Na Cocer Peptides 
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INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
1. Incamake ya CJC-1295
CJC-1295, nk'imisemburo ikura ya hormone ikura, ifasha mukugabanya ibiro, kongera imitsi, kuvugurura uruhu, kunoza ibitotsi, no gukira ibikomere. Ipa ni pentapeptide ya syntetique iri murwego rwo gukura imisemburo ikura peptide (secretagogues). Itera irekura imisemburo ikura kandi ikagira ingaruka ku mikorere itandukanye ya physiologique, harimo kwihutisha gusiba gastrica, kunoza ibimenyetso byo guhagarika amara nyuma yo kubagwa, gutera insuline gusohora, no kurwanya ingaruka za catabolike ya glucocorticoide kumitsi ya magufa no kumagufwa. Kwiga ingaruka ziterwa nibi bice byombi bishobora gutera intambwe nshya mubuzima, ubuvuzi bwa siporo, no kuvura indwara.
CJC-1295 Uburyo bwibikorwa
CJC-1295 ikora cyane cyane ingaruka zayo muguhuza imisemburo ikura ya hormone ikura (GHRHR). Yigana imikorere ya hormone ikura-imisemburo irekura (GHRH), bigatuma glande y'imbere ya pitoito irekura imisemburo ikura (GH). Ugereranije na GHRH karemano, CJC-1295 ifite ubuzima burebure bwigice cya kabiri, bigatuma ishobora gukomeza gutera imbaraga imisemburo ikura. Uku gukangura kuramba bifasha kugumana urugero rwimisemburo ikura yumubiri mumubiri, bigira ingaruka kumurongo wimikorere iterwa na hormone yo gukura.
Ingaruka za CJC-1295
Guteza imbere ibinure byamavuta: Gukura imisemburo bigira uruhare runini muburyo bwo guhinduranya ibinure. CJC-1295 itera gusohora imisemburo ikura, ikongera lipolysis mu ngirabuzimafatizo, igabanya ibinure mo aside irike na glycerol. Ibicuruzwa bimeneka birekurwa mumaraso kandi bigakoreshwa nizindi ngingo ningingo nkisoko yingufu, bigatuma kugabanuka no kugabanya amavuta yumubiri.
Kongera imbaraga z'imitsi hamwe na misa: Gukura imisemburo bigira uruhare runini mu mikurire no gusana. CJC-1295 ituma imisemburo ikura ikura, bityo igatera ikwirakwizwa no gutandukanya ingirabuzimafatizo - ingirangingo fatizo mu mitsi ya skeletale igira uruhare runini mu gusana imitsi no gukura. Gukura imisemburo kandi byongera aside amine hamwe na synthesis ya proteyine mugihe bigabanya kugabanuka kwa poroteyine, bityo bigafasha kongera imitsi no kongera imbaraga imitsi.
Kunoza imiterere yuruhu: Gukura imisemburo igira uruhare muburyo bwo guhinduranya uruhu. Nyuma yo gutera imisemburo ikura ya hormone, CJC-1295 iteza imbere ikwirakwizwa rya fibroblast na synthesis ya kolagen. Fibroblast nubwoko bwibanze bwuruhu rushinzwe kubyara kolagen nibindi bikoresho bya matrice idasanzwe. Kwiyongera kwa synthesis ya kolagen itezimbere uruhu rukomeye kandi rukomeye, bigabanya iminkanyari, kandi bigatuma uruhu rugaragara nkumuto.
Guteza imbere gukira ibikomere: Gukura imisemburo bigira uruhare runini mugusana ingirangingo. CJC-1295 yihutisha ikwirakwizwa ry'uturemangingo no kwimuka mu ngingo zangiritse mu guteza imbere imisemburo ikura, ikorohereza angiogenez, itanga intungamubiri nyinshi na ogisijeni ku ngingo zangiritse, kandi yihutisha gusana ibikomere bitandukanye nko gukira ibikomere no gukiza kuvunika.
CJC-1295 Porogaramu
Siporo n'imyitozo ngororamubiri: Abakinnyi n'abakunzi ba fitness bakunze gukoresha CJC-1295 kugirango bongere imyitozo, bongere imbaraga imitsi, bagabanye amavuta yumubiri, kandi bongere imikorere yimikino nibigize umubiri.
