Cocer Peptides ye ŋlɔe 
ŋkeke 23 enye sia
NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.
Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.
Tsitsi, abe dzɔdzɔmenu si womate ŋu aƒo asa na le nu gbagbewo me ene, nye nusi ŋu dzɔdzɔmeŋutinunya me numekukuwo ku ɖo vevie tso gbaɖegbe ke. Ne nugbagbewo le tsitsim la, lãmenugbagbeviwo gena ɖe tsitsi ƒe nɔnɔme me vivivi, eye lãmenugbagbevi siawo siwo le tsitsim ƒe ƒuƒoƒo ate ŋu akpɔ ŋusẽ gbegblẽ ɖe lãmekawo kple ŋutinuwo ƒe dɔwɔwɔ nyuie dzi, si ahe dɔléle vovovo siwo do ƒome kple tsitsi vɛ. FOX04 – DRI ɖea vi na lãmenugbagbevi siwo le tsitsim la ɖeɖeɖa.
Kpɔɖeŋu bliboa
DSIP peptide, Delta-Sleep-Inducing Peptide, nye ahɔhɔ̃mekawo ƒe dɔwɔwɔ dzi peptide bio-regulator. Edoa alɔ̃dɔdɔ ƒe ɖoɖowɔwɔ ɖe ŋgɔ. Tsɔ kpe ɖe eŋu la, ekpɔa ŋusẽ ɖe ŋutilã ƒe dzoxɔxɔ ƒe ɖoɖowɔwɔ, dzi ƒe tsotso, ʋu ƒe sisi, vevesese ƒe dzidzenu, kple ʋumenugbagbeviɣi ƒe dɔwɔwɔ dzi, eye ŋusẽkpɔɖeamedzi siawo ɖea ŋkeke ƒe ɣeyiɣi ƒe didime dzi nɔnɔ fiana.
DSIP Peptide ƒe Dɔwɔwɔ le Alɔ̃dɔdɔ Ŋu ƒe Mɔnu
Ahɔhɔ̃mekawo ƒe Dɔwɔɖoɖo
5-Hydroxytryptamine (5-HT): 5-HT nye ahɔhɔ̃meka vevi aɖe si do ƒome kplikplikpli kple alɔ̃dɔdɔ ƒe ɖoɖowɔwɔ. Le alɔ̃madɔmadɔ ƒe nɔnɔmewo abe alɔ̃madɔmadɔ ƒe kpɔɖeŋu si PCPA hena vɛ ene me la, 5-HT ƒe agbɔsɔsɔ dzi ɖena kpɔtɔna ŋutɔ. Numekukuwo ɖee fia be DSIP peptidewo ate ŋu ana 5-HT ƒe agbɔsɔsɔ nadzi ɖe edzi le hippocampal lãmenugbagbeviwo me, si ana alɔ̃dɔdɔ nanyo ɖe edzi. 5-HT ate ŋu aɖɔ ahɔhɔ̃mekawo ƒe dzidzɔkpɔkpɔ ɖo to dɔwɔwɔ ɖe lãmenugbagbevi siwo xɔa dɔlékuiwo ƒe hatsotso sue vovovowo dzi me, si ana wòakpɔ ŋusẽ ɖe alɔ̃dɔdɔ kple nyɔnyrɔ̃ ƒe tsatsam dzi. 5-HT1A receptor agonists ateŋu ado non-rapid eye movement (NREM) alɔ̃dɔdɔ ɖe ŋgɔ, gake 5-HT2A receptor antagonists ateŋu aɖe ŋudzɔɣi dzi akpɔtɔ, eye wòana alɔ̃dɔdɔ ƒe ɣeyiɣi bliboa nadzi ɖe edzi. DSIP peptidewo ate ŋu awɔ woƒe ɖoɖowɔwɔ ƒe ŋusẽkpɔɖeamedzi ɖe alɔ̃dɔdɔ dzi to asitɔtrɔ le 5-HT ƒe dodo, egbugbɔgaxɔ, alo kadodo kple eƒe xɔlawo ŋu me.
Dopamine (DA): Dopamine hã wɔa akpa vevi aɖe le alɔ̃dɔdɔ ƒe ɖoɖowɔwɔ me. Le nɔnɔme siwo sɔ me la, dopaminergic neurons ƒe dɔwɔwɔ kpena ɖe ame ŋu wòléa ŋudzɔ. Dopamine ƒe agbɔsɔsɔ ƒe masɔmasɔ ate ŋu ahe alɔ̃dɔdɔ ƒe kuxiwo vɛ. Le alɔ̃madɔmadɔ ƒe kpɔɖeŋu aɖewo me la, dopamine ƒe agbɔsɔsɔ dzi ɖena kpɔtɔna, eye DSIP peptidewo ate ŋu agbugbɔ dopamine ƒe agbɔsɔsɔ aɖo eƒe akpa aɖe. Dopamine ɖɔa ahɔhɔ̃mekawo ƒe dzesiwo ɖo to kadodo kple dopamine xɔla vovovowo me. DSIP peptidewo ate ŋu ana alɔ̃dɔdɔ nanyo ɖe edzi to ŋusẽkpɔkpɔ ɖe dopaminergic neurons ƒe dɔwɔwɔ dzi, dopamine ƒe wɔwɔme, dodo, alo lãmenugbagbeviwo ƒe dɔwɔwɔ dzi kpɔkpɔ me. Ate ŋu awɔ dɔ ɖe enzyme vevi siwo kpɔa gome le dopamine ƒe wɔwɔme me, abe tyrosine hydroxylase ene dzi, akpɔ ŋusẽ ɖe dopamine ƒe wɔwɔme ƒe ablaɖeɖe dzi eye wòato esia me akpɔ ŋusẽ ɖe alɔ̃dɔdɔ kple nyɔnyrɔ̃ ƒe dadasɔ dzi.
Glutamate (Glu): Glutamate ye nye ahɔhɔ̃meka vevitɔ si doa dzidzɔ na ame le lãmekawo ƒe dɔwɔwɔ me. Le alɔ̃madɔmadɔ me la, glutamate ƒe agbɔsɔsɔ ate ŋu atrɔ. Dzɔdzɔmeŋutinunya me numekukuwo ɖee fia be DSIP peptidewo ate ŋu aɖɔ glutamate ƒe agbɔsɔsɔ ɖo le hippocampal lãmenugbagbeviwo me, si ana glutamate ƒe agbɔsɔsɔ si dzi ɖe kpɔtɔ le kpɔɖeŋu aɖewo me nadzi ɖe edzi. Glutamate ɖɔa ahɔhɔ̃mekawo ƒe dzodzo ɖo to kadodo kple ionotropic kple metabotropic glutamate receptors me. DSIP peptidewo ate ŋu alé ahɔhɔ̃mekawo ƒe dzidzɔkpɔkpɔ ƒe dadasɔ me ɖe asi to glutamate xɔla ƒe dɔwɔwɔ dzi kpɔkpɔ alo ŋusẽkpɔkpɔ ɖe glutamate ƒe dodo kple eƒe xɔxlɔ̃ ƒe mɔnuwo dzi, si ana woakpɔ ŋusẽ nyui ɖe alɔ̃dɔdɔ dzi. Woate ŋu atrɔ asi le glutamate tsɔtsɔ yi teƒe bubuwo ƒe dɔwɔwɔ ŋu be woakpɔ glutamate ƒe agbɔsɔsɔ si le lãmenugbagbeviwo godo dzi, si axe mɔ na agbɔsɔsɔ si gbɔ eme alo esi mesɔ gbɔ o be wòagagblẽ nu le alɔ̃dɔdɔ ŋu o.
Melatonin (MT): Melatonin nye amine lãmetsi aɖe si pineal gland ɖena si wɔa akpa vevi aɖe le alɔ̃dɔdɔ kple nyɔnyrɔ̃ ƒe tsatsam dzi kpɔkpɔ me. Le alɔ̃madɔmadɔ ƒe kpɔɖeŋu aɖe si wowɔ le sisiblisi me me la, melatonin ƒe agbɔsɔsɔ le hippocampus me dzi ɖe kpɔtɔ ŋutɔ, eye DSIP peptide te ŋu dzi melatonin ƒe agbɔsɔsɔ ɖe edzi. Melatonin ɖɔa ɣeyiɣi ƒe didime kple alɔ̃dɔdɔ ɖo to kadodo kple MT1 kple MT2 xɔlawo me. DSIP ate ŋu awɔ eƒe ɖoɖowɔwɔ ƒe ŋusẽkpɔɖeamedzi ɖe alɔ̃dɔdɔ dzi to ŋusẽkpɔkpɔ ɖe melatonin ƒe wɔwɔme kple eƒe dodo le pineal gland me dzi, alo to asitɔtrɔ le melatonin xɔlawo ƒe ɖeɖefia kple dɔwɔwɔ ŋu me. Ate ŋu aɖɔ enzyme vevi siwo kpɔa gome le melatonin ƒe wɔwɔme me, abe aromatase N-acetyltransferase (AANAT) ene ƒe dɔwɔwɔ dzi, si ana wòakpɔ ŋusẽ ɖe melatonin ƒe wɔwɔme ƒe agbɔsɔsɔ dzi.
