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Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.
Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadobeghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.
1. Nchịkọta nke CJC-1295
CJC-1295, dị ka analọg nke uto homonụ sịntetik, na-enyere aka n'ibelata ibu, nkwalite ahụ ike, mmeghari anụ ahụ, mmelite ụra, na ọgwụgwọ ọnya. Ipa bụ pentapeptide sịntetik nke nọ na klas nke peptides na-ewepụta homonụ na-eto eto (ndị nzuzo). Ọ na-akpali mwepụta nke homonụ na-eto eto ma na-emetụta usoro ahụike dị iche iche, gụnyere ime ngwa ngwa imeju afọ, na-eme ka mgbaàmà mgbochi eriri afọ na-aga n'ihu, na-akpali mmepụta insulin, na igbochi mmetụta catabolic nke glucocorticoids na akwara na ọkpụkpụ. Ịmụ mmetụta synergistic nke ogige abụọ a nwere ike iduga ọganihu ọhụrụ na ahụike, ọgwụ egwuregwu, na ọgwụgwọ ọrịa ndị metụtara ya.
Usoro ihe omume CJC-1295
CJC-1295 na-arụ ọrụ nke ọma site na mmekọrịta ya na onye na-anabata homonụ na-ewepụta homonụ na-eto eto (GHRHR). Ọ na-eṅomi ọrụ nke hormone na-ewepụta homonụ na-eto eto (GHRH), na-eme ka ụbụrụ pituitary nke dị n'ihu na-ahapụ hormone na-eto eto (GH). E jiri ya tụnyere GHRH eke, CJC-1295 nwere ogologo ndụ ọkara, na-enyere ya aka ịkwalite mmepụta homonụ nke uto. Ihe mkpali a na-adịgide adịgide na-enyere aka ịnọgide na-enwe ọkwa hormone uto kwụsiri ike na ahụ, na-emetụta usoro usoro ọmụmụ physiological dabere na hormone uto.
Mmetụta CJC-1295
Na-akwalite metabolism abụba: hormone na-eto eto na-ekere òkè dị mkpa na metabolism abụba. CJC-1295 na-akpali ntọhapụ nke hormone na-eto eto, na-eme ka lipolysis dị n'ime sel abụba, nke na-agbaji abụba n'ime acid fatty na glycerol. A na-ahapụ ngwaahịa mmebi ndị a n'ime ọbara ma anụ ahụ na akụkụ ahụ ndị ọzọ na-eji ya eme ihe dị ka isi iyi ike, na-eduga n'ịdị arọ na mbelata abụba anụ ahụ.
Na-eme ka ike na oke akwara dịkwuo elu: hormone na-eto eto na-emetụta oke uru ahụ na nrụzi. CJC-1295 na-akwalite mmepụta nke hormone nke na-eto eto, si otú ahụ na-akpali mgbasawanye na ọdịiche nke sel satịlaịtị - sel sel na akwara skeletal nke na-arụ ọrụ dị oke mkpa na nrụzi na uto. Hormone uto na-abawanye nnabata amino acid na njikọ protein ebe ọ na-ebelata ndakpọ protein, si otú a na-enyere aka ịbawanye uru ahụ ma melite ike akwara.
Ime ka ọnọdụ akpụkpọ ahụ dịkwuo mma: hormone na-eto eto na-ekere òkè n'ime usoro metabolism anụ ahụ. Mgbe ihe na-akpali akpali hormone secretion, CJC-1295 na-akwalite mgbasa nke fibroblasts na collagen njikọ. Fibroblasts bụ ụdị sel bụ isi na akpụkpọ ahụ maka imepụta collagen na ihe ndị ọzọ matrix extracellular. Mmụba nke njikọ collagen na-eme ka akpụkpọ ahụ dịkwuo mma na nkwụsi ike, na-ebelata nhazi nke wrinkle, na-eme ka akpụkpọ ahụ dị obere.
Na-akwalite ọgwụgwọ ọnya: hormone na-eto eto na-ekere òkè na-arụsi ọrụ ike na nrụzi anụ ahụ. CJC-1295 na-eme ka mmụba cell na ịkwaga n'ime anụ ahụ mebiri emebi site n'ịkwalite ntọhapụ nke hormone na-eto eto, na-eme ka angiogenesis dịkwuo mma, na-enyekwu ihe oriri na oxygen na anụ ahụ mebiri emebi, ma na-eme ka mmezi nke mmerụ dị iche iche dị ka ọgwụgwọ ọnyá na mgbawa.
Ngwa CJC-1295
Egwuregwu na ahụike: Ndị na-eme egwuregwu na ndị na-anụ ọkụ n'obi na-ejikarị CJC-1295 kwalite ọzụzụ, mee ka ike anụ ahụ dịkwuo elu, belata abụba anụ ahụ, ma melite arụmọrụ egwuregwu na nhazi ahụ.
Mma na mgbochi ịka nká: N'ihi mmetụta na-eme ka akpụkpọ ahụ dịkwuo mma, CJC-1295 nwere ike iji mee ka akpụkpọ anụ ahụ dịkwuo mma, sagging, na nsogbu ndị ọzọ metụtara ịka nká.
Ubi nyocha ahụike: N'ime nyocha ahụike, CJC-1295 na-eje ozi dị ka ngwá ọrụ iji mụọ usoro ọmụmụ physiological metụtara uto homonụ, na-enyere ndị na-eme nchọpụta aka ịghọta nke ọma ọrụ homonụ na-eto eto na usoro physiological na pathological mmadụ, na-enye ntọala usoro iwu maka ịmepụta ụzọ ọgwụgwọ ọhụrụ na ọgwụ.
2. Ipa Mechanism of Action
Na-emeziwanye Mitochondrial Energy Metabolism
Ịkwalite Mmetụta ADP: N'oge ịka nká, mitochondrial sensitivity na ADP na-ebelata, na-emebi arụmọrụ ATP. Nnyocha na-egosi na SS-31 nwere ike ijikọ ozugbo na mitochondrial ADP transporter ANT, na-abawanye nnabata ANT nke ADP, si otú ahụ na-eme ka mmetụta mitochondrial na ADP dịkwuo elu. Na mitochondria muscle merela agadi, ọgwụgwọ SS-31 mụbara nnabata ADP site na ANT, si otú ahụ na-eme ka iku ume mitochondrial dị n'okpuru mkpali ADP, na-amụba mmepụta ATP, na imeziwanye ike metabolism na muscle mitochondria agadi.
Iwu nke ogige iku ume mitochondrial: ogige mitochondrial iku ume bụ akụkụ dị mkpa nke mmepụta ike mitochondrial. N'oge ịka nká, ọrụ nke ogige iku ume na-ebelatakarị. SS-31 nwere ike idowe ma ọ bụ welie ọrụ nke ogige ndị na-eku ume iku ume site n'ịkwado iguzosi ike n'ezi ihe nhazi ha ma ọ bụ na-achịkwa okwu nke protein ndị metụtara ya. Nnyocha ndị gara aga achọpụtala na n'ụdị mitochondrial dysfunction nke ịka nká, a na-eweghachi ọrụ nke mgbagwoju anya iku ume mgbe ọgwụgwọ SS-31 gasịrị, na-atụ aro mmetụta ya dị mma na usoro iku ume mitochondrial.
Ọgụgụ 1 Mmetụta Ipa na ụdị oke nke POI.
Ịkwalite mgbaàmà nkwụsị nke eriri afọ mgbe ị na-arụ ọrụ: N'ụdị oke nke nkwụsị nke eriri afọ na-esote, Ipa gosipụtara mmetụta dị mma n'agbanyeghị ma a na-enye ya dị ka otu dose ma ọ bụ ugboro ugboro. Otu dose na-ebelata oge ịsa afọ nke mbụ, ebe nchịkwa ugboro ugboro na-abawanye ụbara nchikota fecal, oriri oriri, na ibu ibu. Ipa na-eme ka mgbake nke ọrụ eriri afọ na-aga n'ihu ma na-ebelata mgbaàmà ndị metụtara mgbochi eriri afọ.
Nkwalite nke nzuzo insulin: Ipa nwere mmetụta ụfọdụ na anụ ahụ pancreatic, na-akpali ntọhapụ nke insulin site na iberibe anụ ahụ pancreatic na oke nkịtị na nke ọrịa shuga. Nnyocha achọpụtala na ụfọdụ ndị na-egbochi ọwa na ndị na-anabata ndị na-anabata ya, dị ka diltiazem, yohimbine, na propranolol, nwere ike igbochi mmepụta insulin nke Ipa, na-akwado na usoro ya na-emetụta ọwa na ndị na-anabata ya.
Onyonyo 2 Na-egosi mmetụta Ipa na mmepụta insulin site na mpekere anụ ahụ pancreatic nke oke nkịtị na ọrịa shuga.
Na-emegide mmetụta catabolic nke glucocorticoids: N'ụdị oke oke, njikwa nke glucocorticoids (dị ka methylprednisolone) na Ipa budata mụbara oke tetanic nke akwara nwa ehi ma e jiri ya tụnyere nchịkwa glucocorticoid naanị, ma mee okpukpu anọ nke nhazi ọkpụkpụ periosteal. Nke a na-egosi na Ipa nwere ike igbochi mmetụta catabolic nke glucocorticoids na anụ ahụ na ọkpụkpụ skeletal, si otú ahụ na-ejigide ike ike na ọkpụkpụ ọkpụkpụ.
Ngwa Ipa
Ọgwụgwọ ọrịa nke usoro nri digestive: Ipa nwere ụfọdụ mmetụta ọgwụgwọ na ọgwụgwọ ọrịa nke usoro nri nri. Maka mgbaàmà ndị dị ka mgbakasị ahụ na bloating kpatara site na ezughị ezu motility gastric, yana nsogbu nkwụsị nke eriri afọ na-esote na-esote ịwa ahụ abdominal, Ipa nwere ike ịpụta dị ka nhọrọ ọgwụgwọ ọhụrụ.
Nnyocha na ọgwụgwọ metabolism: Ipa nwere ike kpalie insulin secretion ma nwee òkè na nyocha nke metabolism. Ọ nwere ike ịbụ ngwá ọrụ iji mụọ usoro nzuzo insulin, na-enyere ndị na-eme nchọpụta aka ịghọtakwu usoro nhazi nke mmepụta insulin. Maka ụfọdụ ụdị ndị ọrịa metabolism, ọkachasị ndị na-enweta insulin na-ezughị ezu na nzaghachi adịghị mma maka ọgwụgwọ ndị dị adị, Ipa nwere ike ịnye nhọrọ ọgwụgwọ ọhụrụ.
Nkà mmụta ọgwụ na mmezigharị egwuregwu: N'ihe gbasara nkà mmụta ọgwụ egwuregwu na nhazigharị, ike Ipa na-egbochi mmetụta catabolic nke glucocorticoids na mmetụta dị mma na ahụ ike na anụ ahụ na ọkpụkpụ na-eme ka ọ bụrụ onye na-ekwe nkwa maka ngwa ngwa. Maka ndị ọrịa nwere ahụmahụ atrophy muscle na osteoporosis n'ihi iji glucocorticoids ogologo oge maka ọgwụgwọ ọrịa, iji Ipa Ipa mee ihe n'otu oge nwere ike inye aka belata mmetụta ndị a ma kwalite mgbake nke anụ ahụ na skeletal. Maka ndị na-eme egwuregwu na-enwe ike ọgwụgwụ na mmerụ ahụ mgbe ọzụzụ ọzụzụ dị elu, Ipa nwekwara ike mee ka mgbake dị ngwa site n'ịkwalite nrụzi ahụ na uto.
3. Nyocha nke mmetụta synergistic nke CJC-1295 na Ipa
Synergistic nkwalite nke ibu hormone secretion
CJC-1295 na-akpali mmepụta nke hormone na-eto eto site na ijikọ na GHRHR ma na-eṅomi ọrụ nke GHRH, ebe Ipa na-akwalite ntọhapụ nke hormone na-eto eto site na pituitary gland site na-eme ka ndị na-anabata ghrelin rụọ ọrụ. Ha abụọ na-eme ihe na ndị na-anabata ya dị iche iche mana n'ikpeazụ na-abawanye mmepụta nke hormone uto. Mgbe CJC-1295 na Ipa na-eji ọnụ, ha nwere ike synergistically na-akpali uto hormone secretion site dị iche iche mgbaàmà ụzọ. Mwepụta hormone nke uto nke CJC-1295 kpatara nwere ike ime ka uche nke sel pituitary dị n'ihu na Ipa. Nke a synergistic mmetụta nwere ike ime ka budata elu etoju nke ibu hormone secretion tụnyere iji ma umi naanị, si otú ọzọ irè na-achịkwa physiological Filiks metụtara ibu hormone, dị ka abụba metabolism, muscle ibu, na akpụkpọ mmezi.
Mmetụta synergistic na usoro metabolic
N'ihe gbasara abụba metabolism, CJC-1295 na-akwalite lipolysis, ebe Ipa nwere ike imetụta oriri ume na absorption site n'ịhazi ọrụ eriri afọ. The synergistic mmetụta nke abụọ nwere ike n'ihu welie abụba metabolism pụta. Ipa na-eme ka mkpofu gastric dị ngwa ngwa, na-enye ohere ka nri na-abanye n'ime eriri afọ ngwa ngwa maka ịmịnye, nke nwere ike imetụta oriri na nkesa nke anụ ahụ. Enwere ike iji ike nke CJC-1295 butere mmebi abụba na-emepụta nke ọma, na-eduga na mbelata ịdị arọ dị irè karị na mbelata abụba anụ ahụ.
N'ihe gbasara glucose metabolism, mkpali nke CJC-1295 nke homonụ na-eto eto nwere ike imetụta mmetụta insulin n'ụzọ na-edoghị anya, ebe Ipa nwere ike kpalite insulin secretion ozugbo. Mmetụta synergistic nke abụọ nwere ike inye mmetụta nchịkwa zuru oke na metabolism glucose. N'ụdị anụmanụ na-arịa ọrịa shuga, ijikọ CJC-1295 na Ipa nwere ike belata ọkwa glucose ọbara site n'ịkwalite insulin secretion site na Ipa, ma kwalite mmetụta insulin site na CJC-1295, na-eme ka usoro glucose ọbara dịkwuo mma iji nọgide na-enwe ya n'ogo siri ike.
Ọgụgụ 3 Na-egosi mmetụta nke cholinergic, adrenergic, na calcium channel antagonists na ipamorelin (IPA) -wepụtara insulin ntọhapụ site na pancreas nke oke nkịtị na ọrịa shuga.
Mmetụta synergistic na akwara na ọkpụkpụ
N'ihe gbasara akwara, CJC-1295 na-akwalite mgbasa ozi nke satịlaịtị, ọdịiche, na njikọ protein, ebe Ipa na-emegide mmetụta catabolic nke glucocorticoids ma nwee ike ịkwalite nrụzi ahụ. Mgbe ejiri ya na ngwakọta, ha nwere ike inwe mmetụta synergistic na uto na nrụzi ahụ. N'oge mmezi mmerụ ahụ ahụ, CJC-1295 na-eme ka ọrụ satịlaịtị na-arụ ọrụ na mgbasawanye, na-enye ọtụtụ isi mmalite cellular maka ịrụzi anụ ahụ, ebe Ipa na-eme ka mgbasa ọbara na-edozi ahụ na ihe oriri na-edozi ahụ ma na-egbochi ihe ndị nwere ike ime ka catabolic na-eme ka ọ dịkwuo mma, na-emepụta ebe dị mma maka nrụzi anụ ahụ, si otú ahụ na-akwalite n'ụzọ dị irè n'ịkwalite nrụzi mmerụ ahụ na mmụba muscle.
Mmetụta synergistic na nrụzi anụ ahụ na ịmaliteghachi
N'oge usoro ọgwụgwọ ọnya, CJC-1295 na-akwalite mwepụta nke hormone na-eto eto, na-eme ka mmụba cell dịkwuo elu, ma na-akpali angiogenesis, ebe Ipa nwere ike ịkwado nrụzi anụ ahụ site n'ịchịkwa microenvironment mpaghara na ịkwalite ihe oriri na-edozi ahụ. N'oge ọgwụgwọ ọnya, CJC-1295 nwere ike ime ka fibroblasts na-emepụta collagen ngwa ngwa, ebe Ipa nwere ike ịhazigharị ọbara na gburugburu ọnya ahụ, na-enyekwu nri na oxygen maka ọgwụgwọ ọnya. Mmetụta synergistic nke abụọ nwere ike ime ka usoro ọgwụgwọ ọnya dịkwuo ngwa ma melite ogo ọgwụgwọ.
N'ihe banyere nrụzi anụ ahụ akwara, hormone na-eto eto na-ekere òkè na uto, nlanarị, na ọdịiche nke mkpụrụ ndụ akwara, ebe Ipa nwere ike imetụta nrụzi akwara site na ịhazi neurotransmitters na imeziwanye microenvironment mpaghara.
Mpaghara nwere ike itinye maka mmetụta synergistic
Ọgwụ egwuregwu na ahụike
Maka ndị na-eme egwuregwu na ndị na-anụ ọkụ n'obi na-enwe ahụ ike, mmetụta synergistic nke CJC-1295 na Ipa nwere ike ime ka ọganihu dị ịrịba ama na arụmọrụ egwuregwu na nhazi ahụ. Ha synergistic nkwalite nke muscle ibu na abụba metabolism nwere ike inyere ndị na-eme egwuregwu na-amụba muscle ike na uka mgbe ọzọ n'ụzọ dị irè mbenata ahu abụba, si otú eme egwuregwu ntachi obi na mgbawa ike. N'ihe gbasara mgbake mmerụ egwuregwu, mmetụta synergistic ha nwere ike ime ka mmezi nke akwara, ọkpụkpụ, na anụ ahụ dị nro, na-ebelata oge mgbake ndị na-eme egwuregwu ma na-enyere ha aka ịlaghachi na ọzụzụ na asọmpi ngwa ngwa.
Mma na mgbochi ịka nká
N'ebe mara mma na mgbochi ịka nká, mmetụta synergistic nke CJC-1295 na Ipa nwere ike inye nhọrọ ọhụrụ maka ịmegharị anụ ahụ na nkwalite ọrụ ahụ dum. Ha abụọ na-akwalite njikọ nke collagen na cell cell metabolism synergistically, budata imeziwanye akpụkpọ anụ, nkwụsi ike, na radiance ma e jiri ya tụnyere iji naanị ya, ebe ọ na-ebelata nhazi nke wrinkles na ntụpọ afọ. Mmetụta mmekọrịta ha na metabolism na anụ ahụ na-edozi ahụ na-enyekwa aka ịnọgide na-enwe ahụike zuru oke, na-ebelata usoro ịka nká site n'ime ma na-eme ka ọdịdị ahụ na ọrụ physiological dịkwuo elu.
Ubi Ọgwụ Ọgwụ
Ọrịa Sistemụ Digestive: Maka ụfọdụ ọrịa sistemu nri nri, dị ka ụkọ motility nke eriri afọ na-adịghị ala ala na mgbochi intestinal postoperative, mmetụta synergistic nke CJC-1295 na Ipa nwere ike inye usoro ọgwụgwọ ọhụrụ. Ha na-ahazi ọrụ afọ ntachi obi, na-eme ka mkpofu afọ dị ngwa ngwa, ma melite motility eriri afọ, nwere ike ibelata mgbaàmà ndị metụtara ya nke ọma na ịkwalite mgbake onye ọrịa. N'ihi na ndị ọrịa nwere erighị ihe na-edozi ahụ na arọ ọnwụ kpatara digestive usoro ọrịa, na synergistic metabolic ụkpụrụ nke ndị a abụọ mmadụ nwere ike inyere ndị ọrịa mma iweghachi ha nutritional ọnọdụ na ibu ibu.
Ọrịa Endocrine na Metabolic: Na ọgwụgwọ nke ọrịa endocrine na ọrịa metabolic dị ka metabolism na oke ibu, mmetụta synergistic nke CJC-1295 na Ipa nwere ike ijide uru. Mmetụta ha na-achịkwa mmekọrịta ha na glucose metabolism na lipid metabolism na-enye ebumnuche na ụzọ ọhụrụ maka ọgwụgwọ ọrịa ndị a. Site na ijikọta ojiji ha, enwere ike ịchịkwa ọkwa glucose ọbara n'ụzọ dị irè karị, na-eme ka nguzogide insulin dịkwuo mma, na-ebelata abụba anụ ahụ, si otú a na-enye ọgwụgwọ zuru oke maka ọrịa endocrine na ọrịa metabolic.
Ọrịa Musculoskeletal: Maka ọnọdụ ndị dị ka atrophy muscle na osteoporosis, mmetụta synergistic nke CJC-1295 na Ipa nwere ike inye aka kwalite ọganihu ahụ ike na ọkpụkpụ ọkpụkpụ, si otú ahụ na-eme ka ike nke ndị ọrịa na ọkpụkpụ dị mma. N'ime ndị ọrịa nwere atrophy akwara nke kpatara ezumike ụra ogologo oge ma ọ bụ ọrịa kpatara, ijikọ ihe abụọ a eme ihe nwere ike ime ka mgbake na uto akwara dịkwuo elu, si otú ahụ na-eme ka ndụ ndị ọrịa dịkwuo mma. Na ndị ọrịa nwere osteoporosis, mmetụta synergistic ha nwere ike ime ka ọkpụkpụ ọkpụkpụ dịkwuo elu ma gbochie nsogbu ndị dị ka mgbaji.
Mmechi
CJC-1295 na Ipa synergistically na-akwalite uto hormone secretion site dị iche iche ụzọ ụzọ, na-egosi mmeju synergistic mmetụta na mpaghara dị ka metabolic ụkpụrụ (accelerating lipolysis, optimizing glucose metabolism), anụ ahụ mmezi (accelerating ọgwụgwọ, muscle regeneration), na musculoskeletal mmezi (mgbochi-catabolic mmetụta, na-akwalite protein).
Isi mmalite
[1] Van Hout MC, Hearne E. Netnography nke ụmụ nwanyị iji Hormone Growth Synthetic CJC-1295: Pulses and Potions[J]. Ihe eji eme ihe & eji eme ihe, 2016,51(1):73-84.DOI:10.3109/10826084.2015.1082595.
[2] Papak M. Ipa - struktura i funkcija, 2016[C]. https://api.semanticcholar.org/CorpusID:78470780.
[3] Greenwood-Van MB, Tyler K, Mohammadi E, et al. Ịdị irè nke ipamorelin, mimetic ghrelin, na dysmotility gastric na ụdị òké nke postoperative ileus[J]. J Exp Pharmacol, 2012,4:149-155.DOI:10.2147/JEP.S35396.
[4] Adeghate E.
[5] Adeghate EA, Ponery A S. Mechanism nke ntọhapụ insulin nke ipamorelin sitere na pancreas nke oke nkịtị na ọrịa shuga.[J]. Akwụkwọ ozi Neuro Endocrinology, 2004,25 6:403-406. https://api.semanticcholar.org/CorpusID:7118136.
[6] Andersen NB, Malmlöf K, Johansen PB, et al. The hormone uto secretagogue ipamorelin na-emegide mbelata nke glucocorticoid na-akpata mbelata ọkpụkpụ nke oke oke [J]. Hormone uto & nyocha Igf, 2001,11 (5): 266-272.DOI: 10.1054/ghir.2001.0239.
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