By Cocer Peptides 
1 ọnwa gara aga
Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.
Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadobeghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.
Nchịkọta
Prostatitis na-adịghị ala ala bụ ọnọdụ urological nkịtị. Prostamax, onye na-ahụ maka ọgwụgwọ ọhụrụ jikọtara ya na peptides bioactive, na-ekere òkè n'ịkwado ahụike prostate. Na ọgwụgwọ prostatitis na-adịghị ala ala nke nnwale, Prostamax egosipụtawo mmetụta dị mma.
Usoro nke Omume
Mechanism Regulation Regulation: Mbufụt bụ isi ihe na-ebute mmepe nke prostatitis na-adịghị ala ala. Prostamax na-ebelata ike nke mbufụt na-adịghị ala ala, na-ebelata mgbaàmà dịka ọzịza, mkpọchi vaskụla, na ntinye nke lymphoid. Mmetụta a nwere ike jikọta ya na nhazi ya nke ụzọ mgbaàmà metụtara mbufụt. Ọ nwere ike igbochi ntọhapụ nke ụfọdụ ihe ndị na-eme mkpesa ma ọ bụ gbanwee chemotaxis na ịgbalite mkpụrụ ndụ na-egbuke egbuke, si otú ahụ belata nzaghachi mkpali mpaghara. N'oge mbufụt, a na-ahapụ ụfọdụ cytokines dị ka tumor necrosis factor-α (TNF-α) na interleukin-6 (IL-6) n'ọtụtụ buru ibu, na-eme ka ọkpụkpụ na-egbuke egbuke nke na-eduga ná mmebi anụ ahụ na arụ ọrụ. Prostamax nwere ike jikọta ya na ndị na-anabata ya kpọmkwem n'elu cell, mee ka ụzọ mgbaàmà intracellular rụọ ọrụ, ma gbochie nkwupụta na ntọhapụ nke ihe ndị a na-akpasu iwe, si otú ahụ na-ebelata mgbaàmà mkpali.
Tebụl 1. Mmetụta nke ọgwụ Prostamax na oke, olu, na njupụta nke akụkụ ventral nke prostate gland na oke nwere mbufụt aseptic na-adịghị ala ala.
Usoro nchebe cell: Prostamax nwekwara mmetụta mgbochi na mmepe nke fibrosis na usoro atrophy. N'okpuru mkpali mkpali ogologo oge, anụ ahụ prostate na-adịkarị mfe itinye ntinye nke matrix extracellular, na-eduga na fibrosis anụ ahụ na ike siri ike, ebe mkpụrụ ndụ nwekwara ike ịnweta atrophy n'ihi ihe ndị dị ka enweghị nri na-edozi ahụ na nrụgide oxidative. Prostamax nwere ike idowe morphology nkịtị na ọrụ nke mkpụrụ ndụ site n'ịkwalite metabolism cellular na ịkwalite ikike antioxidant. Ọ nwere ike ịkwalite okwu nke enzymes antioxidant intracellular dị ka superoxide dismutase (SOD) na glutathione peroxidase (GSH-Px), kpochapụ ụdị oxygen na-emeghachi omume (ROS) n'ime sel, belata nrụgide oxidative na-akpata mmebi cellular, wee si otú ahụ gbochie atrophy cellular na apoptosis. Ọ na-ekerekwa òkè n'ịchịkwa njikọ na nrụrụ aka nke matrix extracellular, na-egbochi njikọ dị ukwuu nke protein ndị metụtara fibrosis dị ka collagen, na ịkwalite okwu nke matrix metalloproteinases (MMPs) iji nọgide na-enwe metabolism matrix extracellular nkịtị ma gbochie fibrosis anụ ahụ.
Banyere usoro iwu gbasara ọmụmụ: ọgwụ a nwekwara ike ịkwalite mmekọ nwoke na nwanyị anụmanụ. Mmetụta a metụtara nhazi ya nke usoro endocrine ọmụmụ. Prostate, dị ka akụkụ dị mkpa nke usoro ọmụmụ nwoke, nwere ọnọdụ ọrụ ya nwere njikọ chiri anya na ọkwa nke homonụ ịmụ nwa. Prostamax nwere ike imetụta nzuzo na omume nke homonụ ịmụ nwa dị ka androgens site na ịhazi ọrụ nke hypothalamus-pituitary-gonadadal axis. Ọ na-akwalite mmepụta nke hormone na-ewepụta gonadotropin (GnRH), nke n'aka nke ya na-akpali pituitary gland na-ezobe gonadotropins (LH na FSH), na-akwalite njikọ testosterone na nzuzo na testes, si otú ahụ na-amụba ọkwa testosterone ma na-eme ka anụ ahụ nwee ikike mmekọahụ. Ọ nwere ike na-arụ ọrụ ozugbo na mkpụrụ ndụ akwara dị nro na prostate na akụkụ ọmụmụ, na-achịkwa ọrụ nkwekọrịta na ntụrụndụ ha, na-eme ka mgbasa ọbara dị n'ime akụkụ ọmụmụ, na-enye ebe obibi ahụike ka mma maka ọrụ ọmụmụ.
Ịrụ ọrụ
Ịkwalite mgbaàmà mkpali: N'ịgwọ ọrịa prostatitis na-adịghị ala ala, Prostamax na-egosiputa irè dị ukwuu n'ibelata mgbaàmà mkpali. Nnyocha e mere achọpụtala na mgbe ọgwụgwọ Prostamax gasịrị, ọzịza nke anụ ahụ prostate na anụmanụ nnwale belatara nke ukwuu, belata mkpọchi vaskụla, na ntinye nke lymphoid belatara. Nke a abụghị nanị na-ebelata ihe mgbu mpaghara, ịdị arọ, na ihe mgbaàmà ndị ọzọ na-adịghị mma na ndị ọrịa kamakwa na-eme ka microenvironment mpaghara nke prostate dịkwuo mma, na-emepụta ọnọdụ dị mma maka nrụzi anụ ahụ na ịmaliteghachi. Tụnyere ọgwụ ọgwụgwọ ọdịnala, Prostamax nwere ike ịchịkwa mbufụt nke ọma, belata mmebi na-aga n'ihu na anụ ahụ prostate nke mbufụt kpatara, ma belata ohere nke ịmaliteghachi ọrịa.
Ịkwado usoro anụ ahụ prostate: Site na igbochi ọganihu nke fibrosis na atrophy, Prostamax na-enyere aka ịnọgide na-enwe nhazi na ọrụ nkịtị nke prostate anụ ahụ. Fibrosis na atrophy nke anụ ahụ prostate nwere ike ime ka ọ daa n'ọrụ nzuzo ya, na-emetụta àgwà nke semen na nhazi, ma si otú ahụ na-emetụta ọrụ ọmụmụ. Prostamax nwere ike igbochi mgbanwe ndị a ka ọ ghara ime, na-edobe ọdịdị ọdịdị na nhazi nke prostate acini na ducts, na-ahụ na prostate nwere ike na-ezobe mmiri prostate na-emekarị, na ịnọgide na-enwe mmịnye ọbara na sperm motility. Nke a dị mkpa maka ndị ọrịa nwere prostatitis na-adịghị ala ala bụ ndị nwere mkpa ọmụmụ.
Isiokwu 2. Mmetụta nke ọgwụ Prostamax na morphometric indices nke prostate gland na oke nwere prostatitis na-adịghị ala ala,% nke mpaghara ọkọlọtọ nke ngalaba akụkọ ihe mere eme.
Ịkwalite ọrụ metụtara ọmụmụ: ikike Prostamax ịkwalite mmekọahụ n'ime ụmụ anụmanụ n'ụzọ na-apụtaghị ìhè na-egosipụta mmetụta ya dị mma na ọrụ zuru oke nke usoro ọmụmụ. Na ahụike ọmụmụ nwoke, mmekọahụ abụghị naanị metụtara ọrụ mmekọahụ n'onwe ya kamakwa ọ na-ejikọta ya na ọkwa hormone ịmụ nwa, mgbasa ọbara n'ime akụkụ ọmụmụ, na nhazi akwara. Prostamax na-eme ka ahụ ike ịmụ nwa nwoke dịkwuo mma site n'ịhazi usoro anụ ahụ ndị a. Ọ nwere ike melite inye ọbara na penile corpus cavernosum, kwalite ọrụ erectile, ma nwee ike ịbawanye libido, na-akwalite ọrụ ọmụmụ nkịtị. Nke a na-anọchite usoro ọgwụgwọ zuru oke na nkwalite maka ndị ọrịa nwere nsogbu mmekọahụ nke ọrịa prostate kpatara.
Ngwa
Ngwa ọgwụgwọ ụlọ ọgwụ: Maka ndị ọrịa nwere prostatitis na-adịghị ala ala na-adịghị ala ala, enwere ike iji Prostamax naanị maka ọgwụgwọ, na-enyocha ihe mgbaàmà maka mmelite; maka agafeghị oke na ikpe siri ike, enwere ike ijikọ ya na ọgwụ nje, ndị na-egbochi alfa-receptor, na ọgwụ ndị ọzọ maka ọgwụgwọ zuru oke iji nweta nsonaazụ ọgwụgwọ ka mma. N'oge ọgwụgwọ, ndị dọkịta nwere ike nyochaa ịdị irè nke Prostamax site na nyocha oge niile nke nyocha mmiri nke prostate, prostate ultrasound, na ihe ndị ọzọ na-egosi, ma mezie atụmatụ ọgwụgwọ dịka ọ dị mkpa.
Ngwa Ahụike Mgbochi: Nyere mmetụta nchebe Prostamax na anụ ahụ prostate yana mmetụta dị mma ya na ọrụ sistemu ọmụmụ, ọ nwekwara ike mgbochi ahụike ngwa. Maka ndị nọ n'ihe ize ndụ maka ọrịa prostate, dị ka ndị agadi nwoke ma ọ bụ ndị nwere akụkọ ihe mere eme ezinụlọ nke ọrịa prostate, Prostamax nwere ike iwere dị ka ihe mgbakwunye ahụike mgbochi. Site na iji Prostamax na obere doses n'ime ogologo oge, enwere ike idobe ahụike anụ ahụ prostate, yana enwere ike igbochi ihe omume prostatitis na-adịghị ala ala, hyperplasia prostate, na ọrịa ndị ọzọ. Maka ndị mmadụ n'otu n'otu nwere ọrịa prostate dị nro nke àgwà ndụ adịghị mma kpatara, dị ka ịnọ ogologo oge, ịṅụbiga mmanya ókè, ma ọ bụ ịrụbiga ọrụ ókè, Prostamax nwekwara ike ijikwa ma melite ọrụ prostate, si otú ahụ na-eme ka ndụ dịkwuo mma. Mgbe ị na-eji Prostamax maka ebumnuche ahụike mgbochi, ọ dị mkpa iburu n'uche nchekwa ya na usoro ọgwụgwọ kwesịrị ekwesị, yana ekwesịrị iji ya n'okpuru nduzi nke dọkịta ọkachamara ma ọ bụ onye na-ahụ maka nri.
Ọgụgụ 1 Akụkụ akụkụ nke oke prostate nwere prostatitis na-adịghị ala ala na-anata Prostamaks. Mbelata ọnụọgụ nke eriri collagen ma e jiri ya tụnyere njikwa. Picrofuchsin na-agba agba. ×200.
Ngwa ọgwụgwọ ngwakọta: N'ọgwụgwọ ọrịa prostate, otu ọgwụ na-adakarị n'ụzọ zuru ezu okwu ndị dị mgbagwoju anya pathophysiological. Enwere ike iji Prostamax yana usoro ọgwụgwọ ndị ọzọ iji nweta mmetụta synergistic. Mgbe ejikọtara ya na usoro ọgwụgwọ anụ ahụ dị ka ịhịa aka n'ahụ prostate ma ọ bụ ọgwụgwọ okpomọkụ, ọ nwere ike imeziwanye mgbasa ọbara prostate, welie ntinye ọgwụ na nnabata, ma kwalite nrụpụta ọgwụgwọ.
Mmechi
Dị ka ọgwụgwọ peptide ọhụrụ, Prostamax na-egosipụta uru na ngalaba ahụike prostate. Site na usoro ihe omume ya pụrụ iche na mmetụta ya dị ịrịba ama n'ịkwalite mbufụt, ịnọgide na-enwe nhazi anụ ahụ, na ịkwalite ọrụ ọmụmụ, yana ụzọ ngwa ngwa dị iche iche na ọgwụgwọ ụlọ ọgwụ, nlekọta mgbochi, na ọgwụgwọ jikọtara ọnụ, ọ na-enye aka na ọgwụgwọ na mgbochi nke ọrịa prostate.
Isi mmalite
[1] Borovskaya TG, Pakhomova AV, Vychuzhanina AV, et al. Nnwale nyocha nke arụmọrụ ọgwụ Prostamax na ọgwụgwọ nke prostatitis aseptic na-adịghị ala ala na nsogbu ya [J]. Nnyocha ọgbara ọhụrụ na mbufụt, 2013,3 (2): 5.DOI: 10.4236 / mri.2013.23007.
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