Na Cocer Peptides 
1 mahina aku nei
ʻO nā ʻatikala a me nā ʻike huahana i hāʻawi ʻia ma kēia pūnaewele pūnaewele wale nō no ka hoʻolaha ʻana i ka ʻike a me nā kumu hoʻonaʻauao.
ʻO nā huahana i hāʻawi ʻia ma kēia pūnaewele i manaʻo wale ʻia no ka noiʻi in vitro. Hana ʻia ka noiʻi in vitro (Latin: *i ke aniani*, ʻo ia hoʻi i ka ipu aniani) ma waho o ke kino kanaka. ʻAʻole kēia mau huahana he lāʻau lapaʻau, ʻaʻole i ʻae ʻia e ka US Food and Drug Administration (FDA), a ʻaʻole pono e hoʻohana ʻia no ka pale ʻana, mālama, a hoʻōla paha i kekahi maʻi olakino, maʻi, a i ʻole maʻi. Ua pāpā loa ʻia e ke kānāwai ke hoʻokomo i kēia mau huahana i loko o ke kino kanaka a holoholona paha ma kekahi ʻano.
Hoʻolauna
Ma waena o nā noiʻi he nui e pili ana i ka mālama ʻana i ke olakino hanu, ua hōʻike ʻo Bronchogen i kona pono a me ka waiwai o ka hoʻohana ʻana i ke ʻano o ke olakino hanu. E ʻimi kēia ʻatikala i nā hopena maikaʻi o Bronchogen ma ke olakino hanu a me kāna mau noi noi e pili ana i ka noiʻi ʻana.
Kiʻi 1 ʻO ke kinona o ka Bronchogen.
ʻO ka hopena o ka Bronchogen ma ke kūpaʻa DNA
1. ʻO ka loulou kūpono ma waena o ke kūpaʻa DNA a me ke ola hanu
ʻO ka hana maʻamau o nā cell e pili ana i ke ʻano paʻa o DNA. I loko o ka ʻōpū hanu, hiki ke hoʻopōʻino i nā mea kūlohelohe like ʻole e like me nā pollutants a me nā pathogens i ka DNA cellular, a laila e hoʻopilikia ai i nā hana physiological maʻamau o nā ʻōpū hanu a alakaʻi i ke ʻano o nā maʻi hanu. He mea koʻikoʻi ka mālama ʻana i ka paʻa o DNA no ka mālama ʻana i nā hana metabolic maʻamau, proliferative, a me nā hana hoʻoponopono kūlohelohe o nā ʻōpū hanu.
2. ʻO Bronchogen ma ke ʻano he DNA Stabilizer
Ma nā ʻokoʻa like ʻole, hiki i ka Bronchogen ke hoʻololi i nā ʻāpana thermodynamic o DNA. I ka nānā ʻana i ka DNA me ka hoʻohana ʻana i ka microcalorimetry scanning differential, ua ʻike ʻia hiki ke hana ʻo Bronchogen ma ke ʻano he mea hoʻoponopono DNA. Ke launa pū ʻo Bronchogen me DNA mai ka puʻu pipi a me ka ate ʻiole, i loko o kahi ʻāpana waiwai r haiki (r ka ratio molar o Bronchogen a me DNA base pairs, 0.01–0.055), hiki iā ia ke hoʻonui i ka mahana denaturation DNA ma 3.1°C. Hōʻike kēia i ka Bronchogen e hoʻonui i ka paʻa o DNA, e hōʻemi i ka hopena o ka pōʻino DNA i hana ʻia e nā kumu o waho, a ma laila e kōkua ai i ka mālama ʻana i ka hoʻoili ʻike genetic maʻamau a me ka hana cellular i nā ʻōpū hanu.
3. Nā ʻano hoʻopaʻa a me ka mīkini paʻa
Hōʻike nā haʻawina hou aʻe ʻo Bronchogen ʻaʻole ia he adenine-thymine-specific a i ʻole guanine-cytosine-specific ligand. Ua manaʻo ʻia kona ʻano hoʻopaʻa paʻa ikaika a paʻa ʻole, a hoʻopaʻa ʻia i nā kaula ʻelua o ka DNA (ma mua i nā kumu nitrogenous). I loko o ka laulā o nā waiwai r mai 0.01 a i 1.0, e mau ana ka enthalpy melting (ΔH(melt)) o ka paʻakikī, e hōʻike hou ana i ka hana kūikawā a Bronchogen i ka hoʻopaʻa ʻana i ka DNA a me ka hāʻawi ʻana i kahi kumu theoretical ikaika no kāna kuleana i ka mālama ʻana i ke kūpaʻa genomic i nā ʻōpū hanu.
ʻO nā noi kūpono o ka Bronchogen i ka mālama ʻana i nā maʻi hanu
1. Kāohi ʻana i ka maʻi ma muli o ka hoʻopaʻa ʻana o DNA
No ka mea hiki i ka Bronchogen ke hoʻopaʻa i ka hoʻolālā DNA, he hana ia i ka pale ʻana i kekahi mau maʻi hanu i hoʻokumu ʻia e ka pōʻino DNA. ʻO ka poʻe i ʻike ʻia i ka haumia ea no ka wā lōʻihi e piʻi aʻe ka pilikia o nā maʻi hanu e like me ka maʻi kanesa a me ka maʻi pulmonary obstructive maʻi (COPD) ma muli o ka pōʻino DNA i loko o nā pūnaeho hanu. Hiki i ka Bronchogen ke hōʻemi i kēia pilikia ma o ka hoʻonui ʻana i ke kūpaʻa DNA, e hāʻawi ana i kahi hoʻolālā pale no ia mau heluna kanaka.
2. Adjuvant Therapy for Respiratory Inflammation
I ka wā o ka ʻeha hanu, hiki ke hōʻino i ka DNA o nā pūnaeho hanu i nā mea hoʻomake i hoʻokuʻu ʻia e nā pūnaeho inflammatory. Hiki i ka Bronchogen's DNA-stabilizing properties ke ho'ēmi i ka pōʻino i kekahi ʻano, e kōkua ana i ka hoʻoponopono ʻana a me ka hoʻihoʻi ʻana i ka hana o nā cell i poino. ʻO ka mālama ʻana i ka hoʻoili ʻike genetic maʻamau i loko o nā cell he hopena maikaʻi nō hoʻi i ka hoʻoponopono ʻana i ka hōʻike ʻana o nā genes e pili ana i nā pane inflammatory, a laila kōkua i ka mālama ʻana i ka ʻeha hanu.
Ka hopena
ʻOiai ʻo ka noiʻi ʻana i kēia manawa ma Bronchogen ma ke ʻano o ke olakino hanu i ka wā mua, hōʻike nā ʻike i kēia manawa i kona hiki. Mai kona hopena i ka paʻa o DNA a hiki i kāna noi i ka pale ʻana a me ka mālama ʻana i nā maʻi hanu, wehe ʻo Bronchogen i nā kuhikuhi hou no ka noiʻi olakino hanu.
Puna
[1] Monaselidze JR, Khavinson V, Gorgoshidze MZ, et al. Ka hopena o ka peptide bronchogen (Ala-Asp-Glu-Leu) ma ka DNA thermostability [J]. Bulletin of Experimental Biology and Medicine, 2011,150(3):375-377.DOI:10.1007/s10517-011-1146-x.
Loaʻa ka huahana no ka noiʻi wale nō:
