Cocer Peptides ye 
ŋlɔe ɣleti 1 enye sia
NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.
Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.
Kpɔkplɔyiɖeme
Le numekuku gbogbo siwo wowɔ tso gbɔgbɔtsixe ƒe lãmesẽ me léle ɖe asi ŋu dome la, Bronchogen ɖe eƒe dɔwɔwɔ kple asixɔxɔ si woate ŋu azã le gbɔgbɔtsixe ƒe lãmesẽnyawo me fia. Nyati sia adzro ŋusẽ nyui siwo Bronchogen kpɔna ɖe gbɔgbɔtsixe ƒe lãmesẽ dzi kple eƒe zazã ƒe mɔkpɔkpɔwo me le numekuku siwo li dzi.
Nɔnɔmetata 1 Bronchogen ƒe atikewo ƒe wɔwɔme.
Ŋusẽ si Bronchogen Kpɔna Ðe DNA ƒe Liƒo Dzi
1. Kadodo si Ate Ŋu Anɔ DNA ƒe Liƒo Kple Yagbɔgbɔ ƒe Lãmesẽ Dome
Lãmenugbagbeviwo ƒe dɔwɔwɔ nyuie nɔ te ɖe DNA ƒe wɔwɔme si li ke dzi. Le gbɔgbɔtsixe me la, nutome ƒe nu vovovowo abe ɖiƒoƒonuwo kple dɔlékuiwo ene ate ŋu agblẽ nu le lãmenugbagbeviwo ƒe DNA ŋu, si ana woakpɔ ŋusẽ ɖe gbɔgbɔtsixe ƒe lãmenugbagbeviwo ƒe ŋutilã ƒe dɔwɔwɔ nyuie dzi eye wòahe gbɔgbɔmedɔléle vovovowo vɛ. DNA ƒe liƒo me léle ɖe asi le vevie ŋutɔ be woalé gbɔgbɔtsixe ƒe lãmenugbagbeviwo ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ, dzidziɖedzi, kple dɔlélenutsiŋutete ƒe dɔwɔwɔ nyuie si sɔ la ɖe te.
2. Bronchogen abe DNA ƒe Liƒolili ene
Le agbɔsɔsɔ vovovowo me la, Bronchogen ate ŋu akpɔ ŋusẽ ɖe DNA ƒe dzoxɔxɔŋusẽ ƒe nɔnɔmewo dzi. Esi wozã differential scanning microcalorimetry tsɔ le DNA me dzrom la, wokpɔe be Bronchogen ate ŋu awɔ dɔ abe DNA ƒe liƒolili ene. Ne Bronchogen wɔ dɔ kple DNA tso nyitsu ƒe thymus kple sisiblisi ƒe aklã me, le r ƒe asixɔxɔ ƒe didime kpui aɖe me (r nye Bronchogen kple DNA gɔmeɖoanyi eve ƒe molar ratio, 0.01–0.055), ateŋu adzi DNA ƒe denatration ƒe dzoxɔxɔ ɖe edzi 3.1°C. Esia ɖee fia be Bronchogen nana DNA li ke, eɖea afɔku si le DNA ƒe gbegblẽ si gotagomenuwo hena vɛ dzi kpɔtɔna, eye wòtoa esia me kpena ɖe domenyiŋusẽfianu ƒe nyatakakawo ƒe kaka kple lãmenugbagbeviwo ƒe dɔwɔwɔ nyuie ŋu le gbɔgbɔtsixe ƒe lãmenugbagbeviwo me.
3. Nublanu ƒe Nɔnɔmewo Kple Liƒo ƒe Mɔnu
Numekuku bubuwo ɖee fia be Bronchogen menye adenine-thymine-ko alo guanine-cytosine-koŋ ƒe ligand o. Wobua eƒe kadodo ƒomevi be esẽ eye wòdzɔna le vome, eye wòblana ɖe DNA ƒe ka eveawo siaa ŋu (vevietɔ ɖe nitrogen ƒe gɔmeɖoanyiwo ŋu). Le r ƒe asixɔxɔ siwo tso 0.01 va ɖo 1.0 me la, nusi le ʋeʋẽm ƒe enthalpy (ΔH(melt)) gakpɔtɔ nɔa anyi ɖaa, si gaɖe Bronchogen ƒe dɔwɔwɔ ƒe mɔnu tɔxɛ si le DNA ƒe liƒolili me fia eye wòna nukpɔsusu ƒe gɔmeɖoanyi sesẽ aɖe na akpa si wòwɔna le domenyiŋusẽfianu ƒe liƒo léle ɖe te le gbɔgbɔtsixe ƒe lãmenugbagbeviwo me.
Bronchogen Zazã Siwo Woate Ŋu Azã Le Yagbɔdɔlélewo Dada Me
1. Mɔxexe Ðe Dɔléle Nu Si Wotu Ðe DNA ƒe Liƒo Dzi
Esi wònye be Bronchogen ate ŋu ana DNA ƒe wɔwɔme nali ke ta la, ewɔa akpa aɖe le mɔxexe ɖe gbɔgbɔmedɔléle aɖewo siwo DNA ƒe gbegblẽ hena vɛ nu me. Ameha siwo do go ya ƒe ɖiƒoƒo ɣeyiɣi didi la le afɔku me be woaxɔ gbɔgbɔmedɔlélewo abe aɖuɖɔtoemekansa kple aklãdɔléle si xea mɔ na dɔléle si nɔa anyi didi (COPD) le DNA ƒe gbegblẽ le gbɔgbɔtsixe ƒe lãmenugbagbeviwo me ta. Bronchogen ate ŋu aɖe afɔku sia dzi akpɔtɔ to DNA ƒe liƒo dzi ɖeɖe kpɔtɔ me, si ana mɔxexeɖedɔléle nu ƒe mɔnu si ate ŋu ana ame mawo tɔgbe.
2. Kpekpeɖeŋunadɔdamɔnu na Yagbɔgbɔ ƒe Dɔdzẽ
Le gbɔgbɔtsixe ƒe dɔdzẽɣi la, dɔdzẽ ƒe domenɔla siwo dɔdzẽ ƒe lãmenugbagbeviwo ɖena ɖe go ate ŋu agblẽ nu le gbɔgbɔtsixe ƒe lãmenugbagbeviwo ƒe DNA ŋu. Bronchogen ƒe DNA-ɖoɖo ate ŋu aɖe nusiwo gblẽ alea dzi akpɔtɔ vaseɖe afi aɖe, si akpe ɖe lãmenugbagbevi siwo gblẽ la dzadzraɖo kple woƒe dɔwɔwɔ ŋu. Domenyiŋusẽfianu ŋuti nyatakakawo ƒe kaka nyuie le lãmenugbagbeviwo me léle ɖe asi ate ŋu akpɔ ŋusẽ nyui ɖe domenyiŋusẽfianu siwo do ƒome kple dɔdzẽ ƒe ŋuɖoɖowo ƒe ɖeɖefia dzi kpɔkpɔ hã dzi, si ana wòakpe ɖe gbɔgbɔtsixe ƒe dɔdzẽ dada ŋu.
Nyanuwuwuw
Togbɔ be numekuku siwo wowɔ fifia le Bronchogen ŋu le gbɔgbɔtsixe ƒe lãmesẽnyawo me gakpɔtɔ le eƒe gɔmedzedze hã la, nusiwo ŋu woke ɖo fifia ɖee fia be eƒe ŋutete. Tso ŋusẽ si wòkpɔna ɖe DNA ƒe liƒo dzi va ɖo eŋudɔwɔwɔ le mɔxexe ɖe gbɔgbɔmedɔlélewo nu kple wo dada me dzi la, Bronchogen ʋu mɔ yeyewo ɖi na gbɔgbɔtsixe ƒe lãmesẽ ŋuti numekuku.
Dzᴐtsoƒe
[1] Monaselidze JR, Khavinson V, Gorgoshidze MZ, kple ame bubuwo. Dɔ si peptide bronchogen (Ala-Asp-Glu-Leu) wɔna ɖe DNA ƒe dzoxɔxɔ ƒe liƒo dzi[J]. Bulletin of dodokpɔ nugbagbeŋutinunya kple atikewɔwɔ, 2011, 150 (3): 375-377.DOI: 10.1007 / s10517-011-1146-x.
Adzɔnu si li na numekuku zazã ɖeɖeko:
