Los ntawm Cocer Peptides 
1 month ago
Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.
Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.
Taw qhia
Ntawm ntau cov kev tshawb fawb txog kev tswj cov kab mob ua pa, Bronchogen tau pom tias nws ua tau zoo thiab muaj peev xwm siv tau rau hauv kev kho mob ua pa. Tsab ntawv xov xwm no yuav tshawb txog cov txiaj ntsig zoo ntawm Bronchogen rau kev noj qab haus huv ua pa thiab nws daim ntawv thov kev cia siab raws li kev tshawb fawb uas twb muaj lawm.
Daim duab 1 Chemical structure of Bronchogen.
Cov nyhuv ntawm Bronchogen ntawm DNA Stability
1. Lub peev xwm txuas ntawm DNA ruaj khov thiab kev noj qab haus huv ua pa
Kev ua haujlwm ib txwm ntawm cov hlwb nyob ntawm cov qauv ruaj khov ntawm DNA. Hauv cov kab mob ua pa, ntau yam ib puag ncig xws li cov pa phem thiab cov kab mob tuaj yeem ua rau cov cellular DNA, yog li cuam tshuam rau lub cev ua haujlwm ntawm cov hlwb ua pa thiab ua rau muaj cov kab mob ua pa. Kev tswj hwm DNA ruaj khov yog qhov tseem ceeb rau kev txhawb nqa cov txheej txheem metabolic, proliferative, thiab kev tiv thaiv kab mob ntawm cov hlwb ua pa.
2. Bronchogen ua DNA Stabilizer
Ntawm qhov sib txawv ntawm qhov sib txawv, Bronchogen tuaj yeem cuam tshuam cov thermodynamic tsis ntawm DNA. Thaum soj ntsuam DNA siv qhov sib txawv scanning microcalorimetry, nws tau pom tias Bronchogen tuaj yeem ua tus neeg sawv cev DNA stabilizing. Thaum Bronchogen cuam tshuam nrog DNA los ntawm bovine thymus thiab nas lub siab, nyob rau hauv ib tug nqaim r nqi ntau yam (r yog tus molar piv ntawm Bronchogen rau DNA puag khub, 0.01-0.055), nws muaj peev xwm ua kom lub DNA denaturation kub los ntawm 3.1 ° C. Qhov no qhia tau hais tias Bronchogen txhim kho DNA ruaj khov, txo qhov kev pheej hmoo ntawm DNA puas tsuaj los ntawm lwm yam, thiab yog li pab tswj cov ntaub ntawv ntawm caj ces thiab kev ua haujlwm ntawm tes hauv cov hlwb ua pa.
3. Kev khi cov yam ntxwv thiab kev ruaj ntseg tshuab
Cov kev tshawb fawb ntxiv qhia tias Bronchogen tsis yog adenine-thymine-specific lossis guanine-cytosine-specific ligand. Nws txoj hlua khi yog suav tias yog muaj zog thiab tsis sib xws, thiab nws khi rau ob qho tib si ntawm DNA (feem ntau rau cov hauv paus nitrogenous). Nyob rau hauv qhov ntau ntawm r qhov tseem ceeb ntawm 0.01 txog 1.0, melting enthalpy (ΔH (melt)) ntawm cov complex tseem nyob tas mus li, ntxiv piav qhia txog Bronchogen lub cim tshwj xeeb ntawm kev ua haujlwm hauv stabilizing DNA thiab muab lub hauv paus muaj zog theoretical rau nws lub luag haujlwm hauv kev tswj genomic stability nyob rau hauv lub hlwb ua pa.
Muaj peev xwm siv bronchogen hauv kev kho cov kab mob ua pa
1. Kev Tiv Thaiv Kab Mob Raws li DNA Stabilization
Txij li Bronchogen tuaj yeem txhim kho DNA qauv, nws ua lub luag haujlwm tiv thaiv qee yam kab mob ua pa los ntawm DNA puas. Cov pej xeem raug cov pa phem nyob rau lub sij hawm ntev yuav muaj kev pheej hmoo ntawm cov kab mob ua pa xws li mob ntsws cancer thiab kab mob ntsws ntev (COPD) vim DNA puas hauv cov hlwb ua pa. Bronchogen tuaj yeem txo qhov kev pheej hmoo no los ntawm kev txhim kho DNA ruaj khov, muab lub tswv yim tiv thaiv zoo rau cov pej xeem.
2. Adjuvant Therapy for Respiratory Inflamation
Thaum lub sij hawm ua pa o, inflammatory mediators tso tawm los ntawm inflammatory cells yuav ua rau cov DNA ntawm cov hlwb ua pa. Bronchogen's DNA-stabilizing zog tuaj yeem txo qhov kev puas tsuaj rau qee qhov, pab kho thiab rov ua haujlwm ntawm cov hlwb puas. Kev tswj xyuas cov ntaub ntawv ntawm cov noob caj noob ces hauv cov hlwb kuj tseem muaj txiaj ntsig zoo rau kev tswj cov kev qhia ntawm cov noob muaj feem xyuam rau cov lus teb inflammatory, yog li pab kho mob ua pa.
Xaus
Txawm hais tias kev tshawb fawb tam sim no ntawm Bronchogen hauv kev kho mob ua pa tseem nyob rau theem pib, qhov kev tshawb pom tam sim no qhia tau tias nws muaj peev xwm. Los ntawm nws qhov cuam tshuam rau DNA ruaj khov rau nws daim ntawv thov hauv kev tiv thaiv thiab kho cov kab mob ua pa, Bronchogen qhib cov lus qhia tshiab rau kev tshawb fawb txog kev ua pa.
Qhov chaw
[1] Monaselidze JR, Khavinson V, Gorgoshidze MZ, et al. Cov nyhuv ntawm peptide bronchogen (Ala-Asp-Glu-Leu) ntawm DNA thermostability [J]. Bulletin of Experimental Biology and Medicine, 2011,150(3):375-377.DOI:10.1007/s10517-011-1146-x.
Cov khoom muaj rau kev tshawb fawb siv nkaus xwb:
