▎ Kev Tshawb Fawb Cartalax
Kev tshawb fawb keeb kwm ntawm Cartalax yog dab tsi?
Discovery txheej txheem: Nws tau xub pom thaum lub sij hawm kawm ntawm calf raum. Cov polypeptide extract cais tawm ntawm ob lub raum tuaj yeem txhawb kev rov ua dua tshiab ntawm lub raum hlwb hauv cov nas hnub nyoog. Los ntawm kev tshuaj xyuas, nws tau pom tias cov extract muaj ntau yam peptides xws li Cartalax (AED) thiab T-35 (EDL). Qhov kev tshawb pom no ua rau kev tshawb fawb tob los ntawm cov kws tshawb fawb txog cov yam ntxwv thiab kev ua haujlwm ntawm Cartalax.
Kev tshawb fawb txog cov txheej txheem ntawm kev ua: Kev tshawb fawb pom tias Cartalax feem ntau ua rau fibroblasts. Fibroblasts muaj nyob rau hauv cov ntaub so ntswg xws li tib neeg pob txha mos, tawv nqaij, hlab ntsha, thiab ob lub raum. Cartalax cuam tshuam rau cell proliferation thiab apoptosis los ntawm ntau lub tshuab molecular, xws li nce qib ntawm cell proliferation marker Ki-67, txo p53 signaling, thiab activating NF-κB signaling pathway. Cov teebmeem no endow Cartalax nrog lub luag haujlwm ntawm kev txo qis cell senescence, rov ua haujlwm ntawm cov hlwb laus, thiab ncua cov ntaub so ntswg laus, yog li nws raug cais raws li kev tiv thaiv kev laus.
Kev tshawb fawb soj ntsuam: Hauv tib neeg kev sim ua nyob rau hauv St. Petersburg lub koom haum ntawm Bioregulation thiab Gerontology, Cartalax tau siv los kho cov neeg mob osteoarthritis thiab osteoporosis. Cov txiaj ntsig tau pom tias Cartalax tuaj yeem txo qhov mob ntawm 68% ntawm cov neeg mob hauv lub hauv caug osteoarthritis thiab 53% ntawm cov neeg mob spondylarthrosis, txhim kho kev sib koom ua ke, thiab pom cov tsos mob ntawm pob txha pob txha txhim kho ntawm daim duab, thiab kuj muaj qee yam txiaj ntsig rau cov tsos mob ntawm pob txha.
Yuav ua li cas yog lub mechanism ntawm kev txiav txim ntawm Cartalax?
Lub luag haujlwm ntawm Cartalax hauv oxidation ntawm lipid micelle system
Kev cuam tshuam ntawm cov txheej txheem oxidation
Nyob rau hauv ib qho vitro system, Cartalax muaj kev cuam tshuam rau cov txheej txheem oxidation. Ntawm ib sab, nyob rau hauv tej yam kev mob, nws muaj peev xwm inhibit Fe2 +-induced substrate oxidation txheej txheem [1] . Lub oligopeptide exerts cov nyhuv no vim yog kev khi ntawm cationic pib. Qhov no qhia tau hais tias Cartalax tuaj yeem cuam tshuam rau theem pib ntawm cov tshuaj tiv thaiv oxidation los ntawm kev cuam tshuam nrog cations, yog li ua kom qeeb ntawm cov txheej txheem oxidation.
Txawm li cas los xij, nyob rau hauv cov xwm txheej oxidation pib los ntawm azobis (isobutyronitrile), Cartalax yuav ua kom cov oxidation. Nyob rau hauv cov xwm txheej no, nyob rau hauv muaj pes tsawg leeg nrog antioxidants, Cartalax ua raws li ib tug antagonist nrog rau lwm yam peptides ntawm txawv tshuaj qauv, zoo heev txo cov inhibitory los ntawm β-carotene thiab α-tocopherol. Qhov no txhais tau hais tias nyob rau hauv tshwj xeeb oxidation pib tej yam kev mob, lub xub ntiag ntawm Cartalax yuav hloov lub mechanism ntawm kev txiav txim ntawm cov antioxidant, tsis muaj zog nws inhibitory nyhuv ntawm oxidation [1].
Kev sib cuam tshuam nrog lwm yam khoom
Thaum lub sij hawm oxidation txheej txheem ntawm lipid micelle system, Cartalax cuam tshuam nrog lwm cov bioactive oligopeptides, qauv dipeptides thiab tripeptides, thiab antioxidants. Piv txwv li, thaum muaj nyob rau hauv ib qho vitro system nrog cov khoom xws li Veron (Lys-Glu), Vesugen (Lys-Glu-Asp), Pineal (Glu-γ-Asp-delta-Arg), honluten (Glu-I-3-Asp-Gly), Qe (Glu-I-3-Asp-Leu), kriston (Akriston) (Ala-I-3-Glu-I-3-Asp-Gly), Carnosine (β-Ala-His), Glycylglycine (Gly-Gly), Glycylglycylglycine (Gly-Gly-Gly), Prolylproline (Pro-Pro), Prolylproline (Pro-Pro-Pro), thiab nws cov khoom Glutathione Gluta. kev sib txawv [1].
Kev sim tau pom tias nyob rau hauv muaj peptides, tsub zuj zuj ntawm hydroperoxides nce, thiab tus nqi nqus ntawm antioxidants kuj hloov. Qhov no qhia tau hais tias Cartalax tsis tsuas yog cuam tshuam rau cov txheej txheem oxidation nws tus kheej tab sis kuj muaj kev cuam tshuam rau kev sib sau thiab nqus ntawm lwm yam tshuaj thaum lub sij hawm oxidation txheej txheem.
Lub luag haujlwm ntawm mimicking enzymes thiab ntuj oxidation inhibitors
Lub tswv yim muaj pes tsawg leeg ntawm Cartalax mimics cov teebmeem antioxidant ntawm enzymes thiab ntuj oxidation inhibitors hauv vitro, uas muaj nyob hauv cov kab mob muaj sia [1] . Qhov no txhais tau hais tias Cartalax tuaj yeem muaj cov haujlwm zoo ib yam li cov enzymes thiab ntuj antioxidants hauv cov kab mob nyob thiab muaj peev xwm tseem ceeb rau kev tswj cov oxidation tshuav nyiaj li cas.
Cov ntawv thov ntawm Cartalax yog dab tsi?
Kev kho pob txha mos thiab kev noj qab haus huv ntawm cov pob txha: Cartalax pab rov ua kom muaj kev ncaj ncees ntawm cov pob txha mos los ntawm kev txhawb nqa cov protein synthesis ntawm chondrocytes, yog li txo qhov mob thiab txhav thiab txhim kho kev sib koom tes. Cartalax tau pom muaj txiaj ntsig tseem ceeb hauv kev kho cov kab mob xws li spondylarthrosis, osteoarthritis, thiab osteoporosis. Nws tuaj yeem txhawb nqa kev sib txuas ntawm cov pob txha pob txha tseem ceeb xws li collagen, txhawb kev ncaj ncees ntawm cov pob txha mos matrix, thiab pab nws rov qab los ntawm kev puas tsuaj los ntawm kev hnav lossis o. Tsis tas li ntawd, Cartalax kuj muaj kev tiv thaiv ntawm cov kab mob degenerative ntawm tus txha nqaj qaum thiab cov pob qij txha hauv cov neeg laus, pab ncua qhov tshwm sim ntawm cov kab mob no thiab txhim kho lub neej zoo ntawm cov neeg laus [2].
Anti-inflammatory nyhuv: Cartalax muaj cov tshuaj tiv thaiv kab mob thiab tuaj yeem tswj cov kab mob inflammatory. Nws cuam tshuam rau kev tsim cov cytokines los ntawm kev cuam tshuam nrog lawv thiab rov ua kom cov lus teb sib npaug. Nyob rau hauv tus qauv ntawm induced o, Cartalax txo cov theem ntawm pro-inflammatory cytokines (xws li IL-1β, TNF-α, thiab COX-2), thiab nyob rau tib lub sij hawm nce qhov kev nthuav qhia ntawm cov ntsiab lus tseem ceeb ntawm anti-inflammatory thiab cov ntaub so ntswg kho txoj kev xws li IL-10 thiab TGF-β. Grape noob proanthocyanidin extract (GSPE) tuaj yeem txo qhov nce ntawm daim tawv nqaij tuab los ntawm o thiab tswj qhov sib txawv ntawm cov qe ntshav dawb hauv cov ntshav kuaj ntshav. Piv nrog rau cov tshuaj tiv thaiv kab mob indomethacin, GSPE tau pom tias muaj kev tiv thaiv zoo (Radhi H, 2021). Cov tshuaj tiv thaiv kab mob no ua rau Cartalax muaj peev xwm siv tau rau hauv kev kho mob ntawm ntau yam kab mob, tshwj xeeb tshaj yog mob caj dab thiab lwm yam kab mob sib koom ua ke [2].
Cov ntaub so ntswg rov tsim dua tshiab: Cartalax tuaj yeem txhawb nqa lub peev xwm rov tsim dua tshiab ntawm ntau cov ntaub so ntswg los ntawm kev txhawb nqa kev loj hlob ntawm qia hlwb thiab cov hlwb progenitor. Cov kev tshawb fawb hauv vitro tau pom tias Cartalax tuaj yeem ua rau muaj kev loj hlob ntawm mesenchymal qia hlwb (MSCs), uas yog qhov tseem ceeb rau kev kho cov ntaub so ntswg thiab kev saib xyuas vim tias lawv tuaj yeem sib txawv rau hauv cov cell tshwj xeeb uas yuav tsum tau tswj cov ntaub so ntswg. Cov yam ntxwv no ua rau Cartalax muaj cov ntawv thov dav dav hauv thaj chaw ntawm cov ntaub so ntswg engineering thiab tshuaj kho dua tshiab, tshwj xeeb tshaj yog nyob rau hauv kev tsim kho pob txha mos thiab pob txha [2].
Kev tawm dag zog rov qab: Cartalax kuj muaj cov ntawv thov hauv cov tshuaj kis las, tshwj xeeb tshaj yog cov neeg ncaws pob lossis cov neeg uas koom nrog kev tawm dag zog. Nws tuaj yeem txhawb kev noj qab haus huv ntawm kev sib koom tes, txo qis kev tawm dag zog vim kev sib koom ua ke, thiab txhawb kev kho pob txha mos. Rau cov neeg ncaws pob uas feem ntau koom nrog kev cob qhia siab, Cartalax tuaj yeem pab lawv rov qab sai dua tom qab kev cob qhia thiab kev sib tw thiab txo cov teeb meem sib koom ua ke los ntawm kev siv ntau dhau.
Cov kab mob hauv lub cev thiab lub sijhawm perioperative: Cartalax kuj tseem siv rau hauv cov kab mob sib txuas hauv cov kab mob thiab thaum lub sijhawm ua ntej thiab tom qab kev phais ntawm kev phais. Nyob rau hauv cov kab mob ntawm cov kab mob sib txuas, Cartalax pab tswj lub cev tiv thaiv kab mob, txo qhov mob, thiab tiv thaiv kev sib koom tes thiab pob txha mos. Thaum lub sij hawm preoperative thiab postoperative lub sij hawm ntawm kev phais kev sib koom tes, Cartalax tuaj yeem pab tiv thaiv cov pob txha thiab pob qij txha puas thiab txhawb kev rov ua haujlwm tom qab, txo qhov tshwm sim ntawm cov teeb meem tom qab phais.
Tiv thaiv cov kab mob degenerative hauv cov neeg laus: Rau cov neeg laus, Cartalax pab tiv thaiv cov kab mob degenerative ntawm tus txha nqaj qaum thiab pob qij txha. Nrog rau kev loj hlob ntawm lub hnub nyoog, lub ntuj degeneration ntawm pob txha mos thiab cov ntaub so ntswg yog inevitable, tab sis Cartalax tuaj yeem ncua cov txheej txheem no los ntawm kev txhawb nqa kev ua haujlwm ntawm chondrocytes thiab txhawb cov synthesis ntawm collagen, txhim kho kev sib koom ua haujlwm, thiab txhim kho lub neej zoo ntawm cov neeg laus.
Kev noj qab haus huv ntawm daim tawv nqaij: Kev tshawb fawb qhia tias Cartalax tuaj yeem txhim kho elasticity thiab cov qauv ntawm daim tawv nqaij los ntawm kev txhawb nqa cov synthesis ntawm collagen los yog txhim kho kev ua haujlwm ntawm daim tawv nqaij. Qhov no ua rau Cartalax muaj peev xwm siv tau rau hauv thaj chaw ntawm kev tu tawv nqaij thiab tiv thaiv kev laus, tshwj xeeb tshaj yog nyob rau hauv kev txhim kho daim tawv nqaij zoo nkauj thiab txo wrinkles [2].
Kev tiv thaiv lub raum: Qee qhov kev tshawb fawb tau pom tias Cartalax tuaj yeem muaj kev tiv thaiv ntawm lub raum ua haujlwm thiab cov qauv. Nws tuaj yeem tiv thaiv ob lub raum los ntawm kev puas tsuaj los ntawm kev cuam tshuam cov txheej txheem cellular hauv ob lub raum, txo qhov mob thiab oxidative kev nyuaj siab. Qhov kev tiv thaiv lub raum no ua rau Cartalax muaj peev xwm siv tau rau hauv kev kho mob raum kab mob thiab lwm yam kab mob.
Kev tiv thaiv kev laus: Cartalax suav hais tias yog kev tiv thaiv kev laus peptide uas tuaj yeem ua rau qee yam ntawm cov txheej txheem kev laus los ntawm kev cuam tshuam rau ntau yam ntawm tes. Nws tuaj yeem txhim kho tag nrho qhov tseem ceeb thiab kev noj qab haus huv los ntawm kev tswj hwm lub voj voog ntawm tes, txo oxidative kev nyuaj siab thiab inflammatory teb, thiab txhawb cov ntaub so ntswg kho thiab rov tsim dua tshiab. Cov yam ntxwv tiv thaiv kev laus no ua rau Cartalax muaj peev xwm siv tau tus nqi hauv kev ncua cov kab mob kev laus thiab txhim kho kev noj qab haus huv tag nrho [2].
Lub mechanism ntawm kev txiav txim ntawm Cartalax yog complex, muaj ob qho kev cuam tshuam rau cov txheej txheem oxidation. Nws tuaj yeem cuam tshuam nrog ntau yam tshuaj thiab simulate antioxidant zog. Nws daim ntawv thov yog qhov dav, ua kom pom muaj peev xwm hauv ntau qhov chaw xws li kev tsim cov ntaub so ntswg, rov ua kom cov kis las, kho kab mob, thiab kev noj qab haus huv ntawm daim tawv nqaij.
Hais Txog Tus Sau
Cov ntaub ntawv hais saum toj no yog txhua yam tshawb fawb, kho thiab sau los ntawm Cocer Peptides.
Scientific Journal Author
Storozhok NM yog ib tug kws tshawb fawb txuam nrog Tyumen State Medical University, NN Semenov Tsoom Fwv Teb Chaws Tshawb Fawb Chaw rau Tshuaj Physics ntawm Lavxias Academy ntawm Sciences, thiab TYUMEN INST MED. Nws txoj haujlwm suav nrog kev tshawb fawb txog kev tshawb fawb hauv Chemistry, Biochemistry & Molecular Biology, Biophysics, Cell Biology, thiab Physics. Nws tau ua haujlwm tseem ceeb rau cov haujlwm no los ntawm nws txoj haujlwm kev kawm thiab kev tshawb fawb. Storozhok NM tau teev nyob rau hauv qhov kev siv ntawm cov ntaub ntawv pov thawj [1].