Ubwiza no kurwanya gusaza: Bitewe n'ingaruka zabyo zo kuvugurura uruhu, CJC-1295 irashobora gukoreshwa mugutezimbere uruhu rwuruhu, kugabanuka, nibindi bibazo bijyanye no gusaza.
Ubushakashatsi mu buvuzi: Mu bushakashatsi bw’ubuvuzi, CJC-1295 ikora nk'igikoresho cyo kwiga uburyo bwo gukura bw’imisemburo ikura y’imiterere y’imiterere y’imiterere, ifasha abashakashatsi gusobanukirwa neza n’uruhare rw’imisemburo ikura mu mikorere y’imiterere y’imiterere y’imiterere y’umuntu, no gutanga umusingi w’amahame yo guteza imbere uburyo bushya bwo kuvura n’ibiyobyabwenge.
2. Ipa Uburyo bwibikorwa
Kunoza ingufu za Mitochondrial Metabolism
Kongera ibyiyumvo bya ADP: Mugihe cyo gusaza, mitochondrial sensitivite kuri ADP iragabanuka, bikabangamira imikorere ya ATP. Ubushakashatsi bwerekana ko SS-31 ishobora guhuza byimazeyo na ADT itwara mitochondrial ADP, bigatuma ANT ifata ADP, bityo bikongerera imbaraga za mitochondial kuri ADP. Muri mitochondriya yimitsi ishaje, kuvura SS-31 byongereye ADP binyuze muri ANT, bityo byongera ubuhumekero bwa mitochondial biterwa na ADP, kongera umusaruro wa ATP, no kuzamura imbaraga za metabolism mumitsi ya mitochondriya ishaje.
Kugena imiyoboro yubuhumekero ya mitochondrial: Urwego rwubuhumekero rwa Mitochondrial ningingo zingenzi zibyara ingufu za mito-iyambere. Mugihe cyo gusaza, ibikorwa byurwego rwubuhumekero akenshi bigabanuka. SS-31 irashobora gukomeza cyangwa kuzamura ibikorwa byuruhererekane rwubuhumekero muguhindura ubusugire bwimiterere cyangwa kugenzura imvugo za poroteyine zifitanye isano. Ubushakashatsi bwibanze bwerekanye ko muburyo bwo gusaza bujyanye no gusaza biterwa na mitochondrial imikorere idahwitse, ibikorwa byurwego rwubuhumekero bigarurwa nyuma yo kuvurwa kwa SS-31, bikaba byerekana ingaruka nziza zabyo mumikorere yubuhumekero bwa mitochondial.
Igishushanyo 1 Ingaruka za Ipa muburyo bwimbeba ya POI.
Kunoza ibimenyetso byo guhagarika amara nyuma yibikorwa: Muburyo bwimbeba yo guhagarika amara nyuma yo gutangira, Ipa yerekanye ingaruka nziza utitaye ko yatanzwe nkumuti umwe cyangwa inshuro nyinshi. Igipimo kimwe cyagabanije igihe cyo kwiyuhagira bwa mbere, mugihe ubuyobozi bwagiye busubirwamo bwongereye cyane umusaruro mwinshi wa fecal, gufata ibiryo, no kongera ibiro. Ipa itezimbere kugarura imikorere yamara nyuma yibikorwa kandi igabanya ibimenyetso bifitanye isano no guhagarika amara.
Gukangura imisemburo ya insuline: Ipa igira ingaruka runaka ku ngingo zifata pancreatic, itera irekurwa rya insuline mu bice bigize pancreatic tissue mu mbeba zisanzwe na diyabete. Ubushakashatsi bwerekanye ko bamwe mu bahagarika imiyoboro hamwe na antagonist antagonist, nka diltiazem, yohimbine, na propranolol, bashobora kubuza Ipa iterwa na insuline iterwa na insuline, yemeza ko imikorere yayo ifitanye isano niyi nzira.
Igishushanyo cya 2 cyerekana ingaruka za Ipa ku gusohora kwa insuline biva mu bice bya pancreatic tissue ibice byimbeba zisanzwe na diyabete.
Kurwanya ingaruka za catabolike ya glucocorticoide: Muburyo bwimbeba yimbeba ikuze, gufatanya kuyobora glucocorticoide (nka methylprednisolone) na Ipa byongereye cyane tetanic nini ya tetanike yimitsi yinyana ugereranije nubuyobozi bwa glucocorticoid yonyine, kandi bikubye kane igipimo cy amagufwa ya periosteal. Ibi byerekana ko Ipa ishobora kurwanya ingaruka ziterwa na glucocorticoide kumitsi ya skeletale no kumagufa, bityo bikagumana imbaraga zimitsi hamwe nubwinshi bwamagufwa.
Porogaramu Ipa
Kuvura indwara zifata igifu: Ipa igira ingaruka zimwe na zimwe zo kuvura indwara zo mu gifu. Ku bimenyetso nko kutarya no kubyimba biterwa no kutagira gastricike idahagije, hamwe n’ingaruka zo guhagarika amara nyuma yo kubagwa nyuma yo kubagwa mu nda, Ipa irashobora kwigaragaza nkuburyo bushya bwo kuvura.
Ubushakashatsi no kuvura Metabolism: Ipa irashobora gutera insuline kandi ikagira uruhare mubushakashatsi bwa metabolism. Irashobora kuba igikoresho cyo kwiga uburyo bwo gusohora insuline, ifasha abashakashatsi gusobanukirwa neza nuburyo bugenga imisemburo ya insuline. Ku bwoko bumwe na bumwe bw'abarwayi ba metabolism, cyane cyane abafite insuline idahagije hamwe no kutitabira neza imiti isanzwe, Ipa irashobora gutanga uburyo bushya bwo kuvura.
Ubuvuzi bwa siporo no gusubiza mu buzima busanzwe: Mu bijyanye n'ubuvuzi bwa siporo no gusubiza mu buzima busanzwe, ubushobozi bwa Ipa bwo guhangana n'ingaruka za catabolike ya glucocorticoide n'ingaruka nziza ku mitsi n'amagufwa bituma iba umukandida utanga ikizere cyo gusaba. Ku barwayi bahuye n'imitsi atrophyie na osteoporose kubera gukoresha igihe kirekire glucocorticoide mu kuvura indwara, gukoresha Ipa icyarimwe bishobora gufasha kugabanya izo ngaruka no guteza imbere imitsi n'imikorere ya skelete. Kubakinnyi bafite umunaniro wimitsi no gukomeretsa nyuma yimyitozo yimbaraga nyinshi, Ipa irashobora kandi kwihutisha gukira mugutezimbere imitsi no gukura.
3. Gusesengura ingaruka ziterwa na CJC-1295 na Ipa
Gutezimbere guhuza imisemburo ikura
C. Byombi bikora kubyakira bitandukanye ariko amaherezo byongera imisemburo ikura. Iyo CJC-1295 na Ipa bikoreshejwe hamwe, birashobora guhuriza hamwe imbaraga zo gukura imisemburo ya hormone ikura binyuze munzira zitandukanye zerekana ibimenyetso. Isohora imisemburo ikura iterwa na CJC-1295 irashobora kongera ubushobozi bwimikorere ya selile yimbere ya Ipa. Izi ngaruka zishobora gutuma habaho imisemburo ikura cyane ugereranije no gukoresha ibintu byonyine, bityo bikagenga neza imikorere yimiterere ijyanye na hormone yo gukura, nka metabolisme yibinure, imitsi, no gusana uruhu.
Ingaruka zo guhuza imbaraga muguhindura metabolike
Kubijyanye no guhinduranya ibinure, CJC-1295 iteza lipolysis, mugihe Ipa ishobora guhindura imbaraga no gufata neza muguhindura imikorere ya gastrointestinal. Ingaruka zo guhuza byombi zishobora kurushaho kongera ibinure bya metabolism. Ipa yihutisha gusiba gastrica, ituma ibiryo byinjira mu mara mato vuba kugirango byinjire, bishobora kugira ingaruka kumubiri no gukwirakwiza. Ingufu zakozwe na CJC-1295 ziterwa no kugabanuka kwamavuta zirashobora gukoreshwa neza, bigatuma kugabanuka cyane no kugabanya amavuta yumubiri.
Ku bijyanye na glucose metabolism, CJC-1295 itera imisemburo ikura irashobora kugira mu buryo butaziguye ibyiyumvo bya insuline, mu gihe Ipa ishobora kubyutsa insuline. Ingaruka yo guhuza byombi irashobora gutanga ingaruka zuzuye zo kugenzura glucose metabolism. Mu ngero z’inyamaswa za diyabete, gukoresha hamwe CJC-1295 na Ipa birashobora kugabanya urugero rwa glucose yamaraso mu gutera imisemburo ya insuline binyuze muri Ipa, kandi bikanatezimbere insuline ikoresheje CJC-1295, bikarushaho kunoza amategeko ya glucose yamaraso kugirango bikomeze kurwego ruhamye.
