Cocer Peptides ye 
ŋlɔe ɣleti 1 enye sia
NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.
Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.
Kpɔɖeŋu bliboa
Prostatitis si me dɔlékui aɖeke mele o si nɔa anyi didi nye tsinyegoe me dɔléle si bɔ. Prostamax, si nye atike yeye aɖe si do ƒome kple bioactive peptides, wɔa akpa aɖe le prostate ƒe lãmesẽ me léle ɖe asi me. Le dodokpɔ me prostatitis si me dɔlékui mele o si nɔa anyi didi dada me la, Prostamax ɖe ŋusẽkpɔɖeamedzi nyuiwo fia.
Dɔwɔwɔ ƒe Mɔnu
Dɔdzẽ ƒe Dzɔdzɔenyenye ƒe Mɔnu: Dzoxɔxɔ nye nu vevi aɖe si nana ʋumenugbagbeviɣidɔ si me dɔlékui aɖeke mele o si nɔa anyi didi la dzɔna. Prostamax ɖea dɔdzẽ si nɔa anyi didi ƒe sesẽ dzi kpɔtɔna nyuie, si ɖea dzesiwo abe vuvu, ʋukawo ƒe ʋuʋu, kple ʋukawo ƒe gege ɖe lãme na ame ene dzi kpɔtɔna. Ðewohĩ ŋusẽkpɔɖeamedzi sia do ƒome kple eƒe dzesimɔ siwo do ƒome kple dɔdzẽ ƒe ɖoɖowɔwɔ. Ate ŋu axe mɔ ɖe dɔdzẽ ƒe nu aɖewo ƒe dodo nu alo atrɔ asi le dɔlékuiwutikewo ƒe dɔwɔwɔ kple dɔdzẽ ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ŋu, si ana dɔdzẽ ƒe ŋuɖoɖo siwo le teƒea dzi naɖe akpɔtɔ. Le dɔdzẽɣi la, cytokines aɖewo abe tumor necrosis factor-α (TNF-α) kple interleukin-6 (IL-6) ene dona le agbɔsɔsɔ gã aɖe me, si wɔnɛ be dɔdzẽ ƒe dzidziɖedzi si hea lãmenugbagbeviwo ƒe gbegblẽ kple dɔwɔwɔ ƒe gbegblẽ vɛ. Prostamax ate ŋu abla ɖe lãmenugbagbevi tɔxɛ siwo le lãmenugbagbeviwo ƒe anyime ŋu, ana lãmenugbagbeviwo me dzesimɔwo nawɔ dɔ, eye wòaxe mɔ ɖe dɔdzẽ siawo ƒe ɖeɖefia kple woƒe dodo nu, si ana dɔdzẽ ƒe dzesiwo dzi naɖe akpɔtɔ.
Table 1. Ŋusẽ si atike si nye Prostamax kpɔna ɖe prostate gland ƒe akpa si le ʋuka me ƒe lolome, eƒe lolome, kple eƒe kpekpeme dzi le sisiblisi siwo ŋu aseptic inflammation si nɔa anyi didi le me.
Lãmenugbagbeviwo takpɔkpɔ ƒe mɔnu: Prostamax hã kpɔa ŋusẽ ɖe fibrosis kple atrophy ƒe dɔwɔwɔ ƒe tsitsi dzi le mɔxexeɖedɔléle nu. Le dɔdzẽ ƒe dzodzo ɣeyiɣi didi me la, ʋumenugbagbeviɣi ƒe lãkusi te ŋu ƒoa lãmenugbagbeviwo godo fũu akpa, si wɔnɛ be lãmenugbagbeviwo ƒe fibrosis kple sesẽ, evɔ lãmenugbagbeviwo hã ate ŋu ato atrophy me le nusiwo nye nunyiame ƒe agbɔsɔsɔ si mesɔ o kple oxidative stress ta. Prostamax ate ŋu alé lãmenugbagbeviwo ƒe nɔnɔme kple dɔwɔwɔ si sɔ me ɖe asi to lãmenugbagbeviwo ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dodo ɖe ŋgɔ kple antioxidant ŋutete dodo ɖe ŋgɔ me. Ate ŋu adzi lãmenugbagbeviwo me antioxidant enzymes abe superoxide dismutase (SOD) kple glutathione peroxidase (GSH-Px) ƒe ɖeɖefia ɖe dzi, akɔ oxygen ƒomevi siwo wɔa dɔ fũu akpa (ROS) le lãmenugbagbeviwo me, aɖe lãmenugbagbeviwo ƒe gbegblẽ si oxidative stress hena vɛ dzi akpɔtɔ, eye wòato esia me axe mɔ ɖe lãmenugbagbeviwo ƒe tsɔtsrɔ̃ kple apoptosis nu. Ekpɔa gome hã le lãmenugbagbeviwo godo ƒe matriki ƒe wɔwɔme kple eƒe gbegblẽ ƒe dadasɔ dzi kpɔkpɔ me, xea mɔ na protein siwo do ƒome kple fibrosis abe collagen ene ƒe wɔwɔ fũ akpa, eye wòdoa matrix metalloproteinases (MMPs) ƒe ɖeɖefia ɖe ŋgɔ be wòalé lãmenugbagbeviwo godo ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ nyuie ɖe te eye wòaxe mɔ ɖe lãmenugbagbeviwo ƒe fibrosis nu.
Ku ɖe ɖoɖowɔwɔ ƒe mɔnu siwo do ƒome kple vidzidzi ŋu: Atike sia ate ŋu ana lã ƒe gbɔdɔdɔ ƒe ŋutete hã nanyo ɖe edzi. Dɔwɔwɔ sia do ƒome kple eƒe ɖoɖowɔwɔ ɖe vidzidzi ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ŋu. Prostate, abe ŋutsu ƒe vidzidzi ƒe akpa vevi aɖe ene, ƒe dɔwɔwɔ ƒe nɔnɔme do ƒome kplikplikpli kple vidzidzi ƒe lãmetsiwo ƒe agbɔsɔsɔ. Prostamax ate ŋu akpɔ ŋusẽ ɖe vidzidzi ƒe lãmetsiwo abe androgens ene ƒe dodo kple dɔwɔwɔ dzi to hypothalamus-pituitary-gonadal axis ƒe dɔwɔwɔ dzi kpɔkpɔ me. Edoa lãmetsi si naa gonadotropin (GnRH) ƒe dodo ɖe ŋgɔ, si hã doa ŋusẽ lãkusi si le lãkusia me be wòaɖe gonadotropin (LH kple FSH) ɖa, si doa testosterone ƒe wɔwɔme kple eƒe dodo ɖe ŋgɔ le vidzidɔa me, si wɔnɛ be testosterone ƒe agbɔsɔsɔ dzina ɖe edzi eye wònaa lãa ƒe gbɔdɔdɔ ƒe ŋutete dzina ɖe edzi. Ate ŋu awɔ dɔ ɖe lãmeka gbadza siwo le ʋuka me kple vidzidzi ŋutinuwo dzi tẽ, aɖɔ woƒe ʋuʋu kple ɖiɖiɖeme ƒe dɔwɔwɔwo ɖo, ana ʋu nayi edzi le vidzidzi ƒe ŋutinuwo me nyuie wu, eye wòana ŋutilã ƒe nɔnɔme nyuitɔ nanɔ vidzidzidɔwo wɔwɔ me.
Dɔwɔwɔ nyuie
Dzoxɔxɔ ƒe dzesiwo ƒe nyonyo: Le ʋumenugbagbeviɣidɔ si menye dɔlékui o si nɔa anyi didi dada me la, Prostamax ɖea ŋusẽ gã aɖe fiana le dɔdzẽ ƒe dzesiwo dzi ɖeɖe kpɔtɔ me. Numekukuwo ɖee fia be le Prostamax zazã vɔ megbe la, lã siwo wodo kpɔ ƒe ʋukawo ƒe vuvu dzi ɖe kpɔtɔ ŋutɔ, ʋukawo ƒe ʋuʋu dzi ɖe kpɔtɔ, eye ʋumenugbagbeviɣiwo ƒe gege ɖe lãme dzi ɖe kpɔtɔ. Menye ɖeko esia ɖea vevesese si le teƒea, kpekpeme, kple vevesese ƒe dzesi bubuwo dzi kpɔtɔna le dɔnɔwo ŋu ko o, ke enaa tsinyegoe ƒe nuto sue si le teƒea hã nyona ɖe edzi, si wɔnɛ be nɔnɔme nyuiwo nɔa anyi na lãmenugbagbeviwo ɖɔɖɔɖo kple wo gbugbɔgadzɔ. Ne wotsɔe sɔ kple atike siwo wozãna tsã tsɔ daa dɔe la, Prostamax ate ŋu aɖu dɔdzẽ dzi nyuie wu, aɖe nusiwo dɔdzẽ gblẽna le ʋumenugbagbeviɣidɔ ŋu si yia edzi la dzi akpɔtɔ, eye wòaɖe dɔlélea ƒe gbugbɔgadzɔ ƒe afɔkua dzi akpɔtɔ.
Prostate lãmenugbagbeviwo ƒe wɔwɔme dzi kpɔkpɔ: To mɔxexe ɖe fibrosis kple atrophy ƒe ŋgɔyiyi nu me la, Prostamax kpena ɖe ame ŋu be prostate lãmenugbagbeviwo ƒe wɔwɔme kple dɔwɔwɔ nyuie nanɔ anyi. Fibrosis kple prostate tissue ƒe atrophy ate ŋu ana eƒe adzamedɔwɔwɔ naɖiɖi, si akpɔ ŋusẽ ɖe tsinyenye ƒe nyonyome kple eƒe wɔwɔme dzi, eye wòato esia me akpɔ ŋusẽ ɖe vidzidzi ƒe dɔwɔwɔ dzi. Prostamax ateŋu axe mɔ na dɔléle ƒe tɔtrɔ siawo be woagadzɔ o, alé prostate acini kple ducts ƒe nɔnɔme kple wɔwɔme si sɔ me ɖe asi, akpɔ egbɔ be prostate ateŋu aɖe prostate tsi le dzɔdzɔme nu, eye wòana tsinyenye ƒe tsinyenye kple tsinyenye ƒe ʋuʋu nyuie nanɔ anyi. Esia le vevie ŋutɔ na dɔnɔ siwo ŋu prostatitis si nɔa anyi didi le siwo hiã vidzidzi.
Table 2. Ŋusẽkpɔɖeamedzi si atike Prostamax kpɔna ɖe morphometric indices of the prostate gland le sisiblisi siwo ŋu prostatitis si nɔa anyi didi le, % si nye teƒe si woɖo ɖi le histological section me.
Dɔwɔwɔ siwo do ƒome kple vidzidzi ƒe nyonyome: Prostamax ƒe ŋutete be wòana gbɔdɔdɔ ƒe dɔwɔna nadzi ɖe edzi le lãwo me la ɖe ŋusẽ nyui si wòkpɔ ɖe vidzidzi ƒe dɔwɔwɔ bliboa dzi fia le mɔ si mele tẽ o nu. Le ŋutsuwo ƒe vidzidzi ƒe lãmesẽ me la, menye ɖeko gbɔdɔdɔ ƒe dɔwɔna do ƒome kple gbɔdɔdɔ ƒe dɔwɔwɔ ŋutɔ ko o, ke edo ƒome kplikplikpli kple vidzidzi me lãmetsiŋusẽ ƒe agbɔsɔsɔ, ʋu ƒe sisi le vidzidzi ŋutinuwo me, kple ahɔhɔ̃mekawo ƒe dɔwɔwɔ nyuie hã. Prostamax nana ŋutsuwo ƒe vidzidzi ƒe lãmesẽ nyona ɖe edzi to ŋutilã ƒe dɔwɔwɔ siawo dzi kpɔkpɔ me. Ate ŋu ana ʋu nayi ŋutsu ƒe vidzinu ƒe lãkusi me nyuie wu, ana ŋutsu ƒe tsitretsitsi nawɔ dɔ nyuie wu, eye ate ŋu ana gbɔdɔdɔ ƒe dzodzro hã nadzi ɖe edzi, si ana vidzidzi ƒe dɔwɔwɔ nyuie nado. Esia tsi tre ɖi na atikewɔwɔ kple ŋgɔyiyi ƒe mɔnu si me kɔ na dɔnɔ siwo gbɔdɔdɔ ƒe dɔmawɔmawɔ nyuie si tso ʋuka me dɔlélewo gbɔ.
Mᴐbibia
Atikewɔwɔ le kɔdzi: Le dɔnɔ siwo ŋu prostatitis si mebɔ o si nɔa anyi didi si menye dɔlékui o le gome la, woate ŋu azã Prostamax ɖeɖeko atsɔ ada dɔe, eye woalé ŋku ɖe dzesiawo ŋu be woanyo ɖe edzi hã; le dɔléle siwo le titina va ɖo esiwo nu sẽ gome la, woate ŋu atsɔe akpe ɖe dɔlékuiwutikewo, alpha-receptor blockers, kple atike bubuwo ŋu hena atikewɔwɔ bliboe be woakpɔ atikewɔwɔ me tsonu nyuitɔ. Le atikewɔwɔ me la, atikewɔlawo ate ŋu ada Prostamax ƒe dɔwɔwɔ kpɔ to dodokpɔ siwo wowɔna edziedzi le ʋumenugbagbeviɣidɔ me, ʋumenugbagbeviɣidɔ ƒe ultrasound, kple dzesi bubuwo me, eye woatrɔ asi le atikewɔwɔ ƒe ɖoɖoa ŋu ne ehiã.
Lãmesẽnyawo Gbɔkpɔkpɔ ƒe Mɔxexe Ðe Enu: Ne míebu Prostamax ƒe ametakpɔkpɔ ƒe ŋusẽkpɔɖeamedzi ɖe prostate lãmenugbagbeviwo dzi kple ŋusẽ nyui si wòkpɔna ɖe vidzidzi ƒe dɔwɔwɔ dzi ta la, woate ŋu azãe le lãmesẽnyawo me atsɔ axe mɔ ɖe enu hã. Le ameha siwo le afɔku gã me be woaxɔ ʋuka me dɔlélewo, abe ŋutsu tsitsiwo alo amesiwo ƒe ƒome me ʋumenugbagbeviɣidɔ le ene gome la, woate ŋu abu Prostamax be enye lãmesẽtike si woatsɔ axe mɔ ɖe dɔlélewo nu. Ne wozã Prostamax le agbɔsɔsɔ sue aɖe me le ɣeyiɣi didi me la, woate ŋu alé ʋukawo ƒe lãmesẽ me ɖe asi, eye woate ŋu axe mɔ ɖe ʋumenugbagbeviɣidɔ si nɔa anyi didi, ʋumenugbagbeviɣidɔ, kple dɔléle bubuwo ƒe dzɔdzɔ nu. Le ame ɖekaɖeka siwo ƒe ʋuka me dɔmawɔmawɔ nyuie si tso agbenɔnɔ ƒe nɔnɔme gbegblẽwo gbɔ, abe anyinɔƒe didi, ahanono fũ, alo dɔwɔwɔ fũu akpa ene gome la, woate ŋu azã Prostamax hã atsɔ aɖɔ ʋuka ƒe dɔwɔwɔ ɖo ahawɔe wòanyo ɖe edzi, si ana agbenɔnɔ nanyo ɖe edzi. Ne èle Prostamax zãm hena mɔxexeɖedɔléle nu ƒe lãmesẽnyawo la, ele vevie be nàde dzesi eƒe dedienɔnɔ kple agbɔsɔsɔme si sɔ, eye ele be woazãe le ɖɔkta alo nuɖuɖuŋutinunyala bibi aɖe ƒe mɔfiafia te.
Figure 1 Prostate rats siwo ŋu prostatitis si nɔa anyi didi le abacterial xɔ Prostamaks ƒe axadzinɔnɔme. Collagen ka ƒe agbɔsɔsɔ dzi ɖeɖe kpɔtɔ ne wotsɔe sɔ kple esi dzi woɖu. Amadede picrofuchsin ƒe amadede. ×200 ƒe xexlẽme.
Atikewɔwɔ ɖekae zazã: Le ʋumenugbagbeviɣidɔ dada me la, zi geɖe la, atike ɖekawo mete ŋu kpɔa dɔlélenutsiŋutete ƒe nya sesẽawo gbɔ bliboe o. Woate ŋu azã prostamax atsɔ akpe ɖe atikewɔwɔmɔnu bubuwo ŋu be woakpɔ dɔwɔwɔ aduadu ƒe ŋusẽkpɔɖeamedziwo gbɔ. Ne wotsɔe kpe ɖe kamededemɔnu siwo nye ʋuka me ʋu ƒe sisi alo dzoxɔxɔ ƒe atikewɔwɔ ŋu la, ate ŋu ana ʋu si le ʋuka me nanyo ɖe edzi, ana atikewo nage ɖe lãme na ame eye wòaxɔe nyuie wu, eye wòana atikewɔwɔ nawɔ dɔ nyuie wu.
Nyanuwuwuw
Abe peptide-dɔdamɔnu yeye ene la, Prostamax ɖea viɖe siwo le eŋu fiana le ʋumenugbagbeviɣidɔ ƒe lãmesẽnyawo gome. Tso eƒe dɔwɔwɔ ƒe mɔnu tɔxɛ dzi va ɖo eƒe ŋusẽkpɔɖeamedzi ɖedzesi siwo wòkpɔna le dɔdzẽ ƒe nyonyo, lãmenugbagbeviwo ƒe wɔwɔme me léle ɖe asi, kple vidzidzi ƒe dɔwɔwɔ dzi ɖeɖe kpɔtɔ me, kpakple eƒe zazã ƒe mɔnu vovovo siwo le dɔdamɔnu, mɔxexeɖedɔléle nu, kple atikewɔwɔ ƒokpli me la, ekpena ɖe ame ŋu le ʋumenugbagbeviɣidɔ dada kple mɔxexe ɖe enu me.
Dzɔtsoƒewo
[1] Borovskaya T. G., Pakhomova A. V., Vychuzhanina A. V., kple ame bubuwo. Dodokpɔ me nusɔsrɔ̃ tso atike ƒe dɔwɔwɔ nyuie Prostamax le aseptic prostatitis si nɔa anyi didi kple eƒe kuxiwo dada me[J]. Egbegbe Numekuku le Dzoxɔxɔ, 2013,3 (2): 5.DOI: 10.4236 / mri.2013.23007.
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