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▎ Ovagen Ọdịdị
Isi mmalite: PubChem |
Usoro: EDL Ụdị mkpụrụ ndụ: C 15H 25N 3O8 Arọ Molecular: 375.37 g/mol PubChem CID: 444128 Ụdị okwu: NH 2-Glu-Asp-Leu-COOH; glutamyl-aspartyl-leucine |
▎ Ovagen Nnyocha
Kedu ihe ndabere nyocha nke Ovagen?
N'etiti ọnọdụ ibi ndụ na-agbanwe agbanwe-gụnyere ụbara nsị gburugburu ebe obibi, iji ọgwụ nje eme ihe n'ụzọ gabigara ókè, ọgwụgwọ chemotherapy na redio na-agbasa, na ịka nká nke ọnụ ọgụgụ mmadụ - ọnụ ọgụgụ nke ọrịa imeju na eriri afọ ebiliwo nke ukwuu. Ọnọdụ dị ka ịba ọcha n'anya na-adịghị ala ala na cirrhosis na-emetụta ụdị ndụ na ahụike nke ndị ọrịa nke ukwuu. Usoro ọgwụgwọ ọdịnala na-agbasi mbọ ike iweghachi ọrụ imeju na eriri afọ nke ọma nke ọma, ghara igbochi na ịgwọ ọrịa nke ụdị etiologies dị iche iche kpatara, ma gosipụta oke arụmọrụ n'ibelata nsogbu sitere na radiotherapy, chemotherapy, na mmetụta ọgwụ nje. Nke a na-egosi mkpa ọ dị maka usoro ọgwụgwọ ọhụụ ọhụrụ.
Peptides, n'ihi nhazi ha dị iche iche, nwere ike iji ọtụtụ mkpụrụ ndụ intracellular na-emekọrịta ihe, na-emetụta usoro cellular dị ka metabolism, uto, na nrụzi. Ihe ndị bụ isi nke Ovagen gụnyere ogige peptide nke nwere amino asịd akọwapụtara, dị ka AC-3 nke glutamic acid mebere, aspartic acid na leucine. Ngwakọta a na-emetụta usoro nhazi ya na imeju na ọrụ eriri afọ. Site na nyocha banyere Ovagen, ndị ọkà mmụta sayensị enyochala ụzọ dị irè karị maka imezi imeju na ọrụ eriri afọ iji gboo ọgwụgwọ ụlọ ọgwụ na mkpa mgbochi ọrịa.
Kedu ihe bụ usoro ọrụ Ovagen?
Ejikọ nnata na-ebute ntụgharị nrịbama
Nkwekọrịta nnabata nke akọwapụtara: Ọtụtụ homonụ peptide na-arụ ọrụ ha site na ijikọ ndị na-anabata ndị nwere mmekọrịta dị elu, nke bụ protein dị mkpa na-agbasa akpụkpọ ahụ plasma. Hormone peptide ọ bụla na-emekọrịta ihe na onye na-anabata ya a họpụtara dị ka igodo dabara na mkpọchi, na-eme ka mgbasa ozi ziri ezi. Mgbe ejikọtara ya, ihe omume biochemical na-ejikọta saịtị mbụ nke ihe omume homonụ peptide - akpụkpọ ahụ plasma-na nzaghachi sel dị iche iche [1,2].
Ụzọ nrịbama na-arụ ọrụ: njide nnata-peptide na-eme ka ụzọ mgbaàmà intracellular rụọ ọrụ. Dịka ọmụmaatụ, ụfọdụ homonụ peptide na-ejikọta na ndị na-anabata ya na-arụ ọrụ adenylate cyclase, na-akwalite mmepụta nke intracellular second messenger cyclic AMP (cAMP). Dị ka onye ozi bụ isi, cAMP na-arụ ọrụ protein kinase, na-eduga na phosphorylation nke mkpụrụ ndụ akọwapụtara yana ịhazi ọrụ sel lekwasịrị anya. N'ime ụfọdụ anụ ahụ e lekwasịrị anya, dị ka imeju na anụ ahụ adipose, cAMP na-eje ozi dị ka onye ozi nke abụọ na-ebute nzaghachi biochemical kpọmkwem. E wezụga cAMP, ụzọ mgbaàmà ndị ọzọ na ụmụ irighiri ihe ozi na-ekere òkè na usoro peptide; dịka ọmụmaatụ, ion calcium na-arụ ọrụ dị mkpa n'ịhazi nzaghachi cellular na ụfọdụ anụ ahụ [2].
Ihe osise 1 eserese nke ụzọ ndị na-etinye aka na nhazi nke steroidogenesis na anụ ahụ gonadal site na luteinizing hormone [2].
Kedu ihe bụ ọrụ Ovagen?
Ovagen na-akwalite uto hepatocyte ma na-egbochi fibrosis imeju na cirrhosis. Ọ na-eme ka ọrụ imeju dịkwuo mma site n'ịhazi nhazi DNA hepatocyte na usoro ederede. Ovagen na-egosipụtakwa mmetụta mgbochi ịka nká, na-atụgharị mgbanwe DNA metụtara afọ iji weghachite hepatocytes na ọnọdụ ntorobịa. Ovagen na-akwalite ọrụ mgbochi mucosal eriri afọ, na-ebelata mmebi nke eriri afọ nke ihe ndị dị ka ọgwụ nje, nsị gburugburu ebe obibi, chemotherapy, na erighị ihe na-edozi ahụ. Mmetụta nchịkwa ya na imeju na ọrụ eriri afọ n'ofe dị iche iche mkpali na ọrịa na-enye atụmanya ngwa ngwa. Enwere ike iji ya na nlekọta mgbe ịwachara ahụ, ọgwụgwọ ọgwụ nje na-adịte aka, na-ebelata mmetụta ọgwụgwọ ọrịa cancer, na mgbochi metabolism.
Ovagen na nje HIV
Ovagen etinyela uche na nyocha nje HIV n'ihi mmetụta mgbochi ya gosipụtara na nje HIV-1 protease. HIV-1 protease bụ enzyme dị oke egwu maka nlanarị nje, na-ahụ maka ikpochapụ protein viral n'ime ngalaba na-arụ ọrụ. Dị ka onye na-egbochi nje HIV-1, Ovagen nọ n'ọkwa n'etiti ndị na-egbochi protease kacha nta na nke kachasị ike. Omume mgbochi a nwere ike inye aka n'ịchịkwa nje HIV, mepee ụzọ ọhụrụ maka nyocha ọgwụgwọ HIV.
Nnyocha nke Badaya A na-egosi na Ovagen nwere ike igbochi ọrụ protease HIV-1 [3] . HIV-1 protease bụ enzyme dị oke egwu na mmegharị nje, na-ahụ maka ikpochapụ polyproteins ka ha tozuo ma kpokọta ha n'ime ụmụ irighiri nje na-efe efe. Mgbochi ọrụ protease na-akpaghasị usoro mmeghari nke nje virus [3] . Ovagen na-egbochi ọrụ catalytic protease site na ijikọ na saịtị ya na-arụ ọrụ ma ọ bụ gbanwee nhazi ya. Site na ijikọ na saịtị ahụ na-arụ ọrụ, ọ na-egbochi ntinye mkpụrụ na mmeghachi omume nkewa [3].
Mmechi
Ovagen bụ ngwongwo tripeptide na-egosipụta ọtụtụ ihe omume ndu, na-achịkwa ọrụ imeju na eriri afọ. Ọ na-akwalite uto hepatocyte, na-egbochi fibrosis imeju na cirrhosis, na-eme ka ọrụ imeju dịkwuo mma site n'ịgbanwe usoro DNA na usoro ederede, ma gosipụta ikike mgbochi ịka nká. Ovagen na-ewusi ọrụ mgbochi eriri afọ nke eriri afọ, na-ebelata mmebi sitere na ọgwụ nje, nsị gburugburu ebe obibi, chemotherapy, na erighị ihe na-edozi ahụ.
Ovagen bụ ogige tripeptide nwere ọtụtụ ihe omume ndu, na-achịkwa ọrụ imeju na eriri afọ. Ọ na-akwalite uto hepatocyte, na-egbochi fibrosis imeju na cirrhosis, na-eme ka ọrụ imeju dịkwuo mma site n'ịgbanwe usoro DNA na usoro ederede, na-egosipụta ikike mgbochi ịka nká. Ovagen na-ewusi ọrụ mgbochi eriri afọ nke eriri afọ, na-ebelata mmebi nke ọgwụ nje na-akpata, nsị gburugburu ebe obibi, chemotherapy, na erighị ihe na-edozi ahụ.
Banyere Onye dere ya
Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.
Onye ode akwụkwọ akụkọ sayensị
Apoorva Badaya bụ onye nyocha ọkachamara na computational biophysics na structural bioinformatics. O meela akwụkwọ ọmụmụ ihe na-elekwasị anya na ihe omimi nke nje HIV-1 protease, karịsịa n'ihe gbasara mgbochi mgbochi na mmụgharị. Ọrụ ya na-eji usoro ịme anwansị dị elu iji nyochaa ike protein na ịkọwa usoro ọgwụgwọ. Edepụtara Apoorva Badaya na ntụaka ntụaka [3].