Igicapo 3 Erekana ingaruka za cholinergique, adrenergic, na calcium ya antagonistes kuri ipamorelin (IPA) -yatewe na insuline irekura pancreas yimbeba zisanzwe na diyabete.
Ingaruka zo guhuza imitsi n'amagufwa
Ku bijyanye n'imitsi, CJC-1295 iteza imbere ikwirakwizwa ry'utugingo ngengabuzima, gutandukanya, hamwe na poroteyine, mu gihe Ipa irwanya ingaruka ziterwa na glucocorticoide kandi ishobora guteza imbere imitsi. Iyo ikoreshejwe hamwe, irashobora kugira ingaruka zo gukura mumikurire no gusana. Mugihe cyo gusana imitsi, CJC-1295 yihutisha imikorere ya selile nogukwirakwiza, itanga amasoko menshi ya selile yo gusana imitsi, mugihe Ipa yongerera umuvuduko wamaraso hamwe nintungamubiri kandi ikarwanya ibintu bishobora gutera catabolika, bigatuma habaho uburyo bwiza bwo gusana imitsi, bityo bikarushaho gutera imbere gusana imitsi no kwiyongera kwimitsi.
Ingaruka zo guhuza imbaraga mu gusana no kuvugurura
Mugihe cyo gukira ibikomere, CJC-1295 ituma imisemburo ikura ikura, ikihutisha ikwirakwizwa ry ingirabuzimafatizo, kandi igatera angiogenez, mugihe Ipa ishobora koroshya gusana ingirabuzimafatizo igenga ibidukikije byaho ndetse no kongera intungamubiri. Mugihe cyo gukira ibikomere, CJC-1295 irashobora gukangura fibroblast kugirango ihindure kolagene byihuse, mugihe Ipa ishobora kugenga umuvuduko wamaraso ukikije igikomere, igatanga intungamubiri nyinshi na ogisijeni yo gukira ibikomere. Ingaruka zifatika zombi zishobora kwihutisha inzira yo gukira ibikomere no kunoza ireme ryo gukira.
Ku bijyanye no gusana ingirabuzimafatizo, imisemburo ikura igira uruhare mu mikurire, kubaho, no gutandukanya ingirabuzimafatizo, mu gihe Ipa ishobora kugira uruhare mu gusana imitsi mu kugenzura imiyoboro ya neurotransmitter no guteza imbere ibidukikije byaho.
Ahantu hashobora gukoreshwa kugirango habeho ingaruka
Ubuvuzi bwa siporo hamwe nubuzima bwiza
Ku bakinnyi n’abakunzi ba fitness, ingaruka ziterwa na CJC-1295 na Ipa zirashobora gutuma habaho iterambere ryinshi mubikorwa byimikino ngororamubiri no mubigize umubiri. Gutezimbere kwiterambere ryimitsi hamwe no guhinduranya ibinure birashobora gufasha abakinyi kongera imbaraga zimitsi hamwe na misa mugihe bigabanya neza amavuta yumubiri, bityo bikongerera kwihanganira siporo nimbaraga ziturika. Kubijyanye no gukira imvune za siporo, ingaruka zazo zishobora kwihutisha gusana imitsi, amagufwa, hamwe nuduce tworoheje, bigabanya igihe cyo gukira kwabakinnyi kandi bikabafasha gusubira mumyitozo no mumarushanwa byihuse.
Ubwiza no Kurwanya Gusaza
Mu bwiza no kurwanya gusaza, ingaruka ziterwa na CJC-1295 na Ipa zirashobora gutanga uburyo bushya bwo kuvugurura uruhu no kunoza imikorere yumubiri muri rusange. Byombi biteza imbere synthesis ya kolagen hamwe na metabolism y'uruhu hamwe, bigahindura cyane ubworoherane bwuruhu, gukomera, hamwe numucyo ugereranije no gukoresha wenyine, mugihe bigabanya iminkanyari hamwe nu mwanya wimyaka. Ingaruka zazo zo guhuza umubiri no gusana umubiri nabyo bifasha kubungabunga ubuzima muri rusange, kugabanya umuvuduko wo gusaza bivuye imbere no kuzamura isura n'imikorere ya physiologiya.
Umwanya wo Kuvura
Indwara zifungura igifu: Ku ndwara zimwe na zimwe zifata igogora, nko kubura gastrointestinal motifique idakira no guhagarika amara nyuma yo gutangira, ingaruka ziterwa na CJC-1295 na Ipa zishobora gutanga ingamba nshya zo kuvura. Bahuza hamwe imikorere ya gastrointestinal, kwihutisha gusohora gastric, no kunoza amara, birashoboka cyane kugabanya ibimenyetso bifitanye isano no guteza imbere abarwayi. Ku barwayi bafite imirire mibi no gutakaza ibiro biterwa n'indwara zifata igogora, kugenzura imikoreshereze ya metabolike ya miti yombi birashobora gufasha abarwayi kugarura neza imirire yabo nuburemere.
Indwara za Endocrine na Metabolic: Mu kuvura indwara za endocrine na metabolike nka metabolism n'umubyibuho ukabije, ingaruka ziterwa na CJC-1295 na Ipa zishobora kugira agaciro gashoboka. Ingaruka zoguhuza imbaraga kuri glucose metabolism na lipid metabolism itanga intego nshya nuburyo bwo kuvura izo ndwara. Muguhuza imikoreshereze yabyo, glucose yamaraso irashobora kugenzurwa neza, kurwanya insuline bikarushaho kwiyongera, hamwe namavuta yumubiri bikagabanuka, bityo bigatanga ubuvuzi bwuzuye bwindwara za endocrine na metabolike.
Indwara ya musculoskeletal: Kubintu nka atrophy yimitsi na osteoporose, ingaruka ziterwa na CJC-1295 na Ipa zishobora gufasha guteza imbere imitsi no gukura kw'amagufwa, bityo bikazamura imbaraga z'imitsi y'abarwayi ndetse n'ubwiza bw'amagufwa. Ku barwayi bafite imitsi iterwa no kuruhuka igihe kirekire cyangwa uburwayi, gukoresha hamwe ibyo bintu byombi bishobora kwihutisha gukira kwimitsi no gukura, bityo bikazamura imibereho yabarwayi. Ku barwayi barwaye osteoporose, ingaruka zazo zishobora kongera ubwinshi bwamagufwa kandi bikarinda ingorane nko kuvunika.
Umwanzuro
CJC-1295 na Ipa bifatanyiriza hamwe gusohora imisemburo ikura binyuze mu nzira zitandukanye, byerekana ingaruka zuzuzanya mu bice nko kugenzura metabolike (kwihutisha lipolysis, guhindura glucose metabolism), gusana ingirabuzimafatizo (kwihutisha gukira, kuvugurura imitsi), no gufata neza imitsi (kurwanya anti-catabolika, guteza imbere poroteyine).
Inkomoko
1 Gukoresha Ibiyobyabwenge & Gukoresha nabi, 2016,51 (1): 73-84.DOI: 10.3109 / 10826084.2015.1082595.
[2] Papak M. Ipa - struktura i funkcija, 2016 [C]. https://api.semanticscholar.org/CorpusID:78470780.
[3] Greenwood-Van MB, Tyler K, Mohammadi E, n'abandi. Ingaruka za ipamorelin, yigana ghrelin, kuri dysmotility ya gastricike muburyo bwimbeba ya ileus nyuma yo kubagwa [J]. J Exp Pharmacol, 2012,4: 149-155.DOI: 10.2147 / JEP.S35396.
[4] Adeghate E, Ponery AS, Emirates U A. ORIGINALARTICLE Uburyo bwa ipamorelin yatewe na insuline yatewe na pancreas yimbeba zisanzwe na diyabete, 2004 [C].
[5] Adeghate EA, Ponery A S. Uburyo bwa ipamorelin yatewe na insuline irekurwa na pancreas yimbeba zisanzwe na diyabete. [J] Amabaruwa ya Neuro Endocrinology, 2004,25 6: 403-406. https://api.semanticscholar.org/CorpusID:7118136.
[6] Andersen NB, Malmlöf K, Johansen PB, n'abandi. Gukura imisemburo ya secretagogue ipamorelin irwanya glucocorticoid iterwa no kugabanuka kw'amagufwa y'imbeba zikuze [J]. Gukura Hormone & Igf Ubushakashatsi, 2001,11 (5): 266-272.DOI: 10.1054 / ghir.2001.0239.
Ibicuruzwa biboneka mubushakashatsi bukoreshwa gusa:
