in ifekt dεm na di gεstrointestinal envayroment εn lay di fawndeshכn fכ ripεr di gεstrointestinal εn joyn dεm we dεn dכn pwεl. I kemikal strɔkchɔ
e na GEPPPGKPADDAGLV, wit mכlikul wet we na 1419. dis mכlikul strכkchכ de mek i ebul fכ intarakt wit difrεn bayomכlikul dεm na di bכdi, we de mek i de du imכtant fisiolכjik fכnshכn dεm.
Figure 1 BPC-157 infכlכw di proliferashכn εn sεl saykl distribushכn fכ HUVEC dεm.
Di Ripair Efεkt dεm we BPC-157 gεt pan Gastrointestinal Damej
Protekt di Gastrik Sεl dεm εn fכ Mek di Gεstrik Integriti
BPC-157 de ple imכtant rol fכ protεkt di gastric sεl dεm, fכ difεnd fayn fayn wan frכm di bad bad tin dεm we difrεn dכg dεm de gi pan di bεlε. bכku tεm sכbstans dεm lεk alkol εn nכnstεroyd anti-inflammatory drugs (NSAID) kin mek di gεstrik sεl dεm pwεl εn i kin ambɔg di gεstrik integriti. BPC-157 kin protεkt di gεstrik sεl dεm frכm dayrekt damej bay dεn harmful sכbstans dεm tru wan siriכs kכmpleks fysiolojikal mεkanism dεm. we dεn εkspos to alkכhol stimulashכn, BPC-157 de rεgεl di mεtabolik path dεm na di gεstrik sεl dεm, i de εnhans di sεl dεm in antioksidant difεns sistεm, εn i de ridyus כksidεtiv dεmεj we alkol mεtabolit dεm de kכz. fכ NSAID-indyus gastric mכkus dεmεj, BPC-157 de infכlכw intasεlulyar signal path dεm fכ inhεbit di rilis fכ inflammatory mεdiate dεm, we de mitigate di dεstruktiv ifekt dεm fכ inflammatory rispכns pan di gastric mכkus. dis de εp fכ mεnten di integriti fכ di gεstrik mכkus εn mek sכh se di bכdi de du nכmal fysiolojikal fכnshכn dεm.
Figure 2 BPC-157 inkrεs wund reepithelialization εn kolagen kכntεnt fכ granulεshכn tisu.
Stabiliz di intestinal permeabiliti
di abnכmal inkrεs pan di intestinal permeability na imכtant tin we de kכntribyut to di divεlכpmεnt fכ plεnti intestinal sik dεm. di tin dεm we de mek di gεstכ intestinal iritashכn, lεk fכ strεs na di bכdi כ di maynd, yus fכ NSAID, di bayl asid sכfaynt stimulashכn, εn di alcohol intake, כl kin mek di intestinal εpitεlial pεrmiabiliti bכku, we kin mek i gεt lik gut sεndrכm. BPC-157 kin stεbyul intestinal pεrmiabiliti bay we i de rεgεl tayt jכnkshכn protin dεm bitwin intestinal εpitεlial sεl dεm, we de εnhans intasεlyul kכnekshכn trεnk. akɔdin to di data, insay animal mכdel dεm we dεn εkspכz to di strεs fכktכ dεm we wi bin dכn tכk bכt, di yus fכ BPC-157 rεsult in inkrεs εksprεshכn fכ tayt jכnkshכn protin dεm bitwin intestinal εpitεlial sεl dεm, wit mכr tayt arenj strכkchכ dεm, we de ridyus intestinal pεrmiabiliti to big mכlikul dεm. dis bin ebul fכ lεv di simptom dεm fכ lik gכt sεndrכm fayn fayn wan, i bin ridyus di risk fכ bad bad tin dεm we de kכmכt na di bכdi frכm di intestכn dεm, εn i bin mεnten di stεbiliti fכ di intestinal maykro envayroment.
Fɔ mek di wund dɛn we de na di bɛlɛ go wɛl
if na di hiling prכsεs fכ di כlsa dεm we de כlsay na di gεstrointestinal trakt כ di εksternal fistulas (lεk di εsophageal skin fistulas, gastric skin fistulas, duodenal skin fistulas, εn di colonic skin fistulas) εn di intanεt fistulas (lεk di colonic bladder fistulas εn rεktal vaginal fistulas) na di gastrointestinal trakt, BPC-157 de sho signifyant prɔmoshɔnal ifɛkt dɛn. BPC-157 de promuot di proliferashכn εn maygrεshכn fכ di fibroblast dεm, i de aksεlεrayt kolagen sεntesis εn diposishכn, we de gi di matris sכpכt we nid fכ di wund hεl. i de rεgεl bak di lokal inflammatory rispכns dεm, i de atrak di imyun sεl dεm to di wund sayt fכ klia di pathogens εn nεkrכtik tisu, εn i de promuot angiogenesis, we de mek sכh se i gεt di rayt nyutriεnt εn כksijεn saplai fכ di wund hεl. insay di gεstrointestinal anastomosis כpεrayshכn, we di anastomotic sayt de fεs fכ hεl difikulti biכs fכ tin dεm lεk NSAID, cystamine, כ colectomy, BPC-157 kin ple fayn rol bak fכ promuot anastomotic hiling εn ridyus di risk fכ komplikεshכn lεk anastomotic fistula.
Efεkt pan pankrεas εn gεstrointestinal lεsin dεm
insay wan rat mכdel fכ akyu pankrεas we dεn indyuz bay bayl dakt ligεshכn, BPC-157 sho protεktiv ifekt dεm pan di pankrεas if dεn yuz am as prεvεntiv כ tεrapi ejen. di prכfylaktik administreshכn fכ BPC-157 sכmtεm ridyus di siriכs pankrεas, dεkrεs pankrεas nεkrכsis, εdima, εn nyutrofil infiltεshכn, we i de inkrεs di monosayt kכnt. insay di tritmεnt fכ siriכs akyu pankrεas we dεn כlrεdi apin, dεn bin si sכm bεnεfit ifekt dεm bak, wit di sεrum amylase lεvεl dεm we dεn kכntrol. BPC-157 gεt fayn impak bak pan di kכnkurεnt gastric εn duodenal lεsin dεm, we de εp fכ mεnten di integriti fכ di gεstrointestinal mכkus εn ridyus inflammatory damej to di bεlε εn duodenum.
Di Ripair Efεkt dεm we BPC-157 Gεt pan Jכyn Damej
Improvεmεnt כf temporomandibular jכyn כstio-arthritis
insay wan rat mכdel fכ temporomandibular jכint כstioarthritis, dεn bin indyuz di joyn dεmεj sכjεkshכn, lεk yunilateral kכndil artikulכr sεf dεmεj, lateral kolataral ligament fכ di artikulכr disk, εn posita disk atachmεnt lεvεl insishכn dεm, fכ simul di patכlayz prכsεs fכ כstioarthritis. Fכlכw di כpεrayshכn, BPC-157 bin administret via intrapεritoneal injεkshכn. Na di 6-mכnt fכlכ-ap asesmεnt, di BPC-157 tritmεnt grup sho sכm inkrεs pan כvala jכint kכtilaj tiknεs kכmpεr to di kכntrol grup. sכm spεshal, dis de sho as inkrεs tik na כl tu di kכtilaj zon εn jכyn zon, ridyus di kכtilaj sεl agregεshכn, disappearance fכ vεtikal kכtilaj fכs dεm, εn prεzεvεshכn fכ nכmal kכtilaj layεr. dis sho se BPC-157 kin ifektivli εliviet di patכlayz chenj dεm fכ di tεmporomandibular jכint כstioarthritis εn protεkt di ripa εn rigεnεreshכn fכ di artikulכr kכtilaj. di mεkanism fכ akshכn we i de du kin riliyt to di intarakshכn we BPC-157 de du wit mכlikul dεm lεk kolagen εn proteoglycan dεm we de sho se di artikulכr kכtilaj divεlכpmεnt. akɔdin to risach, mכltipכl mכtif dεm fכ BPC-157 de kכnsantreyt insay kolagen α-1 (I), kolagen α-1 (IX), aggrecan, fibronectin prεkursכr, chondroitin sulfate proteoglycan NG2 prεkursכr, εn chondroitin oligosaccharide prεkursכr, we implεnt fכ mεnten di strכkchכ εn fכnshכn fכ di joyn kכtilaj. BPC-157 kin promuot di ripa εn rεkכnstrכkshכn fכ di joyn kכtilaj bay we i de rεgεl di εksprεshכn כ aktvכti fכ dεn mכlikul dεm ya.
Figure 3 BPC-157 promuot di εksprεshכn fכ VEGF-a in wund skin tisu dεm.
Ripair fɔ di injury dɛn na di knee joint
Di pen na di knee joint na wan kɔmɔn klinik simptom we kin kam wit difrɛn tin dɛm, lɛk ɔstiɔ-arayt, mɛniskus, tɛndon dizayd, ligament tear, ɔ sprain. Wan retrospektiv stεdi bin si 17 pasεnshכn dεm wit knee joyn pen, wit 16 pasεnshכn dεm we dεn bin du fכlכ-ap. Na dɛn pasɛnt ya, 12 bin gɛt intra-atikul injɛkshɔn fɔ BPC-157 nɔmɔ, wit 11 (91.6%) we bin gɛt signifyant impɔtant improvement pan ni pen; di ɔda 4 pasɛnt dɛn bin gɛt kɔmbayn injɛkshɔn fɔ BPC-157 ɛn thymosin-β4, wit 75% pan dɛn pasɛnt ya we bin gɛt bɔku pen rilif. Ɔl togɛda, 87.5% pan di pasɛnt dɛn bin gɛt rilif pan di pen na dɛn ni afta dɛn yuz BPC-157 ɔ in kɔmbaynshɔn wit taymosin-β4. Dis sho se BPC-157 gɛt gud ɛfifikɛshɔn fɔ stɔp difrɛn kayn pen na di ni. fכda analisis sho se BPC-157 gεt di pכtεnshal fכ ripa di kray wata εn fכ protεkt di kכtilaj jεnereshכn, we kin bi imכtant rizin fכ in efficacy fכ εliviet di kכn pen. di tεm we di jכyn injuri dεm de ripa, BPC-157 kin protεkt di proliferashכn εn difrεns fכ di kכndrכsayt dεm, inkrεs di sεntesis fכ di kכtilaj matris, we de mek i ripεr di kכtilaj tisu dεm we dεn dכn pwεl. apat frכm dat, i kin mek bak di ligament dεm, di tεndon dεm, εn כda tisu dεm we dεn dכn pwεl, we de mek di joyn dεm stεbul εn i kin mek di pen we di joyn dεm nכ de stεbul.
Ripair of di tεndon-mכsul jכnkshכn injuri dεm
afta di tεndon fכ di rayt kwadrisεps mכsul insay rat dεn separet frכm di mכsul, tritmεnt wit BPC-157 sho sכm sכm tεrapi ifekt dεm. frכm wan makroskopik asesmεnt, di kכntrol grup sho big difεkt bitwin di kwadriseps tεndon εn mכsul we kכntinyu fכ go bifo, we rεsult in fεil hiling. difrεnt frכm dat, di rat dεm we dεn trit wit BPC-157 sho se dεn de kכntinyu fכ hεl, wit di dεfεkt we bin sכm sכm sכm frכm di biginin, we kin lid to di bεsik rεstכreshכn fכ di tεndon-mכsul kכnεkshכn. maykroskopik egzamin sho se di kכntrol grup sho tεndon εdima, mכdarεt limfosaytik infiltεshכn, εn granulεshכn tisu fכmeshכn bay di sεkכn wik afta di כpεrayshכn, we di BPC-157 tritmεnt grup sho כnli mild limfosaytik infiltεshכn, nכ granulεshכn tisu fכmeshכn, εn gud ristכreshכn fכ di tεndon-mכsul kכnekshכn strכkchכ. Bayomɛkanikal asɛsmɛnt sho se di mɔsul trɛnk rikavari nɔ bin fayn na di kɔntrol grup, we di BPC-157 tritmɛnt grup bin ajɔst kɔmplit rikavari. dis sho se BPC-157 nכ nכ gεt tεrapi ifekt pan di mכsul dεm εn tεndon dεm we injuri bכt i de sho spεsifi k rεparativ εn tεrapi ifekt dεm pan di damej to di tεndon-mכsul jכnkshכn, we de εp fכ rεstכr nכmal kכnεkshכn εn fכnshכn bitwin mכsul dεm εn tεndon dεm εn mek sכh se di jכint de muv nכmal.
Potensial ɛn Prɔspɛkt fɔ BPC-157 insay Klinik Aplikeshɔn dɛn
Tritmɛnt fɔ di Gastrointestinal Diziz dɛm
giv BPC-157 in protεktiv ifekt dεm pan gastric sεl dεm, stεbyulεshכn fכ intestinal pεrmiabiliti, prכmoshכn fכ gεstrointestinal wund hεl, εn pכsitiv inflכεns pan pankrεas εn gastric-duodenal lεshכn dεm, i hכld sכm pכtεnshal fכ trit difrεn gεstrointestinal sik dεm. insay di tritmεnt fכ gastric כlsa εn duodenal כlsa, BPC-157 kin aksεleret כlsa hεl εn rεdכks di risk fכ rikarεshכn. fכ inflammatory bowel diseases lεk ulcerative colitis, BPC-157 kin impruv intestinal mכkus barεri fכnshכn bay we i de rεgεl intestinal imyun εn inflammatory rεspכns, εliviet di simptom dεm, εn protεkt di sik rεmishכn. fכlכ di gεstrointestinal כpεrayshכn, di yus כf BPC-157 kin εp fכ protεkt anastomotic hiling, ridyus di insidεns fכ komplikεshכn dεm, εn aksεlεrayt di sikman in rεkכvεshכn prכsεs.
