Na Cocer Peptides 
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INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
Incamake ya BPC-157
BPC-157 ni pentapeptide ya gastrointestinal ihamye yavumbuwe bwa mbere kubera imiti irwanya ibisebe. Iguma itekanye mumitobe ya gastrica yabantu mumasaha arenga 24, ikabasha gukomeza gukora ingaruka zayo mubidukikije ndetse no gushiraho umusingi wo gusana ibyangiritse nigifu. Imiterere yimiti
e ni GEPPPGKPADDAGLV, ifite uburemere bwa molekile ya 1419. Iyi miterere ya molekile ituma ishobora gukorana na biomolecules zitandukanye mumubiri, bityo igakora imirimo yingenzi ya physiologiya.
Igishushanyo 1 BPC-157 igira uruhare mu gukwirakwiza no gukwirakwiza ingirabuzimafatizo za HUVECs.
Ingaruka zo Gusana BPC-157 Kwangirika kwa Gastrointestinal
Kurinda ingirabuzimafatizo no kugumana ubusugire bwa Gastric
BPC-157 igira uruhare runini mu kurinda ingirabuzimafatizo, irinda neza ingaruka mbi z’imiti itandukanye igifu. Ibintu nka alcool hamwe n’imiti idakira ya anti-inflammatory (NSAIDs) akenshi itera kwangirika kwingirabuzimafatizo no guhungabanya ubusugire bwigifu. BPC-157 irashobora kurinda ingirabuzimafatizo zo mu nda ibyangiritse biturutse kuri ibyo bintu byangiza binyuze mu ruhererekane rw’imikorere igoye. Iyo ihuye n’inzoga, BPC-157 igenga inzira ya metabolike mu ngirabuzimafatizo, yongera uburyo bwo kwirinda antioxydeans selile, kandi ikagabanya kwangiza okiside iterwa na metabolite ya alcool. Kubijyanye na NSAID iterwa no kwangirika kwa gastricale, BPC-157 igira ingaruka kumihanda yerekana ibimenyetso kugirango ibuze irekurwa ryabunzi, bityo bigabanye ingaruka mbi zangiza ibisubizo byumuriro kuri mucosa gastric. Ibi bifasha kugumana ubusugire bwa mucosa gastrica no gukora imikorere isanzwe yumubiri wigifu.
Igishushanyo 2 BPC-157 yiyongereye ibikomere reepithelialisation hamwe na kolagen yibigize tissue ya granulation.
Gutezimbere amara
Ubwiyongere budasanzwe bwo gutembera mu mara ni ikintu cyingenzi kigira uruhare mu iterambere ryindwara nyinshi zo munda. Indwara ya Gastrointestinal, nko guhangayika kumubiri cyangwa mumutwe, gukoresha NSAID, kubyutsa aside aside, hamwe no gufata inzoga, byose bishobora gutuma epithelale yo mu mara yiyongera, bigatera syndrome de munda. BPC-157 irashobora guhagarika uburyo bwo mu mara igenga poroteyine zihuza hagati ya selile zo mu nda, bityo bikazamura imbaraga zo guhuza imitsi. Nk’uko imibare ibigaragaza, mu ngero z’inyamaswa zagaragajwe n’impamvu zavuzwe haruguru, gukoresha BPC-157 byatumye habaho kwiyongera kwa poroteyine zifitanye isano n’ingirabuzimafatizo zo mu nda, hamwe n’imiterere itunganijwe neza, bityo bigabanya ubwinjira mu mara kuri molekile nini. Ibi byagabanije neza ibimenyetso bya syndrome de munda, bigabanya ibyago byangiza ibintu byinjira mumaraso biva mu mara, kandi bikomeza umutekano muke wibidukikije.
Guteza imbere igikomere cyo munda
Haba muburyo bwo gukiza ibisebe mu nzira ya gastrointestinal cyangwa fistula yo hanze (nka fistula y'uruhu rwa esophageal, fistula y'uruhu rwa gastrica, fistula y'uruhu rwa duodenal, na fistula y'uruhu rwo mu nda) hamwe na fistula y'imbere (nka fistula ya fonctionnement na fonctionnement ya BP7). BPC-157 iteza imbere gukwirakwiza no kwimuka kwa fibroblast, yihutisha synthesis hamwe no kuyishira, bityo igatanga matrise ikenewe kugirango ikire ibikomere. Igenga kandi ibisubizo by’ibisubizo by’ibanze, ikurura ingirabuzimafatizo aho ikomeretsa kugira ngo ikureho indwara ziterwa na virusi na nekrotique, kandi itera angiogenez, itanga intungamubiri zihagije na ogisijeni kugira ngo bikire ibikomere. Mu kubaga gastrointestinal anastomose, mugihe urubuga rwa anastomotique ruhuye ningorane zo gukira bitewe nimpamvu nka NSAIDs, cystamine, cyangwa colectomie, BPC-157 irashobora kandi kugira uruhare runini mugutezimbere gukira kwa anastomotike no kugabanya ibyago byingutu nka fistula ya anastomotique.
Ingaruka kuri pancreatic na gastrointestinal lesions
Muburyo bwimbeba ya pancreatite ikaze iterwa na duct ligation, BPC-157 yerekanye ingaruka zo gukingira pancreas yaba ikoreshwa nkumuti wo gukumira cyangwa kuvura. Ubuyobozi bwa prophylactique bwa BPC-157 bwagabanije cyane ubukana bwa pancreatite, kugabanuka kwa pancreatic necrosis, edema, na neutrophil infiltration, mugihe byongera umubare wa monocyte. Mu kuvura indwara zikomeye za pancreatite zimaze kugaragara, ingaruka zikomeye nazo zagaragaye, hamwe na serumu amylase igenzurwa. BPC-157 igira kandi ingaruka nziza ku gukomeretsa kwa gastrica na duodenal hamwe, bifasha kugumana ubusugire bwa mucosa gastrointestinal no kugabanya kwangirika kwinda no munda.
Ingaruka zo Gusana BPC-157 ku Byangiritse
Gutezimbere by'agateganyo osteoarthritis
Mu buryo bw'imbeba ya osteoarthritis y'agateganyo, kwangirika kwangiritse kwatewe kubagwa, nko kwangirika kwa condylar kuruhande rumwe, kwangirika kwingingo ya disiki ya arctular, hamwe na disiki yinyuma yibice, kugirango bigereranye inzira ya osteoarthritis. Nyuma yo kubagwa, BPC-157 yatanzwe hakoreshejwe inshinge za intraperitoneal. Mu isuzuma ry’amezi 6 yakurikiranwe, itsinda rya BPC-157 ryerekanye ko ryiyongereye cyane mubyimbye rusange bya karitsiye ugereranije nitsinda rishinzwe kugenzura. By'umwihariko, ibi byagaragaye nkubwiyongere bwubunini muri zone ya karitsiye hamwe na zone ihuriweho, byagabanije guteranya ingirabuzimafatizo, kubura ibice bya veritike ihagaritse, no kubungabunga ibisanzwe bisanzwe. Ibi birerekana ko BPC-157 ishobora kugabanya neza impinduka ziterwa nindwara ya osteoarthritis yigihe gito kandi igateza imbere gusana no kuvugurura karitsiye. Uburyo bwibikorwa byabwo bushobora kuba bufitanye isano n’imikoranire ya BPC-157 na molekile nka kolagen na proteoglycans zijyanye no gukura kwa karitsiye. Nk’uko ubushakashatsi bubyerekana, motif nyinshi za BPC-157 zibanze muri kolagen α-1 (I), kolagen α-1 (IX), aggrecan, fibronectin precursor, chondroitin sulfate proteoglycan NG2 ibanziriza, hamwe na chondroitin oligosaccharide preursor, bifite akamaro kanini mu kubungabunga imiterere n’imikorere ya karitsiye. BPC-157 irashobora guteza imbere gusana no kwiyubaka kwa karitsiye muguhuza imvugo cyangwa ibikorwa bya molekile.
Igicapo 3 BPC-157 yazamuye imvugo ya VEGF-a mubice byuruhu byakomeretse.
Gusana ibikomere byo mu ivi
Kubabara kw'ivi ni ibimenyetso bisanzwe bivura biterwa nibintu bitandukanye, nka osteoarthritis, amarira ya menisque, indwara ya tendon, amarira ya ligament, cyangwa sprain. Ubushakashatsi bwisubireho bwerekanye abarwayi 17 bafite ububabare bwo mu ivi, abarwayi 16 bakurikiranwa. Muri aba barwayi, 12 bahawe inshinge zo mu nda ya BPC-157 bonyine, 11 (91,6%) bafite iterambere ryinshi mu kubabara ivi; abarwayi 4 basigaye bahawe inshinge za BPC-157 na thymosine-β4, aho 75% by'aba barwayi bafite ububabare bukomeye. Muri rusange, 87.5% by'abarwayi bagize ububabare bwo mu ivi nyuma yo gukoresha BPC-157 cyangwa guhuza na thymosine-β4. Ibi byerekana ko BPC-157 ifite imikorere myiza mukugabanya ubwoko butandukanye bwububabare bwivi. Ubundi isesengura ryerekana ko BPC-157 ifite ubushobozi bwo gusana amarira no guteza imbere kubyara karitsiye, bishobora kuba impamvu yingenzi yo gukora neza mukugabanya ububabare bwivi. Mugihe cyo gusana ibikomere byafashwe, BPC-157 irashobora guteza imbere ikwirakwizwa rya chondrocytes no gutandukanya chondrocytes, kongera synthesis ya matrise ya karitsiye, bityo igasana ingirangingo zangiritse. Ikigeretse kuri ibyo, irashobora kandi kugira ingaruka zo kwisubiza ku mitsi yangiritse, imitsi, nizindi ngingo, bigateza imbere hamwe no kugabanya ububabare buterwa no guhungabana.
Gusana ibikomere bihuza imitsi
Nyuma yimitsi yimitsi ya quadriceps iburyo yimbeba yatandukanijwe nimitsi, kuvura hamwe na BPC-157 byagaragaje ingaruka zikomeye zo kuvura. Duhereye ku isuzuma rya macroscopique, itsinda rishinzwe kugenzura ryerekanye inenge nini hagati ya quadriceps tendon n'imitsi byakomeje gutera imbere, bikaviramo gukira kunanirwa. Ibinyuranye, imbeba zavuwe na BPC-157 zerekanaga gukira gukomeje, inenge ikaba nto cyane kuva mugitangira, amaherezo iganisha ku kugarura shingiro guhuza imitsi n'imitsi. Isuzuma rya Microscopique ryerekanye ko itsinda ryagenzuye ryerekanaga ibyorezo bya tendon, gucengera kwa lymphocytike mu buryo butagereranywa, hamwe na granulation tissue mu cyumweru cya kabiri nyuma yo kubagwa, mu gihe itsinda ry’ubuvuzi rya BPC-157 ryerekanye gusa ko ryoroheje ryoroheje rya lymphocytike, nta mitsi ya granulation, ndetse no kugarura imiterere y’imitsi ihuza imitsi. Isuzuma ryibinyabuzima ryerekanye ko imbaraga z imitsi zidakabije mumatsinda yo kugenzura, mugihe BPC-157 yo kuvura yageze gukira byuzuye. Ibi byerekana ko BPC-157 itagira ingaruka zo kuvura gusa imitsi yakomeretse ndetse ikanagaragaza ingaruka zihariye zo kwisubiza no kuvura ibyangiritse ku mitsi ihuza imitsi, bifasha mu kugarura imiyoboro isanzwe n'imikorere hagati y'imitsi n'imitsi kandi bikagenda neza.
Ibishoboka nibitekerezo bya BPC-157 mubikorwa bya Clinical
Kuvura Indwara Zigifu
Bitewe n'ingaruka zo kurinda BPC-157 ku ngirabuzimafatizo zo mu gifu, guhagarara neza mu mara, guteza imbere gukira ibikomere byo mu gifu, no kugira ingaruka nziza ku ndwara ziterwa na pancreatic na gastric-duodenal, ifite imbaraga zikomeye mu kuvura indwara zitandukanye zo mu gifu. Mu kuvura ibisebe byo mu gifu n'ibisebe byo mu nda, BPC-157 irashobora kwihutisha gukira ibisebe no kugabanya ibyago byo kongera kubaho. Indwara zifata amara nka colitis ulcerative, BPC-157 irashobora kunoza imikorere yinzitizi yo munda igenga imikorere yumubiri no gukingira indwara, kugabanya ibimenyetso, no guteza imbere indwara. Nyuma yo kubagwa gastrointestinal, gukoresha BPC-157 birashobora gufasha guteza imbere gukira kwa anastomotique, kugabanya ibibazo byingaruka, no kwihutisha inzira yumurwayi.
Kuvura indwara zifatika
Mu rwego rw’indwara zifatanije, ingaruka za BPC-157 ziterwa no kwangirika kwa osteoarthritis hamwe nigihe cyo gukomeretsa mu ivi bitanga ubumenyi bushya kubishobora gukoreshwa mukuvura osteoarthritis n’imvune za siporo. Ku barwayi ba osteoarthritis, BPC-157 irashobora kuba nk'imiti ishobora guhindura indwara, ntabwo igabanya ibimenyetso byububabare gusa ahubwo inadindiza kwangirika kwa karitsiye, guteza imbere gusana karitsiye, no kunoza imikorere ihuriweho. Mu kuvura ibikomere bya siporo, nk'imvune zo mu mavi no mu maguru zikunze kugaragara mu bakinnyi, BPC-157 irashobora kwihutisha gusana ingirangingo zangiritse, kugabanya igihe cyo gusubiza mu buzima busanzwe, no kongera umuvuduko wo gukira kw'imikino ngororamubiri.
Umwanzuro
Nka bioactive peptide ifite ibikorwa byinshi byo gusana, BPC-157 yerekana imikorere imwe murwego rwo gusana gastrointestinal hamwe no gusana ibikomere.
Inkomoko
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[4] Huang T, Zhang K, Sun L, n'abandi. Umubiri urinda umubiri-157 utera alkali-gutwika ibikomere gukira muri vivo kandi bigatera ikwirakwizwa, kwimuka, na angiogenezi muri vitro [J]. Ibiyobyabwenge Byibiryo, 2015,9: 2485-2499.DOI: 10.2147 / DDDT.S82030.
[5] Kokic N, Sikiric P, Seiwerth S, n'abandi. Pentadecapeptide BPC-157 n'imbeba by'agateganyo hamwe na osteoarthrosis [M]. 2001.https: //www.ubushakashatsi.net/yatangajwe/266736896_Pentadecapeptide_BPC-157_kandi
[6] Sikirić P, Seiwerth S, Grabarević Z, n'abandi. Ingaruka za salutary na prophylactique ya pentadecapeptide BPC 157 kuri pancreatite ikaze ndetse no gukomeretsa gastroduodenal mu mbeba [J]. Indwara zifungura nubumenyi, 1996,41 (7): 1518-1526.DOI: 10.1007 / BF02088582.
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