Ovagène miligaramu 20

▎ Ovagène (Ovagène ) jɔcogo

▎ Ovagen ɲinini

Ovagen ka ɲininiw kɛcogo ye mun ye?

Ɲɛnamaya cogoya caman cɛma — i n’a fɔ sigida bagaw caya, banakisɛfagalanw tali kojugu, chimiothérapie ni radiothérapie jɛnsɛnni, ani jamanadenw ka kɔrɔbaya — sugunɛ ni kɔnɔbara banaw cayara kosɛbɛ. Bana minnu bɛ i n’a fɔ sugunɛbilenni basigilen basigilen ani sirozi, olu bɛ nɔba bila banabagatɔw ka ɲɛnamaya ni u ka kɛnɛya la. Laadala furakɛli bɛ kɛlɛ kɛ walasa ka sugunɛ ni kɔnɔnatumuw ka baara kɛcogo ɲuman segin u cogo kɔrɔ la, u tɛ se ka banaw kunbɛn ani ka u furakɛ ka ɲɛ, bana minnu bɛ sɔrɔ sababu suguya caman fɛ, wa u bɛ se ka danma jira gɛlɛyaw nɔgɔyali la minnu bɛ sɔrɔ radiyofurakɛli fɛ, chimiothérapie fɛ, ani banakisɛfagalanw kɔlɔlɔw fɛ. O b’a jira ko furakɛli fɛɛrɛ kuraw mago bɛ teliya la.

Peptidew, k’a sababu kɛ u jɔcogo suguya caman ye, u bɛ se ka jɛɲɔgɔnya kɛ ni selilu kɔnɔfɛn caman ye, ka nɔ bila selilu ka taabolo la i n’a fɔ farikoloɲɛnajɛ, bonya ani dilancogo. Ovagen ka fɛn kolomaw ye pepitiriw ye minnu bɛ kɛ ni asidi aminikiw kɛrɛnkɛrɛnnenw ye, i n’a fɔ AC-3 min bɛ sɔrɔ asidi glutamiki fɛ, asidi aspartitiki ani leucine fɛ. O danfara in bɛ nɔ bila a labɛncogo la sugunɛ ni kɔnɔbara baara la. Sɛgɛsɛgɛliw sababu fɛ Ovagen kan, dɔnnikɛlaw ye fɛɛrɛ ɲuman dɔ ɲini walasa ka sugunɛ ni kɔnɔbara baarakɛcogo sɛmɛntiya walasa ka kɛnɛyaso furakɛli ni bana kunbɛnni magow ɲɛ.

Ovagen ka baarakɛcogo ye mun ye?

Recepteur sirili bɛ taamasiɲɛw cili daminɛ

Jaabi kɛrɛnkɛrɛnnenw sirili : Pepitiri ɔrimɔni caman bɛ u nɔw jira ni u sirili ye fɛn kɛrɛnkɛrɛnnenw na minnu ka ɲɔgɔndɛmɛ ka bon, olu minnu ye farikolojɔlifɛn nafamaw ye minnu bɛ joli-sira-funu-kɔnɔ. Pepitiri ɔrimɔni kelen-kelen bɛɛ bɛ ɲɔgɔn sɔrɔ n’a minɛbaga dantigɛlen ye i n’a fɔ kilisi min bɛ don dakun na, o bɛ taamasiɲɛw cicogo tigitigi sabati. Ni a sirilen don, biyokimiki ko kɛlenw ka cakɛda bɛ pepitiri ɔrimɔni baara yɔrɔ fɔlɔ siri ɲɔgɔn na — o ye joli-sira-funu-yɔrɔ ye — ka ɲɛsin selilɛri laɲini jaabi suguya caman ma ^[1,2]..

Siginiden siraw baara : Recepteur-peptide sirili bɛ taamasiɲɛw siraw baara selilɛri kɔnɔ. Misali la, pepitiri ɔrimɔni dɔw bɛ siri fɛn minɛyɔrɔw la minnu bɛ adenilati siklazi baara, o bɛ kɛ sababu ye ka AMP (cAMP) ciden filanan sɔrɔ selilɛri kɔnɔ. I n’a fɔ ciden jɔnjɔn, cAMP bɛ poroteyini kinaziw baara, o bɛ na ni substrat kɛrɛnkɛrɛnnenw fosforilasi ye ani ka selilu laɲinitaw baarakɛcogo ɲɛnabɔ. Laɲini yɔrɔ dɔw la, i n’a fɔ sugunɛ ni tulumafɛnw, cAMP bɛ kɛ ciden filanan fɔlɔ ye min bɛ ɔrimɔni kɛrɛnkɛrɛnnenw ka biyokimiki jaabiw lawuli. cAMP kɔfɛ, taamasiɲɛ sira wɛrɛw ni ciden mɔlikuluw bɛ u sen don pepitiri fɛɛrɛw la; misali la, kalisiyɔmu ionw jɔyɔrɔ ka bon kosɛbɛ selilɛriw ka jaabiw labɛnni na farikolo yɔrɔ dɔw la ^{[2] .}.

Jaa 1 Sira minnu bɛ stɛroyidini labɛnni na gonadal farikolo yɔrɔw ja ni luteinizing hormone ye ^{[2] .}.

Ovagen ka baara ye mun ye?

Ovagen bɛ sugunɛbilenniw falen ani ka sugunɛbilenni ni sirozi bali. A bɛ sugunɛ baara ɲɛ ka taa a fɛ ni a bɛ sugunɛbilenni ADN jɔcogo ni a sɛbɛnni kɛcogo ɲɛnabɔ. Ovagen fana bɛ kɔrɔya kɛlɛli nɔ jira, ka ADN caman cili kɔsegin kɔrɔya fɛ walasa ka sugunɛbilenniw segin u cogo kɔrɔ la. Ovagen bɛ kɔnɔbara basigilen baara ɲɛ, ka kɔnɔbara basigilen tiɲɛni nɔgɔya, min bɛ sɔrɔ fɛnw fɛ i n’a fɔ banakisɛfagalanw, sigida bagaw, chimiothérapie, ani balodɛsɛ. A ka sariyasunba nɔ minnu bɛ sugunɛ ni kɔnɔbara baara la funu ni bana suguya caman na, o bɛ baarakɛcogo caman di. A bɛ se ka kɛ opereli kɔfɛ ladonni na, banakisɛfagalanw furakɛli kuntaalajan na, kansɛri furakɛli kɔlɔlɔw nɔgɔyali la, ani sukarodunbana kunbɛnni na.

Ovagen ni sidabanakisɛ

Ovagen ye mɔgɔw ɲɛnajɛ sidabana ɲininiw na k’a sababu kɛ a ka balilan jiralen ye sidabanakisɛ-1 protéase la. Sidabanakisɛ-1 poroteyizi ye anzimu nafamaba ye banakisɛw ka ɲɛnamaya kama, a ka baara ye ka banakisɛfagalanw tila ka kɛ yɔrɔ fitininw ye minnu bɛ baara kɛ. I n’a fɔ sidabanakisɛ-1 poroteyizi balilan, Ovagen bɛ poroteyizi balilan dɔntaw la minnu ka dɔgɔn ani minnu fanga ka bon. Nin balili wale in bɛ se ka dɛmɛ don sidabanakisɛ caman sɔrɔli kɛlɛli la, ka sira kura dabɔ sidabana furakɛli ɲininiw kama.

Badaya A ka ɲininiw y’a jira ko Ovagen bɛ se ka sidabanakisɛ-1 protéase baara bali ^[3] . Sidabanakisɛ-1 poroteyizi ye anzimu nafamaba ye banakisɛw caya la, a ka baara ye ka poliporotɛniw tigɛ walasa u ka kɔgɔ ani k’u lajɛ ka kɛ banakisɛfagalanw ye. Protéase baara balili bɛ banakisɛw cayacogo tiɲɛ ^[3] . Ovagen bɛ protease katalitiki baara bali ni a sirili ye a baarakɛyɔrɔ la walima k’a cogoya Changer. Ni a sirilen don yɔrɔ la min bɛ baara kɛ, a bɛ substrat doncogo ni cleavage reaction bali ^{[3] .}.

Kuncɛli

Ovagen ye pepitiri saba ye min bɛ ɲɛnamaya kɛcogo caman jira, a bɛ sugunɛ ni kɔnɔbara baarakɛcogo ɲɛnabɔ fɔlɔ. A bɛ sugunɛbilenniw falen, ka sugunɛbilenni ni sirozi bali, ka sugunɛ baara sabati ni ADN jɔcogo ni a sɛbɛnnicogo caman sɛmɛntiya ye, ani ka kɔrɔya kɛlɛli seko jira. Ovagen bɛ kɔnɔbara basigilen baara barika bonya, ka tiɲɛni nɔgɔya banakisɛfagalanw fɛ, sigida bagaw fɛ, chimiothérapie fɛ, ani balodɛsɛ fɛ.

Ovagen ye pepitiri saba ye min ka baara bɛ kɛ ni fɛnɲɛnamaw ye, a bɛ sugunɛ ni kɔnɔbara baara ɲɛnabɔ fɔlɔ. A bɛ sugunɛbilenniw falen, ka sugunɛbilenni ni sirozi bali, ka sugunɛ baara sabati ni ADN jɔcogo ni a sɛbɛnnicogo caman sɛmɛntiya ye, ani ka kɔrɔya kɛlɛli seko jira. Ovagen bɛ kɔnɔbara basigilen baara barika bonya, ka tiɲɛni nɔgɔya banakisɛfagalanw, sigida bagaw, chimiothérapie ani balodɛsɛ fɛ.

A sɛbɛnbaga ko la

Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.

Dɔnniya gafe sɛbɛnbaga

Apoorva Badaya ye ɲininikɛla ye min ka baara ɲɛsinnen bɛ jatebɔ biyofiziki ni structurel biyoinformatique ma. A ni kalanw kɛra ɲɔgɔn fɛ minnu sinsinnen bɛ sidabanakisɛ-1 poroteyizi molekiyɔmuw ka baarakɛcogo kan, kɛrɛnkɛrɛnnenya la, ka ɲɛsin farikolojɔlifɛnw sirili ni fɛn falenw ma. A ka baara bɛ baara kɛ ni simulation fɛɛrɛ kɔrɔw ye walasa ka farikolojɔlifɛnw sɛgɛsɛgɛli sɛgɛsɛgɛ ani ka furakɛli fɛɛrɛw kunnafoni. Apoorva Badaya tɔgɔ sɛbɛnnen bɛ citation (citation) kɔnɔ [3].

▎ Sɛbɛn minnu bɛ tali kɛ o la

[1] Barker S. Pepitiri ɔrimɔni ka baara kɛcogo; 2020: 47-71.DOI: 10.1201/9781003076926-3. Bamako, Mali.

[2] K., J., Catf, ani a ɲɔgɔnnaw. PEPTIDE HƆRƆMƆNW KA BAARAKƐCOGO MINNU BƐ KƐ ƝƐNABƆLI KAN.; 2004. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

[3] Badaya A, Sasidhar YU, ani mɔgɔw ye baara kɛ ni u ye. Sidabanakisɛ-1 poroteyizi ka baara balili ni farikolojɔlifɛnw sirili ye ani fɛn falenw minnu sɛgɛsɛgɛra ni molekiyɔmu dinamiki simulasiw ye. Dɔnniya Laseliw san 2020; 10(1): 5501.DOI: 10.1038/s41598-020-62423-y. Bamako, Mali.

BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.  

Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.