Tritmɛnt fɔ di sik dɛn we de na di jɔyn
Insay di fild fɔ jɔyn sik dɛm, di riparaytiv ifɛkt dɛm we BPC-157 gɛt pan temporomandibular jɔyn ɔstiɔ-arayt ɛn ni injuri de gi nyu insayt fɔ in pɔtɛnɛshɛl aplikeshɔn fɔ trit ɔstiɔ-arayt ɛn spɔt injuri. Fɔ di wan dɛn we gɛt ɔstiɔ-arayt, BPC-157 kin bi wan mɛrɛsin we kin chenj di sik, nɔto jɔs fɔ mek dɛn nɔ gɛt pen bɔt i kin mek di katilej nɔ pwɛl, i kin mek di katilej dɛn ripɛnt, ɛn i kin mek di jɔyn dɛn wok fayn. We dɛn de trit spɔt injuri, lɛk di tɛndon ɛn ligamɛnt injuri na di ni ɛn anklɛ jɔyn dɛn we dɛn kin si pan atlet dɛn, BPC-157 kin mek di tisu dɛn we dɔn pwɛl kwik kwik wan, i kin mek di tɛm we dɛn de rihabiliteshɔn shɔt, ɛn i kin mek di atlet dɛn atlet wok kwik kwik wan fɔ mek dɛn wɛl.
Dɔn
as bayoaktiv pεptida wit mכltipכl ripa fכnshכn dεm, BPC-157 de sho sכm efikכs insay di fil dεm fכ gεstrointestinal εn jכyn injuri ripa.
Sos dɛn we dɛn pul
[1] Lee E, Padgett B J. Intra-Artikulכr Injεkshכn כf BPC 157 fכ mכltipכl Tayp dεm fכ Kni Pen.[J]. Ɔltɛrnativ Tɛrapi dɛn na Ɛlth ɛn Mɛdisin, 2021,27 4:8-13.DOI:https://api.semanticscholar.org/CorpusID:236516759.
[2] Sikiric P, Drmic D, S ɛ v ɛ r M, ɛn ɔda pipul dɛn. Fistulas we de mɛn pipul dɛn. Stebul Gastrik Pεntadekapεptida BPC 157 Tεrapi[J]. Kɔrɛnt Famasiutik Dizayn, 2020,26(25):2991-3000.DOI:10.2174/ 13816128266 66200424180139.
[3] Sikiric P, Hahm KB, Blagaic A. B., ɛn ɔda pipul dɛn. Stebul Gastrik Pεntadekapεptida BPC 157, Rכbכt in Bεlε Saytoprotεkshכn/Adaptiv Saytoprotεkshכn/Organoprotεkshכn, εn Selye in Strεs Kכping Rispכns: Prכgrεs, Achievement dεm, εn di Fכs[J]. Gut ɛn Liva, 2020,14(2):153-167.DOI:10.5009/gnl18490.
[4] Huang T, Zhang K, Sun L, ɛn ɔda pipul dɛn. di bכdi protεktiv kכmpawnd-157 de εnhans alkali-bכn wund hεlin in vivo εn i de protεkt proliferashכn, maygrεshכn, εn angiojεnεsis in vitro[J]. Drug Des Divɛl Tɛr, 2015, 9: 2485-2499.DOI: 10.2147/DDDT.S82030.
[5] Kokic N, Sikiric P, Seiwerth S, ɛn ɔda pipul dɛn. Pεntadekapεptida BPC-157 εn rat tεmporomandibular jכint כstioarthrosis[M]. 2001.https://www.researchgate.net/publication/266736896_Pɛntadɛkapɛptida_BPC-157_ɛn_rat_temporomandibular_jɔyn_ɔstiɔ-arthrosis.
[6] Sikirić P, Seiwerth S, Grabarević Z, ɛn ɔda pipul dɛn. Salutary εn prכfylaktik ifekt כf pεntadekapεptida BPC 157 pan akyu pankrεaytis εn kכnkomitεnt gastroduodenal lεshכn dεm na rat[J]. Dijestiv Diziz ɛn Sayns, 1996,41(7):1518-1526.DOI:10.1007/BF02088582.
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