Figure 2 FOXO4 ƒe ɖeɖefia le amegbetɔ ƒe vidzidɔ me si wokpɔ to immunofluorescent staining me.
Ŋusẽ si wòkpɔna ɖe ahɔhɔ̃mekawo ƒe lãmenugbagbeviwo dzi
Le alɔ̃madɔmadɔ ƒe kpɔɖeŋu si PCPA hena vɛ me la, HE ƒe amadede ɖee fia be kpɔɖeŋu ƒuƒoƒoa ƒe gbetedziwo ɖe lãmenugbagbeviwo dome teƒe siwo dzi ɖe edzi ŋutɔ, lãmenugbagbeviwo ƒe lolome sue wu, nɔnɔme si mesɔ o, kple matrix si me mekɔ o le hippocampal lãmenugbagbeviwo me fia. To vovo na ema la, ƒuƒoƒo si wotsɔ DSIP peptide da dɔe (abe alɔ̃dɔdɔ ƒe peptide si wotsɔ ƒo ƒu kple peptide ƒuƒoƒo si gena ɖe lãmenugbagbeviwo me si nye P-DSIP ene) ɖe lãmenugbagbeviwo dome teƒe siwo dzi ɖe kpɔtɔ, lãmenugbagbeviwo ƒe ɖoɖowɔwɔ ɖe ɖoɖo nu wu, kple mama ɖekae wu le hippocampal lãmenugbagbeviwo me fia. Esia fia be DSIP peptide ate ŋu ana alɔ̃dɔdɔ ƒe nugbegblẽ le hippocampal ahɔhɔ̃mekawo ŋu nanyo ɖe edzi, alé woƒe nɔnɔme kple wɔwɔme si sɔ me ɖe asi, si ana woakpɔ egbɔ be woƒe ŋutilã ƒe dɔwɔwɔ sɔ, eye wòana alɔ̃dɔdɔ ƒe ɖoɖowɔwɔ nanɔ bɔbɔe. Ahɔhɔ̃mekawo ƒe wɔwɔme si sɔ ye nye gɔmeɖoanyi na ahɔhɔ̃mekawo ƒe dzesiwo ƒe kaka kple woƒe ƒoƒo ɖekae. DSIP peptide ƒe ametakpɔkpɔ ƒe ŋusẽkpɔɖeamedzi ɖe ahɔhɔ̃mekawo ƒe lãmenugbagbeviwo dzi ate ŋu akpe ɖe ahɔhɔ̃mekawo ƒe mɔ siwo do ƒome kple alɔ̃dɔdɔ ƒe ɖoɖowɔwɔ ŋu ƒe dɔwɔwɔ nyuie ake.
DSIP peptides ate ŋu akpɔ ŋusẽ ɖe ahɔhɔ̃mekawo ƒe elektrikŋusẽ ƒe dɔwɔwɔ dzi. Ahɔhɔ̃mekawo ɖoa nyatakakawo to dɔwɔwɔ ƒe ŋutetewo wɔwɔ me, eye ahɔhɔ̃mekawo ƒe elektrikŋusẽ ƒe dɔwɔwɔ ƒe ɖoɖowo trɔna ne wole alɔ̃ dɔm. DSIP peptidewo ate ŋu aɖɔ ion-mɔ̃ siwo le ahɔhɔ̃mekawo ƒe lãmenugbagbeviwo ƒe lãkusiwo dzi, atrɔ ahɔhɔ̃mekawo ƒe dzodzo kple tudada zi gbɔ zi geɖe, si ana woakpɔ ŋusẽ ɖe alɔ̃dɔdɔ ƒe nɔnɔmewo dzi. Woate ŋu ana potassium ion-mɔ̃ aɖewo ƒe dɔwɔwɔ nanyo ɖe edzi, si ana ahɔhɔ̃mekawo nate ŋu age ɖe gbɔɖemeƒe eye wòana alɔ̃dɔdɔ nadze egɔme.
Mɔnu siwo do ƒome kple ʋu kple ahɔhɔ̃ ƒe mɔxenu
Ʋu kple ahɔhɔ̃ ƒe mɔxenu (BBB) nye mɔxenu vevi aɖe le ʋu kple ahɔhɔ̃mekawo dome, si xea mɔ na nu geɖe ƒe gege ɖe ʋu me yi ahɔhɔ̃mekawo me. Aminopeptidases ye ʋãa DSIP peptidewo ƒe asitɔtrɔ le ʋu kple ahɔhɔ̃ ƒe mɔxenu ŋu. Le nyitsu ƒe ahɔhɔ̃ me ʋuka suewo ƒe lãmenugbagbevi siwo wode agble me (BBMEC, si nye ʋu-ahɔhɔ̃ ƒe mɔxenu ƒe kpɔɖeŋu) me la, peptidyl dipeptidase A ate ŋu atrɔ asi le DSIP hã ŋu to dipeptide alo tripeptide siwo tso nonapeptide sia ƒe carboxy ƒe nuwuƒe la ɖeɖe ɖe wo nɔewo yome me. Ne wotsɔ peptidyl dipeptidase A mɔxenuwo (abe captopril) kple aminopeptidase mɔxenuwo (abe besartan ene) kpe ɖe eŋu la, woate ŋu ana DSIP ƒe asitɔtrɔ le BBMECwo me nali ke keŋkeŋ, si fia be ne woɖɔ enzyme siawo ƒe dɔwɔwɔ ɖo la, DSIP peptide geɖe ate ŋu atso ʋu kple ahɔhɔ̃ ƒe mɔxenu eye woaɖo ahɔhɔ̃mekawo gbɔ atsɔ awɔ woƒe alɔ̃dɔdɔ ƒe dɔwɔwɔ dzi. Numekuku aɖe dze agbagba be yewoatsɔ DSIP peptidewo aƒo ƒu kple peptide siwo ate ŋu atso ʋu kple ahɔhɔ̃ ƒe mɔxenu (abe CBBBP ene) atsɔ awɔ DSIP-CBBBP fusion peptides. Fusion peptide siawo ate ŋu aɖɔ ahɔhɔ̃mekawo ƒe dɔwɔwɔ ɖo nyuie wu, abe 5-HT, glutamate, dopamine, kple melatonin ene, si wɔnɛ be wokpɔa ŋusẽ nyuitɔ ɖe alɔ̃dɔdɔ ƒe nyonyo dzi. Ne wowɔ DSIP peptidewo ƒe ŋutete be woatso ʋu kple ahɔhɔ̃ ƒe mɔxenu wòanyo wu la, woate ŋu ana woƒe ɖoɖowɔwɔ ƒe ŋusẽkpɔɖeamedzi ɖe alɔ̃dɔdɔ dzi nadzi ɖe edzi.
Akpa si DSIP peptides wɔna le alɔ̃dɔdɔ ƒe nyonyo me
1. Alɔ̃dɔdɔ ƒe ɣeyiɣi bliboa dzi ɖeɖe kpɔtɔ
Le dodokpɔ siwo wowɔ le lãwo ŋu me la, DSIP peptidewo ɖe ŋutete si le wo si be woadzi alɔ̃dɔdɔ ƒe ɣeyiɣi bliboa ɖe edzi le lãwo me fia, eɖanye be wodo wo to ʋuka me alo to ŋɔti me o. Le dodokpɔ siwo wowɔ le New Zealand avugbɔ̃e ɣiwo ŋu me la, DSIP peptide dodo ɖe ʋuka me na alɔ̃dɔdɔ ƒe ɣeyiɣi bliboa dzi ɖe edzi ŋutɔ ne wotsɔe sɔ kple ƒuƒoƒo si me wokpɔa dze le. Dodo ɖe no me hã wɔ dɔ nenema ke, eye New Zealand avugbɔ̃e ɣiwo ƒe ƒuƒoƒo si wodo ɖe no me ɖe alɔ̃dɔdɔ ƒe ɣeyiɣi bliboa didi ŋutɔ wu ƒuƒoƒo si me dze le. Esia ɖee fia be DSIP peptide ate ŋu ado alɔ̃dɔdɔ ƒe gɔmedzedze ɖe ŋgɔ nyuie le lãwo me eye wòana alɔ̃dɔdɔ nanɔ anyi didi. Alɔ̃dɔdɔ ƒe ɣeyiɣi bliboa ƒe dzidziɖedzi le vevie ŋutɔ na ŋutilã ƒe hayahaya kple ŋutilã ƒe dɔwɔwɔ nyuie, elabena enaa ŋutinuwo kple ɖoɖowo katã gbɔ ɖe eme nyuie, si kpena ɖe ame ŋu le lãmenugbagbeviwo ɖɔɖɔɖo, lãmenugbagbeviwo ƒe dɔwɔwɔ nyuie, kple dɔwɔwɔ bubuwo me.
Le sisiblisi ƒe kpɔɖeŋu si wodo ɖe ya si mebɔ o si nɔa anyi didi (HH) me la, wotsɔ phosphorylated DSIP peptide (p-DSIP) de nu nyaa me. Le emetsonuwo nu la, p-DSIP do alɔ̃dɔdɔ si me ŋkuʋuʋu kabakaba o (NREM) kple ŋkuʋuʋu kabakaba (REM) ɖe ŋgɔ le sisiblisiwo me, si na alɔ̃dɔdɔ ƒe ɣeyiɣi bliboa dzi ɖe edzi. Esia ɖee fia be DSIP peptide doa alɔ̃dɔdɔ ɖe ŋgɔ le alɔ̃dɔdɔ ƒe nɔnɔme vovovowo me, si naa alɔ̃dɔdɔ ƒe wɔwɔme nyona ɖe edzi eye wònaa alɔ̃dɔdɔ ƒe nyonyome nyona ɖe edzi.
2. Alɔ̃dɔdɔ blewu ƒe ɣeyiɣi didi didi
Alɔ̃dɔdɔ blewu (SWS), si wogayɔna be alɔ̃dɔdɔ deto, le vevie ŋutɔ na ŋutilã ƒe hayahaya kple edzadzraɖo. DSIP peptide didia alɔ̃dɔdɔ blewu ƒe ɣeyiɣi didi ɖe edzi ŋutɔ le lãwo me. Le dodokpɔ siwo wowɔ le New Zealand avugbɔ̃e ɣiwo ŋu me la, DSIP dodo ɖe ʋuka me kple to no me siaa na be wodɔ alɔ̃ blewu le ƒuƒoƒo si ŋu wowɔ atike ɖo me ne wotsɔe sɔ kple ƒuƒoƒo si me wode dzee. Le alɔ̃dɔdɔ blewu ƒe afɔɖeɖea me la, lãmenugbagbeviwo ƒe dɔwɔwɔ dzi ɖena kpɔtɔna, eye ŋutilã ƒe dɔwɔwɔ abe dzi ƒe tsotso kple gbɔgbɔ ene dzi ɖena kpɔtɔna, si wɔnɛ be ŋutilãa ƒoa eɖokui ɖe eɖokui dzadzraɖo kple ŋusẽ dzadzraɖo me. DSIP peptidewo ate ŋu ana alɔ̃dɔdɔ blewu nadidi ɖe edzi, si ana ŋutilãa ƒe hayahaya ƒe ŋutete nadzi ɖe edzi, ɖeɖiteameŋu dzi naɖe akpɔtɔ, eye wòado ŋusẽ dɔlélenutsiŋutete.
Le ahɔhɔ̃mekawo ƒe nukpɔsusu nu la, DSIP peptidewo ate ŋu aɖɔ ahɔhɔ̃mekawo ƒe agbɔsɔsɔ ɖo, ana 5-HT kple melatonin ƒe agbɔsɔsɔ nadzi ɖe edzi, eye woaxe mɔ ɖe ahɔhɔ̃mekawo ƒe dzodzo fũ le ahɔhɔ̃a me nu, si ana alɔ̃dɔdɔ blewu ƒe gɔmedzedze kple edziléle ɖe ŋgɔ. Eƒe ametakpɔkpɔ ƒe ŋusẽkpɔɖeamedzi ɖe ahɔhɔ̃mekawo dzi, woƒe wɔwɔme kple dɔwɔwɔ nyuie me léle ɖe asi, hã kpena ɖe ahɔhɔ̃mekawo ƒe nɔnɔme si sɔ na alɔ̃dɔdɔ blewu ŋu.
3. Nuwɔna siwo do ƒome kple alɔ̃dɔdɔ ƒe nyonyo
Le nuwɔna dodokpɔwo me, abe dodokpɔ si wowɔna le gbedadaƒo, dodokpɔ si wodona ɖe dzi kpe ɖe maze ŋu, kple dodokpɔ si me wotsɔa asike ƒoa ƒui ene me la, DSIP peptidewo ɖe ŋgɔyiyi gã aɖe fia le lã siwo medɔa alɔ̃ o ƒe nuwɔna me. Le dodokpɔ si wowɔ le gbedadaƒo me la, kpɔɖeŋu ƒuƒoƒoa me sisiblisiwo ɖee fia be ʋuʋu ƒe didime kple dɔwɔna ƒe ɣeyiɣi dzi ɖe kpɔtɔ ŋutɔ, gake sisiblisi siwo wotsɔ DSIP peptide da dɔe (le kpɔɖeŋu me, P-DSIP ƒuƒoƒoa) ɖe ʋuʋu ƒe didime kple dɔwɔwɔ ƒe ɣeyiɣi si dzi ɖe edzi ŋutɔ fia, si ɖee fia be DSIP peptide ate ŋu ana sisiblisi siwo melɔ̃na o ƒe dɔwɔwɔ ƒe ŋutete nanyo ɖe edzi eye wòaɖe dɔwɔwɔ ƒe mɔxexe si alɔ̃madɔmadɔ hena vɛ dzi akpɔtɔ. Le dodokpɔ si nye elevated plus maze me la, zi nenie kpɔɖeŋu ƒuƒoƒoa me sisiblisiwo ge ɖe alɔ si le ʋuʋu ɖi me kple ɣeyiɣi si wozã le alɔ si le ʋuʋu ɖi me dzi ɖe kpɔtɔ ŋutɔ. Gake le DSIP peptide dodo vɔ megbe, abe le P-DSIP ƒuƒoƒoa me ene la, zi nenie sisiblisiwo ge ɖe alɔ si le ʋuʋu ɖi me kple ɣeyiɣi si wozã le alɔ si le ʋuʋu ɖi me dzi ɖe edzi ŋutɔ, si ɖee fia be DSIP peptide ate ŋu ana sisiblisi siwo medɔa alɔ̃ o ƒe nuwɔna si ɖi dzimaɖitsitsi nanyo ɖe edzi. Le asike ƒe ʋuʋu dodokpɔa me la, kpɔɖeŋu ƒuƒoƒoa me sisiblisiwo ɖee fia be ɣeyiɣi si me womate ŋu aʋuʋu o dzi ɖe edzi ŋutɔ eye avuwɔwɔ ƒe ɣeyiɣi dzi ɖe kpɔtɔ ŋutɔ. Gake le DSIP peptide (abe GABA ƒuƒoƒo, P-DSIP ƒuƒoƒo, kple DSIP ƒuƒoƒo ene) dodo vɔ megbe la, sisiblisiawo ɖee fia be ɣeyiɣi si me womete ŋu ʋãna o dzi ɖe kpɔtɔ ŋutɔ eye ɣeyiɣi si wotsɔ ʋlia avu la dzi ɖe edzi ŋutɔ, si ɖee fia be DSIP peptide ate ŋu ana nuwɔna si le abe blanuiléle ene nanyo ɖe edzi le sisiblisi siwo medɔa alɔ̃ o me. DSIP peptide ate ŋu ana seselelãme kple nuwɔna ƒe nya siwo alɔ̃madɔmadɔ hena vɛ nanyo ɖe edzi.
DSIP Peptide zazã le Alɔ̃dɔdɔ ƒe Ðoɖowɔwɔ me
Le dɔdamɔnu ŋuti numekukuwo me la, le dɔdaƒe ƒe ŋkuléleɖenuŋu sue aɖewo me la, esi wodo atike siwo do ƒome kple DSIP peptide na dɔnɔ siwo ŋu alɔ̃madɔmadɔ le vɔ la, dɔnɔ aɖewo ƒe alɔ̃dɔdɔ ƒe nyonyome nyo ɖe edzi le mɔ vovovowo nu, abe ɣeyiɣi kpui si wodze alɔ̃dɔdɔ gɔme, alɔ̃dɔdɔ ƒe goglome dzi ɖe edzi, kple zã me nyɔnyrɔ̃ dzi ɖeɖe kpɔtɔ ene. Tsɔ kpe ɖe eŋu la, woate ŋu azã DSIP peptide ɖeɖeko atsɔ ada alɔ̃madɔmadɔ alo atsɔe akpe ɖe alɔ̃dɔdɔ ƒe atike bubu siwo wozãna tsã ŋu. Numekukuwo ɖee fia be ne wotsɔ DSIP peptidewo kpe ɖe dzimaɖitsitsi alo blanuilélenutsitike aɖewo ŋu la, woɖea dɔwɔwɔ aduadu fiana, si wɔnɛ be dɔnɔwo ƒe alɔ̃dɔdɔ ƒe nyonyome kple seselelãme ƒe nɔnɔme nyona ɖe edzi nyuie. Ne wozã DSIP peptidewo kpe ɖe benzodiazepines ŋu la, ate ŋu aɖe benzodiazepines ƒe agbɔsɔsɔ dzi akpɔtɔ, aɖe afɔku si le dɔléle gbegblẽwo me dzi akpɔtɔ, eye wòana atikewɔwɔ nawɔ dɔ nyuie wu.
Nyanuwuwuw
Abe dzɔdzɔme alɔ̃dɔdɔ ƒe ɖoɖowɔla ene la, DSIP peptide ɖea dɔwɔwɔ nyuie fiana le alɔ̃dɔdɔ ƒe ɖoɖowɔwɔ ƒe mɔnuwo, alɔ̃dɔdɔ ƒe nyonyome ƒe ŋusẽkpɔɖeamedziwo, kple eŋudɔwɔwɔ ƒe akpawo me.
Dzɔtsoƒewo
[1] Mu X, Qu L, Yin L, kple ame bubuwo. Pichia pastoris ɖea peptide siwo tso ʋu-ahɔhɔ̃ ƒe mɔxenu kple DSIP fusion peptide ƒe dɔwɔwɔ nyuie le alɔ̃madɔmadɔ ƒe sisiblisi siwo PCPA hena vɛ ƒe kpɔɖeŋuwo me[J]. Liƒowo le Atikeŋutinunya me, 2024,15. https://api.semanticscholar.org/CorpusID: 273205621. Ƒe 1999 ƒe ɣleti gbãtɔ me
[2] Roy K, Chauhan G, Kumari P, kple ame bubuwo. Phosphorylated delta sleep inducing peptide gbugbɔa teƒe ƒe ŋkuɖodzinu kple p-CREB ƒe ɖeɖefia ɖoa anyi to alɔ̃dɔdɔ ƒe xɔtuɖaŋu ƒe nyonyo le teƒe kɔkɔwo me[J]. Agbeŋutinunya, 2018, 209: 282-290.DOI: 10.1016 / j.lfs.2018.08.026.
[3] Augustijns P. F., Ng. K. Y., Williams T. M., kple ame bubuwo. Peptidyl dipeptidase A-catalyzed metabolism of delta sleep-inducing peptide le nyiwo ƒe ahɔhɔ̃ ƒe microvessel endothelial cells me: lãmenugbagbeviwo ƒe dekɔnu ƒe kpɔɖeŋu si nye ʋu ƒe ahɔhɔ̃ ƒe mɔxenu[J]. Biochemical kple Biophysical Numekuku Kadodowo, 1995, 210 (3): 987-994.DOI: 10.1006 / bbrc.1995.1754.
[4] Yehuda S, Carasso R L. DSIP--dɔwɔnu si woatsɔ aku nu me le alɔ̃dɔdɔ ƒe gɔmedzedze ƒe mɔnu ŋu: numetoto[J]. Dukɔwo Dome Ahɔhɔ̃ŋutinunya ƒe Agbalẽ, 1988,38 (3-4): 345-353.DOI: 10.3109/00207458808990695.
[5] Obál F. J., Kovalzon V. M., Kalikhevich V. N., kple ame bubuwo. Dɔwɔwɔ ƒe ƒomedodo le delta-sleep-inducing peptide (DSIP) ƒe ŋusẽkpɔɖeamedzi ɖe sisiblisi ƒe alɔ̃dɔdɔ dzi[J]. Atikeŋutinunya Biochemistry kple Nuwɔna, 1986, 24 (4): 889-894.DOI: 10.1016 / 0091-3057 (86) 90432-6.
Adzɔnu si li na numekuku zazã ɖeɖeko:
