Na Cocer Peptides 
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INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
Intangiriro
Mu bushakashatsi bwinshi bwerekeye kubungabunga ubuzima bw’ubuhumekero, Bronchogen yerekanye akamaro kayo n’agaciro gashobora gukoreshwa mu rwego rw’ubuzima bw’ubuhumekero. Iyi ngingo izasesengura ingaruka nziza za Bronchogen ku buzima bwubuhumekero nuburyo bukoreshwa bushingiye ku bushakashatsi buriho.
Igishushanyo 1 Imiterere yimiti ya Bronchogen.
Ingaruka za Bronchogen kuri ADN ihamye
1. Isano ishobora kuba hagati ya ADN ihamye nubuzima bwubuhumekero
Imikorere isanzwe ya selile biterwa nimiterere ihamye ya ADN. Mu myanya y'ubuhumekero, ibintu bitandukanye bidukikije nk'ibyuka bihumanya na virusi bishobora kwangiza ADN selile, bityo bikagira ingaruka ku mikorere isanzwe ya physiologique y'uturemangingo tw’ubuhumekero kandi biganisha ku ndwara z’ubuhumekero. Kugumana ADN itajegajega ningirakamaro mugukomeza imirimo isanzwe ya metabolike, ikwirakwiza, kandi ikingira umubiri ingirabuzimafatizo zubuhumekero.
2. Bronchogen nkumushinga wa ADN
Mubitekerezo bitandukanye, Bronchogen irashobora guhindura ibipimo bya termodinamike ya ADN. Iyo usesenguye ADN ukoresheje microcalorimetry itandukanye yo gusikana, byagaragaye ko Bronchogen ishobora gukora nka ADN ituza. Iyo Bronchogen ikoranye na ADN ivuye muri bovine thymus numwijima wimbeba, murwego r r r ruto r (r ni igipimo cyimitsi ya Bronchogen na ADN ibice bibiri, 0.01–0.055), irashobora kongera ubushyuhe bwa ADN kuri 3.1 ° C. Ibi byerekana ko Bronchogen yongera imbaraga za ADN, igabanya ibyago byo kwangirika kwa ADN iterwa nimpamvu zituruka hanze, bityo bigafasha gukomeza amakuru asanzwe akwirakwizwa no gukora selile mumyanya y'ubuhumekero.
3. Guhuza Ibiranga nuburyo bukoreshwa
Ubundi bushakashatsi bwerekana ko Bronchogen atari adenine-thymine yihariye cyangwa ligand ya guanine-cytosine. Ubwoko bwayo bufatika bufatwa nkibikomeye kandi bidasanzwe, kandi buhuza imirongo yombi ya ADN (cyane cyane kuri azote). Mu rwego rwa r agaciro kuva 0.01 kugeza 1.0, gushonga (ΔH (gushonga)) yikigo bikomeza guhoraho, bikagaragaza uburyo bwihariye bwa Bronchogen bwibikorwa muguhagarika ADN no gutanga urufatiro rukomeye rwuruhare rwarwo mukubungabunga umutekano wa genoside mungingo zubuhumekero.
Ibishobora gukoreshwa bya Bronchogen mukuvura indwara zubuhumekero
1. Kwirinda indwara bishingiye ku guhagarika ADN
Kubera ko Bronchogen ishobora guhagarika imiterere ya ADN, igira uruhare mu gukumira indwara zimwe na zimwe z'ubuhumekero ziterwa no kwangirika kwa ADN. Abaturage bahuye n’umwanda uhumanya ikirere bafite ibyago byinshi byo kwandura indwara zubuhumekero nka kanseri yibihaha nindwara zidakira zifata ibihaha (COPD) kubera kwangirika kwa ADN mu ngirabuzimafatizo. Bronchogen irashobora kugabanya ibi byago byongera ADN itajegajega, itanga ingamba zo gukumira abo baturage.
2. Ubuvuzi bwa Adjuvant bwo kuvura indwara z'ubuhumekero
Mugihe cyo guhumeka, abunzi ba inflammatory barekuwe na selile inflammatory barashobora kwangiza ADN ya selile yubuhumekero. Imiterere ya ADN ya Bronchogen irashobora kugabanya ibyangiritse kurwego runaka, ifasha mugusana no kugarura imikorere kwingirangingo zangiritse. Kugumana amakuru asanzwe yandurira mu ngirabuzimafatizo birashobora kandi kugira ingaruka nziza muguhindura imiterere ya genes zijyanye no gusubiza, bityo bigafasha mukuvura indwara zubuhumekero.
Umwanzuro
Nubwo ubushakashatsi buriho kuri Bronchogen mubijyanye nubuzima bwubuhumekero buracyari mu ntangiriro, ubushakashatsi buriho bwerekana ubushobozi bwabwo. Kuva ingaruka zagize kuri ADN itajegajega kugeza ikoreshwa mu gukumira no kuvura indwara z’ubuhumekero, Bronchogen ifungura icyerekezo gishya cy’ubushakashatsi ku buzima bw’ubuhumekero.
Inkomoko
[1] Monaselidze JR, Khavinson V, Gorgoshidze MZ, n'abandi. Ingaruka za peptide bronchogen (Ala-Asp-Glu-Leu) kuri ADN yubushyuhe bwa ADN [J]. Amatangazo y’ibinyabuzima n’Ubuvuzi, 2011,150 (3): 375-377.DOI: 10.1007 / s10517-011-1146-x.
Ibicuruzwa biboneka mubushakashatsi bukoreshwa gusa:
