▎ Nnyocha Cartalax
Kedu ihe ndabere nyocha nke Cartalax?
Usoro nchọpụta: Achọpụtara ya na mbụ n'oge ọmụmụ nke akụrụ nwa ehi. Mwepụta nke polypeptide dịpụrụ adịpụ na akụrụ nwere ike kpalite mmeghari nke mkpụrụ ndụ akụrụ na oke oke. Site na nyocha, a chọpụtara na mpụta ahụ nwere peptides dị iche iche dị ka Cartalax (AED) na T-35 (EDL). Nchọpụta a kpalitere nyocha miri emi nke ndị ọkà mmụta sayensị gbasara njirimara na ọrụ Cartalax.
Nnyocha na usoro nke ime ihe: Nnyocha achọpụtala na Cartalax na-emekarị na fibroblasts. Fibroblasts dị n'ọtụtụ ebe na anụ ahụ dị ka cartilage mmadụ, akpụkpọ anụ, arịa ọbara, na akụrụ. Cartalax na-emetụta mgbasawanye cell na apoptosis site na ọtụtụ usoro molekụla, dị ka ịbawanye ọkwa nke Ki-67 akara ngosi cell, na-ebelata p53 akara, ma na-eme ka ụzọ akara NF-κB rụọ ọrụ. Mmetụta ndị a na-enye Cartalax ọrụ nke ibelata senescence cell, iweghachi ọrụ nke sel ndị agadi, na igbu oge ịka nká anụ ahụ, ya mere a na-ekewa ya dị ka onye na-ahụ maka ihe ndị na-ahụ maka ime agadi.
Nnyocha ụlọ ọgwụ: N'ime ule ụmụ mmadụ e mere na St. Petersburg Institute of Bioregulation and Gerontology, Cartalax na-agwọ ndị ọrịa nwere ọrịa ogbu na nkwonkwo na ọkpụkpụ ọkpụkpụ. Nsonaazụ gosiri na Cartalax nwere ike belata ihe mgbu nke 68% nke ndị ọrịa nwere osteoarthritis ikpere na 53% nke ndị ọrịa nwere spondylarthrosis, kwalite mmegharị nkwonkwo, ma gosipụta ihe ịrịba ama nke mmụba cartilage na eserese, ma nweekwa uru ụfọdụ maka mgbaàmà nke ọkpụkpụ ọkpụkpụ.
Gịnị bụ usoro nke Cartalax?
Ọrụ Cartalax na oxidation nke lipid micell system
Mmetụta na usoro oxidation
Na usoro in vitro, Cartalax nwere mmetụta dị mgbagwoju anya na usoro oxidation. N'otu aka ahụ, n'okpuru ọnọdụ ụfọdụ, ọ nwere ike igbochi usoro oxidation substrate Fe2 + na-ebute [1] . Oligopeptide na-arụ ọrụ a n'ihi njikọ nke onye mmalite cationic. Nke a na-egosi na Cartalax nwere ike igbochi mmalite mmalite nke mmeghachi omume oxidation site na iji cations na-emekọrịta ihe, si otú ahụ na-ebelata usoro oxidation.
Otú ọ dị, n'okpuru ọnọdụ oxidation nke azobis (isobutyronitrile) malitere, Cartalax ga-eme ka oxidation ahụ dịkwuo elu. N'okpuru ọnọdụ ndị a, na ihe mejupụtara ya na antioxidants, Cartalax na-eme dị ka onye na-emegide ya na peptides ndị ọzọ nke usoro kemịkal dị iche iche, na-ebelata mmetụta mgbochi nke β-carotene na α-tocopherol. Nke a pụtara na n'okpuru ọnọdụ mmalite oxidation kpọmkwem, ọnụnọ Cartalax nwere ike gbanwee usoro ọrụ nke antioxidant, na-ebelata mmetụta mgbochi ya na oxidation [1].
Mmekọrịta na ihe ndị ọzọ
N'oge usoro oxidation nke lipid micell system, Cartalax na-emekọrịta ihe na oligopeptides bioactive ndị ọzọ, ụdị dipeptides na tripeptides, na antioxidants. Dịka ọmụmaatụ, mgbe ị na-arụkọ ọrụ na sistemu in vitro nwere ihe ndị dị ka Veron (Lys-Glu), Vesugen (Lys-Glu-Asp), Pineal (Glu-γ-Asp-delta-Arg), honluten (Glu-I-3-Asp-Gly), Egg (Glu-I-3-Asp-Leu), krista-3-gen (Ala-I-3-Glu-I-3-Asp-Gly), Carnosine (β-Ala-His), Glycylglycine (Gly-Gly), Glycylglycylglycine (Gly-Gly-Gly), Prolylproline (Pro-Pro), Prolylproline (Pro-Pro-Pro), na Glutathione (gays-Glu) Njirimara.
Nnwale egosila na n'ihu nke peptides, mkpokọta hydroperoxides na-abawanye, na nnabata nke antioxidants na-agbanwekwa. Nke a na-egosi na Cartalax ọ bụghị nanị na-emetụta usoro oxidation n'onwe ya kamakwa ọ na-enwe mmetụta na nchịkọta na ntinye nke ihe ndị ọzọ n'oge usoro oxidation.
Ọrụ nke iṅomi enzymes na ihe mgbochi oxidation eke
Ngwakọta nke Cartalax a tụrụ aro na-eṅomi mmetụta antioxidant nke enzymes na ndị na-egbochi oxidation eke in vitro, bụ nke dị n'ime ihe ndị dị ndụ [1] . Nke a pụtara na Cartalax nwere ike ịnwe ọrụ yiri nke enzymes na antioxidants eke na ihe ndị dị ndụ ma nwee uru ọ bara maka idowe nguzozi oxidation nke ntule.
Kedu ihe bụ ngwa Cartalax?
Ndozi cartilage na ahụike nkwonkwo: Cartalax na-enyere aka weghachite iguzosi ike n'ezi ihe nke anụ ahụ cartilage site n'ịkwalite njikọ protein nke chondrocytes, si otú ahụ belata mgbu na nkwonkwo nkwonkwo na imeziwanye ọrụ nkwonkwo. Cartalax egosila mmetụta dị ukwuu na ọgwụgwọ ọrịa ndị dị ka spondylarthrosis, osteoarthritis, na osteoporosis. Ọ nwere ike ịkwalite njikọ nke protein cartilage isi dị ka collagen, na-akwado iguzosi ike n'ezi ihe nke matrix cartilage, ma nyere ya aka ịgbake site na mmebi nke iyi ma ọ bụ mbufụt kpatara. Tụkwasị na nke ahụ, Cartalax nwekwara mmetụta mgbochi na ọnya mmebi nke ọkpụkpụ azụ na nkwonkwo na ndị agadi, na-enyere aka igbu oge nke ọnya ndị a ma melite ogo ndụ nke ndị agadi [2]..
Mmetụta mgbochi mkpali: Cartalax nwere ihe mgbochi mkpali ma nwee ike ịhazi nzaghachi mkpali. Ọ na-emetụta mmepụta nke cytokines site na iso ha na-emekọrịta ihe ma na-eweghachi nzaghachi mkpali ziri ezi. N'ihe atụ nke mbufụt na-akpata, Cartalax belatara ọkwa nke cytokines pro-inflammatory (dị ka IL-1β, TNF-α, na COX-2), ma n'otu oge ahụ mụbara nkwupụta nke isi akụkụ nke mgbochi mkpali na ụzọ nrụzi anụ ahụ dị ka IL-10 na TGF-β. Mkpụrụ grape proanthocyanidin wepụ (GSPE) nwere ike belata mmụba nke ọkpụkpụ akpụkpọ ahụ nke mbufụt na-akpata ma na-ahazi ọnụọgụ dị iche iche nke mkpụrụ ndụ ọbara ọcha na nlele ọbara ọbara. Tụnyere ọgwụ mgbochi mkpali indomethacin, GSPE egosila mmetụta mgbochi mkpali dị mma (Radhi H, 2021). Mmetụta mgbochi mkpali a na-eme ka Cartalax nwee uru ngwa ngwa n'ịgwọ ọrịa ọrịa dị iche iche, karịsịa na ọrịa ogbu na nkwonkwo na ọrịa nkwonkwo ndị ọzọ [2].
Mweghachi anụ ahụ: Cartalax nwere ike ịkwado ikike nrụpụta nke anụ ahụ dị iche iche site n'ịkwalite mmụba nke mkpụrụ ndụ stem na sel progenitor. Nnyocha ọmụmụ vitro egosila na Cartalax nwere ike ịbawanye ụba nke mkpụrụ ndụ mesenchymal stem cell (MSC), nke dị oke mkpa maka nrụzi na nrụzi anụ ahụ n'ihi na ha nwere ike ịmata ọdịiche dị n'ụdị cell pụrụ iche chọrọ iji nọgide na-arụ ọrụ anụ ahụ. Njirimara a na-eme Cartalax nwere atụmanya ngwa sara mbara n'ọhịa nke injinịa anụ ahụ na ọgwụ na-emegharị ahụ, ọkachasị na mmeghari nke cartilage na anụ ahụ ọkpụkpụ [2].
Mgbake mgbatị ahụ: Cartalax nwekwara ngwa na ọgwụ egwuregwu, karịsịa n'etiti ndị na-eme egwuregwu ma ọ bụ ndị na-emega ahụ siri ike. Ọ nwere ike ịkwado ahụike nkwonkwo, belata mmebi nkwonkwo nke mmega ahụ kpatara, ma kwalite mmezi nke cartilage. Maka ndị na-eme egwuregwu na-etinyekarị aka na ọzụzụ dị elu, Cartalax nwere ike inyere ha aka ịgbake ngwa ngwa mgbe ọzụzụ na asọmpi ma belata nsogbu nkwonkwo kpatara site na ịṅụbiga mmanya ókè.
Ọrịa sistemu na oge perioperative: A na-etinyekwa Cartalax na ọrịa anụ ahụ sistemu sistemu yana n'oge a na-arụ ọrụ tupu ịwa ahụ na oge ịwa ahụ nkwonkwo. N'ọrịa anụ ahụ na-ejikọta sistemu, Cartalax na-enyere aka ịhazi nzaghachi mgbochi ahụ, belata mbufụt, ma chebe nkwonkwo na anụ ahụ cartilage. N'oge a na-arụ ọrụ tupu ịwa ahụ na nke na-esote oge ịwa ahụ nkwonkwo, Cartalax nwere ike inye aka gbochie ọkpụkpụ na nkwonkwo ma kwalite mgbake mgbe ọ gasịrị, na-ebelata ihe omume nke mgbagwoju anya.
Mgbochi nke mmerụ ahụ na-emebi emebi na ndị agadi: Maka ndị agadi, Cartalax na-enyere aka igbochi mmebi nke ọkpụkpụ azụ na nkwonkwo. Site na mmụba nke afọ, mmebi anụ ahụ nke cartilage na nkwonkwo nkwonkwo bụ ihe a na-apụghị izere ezere, ma Cartalax nwere ike igbu oge usoro a site n'ịkwalite ọrụ nke chondrocytes na ịkwalite njikọ nke collagen, meziwanye ọrụ nkwonkwo, ma melite ndụ ndụ nke ndị agadi.
Ahụ ike akpụkpọ: Nnyocha na-egosi na Cartalax nwere ike ịkwalite ngbanwe na nhazi nke akpụkpọ ahụ site n'ịkwalite njikọ nke collagen ma ọ bụ meziwanye ọrụ nke mkpụrụ ndụ akpụkpọ ahụ. Nke a na-eme ka Cartalax nwee uru ngwa ngwa na ngalaba nlekọta anụ ahụ na mgbochi ịka nká, ọkachasị n'ịkwalite ụdị anụ ahụ yana ibelata wrinkles [2].
Nchedo gbasara akụrụ: Ụfọdụ ọmụmụ egosila na Cartalax nwere ike inwe mmetụta nchebe na ọrụ gbasara akụrụ na nhazi. Ọ nwere ike ichebe akụrụ site na mmebi site na imetụta usoro cellular na akụrụ, na-ebelata mbufụt na nrụgide oxidative. Mmetụta nchebe gbasara akụrụ a na-eme ka Cartalax nwee uru ngwa ngwa na ọgwụgwọ ọrịa akụrụ na ọrịa ndị metụtara ya.
Mgbochi ịka nká: A na-ewere Cartalax dị ka peptide na-egbochi ịka nká nke nwere ike ime ka akụkụ ụfọdụ nke usoro ịka nká kwụsịlata site na-emetụta usoro cellular dị iche iche. Ọ nwere ike imeziwanye ike na ahụike n'ozuzu ya site n'ịhazi okirikiri cell, ibelata nrụgide oxidative na nzaghachi mkpali, na ịkwalite nrụzi anụ ahụ na ịmaliteghachi. Njirimara mgbochi ịka nká a na-eme ka Cartalax nwee uru ngwa n'igbu oge ọrịa ndị metụtara ịka nká na imeziwanye ahụike zuru oke [2].
Usoro ọrụ nke Cartalax dị mgbagwoju anya, na-enwe mmetụta abụọ na usoro oxidation. Ọ nwere ike iji ihe dị iche iche na-emekọrịta ihe ma mee ka ọrụ antioxidant. Ngwa ya dị ukwuu, na-egosipụta ikike n'ọtụtụ mpaghara dị ka mmeghari anụ ahụ, mgbake egwuregwu, ọgwụgwọ ọrịa, na ahụike anụ ahụ.
Banyere Onye dere ya
Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.
Onye ode akwụkwọ akụkọ sayensị
Storozhok NM bụ onye nchọpụta metụtara Tyumen State Medical University, NN Semenov Federal Research Center for Chemical Physics na Russian Academy of Sciences, na TYUMEN INST MED. Ọrụ ya gụnyere nyocha interdisciplinary na Chemistry, Biochemistry & Molecular Biology, Biophysics, Cell Biology, and Physics. O meela nnukwu enyemaka na ngalaba ndị a site na mmemme agụmakwụkwọ na nyocha. Edepụtara Storozhok NM n'akwụkwọ ntụaka [1].
