Bya Cocer Peptides 
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EBINTU BYONNNA N’AMAWULIRE GW’EBINTU EBIweereddwa KU MUTINDO GUNO BIKOZESEBWA KU KUSASANYA AMAWULIRE N’EBIKOLWA BY’OKUSOMESA.
Ebintu ebiweereddwa ku mukutu guno bigendereddwamu kunoonyereza mu kisenge (in vitro research) byokka. Okunoonyereza mu vitro (Olulattini: *mu ndabirwamu*, ekitegeeza mu bikozesebwa mu ndabirwamu) kukolebwa ebweru w’omubiri gw’omuntu. Ebintu bino si bya ddagala, tebikkiriziddwa kitongole kya Amerika ekivunaanyizibwa ku by’emmere n’eddagala (FDA), era tebirina kukozesebwa kuziyiza, kujjanjaba oba kuwonya mbeera yonna ya bujjanjabi, bulwadde oba bulwadde. Kikugirwa nnyo mu mateeka okuyingiza ebintu bino mu mubiri gw’omuntu oba ebisolo mu ngeri yonna.
Okulambika kwa BPC-157
BPC-157 ye pentapeptide enywevu mu lubuto eyasooka okuzuulibwa olw’obusobozi bwayo obw’okulwanyisa amabwa. Kisigala nga kinywevu mu mubisi gw’omu lubuto lw’omuntu okumala essaawa ezisukka mu 24, ne kigisobozesa okukola ebikolwa byayo obutasalako mu mbeera y’olubuto n’okussaawo omusingi gw’okuddaabiriza okwonooneka kw’olubuto n’ennyondo. Ensengekera yaayo ey’eddagala
e ye GEPPPGKPADDAGLV, ng’erina obuzito bwa molekyu 1419. Ensengekera ya molekyu eno egisobozesa okukwatagana ne molekyu ez’enjawulo mu mubiri, bwe kityo n’ekola emirimu emikulu egy’omubiri.
Ekifaananyi 1 BPC-157 ekwata ku kweyongera n’okusaasaana kw’enzirukanya y’obutoffaali bwa HUVECs.
Ebikolwa by’okuddaabiriza BPC-157 ku kwonooneka kw’olubuto n’ekyenda
Okukuuma Obutoffaali bw’omu lubuto n’okukuuma obulungi bw’olubuto
BPC-157 ekola kinene mu kukuuma obutoffaali bw’olubuto, okukuuma obulungi obulabe bw’eddagala ery’enjawulo ku lubuto. Ebintu ng’omwenge n’eddagala eriziyiza okuzimba eritali lya steroid (NSAIDs) bitera okwonoona obutoffaali bw’olubuto n’okutaataaganya obulungi bw’olubuto. BPC-157 esobola okukuuma obutoffaali bw’omu lubuto obutayonoonebwa butereevu ebintu bino eby’obulabe okuyita mu nkola ezitali zimu ez’omubiri. Bw’ekwatibwa okusikirizibwa kw’omwenge, BPC-157 etereeza amakubo g’enkyukakyuka mu butoffaali bw’olubuto, enyweza enkola y’obutoffaali ey’okwekuuma obutafaali obuziyiza obuwuka obuleeta obulwadde, era ekendeeza ku kwonooneka kw’okwokya okuleetebwa ebirungo ebikyusa omwenge. Ku lw’okwonooneka kw’omubiri gw’olubuto okuleetebwa NSAID, BPC-157 ekwata ku makubo g’obubonero mu butoffaali okuziyiza okufulumya abatabaganya okuzimba, bwe kityo ne kikendeeza ku bikolwa eby’okuzikiriza eby’okuddamu kw’okuzimba ku musulo gw’olubuto. Kino kiyamba okukuuma obulungi bw’omubiri gw’olubuto n’okukakasa emirimu gy’omubiri egya bulijjo egy’olubuto.
Ekifaananyi 2 BPC-157 yeeyongera mu biwundu reepithelialization n’ebirimu kolagini mu bitundu by’omubiri ebikola granulation.
Okutebenkeza obutambuzi bw’ekyenda
Okweyongera mu ngeri etaali ya bulijjo mu kuyita mu byenda nsonga nkulu eyamba okukula kw’endwadde nnyingi ez’ekyenda. Ebinyiiza mu lubuto, gamba ng’okunyigirizibwa mu mubiri oba mu birowoozo, okukozesa NSAID, okusikirizibwa eddagala erikola asidi w’omusaayi, n’okunywa omwenge, byonna bisobola okuvaako okweyongera okuyita mu bitundu by’ekyenda, ekivaako obulwadde bw’ekyenda ekikulukuta. BPC-157 esobola okutebenkeza okuyita kw’ekyenda nga etereeza obutoffaali obukwatagana obulungi wakati w’obutoffaali bw’ekyenda, bwe kityo n’eyongera amaanyi g’okuyungibwa wakati w’obutoffaali. Okusinziira ku data, mu bikolwa by’ebisolo ebyakwatibwa ensonga z’okunyigirizibwa ezoogeddwako waggulu, okukozesa BPC-157 kwavaamu okweyongera kw’okwolesebwa kwa puloteyina ezikwatagana ennyo wakati w’obutoffaali bw’ekyenda, nga zirina ensengekera ezitegekeddwa obulungi ennyo, bwe kityo ne kikendeeza ku kuyita kw’ekyenda eri molekyu ennene. Kino kyakendeeza bulungi obubonero bw’obulwadde bw’ekyenda ekikulukuta, kyakendeeza ku bulabe bw’ebintu eby’obulabe okuyingira mu musaayi okuva mu byenda, era ne kikuuma obutebenkevu bw’obutonde obutono obw’ekyenda.
Okutumbula okuwona kw’ebiwundu by’omu lubuto
Ka kibeere mu nkola y’okuwona amabwa mu nkola yonna ey’omu lubuto oba ebizimba eby’ebweru (nga ebizimba by’olususu lw’omumwa gwa nnabaana, ebizimba by’olususu mu lubuto, ebizimba by’olususu lw’omu lubuto, n’ebizimba by’olususu lw’omu lubuto) n’ebizimba eby’omunda (nga ebizimba by’omusuwa gw’omu lubuto n’ebizimba by’omu lubuto) eby’omu lubuto, BPC-157 eraga ebikulu ebiva mu kutumbula. BPC-157 etumbula okukula n’okusenguka kwa fibroblasts, eyanguya okukola kolagini n’okuteekebwa, bwe kityo n’ewa obuwagizi bwa matrix obwetaagisa okuwona ebiwundu. Era etereeza enkola y’okuzimba mu kitundu, esikiriza obutoffaali bw’abaserikale b’omubiri okugenda mu kifo ky’ekiwundu okugogola obuwuka obuleeta endwadde n’ebitundu ebifudde, era etumbula okuzimba emisuwa, okukakasa nti ebiriisa ebimala ne omukka gwa oxygen biweebwa ebiwundu okuwona. Mu kulongoosa anastomosis y’omu lubuto, ekifo eky’okusengejja bwe kisanga obuzibu mu kuwona olw’ensonga nga NSAIDs, cystamine, oba colectomy, BPC-157 nayo esobola okukola kinene mu kutumbula okuwona mu anastomotic n’okukendeeza ku bulabe bw’ebizibu nga anastomotic fistula.
Ebikosa ebiwundu by’olubuto n’ekyenda
Mu nkola y’envunza ey’obulwadde bw’olubuto obw’amaanyi obuleetebwa okusiba omukutu gw’omusaayi, BPC-157 yalaga ebikolwa eby’obukuumi ku kyenda oba nga ekozesebwa ng’ekiziyiza oba ekijjanjaba. Okugaba BPC-157 mu ngeri ey’okuziyiza kyakendeeza nnyo ku buzibu bw’obulwadde bw’olubuto, okukendeeza ku kufa kw’olubuto, okuzimba, n’okuyingira kw’obusimu obuyitibwa neutrophil, ate nga kyongera ku muwendo gw’obutoffaali obuyitibwa monocyte. Mu kujjanjaba obulwadde bw’olubuto obw’amaanyi obwaliwo edda, emigaso egy’amaanyi nagyo gyalabibwa, ng’emiwendo gya serum amylase gifugibwa. BPC-157 era erina akakwate akalungi ku biwundu by’olubuto n’omu lubuto ebibeerawo mu kiseera kye kimu, eyamba okukuuma obulungi bw’omubiri gw’omu lubuto n’okukendeeza ku kwonooneka kw’okuzimba mu lubuto n’ennywanto.
Ebikolwa by’okuddaabiriza BPC-157 ku kwonooneka kw’ebinywa
Okulongoosa mu bulwadde bw’amagumba g’ekiwanga (temporomandibular joint osteoarthritis).
Mu nkola y’envunza ey’obulwadde bw’amagumba mu kiwanga, okwonooneka kw’ennyondo kwaleetebwa mu kulongoosebwa, gamba ng’okwonooneka kw’ennyindo ku ludda olumu, omusipi ogw’ebbali ogw’omugongo ogwa disiki y’ennyindo, n’okusalako ku ddaala ly’okukwatagana kwa disiki ey’emabega, okukoppa enkola y’obulwadde bw’amagumba. Oluvannyuma lw’okulongoosebwa, BPC-157 yaweebwa nga bayita mu mpiso mu lubuto. Mu kwekenneenya okw’okugoberera okw’emyezi 6, ekibinja ky’abajjanjabi ba BPC-157 kyalaga okweyongera okw’amaanyi mu buwanvu bw’amagumba g’ennyondo okutwalira awamu bw’ogeraageranya n’ekibinja ekifuga. Okusingira ddala, kino kyalabika ng’obuwanvu obweyongera mu kitundu ky’amagumba n’ekitundu ky’ennyondo, okukendeeza ku kugatta obutoffaali bw’amagumba, okubula kw’enjatika z’amagumba eziyimiridde, n’okukuuma layering y’amagumba eya bulijjo. Kino kiraga nti BPC-157 esobola bulungi okukendeeza ku nkyukakyuka z’obulwadde bw’amagumba g’ekiwanga (temporomandibular joint osteoarthritis) n’okutumbula okuddaabiriza n’okuzza obuggya eggumba ly’omubiri (articular cartilage). Enkola yaayo ey’okukola eyinza okuba nga yeekuusa ku nkolagana ya BPC-157 ne molekyo nga kolagini ne proteoglycans ezikwatagana n’okukula kw’amagumba g’omubiri. Okusinziira ku kunoonyereza, ebifaananyi ebingi ebya BPC-157 bikuŋŋaanyiziddwa mu kolagini α-1 (I), kolagini α-1 (IX), aggrecan, fibronectin precursor, chondroitin sulfate proteoglycan NG2 precursor, ne chondroitin oligosaccharide precursor, ebikulu ennyo mu kukuuma ensengekera n’enkola y’eggumba ly’ekiwanga. BPC-157 eyinza okutumbula okuddaabiriza n’okuddamu okuzimba eggumba ly’ekiwanga nga etereeza okwolesebwa oba emirimu gya molekyo zino.
Ekifaananyi 3 BPC-157 yatumbula okwolesebwa kwa VEGF-a mu bitundu by’olususu ebifunye ebisago.
Okuddaabiriza obuvune mu kinywa ky’okugulu
Obulumi bw’ennyondo z’okugulu kabonero akatera okuva ku nsonga ez’enjawulo, gamba ng’obulwadde bw’amagumba, okukutuka kw’ekibumba, obuzibu mu misuwa, okukutuka kw’emisuwa oba okunyiga. Okunoonyereza okwakolebwa emabegako kwalaba abalwadde 17 nga balumwa ennyondo z’okugulu, ng’abalwadde 16 baagobererwa. Mu balwadde bano, 12 baafuna empiso za BPC-157 yokka mu bitundu by’omubiri, nga 11 (91.6%) baafuna okulongoosa okw’amaanyi mu bulumi bw’okugulu; abalwadde 4 abasigadde baafuna empiso za BPC-157 ne thymosin-β4 nga zigatta, nga 75% ku balwadde bano baafuna okukendeera okw’amaanyi mu bulumi. Okutwaliza awamu, abalwadde 87.5% baafuna obuweerero mu bulumi bw’okugulu oluvannyuma lw’okukozesa BPC-157 oba okugatta kwayo ne thymosin-β4. Kino kiraga nti BPC-157 erina obusobozi obulungi mu kukendeeza ebika by’obulumi bw’okugulu obw’enjawulo. Okwongera okwekenneenya kulaga nti BPC-157 erina obusobozi okuddaabiriza amaziga n’okutumbula okukola amagumba, ekiyinza okuba ensonga enkulu lwaki ekola bulungi mu kukendeeza ku bulumi bw’okugulu. Mu nkola y’okuddaabiriza obuvune bw’ennyondo, BPC-157 eyinza okutumbula okukula n’okwawukana kwa chondrocytes, okwongera ku kusengejja matrix y’amagumba, bwe kityo n’eddaabiriza ebitundu by’amagumba ebyonooneddwa. Okugatta ku ekyo, kiyinza n’okukola ekikolwa eky’okuddaabiriza emisuwa, emisuwa, n’ebitundu ebirala ebyonooneddwa, ne kitereeza okutebenkera kw’ennyondo n’okukendeeza ku bulumi obuva ku butabeera mu ntebenkevu bw’ennyondo.
Okuddaabiriza obuvune obuva mu kukwatagana kw’emisuwa n’ebinywa
Oluvannyuma lw’omusuwa gw’ekinywa kya quadriceps ekya ddyo mu nvunza okwawulwa ku kinywa, obujjanjabi ne BPC-157 bwalaga ebikolwa eby’amaanyi mu bujjanjabi. Okusinziira ku kwekenneenya okunene, ekibinja ekifuga kyalaga ekikyamu ekinene wakati w’omusuwa gw’omugongo ogw’ennya n’ebinywa ekyagenda mu maaso, ekyavaamu okuwona okulemererwa. Okwawukana ku ekyo, envunza ezajjanjabwa ne BPC-157 zalaga okuwona okugenda mu maaso, ng’ekikyamu kitono nnyo okuva ku ntandikwa, okukkakkana nga kivuddeko okuzzaawo omusingi gw’okuyungibwa kw’emisuwa n’ebinywa. Okukebera mu microscopic kwalaga nti ekibinja ekifuga kyalaga okuzimba emisuwa, okuyingira mu lymphocytic okw’ekigero, n’okutondebwa kw’ebitundu by’omubiri ebiyitibwa granulation tissue mu wiiki eyookubiri oluvannyuma lw’okulongoosebwa, so nga ekibinja ekyajjanjabwa BPC-157 kyalaga okuyingira kw’obutoffaali obutono bwokka, tewali kutondebwa kwa bitundu bya granulation, n’okuzzaawo obulungi ensengekera y’okuyungibwa kw’emisuwa n’ebinywa. Okukebera obulamu (biomechanical assessment) kwalaga nti okuddamu amaanyi g’ebinywa kwali kubi mu kibinja ekifuga, ate ekibinja eky’obujjanjabi bwa BPC-157 kyatuuka ku kudda engulu mu bujjuvu. Kino kiraga nti BPC-157 tekoma ku kukola bujjanjabi ku binywa n’emisuwa ebifunye obuvune wabula era eraga ebikolwa eby’enjawulo eby’okuddaabiriza n’okujjanjaba ku kwonooneka kw’enkolagana y’emisuwa n’ebinywa, ekiyamba mu kuzzaawo enkolagana eya bulijjo n’enkola wakati w’ebinywa n’emisuwa n’okukakasa okutambula kw’ennyondo okwa bulijjo.
Obusobozi n’Essuubi lya BPC-157 mu Kukozesebwa mu Bujjanjabi
Obujjanjabi bw’endwadde z’omu lubuto
Okusinziira ku ngeri BPC-157 gy’ekuuma obutoffaali bw’olubuto, okutebenkeza okuyita kw’ekyenda, okutumbula okuwona kw’ebiwundu by’omu lubuto, n’okukwata obulungi ku biwundu by’olubuto n’omu lubuto n’omu lubuto, erina obusobozi obw’amaanyi mu kujjanjaba endwadde ez’enjawulo ez’omu lubuto. Mu kujjanjaba amabwa g’omu lubuto n’amabwa g’omu lubuto, BPC-157 esobola okwanguya amabwa okuwona n’okukendeeza ku bulabe bw’okuddamu okulwala. Ku ndwadde z’ekyenda ezizimba nga ulcerative colitis, BPC-157 eyinza okulongoosa enkola y’ekiziyiza ky’ekyenda ng’etereeza abaserikale b’ekyenda n’okuddamu kw’okuzimba, okukendeeza ku bubonero, n’okutumbula okusonyiyibwa kw’obulwadde. Oluvannyuma lw’okulongoosebwa mu lubuto, okukozesa BPC-157 kuyinza okuyamba okutumbula okuwona kw’omubiri (anastomotic healing), okukendeeza ku bizibu ebivaamu, n’okwanguyiza omulwadde okuwona.
Okujjanjaba endwadde z’ennyondo
Mu nsonga z’endwadde z’ennyondo, BPC-157’s reparative effects on temporomandibular joint osteoarthritis and knee injuries ziwa amagezi amapya ku ngeri gye ziyinza okukozesebwamu mu kujjanjaba obulwadde bw’amagumba n’obuvune mu mizannyo. Ku balwadde b’amagumba, BPC-157 eyinza okukola ng’eddagala eriyinza okukyusa endwadde, si kukendeeza bubonero bwa bulumi bwokka wabula n’okukendeeza ku kuvunda kw’amagumba, okutumbula okuddaabiriza amagumba, n’okulongoosa enkola y’ennyondo. Mu kujjanjaba obuvune mu mizannyo, gamba ng’obuvune bw’emisuwa n’emisuwa mu binywa by’okugulu n’enkizi ebitera okulabibwa mu bannabyamizannyo, BPC-157 esobola okwanguya okuddaabiriza ebitundu ebyonooneddwa, okukendeeza ku budde bw’okuddaabiriza, n’okutumbula sipiidi y’okudda engulu kw’omutindo gw’emizannyo gw’abazannyi.
Mu bufunzi
Nga peptide ekola ku bulamu ng’erina emirimu mingi egy’okuddaabiriza, BPC-157 eraga obulungi obumu mu bitundu by’okuddaabiriza obuvune mu lubuto n’ennyondo.
Ensonda
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[2] Sikiric P, Drmic D, Sever M, n’abalala. Okuwona Fistulas. Enzijanjaba enywevu mu lubuto Pentadecapeptide BPC 157 Obujjanjabi[J]. Enteekateeka y’eddagala eriwo kati, 2020,26 (25): 2991-3000.DOI: 10.2174/ 13816128266 66200424180139.
[3] Sikiric P, Hahm KB, Blagaic A. B., n’abalala. Stable Gastric Pentadecapeptide BPC 157, Robert's Stomach Cytoprotection/Adaptive Cytoprotection/Organoprotection, n'okuddamu kwa Selye okugumira situleesi: Enkulaakulana, Ebituukiddwaako, n'ebiseera eby'omu maaso[J]. Ebyenda n'ekibumba, 2020,14 (2): 153-167.DOI: 10.5009 / gnl18490.
[4] Huang T, Zhang K, Sun L, n’abalala. Ekirungo ekikuuma omubiri-157 kyongera ku kuwona kw’ebiwundu eby’okwokya alkali mu vivo era kitumbula okukula, okusenguka, n’okutondebwa kw’emisuwa mu vitro[J]. Eddagala Des Devel Ther, 2015,9:2485-2499.DOI:10.2147/DDDT.S82030.
[5] Kokic N, Sikiric P, Seiwerth S, n’abalala. Pentadecapeptide BPC-157 n’obulwadde bw’amagumba mu kiwanga ky’envunza [M]. 2001.https://www.researchgate.net/publication/266736896_Pentadecapeptide_BPC-157_n’envunza_obulwadde bw’amagumba g’ekiwanga.
[6] Sikirić P, Seiwerth S, Grabarević Z, n’abalala. Salutary and prophylactic effect ya pentadecapeptide BPC 157 ku acute pancreatitis n’ebiwundu by’omu lubuto ebikwatagana mu nvunza[J]. Endwadde z’okugaaya emmere ne Sayansi, 1996,41 (7): 1518-1526.DOI:10.1007/BF02088582.
Ekintu ekiriwo okukozesebwa mu kunoonyereza kwokka:
