By Cocer Peptides 
Watanni 1 da suka gabata
DUKKANIN LABARI DA BAYANIN KYAUTATAWA DA AKE BAYAR A WANNAN SHAFIN KAWAI DOMIN WATSA BAYANI NE DA MANUFOFIN ILIMI.
Kayayyakin da aka bayar akan wannan gidan yanar gizon an yi niyya ne kawai don binciken in vitro. Binciken in vitro (Latin: *a cikin gilashi*, ma'ana a cikin gilashin gilashi) ana gudanar da shi a wajen jikin mutum. Waɗannan samfuran ba magunguna ba ne, Hukumar Abinci da Magunguna ta Amurka (FDA) ba ta amince da su ba, kuma dole ne a yi amfani da su don hanawa, magani, ko warkar da duk wani yanayi na likita, cuta, ko cuta. Doka ta haramta shigar da waɗannan samfuran cikin jikin mutum ko dabba ta kowace hanya.
Gabatarwa
Daga cikin nazarin da yawa kan kula da lafiyar numfashi, Bronchogen ya nuna ingancinsa da yuwuwar ƙimar aikace-aikacen a fagen lafiyar numfashi. Wannan labarin zai bincika ingantaccen tasirin Bronchogen akan lafiyar numfashi da kuma abubuwan da ake buƙata na aikace-aikacen sa dangane da binciken da ake ciki.
Hoto 1 Tsarin sinadaran Bronchogen.
Tasirin Bronchogen akan Kwanciyar DNA
1. Haɗin Haɗin Kai Tsakanin Kwanciyar DNA da Lafiyar Numfashi
Ayyukan al'ada na sel ya dogara ne akan tsayayyen tsarin DNA. A cikin sassan numfashi, abubuwa daban-daban na muhalli kamar masu gurɓata yanayi da ƙwayoyin cuta na iya lalata DNA ta salula, ta haka yana shafar ayyukan al'ada na al'ada na sel na numfashi da kuma haifar da jerin cututtuka na numfashi. Kula da kwanciyar hankali na DNA yana da mahimmanci don ci gaba da aiki na yau da kullun na rayuwa, haɓakawa, da ayyukan sarrafa rigakafi na sel na numfashi.
2. Bronchogen a matsayin DNA Stabilizer
A wurare daban-daban, Bronchogen na iya rinjayar ma'aunin thermodynamic na DNA. Lokacin yin nazarin DNA ta amfani da microcalorimetry daban-daban na sikanin, an gano cewa Bronchogen na iya aiki azaman wakili na tabbatar da DNA. Lokacin da Bronchogen ke hulɗa da DNA daga hanta thymus na bovine da linzamin kwamfuta, a cikin kunkuntar darajar r (r shine ma'aunin molar Bronchogen zuwa DNA tushe nau'i-nau'i, 0.01-0.055), zai iya ƙara yawan zafin jiki na DNA ta 3.1 ° C. Wannan yana nuna cewa Bronchogen yana haɓaka kwanciyar hankali na DNA, yana rage haɗarin lalacewar DNA da ke haifar da abubuwan waje, kuma ta haka yana taimakawa wajen kula da watsa bayanan kwayoyin halitta na al'ada da aikin salula a cikin ƙwayoyin numfashi.
3. Halayen ɗaurewa da Ƙarfafawa
Ƙarin karatu ya nuna cewa Bronchogen ba adenine-thymine-specific ko guanine-cytosine-specific ligand. Ana ɗaukar nau'in ɗaurin sa mai ƙarfi da bazuwar, kuma yana ɗaure ga sassan DNA guda biyu (musamman zuwa tushen nitrogenous). A cikin kewayon r dabi'u daga 0.01 zuwa 1.0, narkewar enthalpy (ΔH (narke) na hadaddun ya kasance mai tsayi, yana kara nuna tsarin aikin Bronchogen na musamman don daidaita DNA da kuma samar da tushen ka'ida mai ƙarfi don rawar da take takawa wajen kiyaye kwanciyar hankali na genomic a cikin sel na numfashi.
Yiwuwar Aikace-aikacen Bronchogen a cikin Maganin Cututtukan Numfashi
1. Rigakafin Cututtuka Bisa Tsarin DNA
Tun da Bronchogen zai iya daidaita tsarin DNA, yana taka rawa wajen hana wasu cututtuka na numfashi da lalacewa ta DNA ke haifarwa. Yawan mutanen da aka fallasa ga gurɓacewar iska na dogon lokaci suna fuskantar haɗarin cututtukan numfashi kamar kansar huhu da cututtukan huhu na huhu (COPD) saboda lalacewar DNA a cikin ƙwayoyin numfashi. Bronchogen na iya rage wannan haɗari ta hanyar haɓaka kwanciyar hankali na DNA, yana ba da dabarun rigakafi ga irin waɗannan al'ummomi.
2. Magungunan Adjuvant don Kumburi na Numfashi
A lokacin kumburin numfashi, masu shiga tsakani da aka saki ta hanyar ƙwayoyin kumburi na iya lalata DNA na ƙwayoyin numfashi. Abubuwan da ke tabbatar da DNA na Bronchogen na iya rage irin wannan lalacewa zuwa wani ɗan lokaci, yana taimakawa wajen gyarawa da dawo da aikin ƙwayoyin da suka lalace. Tsayawa watsa bayanan kwayoyin halitta na yau da kullun a cikin sel na iya samun tasiri mai kyau akan daidaita maganganun kwayoyin halittar da ke da alaƙa da martani mai kumburi, don haka taimakawa wajen magance kumburin numfashi.
Kammalawa
Kodayake bincike na yanzu akan Bronchogen a fagen lafiyar numfashi yana kan matakin farko, binciken da ake samu ya nuna yuwuwar sa. Daga tasirinsa akan kwanciyar hankali na DNA zuwa aikace-aikacensa a cikin rigakafi da magance cututtukan numfashi, Bronchogen yana buɗe sabbin kwatance don binciken lafiyar numfashi.
Source
[1] Monaselidze JR, Khavinson V, Gorgoshidze MZ, et al. Tasirin bronchogen peptide (Ala-Asp-Glu-Leu) akan thermosability na DNA[J]. Bulletin na Kwayoyin Gwaji da Magunguna, 2011,150(3):375-377.DOI:10.1007/s10517-011-1146-x.
Samfura akwai don amfani da bincike kawai:
