▎ Binciken Cartalax
Menene asalin bincike na Cartalax?
Hanyar ganowa: An fara gano shi a lokacin nazarin kodan maraƙi. Tushen polypeptide da ke ware daga kodan ya sami damar haɓaka sabunta ƙwayoyin koda a cikin berayen da suka tsufa. Ta hanyar bincike, an gano cewa tsantsa ya ƙunshi nau'ikan peptides kamar Cartalax (AED) da T-35 (EDL). Wannan binciken ya haifar da zurfafa bincike na masana kimiyya akan halaye da ayyukan Cartalax.
Bincike kan hanyar aiki: Nazarin ya gano cewa Cartalax galibi yana aiki akan fibroblasts. Fibroblasts suna yadu a cikin kyallen takarda kamar guringuntsi na mutum, fata, tasoshin jini, da kodan. Cartalax yana rinjayar yaduwar kwayar halitta da apoptosis ta hanyar tsarin kwayoyin halitta da yawa, irin su ƙara yawan matakin Ki-67 mai haɓakawa, rage alamar p53, da kunna hanyar siginar NF-κB. Wadannan tasirin suna ba da Cartalax tare da ayyuka na rage jin daɗin tantanin halitta, maido da aikin tsofaffin ƙwayoyin sel, da jinkirta tsufa na nama, don haka an lasafta shi azaman mai kula da yanayin tsufa.
Binciken asibiti: A cikin gwajin ɗan adam da aka gudanar a Cibiyar Nazarin Bioregulation da Gerontology ta St. Sakamakon ya nuna cewa Cartalax zai iya rage zafi na 68% na marasa lafiya tare da osteoarthritis na gwiwa da 53% na marasa lafiya tare da spondylarthrosis, inganta motsi na haɗin gwiwa, da kuma nuna alamun ingantawar guringuntsi akan hoto, kuma yana da wasu amfani ga alamun osteoporosis.
Menene tsarin aikin Cartalax?
Matsayin Cartalax a cikin oxidation na tsarin lipid micelle
Tasiri akan tsarin iskar shaka
A cikin tsarin in vitro, Cartalax yana da tasiri mai rikitarwa akan tsarin iskar oxygen. A gefe guda, a ƙarƙashin wasu sharuɗɗa, zai iya hana Fe2 + -induced substrate oxidation process [1] . Oligopeptide yana yin wannan tasiri saboda ɗaurin mai ƙaddamar da cationic. Wannan yana nuna cewa Cartalax na iya tsoma baki tare da matakin farawa na amsawar iskar oxygen ta hanyar yin hulɗa tare da cations, don haka rage saurin iskar oxygen.
Koyaya, a ƙarƙashin yanayin oxidation wanda azobis (isobutyronitrile) ya fara, Cartalax zai haɓaka iskar oxygen. A karkashin waɗannan yanayi, a cikin abun da ke ciki tare da antioxidants, Cartalax yana aiki a matsayin mai adawa da sauran peptides na tsarin sinadarai daban-daban, yana rage tasirin hanawa na β-carotene da α-tocopherol. Wannan yana nufin cewa a ƙarƙashin takamaiman yanayin ƙaddamarwar iskar oxygen, kasancewar Cartalax na iya canza tsarin aikin antioxidant, yana raunana tasirin hanawa akan iskar shaka [1].
Yin hulɗa tare da wasu abubuwa
A lokacin tsarin iskar oxygenation na tsarin lipid micelle, Cartalax yana hulɗa tare da sauran oligopeptides bioactive, samfurin dipeptides da tripeptides, da antioxidants. Misali, lokacin da ake kasancewa tare a cikin tsarin in vitro tare da abubuwa kamar Veron (Lys-Glu), Vesugen (Lys-Glu-Asp), Pineal (Glu-γ-Asp-delta-Arg), honluten (Glu-I-3-Asp-Gly), Egg (Glu-I-3-Asp-Leu), krista-Gista-3 (Ala-I-3-Glu-I-3-Asp-Gly), Carnosine (β-Ala-His), Glycylglycine (Gly-Gly), Glycylglycylglycine (Gly-Gly-Gly), Prolylproline (Pro-Pro), Prolylproline (Pro-Pro-Pro), Prolylproline (Pro-Pro-Pro), da Glutathione (gays-Glu Properties) ..
Gwaje-gwaje sun nuna cewa a gaban peptides, yawan tarin hydroperoxides yana ƙaruwa, kuma yawan sha na antioxidants shima yana canzawa. Wannan yana nuna cewa Cartalax ba wai kawai yana rinjayar tsarin iskar oxygen da kanta ba amma kuma yana da tasiri akan tarawa da shayar da wasu abubuwa yayin tsarin iskar oxygen.
Matsayin kwaikwayon enzymes da masu hana iskar oxygenation na halitta
Abubuwan da aka tsara na Cartalax suna kwaikwayon tasirin antioxidant na enzymes da masu hana iskar oxygen na halitta a cikin vitro, waɗanda ke cikin halittu masu rai [1] . Wannan yana nufin cewa Cartalax na iya samun ayyuka masu kama da na enzymes da antioxidants na halitta a cikin rayayyun halittu kuma yana da mahimmancin mahimmanci don kiyaye ma'auni na oxygenation na kwayoyin halitta.
Menene aikace-aikacen Cartalax?
Gyaran guringuntsi da lafiyar haɗin gwiwa: Cartalax yana taimakawa wajen dawo da mutuncin nama na guringuntsi ta hanyar ƙarfafa haɗin furotin na chondrocytes, don haka rage ciwon haɗin gwiwa da ƙumburi da inganta aikin haɗin gwiwa. Cartalax ya nuna tasiri mai mahimmanci a cikin maganin cututtuka irin su spondylarthrosis, osteoarthritis, da osteoporosis. Yana iya inganta haɗin haɗin sunadarai na guringuntsi masu mahimmanci irin su collagen, goyan bayan tsarin tsari na matrix na guringuntsi, da kuma taimaka masa ya dawo daga lalacewa ta hanyar lalacewa ko kumburi. Bugu da ƙari, Cartalax kuma yana da tasiri na rigakafi a kan cututtukan cututtuka na kashin baya da haɗin gwiwa a cikin tsofaffi, yana taimakawa wajen jinkirta faruwar waɗannan raunuka da inganta rayuwar tsofaffi [2]..
Tasirin ƙwayar cuta: Cartalax yana da kaddarorin anti-mai kumburi kuma zai iya daidaita amsawar kumburi. Yana rinjayar samar da cytokines ta hanyar yin hulɗa tare da su kuma ya mayar da daidaitattun amsawar kumburi. A cikin samfurin ƙumburi da aka haifar, Cartalax ya rage matakan cytokines pro-inflammatory (irin su IL-1β, TNF-α, da COX-2), kuma a lokaci guda ya karu da ma'anar mahimman abubuwan da ke tattare da ƙwayoyin cuta da hanyoyin gyaran nama kamar IL-10 da TGF-β. Tsantsar nau'in innabi na proanthocyanidin (GSPE) na iya rage yawan kaurin fata da kumburi ke haifar da shi kuma ya daidaita adadin adadin fararen jini a cikin samfuran jini na jini. Idan aka kwatanta da indomethacin na anti-mai kumburi, GSPE ya nuna sakamako mai kyau na maganin kumburi (Radhi H, 2021). Wannan tasirin anti-mai kumburi ya sa Cartalax ya sami ƙimar aikace-aikacen da za a iya amfani da shi a cikin maganin cututtukan kumburi daban-daban, musamman a cikin cututtukan arthritis da sauran cututtukan haɗin gwiwa [2].
Farfaɗowar nama: Cartalax na iya goyan bayan yuwuwar haɓakawa na kyallen takarda daban-daban ta hanyar haɓaka haɓakar ƙwayoyin sel da sel masu tasowa. Nazarin in vitro ya nuna cewa Cartalax na iya ƙara yawan haɓakar ƙwayoyin ƙwayoyin cuta na mesenchymal (MSCs), waɗanda ke da mahimmanci don gyara nama da kiyayewa saboda suna iya bambanta cikin nau'ikan tantanin halitta na musamman da ake buƙata don kula da aikin nama. Wannan halayyar ta sa Cartalax ya sami fa'idodin aikace-aikace a fannonin injiniyan nama da magani na farfadowa, musamman a cikin sabuntar guringuntsi da kyallen kasusuwa [2].
Gyaran motsa jiki: Cartalax kuma yana da aikace-aikace a cikin magungunan wasanni, musamman tsakanin 'yan wasa ko mutanen da ke yin motsa jiki mai tsanani. Zai iya tallafawa lafiyar haɗin gwiwa, rage lalacewar haɗin gwiwar motsa jiki, da inganta gyaran guringuntsi. Ga 'yan wasan da sukan shiga horo mai tsanani, Cartalax na iya taimaka musu su dawo da sauri bayan horo da gasa da kuma rage matsalolin haɗin gwiwa da ke haifar da wuce gona da iri.
Cututtuka na tsari da lokacin aiki: Ana kuma amfani da Cartalax a cikin cututtukan nama na nama da kuma lokacin da aka fara aiki da kuma bayan tiyata na haɗin gwiwa. A cikin cututtuka na nama na tsarin jiki, Cartalax yana taimakawa wajen daidaita amsawar rigakafi, rage kumburi, da kare haɗin gwiwa da kyallen takarda. A lokacin da ake yin aiki da kuma bayan tiyata na haɗin gwiwa, Cartalax zai iya taimakawa wajen hana lalacewar kashi da haɗin gwiwa da inganta farfadowa bayan tiyata, rage abin da ya faru na rikice-rikice.
Rigakafin cututtukan cututtuka a cikin tsofaffi: Ga tsofaffi, Cartalax yana taimakawa wajen hana cututtukan cututtuka na kashin baya da haɗin gwiwa. Tare da haɓakar shekaru, haɓakar dabi'a na guringuntsi da nama na haɗin gwiwa ba makawa ne, amma Cartalax na iya jinkirta wannan tsari ta hanyar ƙarfafa ayyukan chondrocytes da inganta haɓakar collagen, inganta aikin haɗin gwiwa, da inganta rayuwar tsofaffi.
Lafiyar fata: Bincike ya nuna cewa Cartalax na iya haɓaka elasticity da tsarin fata ta hanyar haɓaka haɗin collagen ko inganta aikin ƙwayoyin fata. Wannan ya sa Cartalax ya sami yuwuwar ƙimar aikace-aikacen a fagen kula da fata da rigakafin tsufa, musamman don inganta yanayin fata da rage wrinkles [2].
Kariyar Renal: Wasu bincike sun nuna cewa Cartalax na iya samun tasiri mai kariya akan aikin koda da tsari. Yana iya kare kodan daga lalacewa ta hanyar rinjayar tsarin salula a cikin kodan, rage kumburi da damuwa na oxidative. Wannan tasirin kariya na koda yana sa Cartalax ya sami yuwuwar ƙimar aikace-aikacen a cikin maganin cututtukan koda da cututtukan da ke da alaƙa.
Anti-tsufa: Ana ɗaukar Cartalax azaman peptide anti-tsufa wanda zai iya rage wasu al'amura na tsarin tsufa ta hanyar shafar hanyoyin salula daban-daban. Yana iya inganta gaba ɗaya mahimmanci da lafiya ta hanyar daidaita tsarin tantanin halitta, rage damuwa na oxyidative da amsa mai kumburi, da inganta gyaran nama da farfadowa. Wannan halayyar anti-tsufa ta sa Cartalax yana da yuwuwar ƙimar aikace-aikacen a cikin jinkirta cututtukan da ke da alaƙa da tsufa da haɓaka lafiyar gabaɗaya [2].
Tsarin aikin Cartalax yana da rikitarwa, yana da tasiri biyu akan tsarin iskar oxygen. Yana iya yin hulɗa tare da abubuwa iri-iri kuma ya kwaikwayi ayyukan antioxidant. Aikace-aikacen sa suna da yawa, suna nuna yuwuwar a fannoni da yawa kamar farfadowar nama, dawo da wasanni, maganin cututtuka, da lafiyar fata.
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Mawallafin Jaridar Kimiyya
Storozhok NM wani mai bincike ne da ke da alaƙa da Jami'ar Kiwon Lafiya ta Jihar Tyumen, Cibiyar Nazarin Tarayya ta Tarayya don Kimiyyar Kimiyyar Kimiyya a Cibiyar Kimiyya ta Rasha, da TYUMEN INST MED. Ayyukansa sun haɗa da bincike na interdisciplinary a Chemistry, Biochemistry & Molecular Biology, Biophysics, Cell Biology, and Physics. Ya ba da gudummawa sosai ga waɗannan fagagen ta hanyar ayyukan ilimi da bincike. An jera Storozhok NM a cikin ambaton ambaton [1].
