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▎ NAD + Jatebɔ
Sɔrɔyɔrɔ: PubChem |
Tɛmɛsira: N/A Formula molekilɛri: C 21H 27N 7O 14P2 Molecules girinya: 663,4 g/mol CAS nimɔrɔ: 53-84-9 PubChem CID: 5892 ye Kɔrɔɲɔgɔnmaw: nadide;coenzyme I;beta-NAD;Codehydrogenase I |
▎ NAD + Sɛgɛsɛgɛli
NAD+ ye mun ye?
NAD+ (Nicotinamide Adenine Dinucleotide) ye coenzyme nafamaba ye min bɛ sɔrɔ kosɛbɛ fɛnɲɛnama ɲɛnamaw la. A bɛ sɔrɔ adenosini ribonuklɛtidi ni nikotinamidi ribonuklɛtidi ka jɛɲɔgɔnya fɛ fositɛri kulu dɔ fɛ. I n’a fɔ coenzyme koloma min bɛ redox reactions la, NAD+ jɔyɔrɔ ka bon selilɛriw ka farikoloɲɛnajɛ la. A bɛ se ka fɛn caman tigɛli kɛ oksidan cogoya (NAD+) ni cogoya dɔgɔyalen (NADH) cɛ, ka a sen don fanga sɛnɛcogo la i n’a fɔ glycolyse, acid citric cycle, ani oxidative phosphorylation, o bɛ seliluw dɛmɛ ka dumuni caman wuli ka kɛ fanga ye (ATP). Ka fara o kan, NAD+ bɛ kɛ cofactor wajibiyalen ye anzimu suguya caman na (i n’a fɔ PARP ani Sirtuins), a bɛ a sen don walew la minnu ɲɛsinnen bɛ ADN dilancogo ma, selilɛri taamasiɲɛw, ani kɔrɔya kɛlɛli.
NAD+ ka ɲininiw kɛcogo ye mun ye?
Cofacteur essentiel dans les réactions multiples:
NAD+ ye cofactor nafama ye redox reactions caman na (Shats I, 2020). Kɔnɔnatumuw kɔnɔ, a sen bɛ selilɛriw ka baara caman na i n’a fɔ fanga sɛnɛcogo, jamu sabatili, ani farikolo tangacogo. Misali la, fanga sɛnɛcogo la, NAD+ bɛ kɛ i n’a fɔ ɛlektrɔniki tabaga ye walew la i n’a fɔ glycolyse ani tricarboxylic acid cycle, a bɛ a sen don redox reactions (redox reactions) la walasa ka kemikali fanga caman tigɛli kɛ balofɛnw na i n’a fɔ glucose ka kɛ fanga suguya ye min bɛ se ka baara kɛ ni seliluw ye.
Jɛɲɔgɔnya ni Enzyme caman ye:
NAD+ fana bɛ baara kɛ ni anzimu caman ye, i n’a fɔ ADN dilan anzimu poli-(adenosine diphosphate-ribose) polymerase (PARP), proteine deacylase SIRTUINS, ani ADP ribose enzyme cyclique CD38. O anzimu ninnu bɛ selilɛriw ka baarakɛcogo ɲɛnabɔ, i n’a fɔ ADN dilancogo, jeninida jiracogo, ani selilɛriw ka sɛrɛkiliw labɛnni, u kɛtɔ ka NAD+ dun.
NAD+ ka baarakɛcogo ye mun ye?
I n’a fɔ Coenzyme min bɛ Redox Reactions (Redox Reactions) la
Cellular Redox Homeostasis marali:
A ka c'a la, 'NAD' bɛ tali kɛ nikotinamidi adenini dinukiliyɔtidi ka kemikaliya kɔkolo la, k'a sɔrɔ 'NAD+' ani 'NADH' bɛ tali kɛ a cogoya oksidan ni dɔgɔyalen na, u kelen-kelen bɛɛ. NAD+ jɔyɔrɔ ka bon biyokimiki taabolo caman kɔlɔsili la, wa NAD+/NADH hakɛ nafa ka bon kosɛbɛ walasa ka selilu redox homeostasis mara [1] . Redox balansi min bɛ selilu kɔnɔ, o nafa ka bon selilɛriw ka baara kɛcogo ɲumanw na, i n’a fɔ fanga sɛnɛcogo, farikolo tangacogo, a ɲɔgɔnnaw NAD+ bɛ kɛ i n’a fɔ ɛlektrɔniki minɛbaga walima a dibaga redox walew la, a bɛ a sen don selilu kɔnɔ fanga sɔrɔli taabolo la, i n’a fɔ asidi trikarboksiliki sɛrɛkili ani oksidan fosforilasi.
Fanga sɛnɛcogo ɲɛnabɔli:
NAD+ sen bɛ fanga sɛnɛcogo jɔnjɔn caman na. Misali la, glycolyse ni asidi tricarboxylic cycle kɔnɔ, NAD+ bɛ sɔn idɔrɔzi atomuw ma, wa a bɛ wuli ka kɛ NADH ye. O kɔfɛ, NADH bɛ ɛlektrɔnikiw bila oksizɛni na ɛlektrɔnikiw tacogo cakɛda fɛ min bɛ mitokondriyaw kɔnɔna na walasa ka ATP dilan. O fanga sɛnɛcogo in labɛnni nafa ka bon farikolokisɛw ka ɲɛnamaya n’u ka baara la, kɛrɛnkɛrɛnnenya la farikolo yɔrɔw la fanga ɲinini ka ca minnu na i n’a fɔ dusukun ni kunsɛmɛ [1] ..
Ka i sen don Enzymatic Reactions (Anzimuw ka waleyaw) la
Jɔrɔ min bɛ Poli(ADP-ribose) Polimerase 1 (PARP1) la:
NAD+ bɛ kɛ i n’a fɔ anzimu min bɛ PARP1 dɔn walima min bɛ a dun, wa a sen bɛ baara koloma caman na. PARP1 jɔyɔrɔ ka bon ADN tiɲɛni dilancogo la. Ni farikolokisɛw ye ADN tiɲɛ, PARP1 bɛ baara kɛ, ka NAD+ kɛ ka poli ADP-ribose (PAR) cakɛdaw labɛn, o kɔfɛ, u bɛ nɔrɔ farikolojɔlifɛnw na, o la, ADN dilancogo bɛ ɲɛ. Nka, PARP1 baarakɛli kojugu bɛna NAD+ hakɛ caman dun, o bɛ na ni NAD+ hakɛ dɔgɔyali ye farikolo kɔnɔ, o min bɛ nɔ bila fanga sɛnɛcogo la ani farikolokisɛw ka ɲɛnamaya la [1,.
Jɔrɔ min bɛ ADP-ribose cyclique (cADPR) sintaziw la:
ADP-ribose sintazi cycliques i n’a fɔ CD38 ani CD157 fana ye NAD+ dun enzymes ye. O anzimu ninnu bɛ NAD+ kɛ ka cADPR dilan. cADPR bɛ kɛ i n’a fɔ ciden filanan walasa ka a sen don kalisiyɔmu taamasiɲɛw la, ka kalisiyɔmu ion hakɛ labɛn selilɛri kɔnɔ, ani o cogo la, a bɛ nɔ bila selilɛri baara suguya caman na, i n’a fɔ farikolo sɔgɔsɔgɔli ani farikolojidɛsɛbanakisɛw bɔli.
Jɔrɔ min bɛ Sirtuin Protéine Deacetylases la:
Sirtuin protein deacetylases (SIRT) fana bɛ u jigi da NAD+ kan walasa ka baara kɛ. SIRTw bɛ jeninida jiracogo, selilɛriw ka farikoloɲɛnajɛ ani degun jaabiw ɲɛnabɔ ni u bɛ farikolojɔli dumuniw deasetilasi kɛ. Ni NAD+ hakɛ ka ca, SIRTw ka baara bɛ bonya, o bɛ kɛ sababu ye ka farikolokisɛw ka kɛnɛya ni u ka ɲɛnamaya sabati. Misali la, cogoyaw la i n’a fɔ kalori hakɛ dantigɛli, NAD+ hakɛ bɛ bonya farikolo kɔnɔ, o bɛ SIRTw baara, o bɛ ɲɛnamaya janya ani ka farikoloɲɛnajɛ kɛnɛya sabati.
Jɔrɔ min bɛ Axonal Degeneration (Axonal degeneration) la
NMNAT2 ni SARM1 cɛ jɛɲɔgɔnya:
Axonal degeneration taabolo senfɛ, NAD+ synthase NMNAT2 ani pro-degeneration factor SARM1 jɔyɔrɔ ka bon kosɛbɛ. NMNAT2 ye axonal survival factor ye, ka sɔrɔ SARM1 bɛ ni NADase ni a ɲɔgɔnna baara ye ani a ye pro-degeneration factor ye. O fila ni ɲɔgɔn cɛ jɛɲɔgɔnya nafa ka bon walasa ka axonal integrity sabati. A ka c’a la, axonal degeneration bɛ sɔrɔ cɛmancɛ taamasiɲɛ sira dɔ fɛ, min bɛ ɲɛnabɔ kosɛbɛ nin farikolojɔlifɛn koloma fila ninnu fɛ minnu nɔ bɛ ɲɔgɔn sɔsɔ. Misali la, farikolojidɛsɛbanaw la i n’a fɔ Alzheimer ni Parkinson ka bana, axons bɛ tiɲɛ sani senfagabana selilɛri farikolow ka sa, wa o axons degeneration fana ka ca axonal jogindaw la i n’a fɔ hereditary spastic paraplegia. Nin bana ninnu na, nin taamasiɲɛw sira in baarakɛli bɛ se ka kɛ sababu ye ka axonal pathological changes sɔrɔ [3, 4]..
SARM1 ka yɛrɛlafasali fɛɛrɛ min bɛ kɛ ni NAD+ ye:
Kɔlɔsiliw y’a jira ko NAD+ ye ligandi ye min ma labɛn SARM1 ka armadillo/heat repeat motifs (ARM) yɔrɔ la. NAD+ sirili ARM yɔrɔ la, o bɛ SARM1 ka Toll/interleukin-1 minɛbaga (TIR) yɔrɔ NADase baara bali domani ɲɔgɔndan fɛ. NAD+ siriyɔrɔ tiɲɛni walima ARM-TIR jɛɲɔgɔnya bɛna kɛ sababu ye ka SARM1 ka baarakɛcogo jɔnjɔn sɔrɔ, o bɛ na ni axonal degeneration ye. O b’a jira ko NAD+ bɛ kɛ sababu ye ka nin farikolojɔlifɛn in yɛrɛ balili kɛ [5] ..
Jɔrɔ min bɛ dusukun ni jolisiraw banaw na
Dusukun ni jolisiraw ka kɛnɛya lakanani:
NAD+ bɛ mɔgɔ tanga dusukun ni jolisiraw banaw ma. Misali la, NAD+ bɛ se ka dusukun tanga banaw ma i n’a fɔ farikoloɲɛnajɛ, dusukun tantanni, joli segin-seginni, joli segin-segin, ani tansiyɔn jiginni. A lakanani fɛɛrɛ bɛ se ka kɛ fɛn caman ye i n’a fɔ fanga sɛnɛcogo ɲɛnabɔli, redox balansi marali, ani funu jaabi balili. Ni mɔgɔ kɔrɔbayara walima ni degun bɛ a la, NAD+ hakɛ bɛ dɔgɔya farikolo kɔnɔ, o bɛ na ni fɛn caman yeli ye farikoloɲɛnajɛ cogoya la ani ka dɔ fara banaw sɔrɔli kan. O la, ka NAD+ hakɛ mara dusukun na walima ka dɔ bɔ a bɔnɛni na, o nafa ka bon kosɛbɛ dusukun ni jolisiraw ka kɛnɛya la [1] ..
Jɔrɔ min bɛ Sɔgɔsɔgɔninjɛ la
A nɔ min bɛ sɔrɔ Mikobakteriyɔmu tuberculose (Mtb) la:
Mikobacterium tuberculosis (Mtb) la, sumaya banakisɛ, NAD dilanni anzimu laban, NAD sintetazi (NadE), ani NADP biyosyntɛzi laban anzimu, NAD kinase (PpnK), olu bɛ farikoloɲɛnajɛ ni fɛnɲɛnamafagalanw nɔ tɛ kelen ye. NadE baarakɛbaliya bɛ na ni NAD ni NADP jidagayɔrɔw dɔgɔyali ye ɲɔgɔn fɛ ani Mtb ka ɲɛnamaya kɛcogo dɔgɔyali, k’a sɔrɔ PpnK baarakɛbaliya bɛ NADP jidagayɔrɔ dɔgɔya cogo sugandilen na nka a bɛ bonya dabila dɔrɔn. Enzyme kelen-kelen bɛɛ baarakɛbaliya bɛ taa ni farikoloɲɛnajɛ caman yeli ye kɛrɛnkɛrɛnnenya la anzimu min tɔɔrɔlen don ani a ni a ɲɔgɔnna microbiologique phenotype. NAD dɔgɔyali banakisɛfagalan hakɛ bɛ se ka kɛ sababu ye ka NAD-dependant metabolic siraw labɛncogo kura musaka kɛ ka sɔrɔ a ma nɔ bila NADH/NAD hakɛ la, ka sɔrɔ NAD dɔgɔyali banakisɛfagalan hakɛ bɛ se ka NADH/NAD hakɛ tiɲɛ ani ka oksizɛni ninakili bali. Nin sɔrɔlen ninnu bɛ farikoloɲɛnajɛ kɛrɛnkɛrɛnnenw jira minnu tun ma dɔn fɔlɔ minnu bɛ tali kɛ cofactor fila la minnu bɛ sɔrɔ yɔrɔ bɛɛ jiginni na, o b’a jira ko NAD biosynthèse inhibiteurs ka kan ka bila jɔyɔrɔ fɔlɔ la sumaya furaw dilanni na, .
Jɔrɔ min bɛ kɔrɔya ni banaw la
NAD hakɛ min bɛ sɔrɔ selilɛriw kɔnɔ, o dɔgɔyali min bɛ tali kɛ kɔrɔya la:
Ni mɔgɔ kɔrɔbayara, NAD+ hakɛ bɛ dɔgɔya dɔɔni dɔɔni selilɛri kɔnɔ. Nin NAD+ hakɛ dɔgɔyali bɛ tali kɛ farikolokisɛ kɔrɔlenw ka farikoloɲɛnajɛ cogoya caman yeli la, wa a bɛ se ka dɔ fara banaw sɔrɔli kan. Banakisɛ caman, i n’a fɔ dusukunnabana, fasa, farikolojidɛsɛbanaw, kansɛri, ani kɔrɔya, olu bɛ tali kɛ NAD+ hakɛ min bɛ farikolo kɔnɔ, o tiɲɛni tilennen walima a tilennen tɛ [2,.
Jɛɲɔgɔnya min bɛ NAD+ Biosynthèse ni Enzymes ni banaw dunni cɛ:
NAD+ biyosintɛzi ni anzimu minnu bɛ dumuni dun, olu sen bɛ ɲɛnamaya sira jɔnjɔn caman na, minnu bɛ nɔ bila jeninida sɛbɛnni na, selilɛri taamasiɲɛw la, ani selilɛriw ka sɛgɛsɛgɛli la. O la, bana caman bɛ tali kɛ nin anzimu ninnu ka baara kɛcogo jugu la. Misali la, farikolojidɛsɛbanaw la, NAD+-degun fɛɛrɛw bɛ farikolojɔli dumuniw de kan i n’a fɔ WLDw, NMNAT2, ani SARM1, o b’a jira ko farikolojidɛsɛbanaw bɛ tali kɛ NAD+ ni fanga sɛnɛcogo la u yɛrɛ la
Source:PubMed [7] Bamako, Mali.
NAD+ ka baarakɛcogo ye jumɛnw ye?
A kɛcogo Dusukunnabanaw la
Lakanali nɔ:
NAD+ jɔyɔrɔ ka bon dusukunnabanaw la, wa a bɛ se ka dusukun tanga bana suguya caman ma. Misali la, NAD+ bɛ se ka dusukun tanga banaw ma i n’a fɔ farikoloɲɛnajɛ, dusukun tantanni, joli segin-seginni, joli seginni, ani tansiyɔn jiginni [1] . O bɛ kɛ barisa NAD+ bɛ kɛ i n’a fɔ anzimu dɔnni walima a bɛ dumuni kɛ anzimuw la i n’a fɔ poli(ADP-ribose) polimerazi 1 (PARP1), cyclique ADP-ribose (cADPR) synthases (CD38 ani CD157), ani sirtuin protein deacetylases (Sirtuins, SIRTs), wa a sen bɛ taabolo jɔnjɔn caman na dusukunnabanaw la.
Balance Redox marali:
NAD+/NADH hakɛ nafa ka bon kosɛbɛ walasa ka farikolokisɛw ka redox homeostasis mara ani ka fanga sɛnɛcogo ɲɛnabɔ [1] . O la, ka NAD+ hakɛ mara dusukun na walima ka dɔ bɔ a bɔnɛni na, o nafa ka bon kosɛbɛ dusukun ni jolisiraw ka kɛnɛya la.
A kɛcogo minnu bɛ kɛ Anti-aging (Kɔrɔya kɛlɛli) la
Ka ɲɛnamaya janya:
Molecules kɔrɔbayali sababuw ni ɲɛnamaya jan fɛɛrɛw ye caya ye san tan tɛmɛnenw kɔnɔ. Nikotinamidi adenini dinukiliyɔtidi (NAD) n’a ɲɛfɛfɛnw, i n’a fɔ nikotinamidi ribosidi, nikotinamidi mononukiliyɔtidi, nikotinamidi, ani asidi nikotiniki, olu ye mɔgɔw mago don u la i n’a fɔ fɛnɲɛnɛma minnu bɛ se ka diya u ye fɛnɲɛnamafagalan misɛnninw tali la i n’a fɔ fɛn minnu bɛ se ka kɛ fɛnɲɛnamafagalanw ye ani/walima furakɛlifɛnw. Nin furakisɛ ninnu y’a jira ko u bɛ se ka kɔrɔya cogoyaw ɲɛ ka kɛɲɛ ni u faralen ye ɲɔgɔn kan, wa u bɛ se ka misali fɛnɲɛnamaw ka saya bali [8] ..
Ka nɔ bila ɲɛnamaya kɛcogo labɛnni na:
Ɲɛnamaya misaliw la i n’a fɔ funteni, sɛgɛsɛgɛliw y’a jira ko NAD ɲɛbilafɛnw jɔyɔrɔ ka bon kɔrɔya ni ɲɛnamaya jan na. Yezu ka ɲɛnamaya kɛcogo waatibolodacogo (CLS) ani a si hakɛ cayalenba (RLS) kalanni fɛ, an bɛ se ka NAD farikoloɲɛnajɛ kɛcogo faamuya ka ɲɛ ani a jɔyɔrɔ min bɛ a labɛnni na kɔrɔya ni a si jan na.
Baara minnu bɛ se ka kɛ sumaya furakɛli la
Dɔrɔgu laɲini:
NAD dilanni anzimu laban min ye NAD sintetazi (NadE) ye, o baarakɛbaliya min bɛ Mycobacterium tuberculosis (Mtb) kɔnɔ, o bɛ na ni NAD ni NADP jidagayɔrɔw dɔgɔyali ye ɲɔgɔn fɛ ani ka Mtb ka ɲɛnamaya dɔgɔya, ka sɔrɔ NADP biyosinɛzi laban anzimu, NAD kinase (PpnK) baarakɛbaliya bɛ NADP jidagayɔrɔ dɔgɔya cogo sugandilen na nka a bɛ jɔ dɔrɔn (Sharma R, 2023) Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew. O b’a jira ko NAD sintezi balilanw de bɛ fɔlɔ sumaya furaw dilanni na, barisa NAD dɛsɛ ye banakisɛfagalan ye, ka sɔrɔ NADP dɛsɛ ye banakisɛfagalan ye.
Fɛnɲɛnɛmafagalanw yeli ni mikrobiyɔmuw ka fenotipiw:
Enzyme kelen-kelen bɛɛ baarakɛbaliya bɛ taa ni farikoloɲɛnajɛ caman yeli ye minnu kɛrɛnkɛrɛnnen don anzimu min tɔɔrɔlen don ani a ni o ɲɔgɔnna mikrobiyɔmu fenotipi. NAD dɛsɛ hakɛ min bɛ banakisɛfagalanw tali la, o bɛ kɛ sababu ye ka farikoloɲɛnajɛ siraw labɛn kokura minnu bɛ tali kɛ NAD la, k’a sɔrɔ a ma nɔ bila NADH/NAD hakɛ la, ka sɔrɔ banakisɛfagalanw ka NAD dɔgɔyali hakɛ bɛ na ni NADH NAD hakɛ tiɲɛni ye ani ka oksizɛni ninakili bali / .
Jɔrɔ min bɛ selilɛriw ka fɛnɲɛnamafagalanw na
Baara nafama caman:
NAD(H) ni NADP(H) jatera laada la i n’a fɔ cofactors minnu bɛ redox reactions jatebaliya la, o la, ɛlektrɔniki jiginni mitokondriyaw kɔnɔ. Nka, NAD sira fɛnɲɛnamafagalanw bɛ baara nafama caman wɛrɛw kɛ, i n’a fɔ jɔyɔrɔw taamasiɲɛw siraw la, bamanankan baarakɛcogo caman caman cili, fɛn caman cili epijenitiki la, ani ka ARN sabatili n’a baara ɲɛnabɔ ARN ka NAD capping fɛ.
Metaboliki taabolo fangama:
Fɛn minnu tɛ oksidan ye, olu laban bɛ na ni nin nukilitɔn ninnu ka katabolisme net ye, o b’a jira ko NAD farikoloɲɛnajɛ ye wale ye min bɛ fanga sɔrɔ kosɛbɛ. Tiɲɛ na, kɔsa in na, sɛgɛsɛgɛliw y’a jira ka jɛya ko farikolo yɔrɔ dɔw la, NAD tilancɛ bɛ se miniti damadɔ ma [9] ..
Jɔrɔ min bɛ selilɛriw ka ɲɛnamayako la
NAD ka fɛnɲɛnamafagalanw (métabolisme extérieur cellulaire):
NAD min bɛ bɔ selilɛri kɔkan, o ye taamasiɲɛ jɔnjɔn ye farikolo ni bana cogoya wɛrɛw la. A bɛ baara kɛ k’a ɲɛsin purinerji minɛbaga kɛrɛnkɛrɛnnenw baara ma walima k’a kɛ fɛn ye min tɛ ɲɛ i n’a fɔ ɛkzonukiliziw (i n’a fɔ CD73, nukilitɔn pirofosfatazi/fosfodiɛsitɛrizi 1, CD38 ani a paralog CD157, ani ɛkto-ADP-ribosiltransferases). O anzimu ninnu bɛ NAD sɔrɔli dantigɛ ni NAD jilama ye, o la u bɛ a taamasiɲɛ tilennen nɔ labɛn (Gasparrini M, 2021). Ka fara o kan, u bɛ se ka taamasiɲɛ misɛnninw dilan ka bɔ NAD la, i n’a fɔ adenosini min bɛ farikolo tangalan caman sɛgɛsɛgɛ, walima ka NAD kɛ ka ADP-ribosylate kɛ farikolo kɔkanna farikolojɔlan suguya caman na ani membrane receptors, o bɛ nɔba bila farikolo tangacogo la, funu jaabi la, tumuw bɔli la, ani bana wɛrɛw. Nikotinamidi fosforibosiltransferase ni nikotiniki asidi fosforibosiltransferase fana bɛ sɔrɔ selilu kɔkan, olu bɛ kɛ sababu ye ka wale jɔnjɔnw kɛ NAD kisi sira la selilu kɔnɔ. Nin anzimu ninnu cogoyaw bɛ kɛ i n’a fɔ sitokiniw minnu bɛ funu dɛmɛni baara kɛ [10] ..
Kuncɛli la, NAD+ kɛra fɛnba ye min bɛ kɛnɛya ni banaw cɛsiri, a kɛtɔ ka fanga sɛnɛcogo ɲɛnabɔ, ka kɔrɔya bila kɔfɛ, ka farikolo tangacogo ɲɛnabɔ, ani ka lakana di sigida caman ma. Ni aw ye a ɲɛfɛfɛnw fara a kan, o bɛ se ka mitokondriyaw ka baara ɲɛ ani ka farikoloɲɛnajɛ ni farikolojidɛsɛbanaw taabolo sumaya. A bɛ seko jira dusukun ni jolisiraw lakanani, banakisɛfagalanw, ani kɔrɔya kɛlɛli siratigɛ la, ka furakɛli laɲini kura di banaw ma minnu bɛ sɔrɔ kɔrɔya fɛ.
A sɛbɛnbaga ko la
Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.
Dɔnniya gafe sɛbɛnbaga
Jiang YF ye ɲininikɛla ye min ni baarada tɔgɔba caman bɛ ɲɔgɔn na, i n’a fɔ Pekin Iniwɛrisite, Lanzhou Jiaotong Iniwɛrisite, jamana ni sigida injiniyɛri jɛ-ka-baara ɲininikɛyɔrɔ min ɲɛsinnen bɛ seko ni dɔnko ni baarakɛcogo ma, Pekin Ɛntɛrinɛti ni seko ni dɔnko ɲininikɛyɔrɔ min ɲɛsinnen bɛ dumuni faralenw ma, Sinuwa dɔnniyakalanso, dɔnniya ni seko ni dɔnko Iniwɛrisite (CAS), Pekin Teknoloji ni Jago Iniwɛrisite, ani Dɔgɔtɔrɔso Iniwɛrisite. A ka ɲininiw bɛ Kɛ ‘yɔrɔ caman na, i n’a fɔ chimie, banakɔtaa, ɛntɛrinɛti, kansɛri ani mankanko. A ka baara bɛ fɛɛrɛ caman jira, min bɛ dɔnniya ni fɛɛrɛbɔ yiriwaliw fara ɲɔgɔn kan o dakunw bɛɛ kɔnɔ. Jiang YF tɔgɔ sɛbɛnnen bɛ citation (citation) ka ɲɛfɔli kɔnɔ [5].
