Na Cocer Peptides bin rayt am 
1 mɔnt dɔn pas
ƆL DI ATIKUL ƐN PRODƆKT INFƆMƐSHƆN WE DƐN GI NA DIS WƐBSAYT NA FƆ ƆL FƆ DI INFƆMƐSHƆN ƐN FƆ EDYUKESHƆN.
Di prɔdak dɛn we dɛn gi na dis wɛbsayt na fɔ in vitro risach nɔmɔ. in vitro risach (Latin: *in glas*, we min insay glas) dεn de du am ausayd mכtalman bכdi. Dɛn prɔdak ya nɔto mɛrɛsin, dɛn nɔ gɛt di aprɔval frɔm di US Food and Drug Administration (FDA), ɛn dɛn nɔ fɔ yuz dɛn fɔ protɛkt, trit, ɔ mɛn ɛni mɛrɛsin, sik, ɔ sik. Di lɔ nɔ gri fɔ mek dɛn put dɛn tin ya insay mɔtalman ɔ animal bɔdi ɛni we.
Sho
pan di plεnti stכdi dεm we dεn du fכ mεnten di rεspiretכri hεlth, Bronchogen dεn dכn sho in efficacy εn pכtεnshal aplikεshכn valyu insay di fild fכ rεspiretכri hεlth. Dis atikul go εksplכr di gud ifekt dεm we Bronchogen gεt pan di rεspiretכri hεlth εn in aplikεshכn prכspek dεm bays pan di risach we dεn de du naw.
Figure 1 Kεmikכl strכkchכ fכ Bronchogen.
Di Effekt we Bronchogen gɛt pan DNA Stebiliti
1. Di Pכtεnshal Link Bitwin DNA Stebiliti εn Respiratory Hεlth
di nכmal wok we di sεl dεm de du de dipכnt pan di stebul strכkchכ fכ DNA. insay di rεspiretכri trakt, difrεn tin dεm we de na di envayroment lεk di pכlutant dεm εn di pathogens kin pwεl di sεl DNA, we de afekt di nכmal fysiolojikal fכnshכn dεm fכ di rεspiretכri sεl dεm εn i kin mek dεn gεt siriכs sik dεm na di rεspiretכri. fכ mεnten di DNA stεbiliti implεnt fכ sכstain di nכmal mεtabolik, proliferativ, εn imyun rεgεlεtכri fכnshכn dεm fכ di rεspiretכri sεl dεm.
2. Bronkojen as DNA Stabiliza
pan difrεn kכnsantreshכn, Bronchogen kin infכlכw di tεmכdaynamik paramita dεm fכ DNA. we dεn analכz DNA yuz difrεnt skan maykrokalorimetri, dεn fכnshכn se Bronchogen kin akt lεk DNA stεbyulεshכn ejen. we Bronchogen intarakt wit DNA frכm bovin taymus εn maws liva, insay wan sכm r valyu rεnj (r na di molar rεshכn fכ Bronchogen to DNA bays pe, 0.01–0.055), i kin inkrεs di DNA dεnaturashכn tεmprachכ bay 3.1°C. dis de sho se Bronchogen de mek di DNA stebul, i de ridyus di risk fכ DNA dεm we di εksternal tin dεm de kכz, εn dat de εp fכ mεnten nכmal jεnεtik infכmeshכn transmishכn εn sεl fכnshכn insay di rεspiretכri sεl dεm.
3. Binding Karakta ɛn Stebiliti Mɛkanism
fכda stכdi dεm sho se Bronchogen nכto adenine-thymine-spεsifi k כ guanine-cytosine-spεsifi k ligand. di kayn we aw i de biεn dεn kin tek am se i strכng εn random, εn i de biεn di tu strεn dεm na di DNA (fכs fכ naytrojen bays dεm). insay di rεnj כf r valyu frכm 0.01 to 1.0, di mεlt εntalpi (ΔH(mεlt)) fכ di kכmpleks de kכnstant, we de sho fכs di Bronchogen in yכnik mεkanism fכ akshכn fכ stεbyul DNA εn de gi strכng tiori bεsis fכ in rol fכ mεnten jεnomik stεbiliti insay rεspiretכri sεl dεm.
Pכtεnshal Aplikεshכn dεm fכ Bronchogen in di Tritmεnt fכ Respiratory Disizin dεm
1. Prɛvenshɔn fɔ Sik Bays pan DNA Stabilizayshɔn
biכs Bronchogen kin stεbyul di DNA strכkchכ, i de ple rol fכ mek sכm sik dεm we de kכmכt na di rεspiretכri we dεn kin kכz fכ DNA dεm we dεn dכn pwεl. di pipul dεm we de εkspos to lכng tεm εya pכlyushכn de pan inkrεs risk fכ gεt sik dεm we de fכ blo lεk lכng kεnsar εn krכnik obstruktiv pulmonari sik (COPD) biכs fכ DNA dεm we de na di rεspiretכri sεl dεm. brכnkojen kin ridyus dis risk bay we i de εnhans DNA stεbiliti, we de gi wan pכtεnshal prεvεntiv stratεji fכ dεn kayn populeshכn dεm ya.
2. Adjuvant Tεrapi fכ Respiratory Inflamεshכn
di tεm we di rεspiretכri inflameshn de, inflammatory mεdiate dεm we di inflammatory sεl dεm de rilis kin pwεl di DNA fכ di rεspiretכri sεl dεm. di prכpati dεm we di brכnkojen in DNA-stεbyulεshכn kin sכmtεm sכm kayn dεm, we kin εp fכ ripa εn fכ wok bak fכ di sεl dεm we dεn dכn pwεl. fכ mεnten nכmal jεnεtik infכmeshכn transmishכn insay sεl dεm kin gεt fayn ifekt bak fכ rεgεl di εksprεshכn fכ di jin dεm we riliyt to inflammatory rεspכns, we de εp fכ trit di rεspiretכri inflameshn.
Dɔn
Pan ɔl we di risach we dɛn de du naw bɔt Bronchogen pan di fild fɔ respiratory health stil de na in fɔs stej, di tin dɛn we dɛn dɔn fɛn naw de sho se i ebul fɔ du am. frכm in impak pan DNA stεbiliti to in aplikεshכn fכ prεvεnshכn εn tritmεnt fכ rεspiretכri sik dεm, Bronchogen de opin nyu dairekshכn fכ rεspiretכri hεlth risεch.
Usay i kɔmɔt
[1] Monaselidze JR, Khavinson V, Gɔrgoshidze MZ, ɛn ɔda pipul dɛn. Efεkt כf di pεptida brכnkojen (Ala-Asp-Glu-Leu) pan DNA tεmכstεbiliti[J]. Bulletin of Ekspirimɛnt Bayoloji ɛn Mɛdisin, 2011,150(3):375-377.DOI:10.1007/s10517-011-1146-x.
Prodak we de fɔ yuz fɔ risach nɔmɔ:
