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1kits (10Vials) .
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▎ Ovagen ƒe Dɔwɔɖoɖo
Dzɔtsoƒe: PubChem |
Nusiwo kplɔ wo nɔewo ɖo: EDL Molekyulãwo ƒe Mɔfiame: C 15H 25N 3O8 Molekyulãwo ƒe Kpekpeme: 375.37 g/mol PubChem ƒe CID:444128 Nya siwo sɔ kple wo nɔewo: NH 2-Glu-Asp-Leu-COOH; glutamyl-aspartyl-leucine si wotsɔna ƒoa ƒui |
▎ Ovagen Ŋuti Numekuku
Nukae nye numekuku si wowɔ le Ovagen ŋu?
Le agbenɔnɔ ƒe nɔnɔme siwo le tɔtrɔm—siwo dometɔ aɖewoe nye aɖi siwo le nutoa me ƒe dzidziɖedzi, dɔlékuiwutikewo zazã fũ akpa, atikewɔmɔnu kple keklẽŋusẽdɔdamɔnu si bɔ, kple amewo ƒe tsitsi—la, aklã kple dɔgbomedɔlélewo dzi ɖe edzi ŋutɔ. Nɔnɔmewo abe aklãdɔléle si nɔa anyi didi kple aklãdɔléle si nɔa anyi didi ene kpɔa ŋusẽ ɖe dɔnɔwo ƒe agbenɔnɔ kple lãmesẽ dzi vevie. Atikewɔwɔ deŋgɔwo ʋlina vevie be yewoagbugbɔ aklã kple dɔgbo ƒe dɔwɔwɔ aɖo anyi nyuie, womete ŋu xea mɔ na dɔléle siwo tsoa dɔléle vovovowo gbɔ hedaa wo bliboe o, eye womeɖea ŋusẽ boo aɖeke fiana le kuxi siwo dona tso keklẽŋusẽdɔdamɔnu, atikewɔmɔnu, kple dɔlékuiwutikewo ƒe nugbegblẽ le ame ŋu me dzi ɖeɖe kpɔtɔ me o. Esia te gbe ɖe alesi wòhiã kpata be woazã atikewɔwɔmɔnu yeyewo dzi.
Peptides, le woƒe wɔwɔme vovovowo ta, ateŋu awɔ dɔ kple lãmenugbagbeviwo me molecule geɖe, si kpɔa ŋusẽ ɖe lãmenugbagbeviwo ƒe dɔwɔwɔ abe lãmenugbagbeviwo ƒe dɔwɔwɔ, tsitsi, kple nuwo ɖɔɖɔɖo ene dzi. Ovagen ƒe akpa veviwo dometɔ aɖewoe nye peptide complexes siwo me amino acid tɔxɛwo le, abe AC-3 si glutamic acid, aspartic acid, kple leucine wɔ ene. Nusiwo wowɔ sia kpɔa ŋusẽ ɖe eƒe ɖoɖowɔwɔ ƒe mɔnuwo dzi le aklã kple dɔgbo ƒe dɔwɔwɔ dzi. To numekuku le Ovagen ŋu me la, dzɔdzɔmeŋutinunyalawo ku mɔnu si wɔa dɔ wu si dzi woato atrɔ asi le aklã kple dɔgbo ƒe dɔwɔwɔ ŋu be wòakpɔ atikewɔwɔ kple mɔxexe ɖe dɔléle nu ƒe hiahiãwo gbɔ.
Nukae nye Ovagen ƒe dɔwɔwɔ ƒe mɔnu?
Receptor Binding Dze Dzesiwo ƒe Tɔtrɔ Gɔme
Xɔla ƒe Blibo Tɔxɛ: Peptide lãmetsi geɖe wɔa woƒe ŋusẽkpɔɖeamedzi to kadodo kple lãmenugbagbevi tɔxɛ siwo ƒe ƒomedodo deŋgɔ, siwo nye protein vevi siwo keke ta le ʋumenugbagbeviɣia me. Peptide lãmetsi ɖesiaɖe wɔa dɔ kple eƒe xɔla si woɖo ɖi abe safui si wotsɔ blaa gaƒoɖokui ene, si wɔnɛ be dzesiwo ƒe kaka pɛpɛpɛ. Ne woblae la, nugbagbeŋutinunya me nudzɔdzɔ gbogbo aɖewo doa ka kple afisi peptide lãmetsiŋusẽ wɔa dɔ le le gɔmedzedzea me—si nye ʋumenugbagbeviɣidɔ—e kple lãmenugbagbevi vovovo siwo woɖo taɖodzinu na ƒe ŋuɖoɖo [1,2]..
Dzesimɔwo ƒe Dɔwɔwɔ: Receptor-peptide ƒe kadodo nana lãmenugbagbeviwo me dzesimɔwo wɔa dɔ. Le kpɔɖeŋu me, peptide lãmetsi aɖewo blana ɖe lãmetsi siwo naa adenylate cyclase wɔa dɔ ŋu, si doa lãmenugbagbeviwo me dɔla evelia si nye cyclic AMP (cAMP) ƒe wɔwɔ ɖe ŋgɔ. Abe dɔla vevi ene la, cAMP naa protein kinases wɔa dɔ, si wɔnɛ be substrate tɔxɛwo ƒe phosphorylation eye wòɖɔa lãmenugbagbevi siwo woɖo taɖodzinu na ƒe dɔwɔwɔwo ɖo. Le lãkusi aɖewo siwo woɖo taɖodzinu na, abe aklã kple ami ƒe lãkusi ene me la, cAMP nyea dɔla evelia vevitɔ si ʋãa lãmetsiŋusẽ tɔxɛwo ƒe dɔlékuiwo ƒe dɔwɔwɔ. Le cAMP godo la, dzesimɔ bubuwo kple dɔla moleculewo kpɔa gome le peptide ƒe dɔwɔwɔwo me; le kpɔɖeŋu me, calcium ions wɔa akpa vevi aɖe le lãmenugbagbeviwo ƒe dɔwɔwɔ le lãmeka aɖewo me dzi kpɔkpɔ me [2] ..
Nɔnɔmetata 1 Mɔ siwo kpɔa gome le steroidogenesis ƒe ɖoɖowɔwɔ me le gonadal tissue me to luteinizing hormone dzi ƒe nɔnɔmetata [2]..
Dɔ kae Ovagen wɔna?
Ovagen doa aklãmenugbagbeviwo ƒe tsitsi ɖe ŋgɔ eye wòxea mɔ na aklã ƒe fibrosis kple cirrhosis. Enaa aklã ƒe dɔwɔwɔ nyona ɖe edzi to aklãmenugbagbeviwo ƒe DNA ƒe wɔwɔme kple woƒe nuŋɔŋlɔ ƒe ɖoɖowo dzi kpɔkpɔ me. Ovagen ɖea ŋusẽ si tsi tre ɖe tsitsi ŋu hã fiana, si trɔa DNA ƒe tɔtrɔ siwo do ƒome kple tsitsi be aklãmenugbagbeviwo nagaɖo sɔhɛmenɔnɔ ƒe nɔnɔme me wu. Ovagen doa ŋusẽ dɔgbo ƒe ʋuka si xea mɔ na dɔgboa ƒe dɔwɔwɔ, si ɖea nusiwo abe dɔlékuiwutikewo zazã, aɖi siwo le nutoa me, atikewɔmɔnu, kple nunyuimakpɔɖui hena vɛ dzi kpɔtɔna. Eƒe ɖoɖowɔwɔ ƒe ŋusẽkpɔɖeamedzi ɖe aklã kple dɔgbo ƒe dɔwɔwɔ dzi le dɔdzẽ kple dɔléle ƒe nɔnɔme vovovowo me naa mɔkpɔkpɔ geɖe be woazãe. Woate ŋu azãe le dɔwɔwɔ nɛ vɔ megbe, dɔlékuiwutikewo zazã ɣeyiɣi didi, kansa dada ƒe nugbegblẽ le ame ŋu dzi ɖeɖe kpɔtɔ, kple suklidɔ nutsitsi me.
Ovagen kple HIV dɔlékuia
Ovagen xɔ susu le HIV ŋuti numekuku me le esi woɖee fia be exea mɔ ɖe HIV-1 protease nu ta. HIV-1 protease nye enzyme vevi aɖe na dɔlékuiwo ƒe agbetsitsi, si ƒe dɔe nye be wòmaa dɔlékui ƒe proteinwo ɖe akpa sue siwo wɔa dɔ me. Abe HIV-1 protease mɔxenu ene la, Ovagen le protease mɔxenu suetɔ kple ŋusẽtɔ kekeake siwo wonya dome. Mɔxexeɖedɔ sia ate ŋu akpe ɖe HIV dɔlékui ƒe dzidziɖedzi dzi ɖuɖu ŋu, si aʋu mɔ yeyewo na HIV dɔlékui dada ŋuti numekuku.
Numekuku si Badaya A wɔ ɖee fia be Ovagen ate ŋu axe mɔ ɖe HIV-1 protease ƒe dɔwɔwɔ nu [3] . HIV-1 protease nye enzyme vevi aɖe le dɔlékuiwo ƒe dzidziɖedzi me, si ƒe dɔe nye be wòmaa protein geɖe me be woatsi ahaƒo wo nu ƒu ɖe dɔlékui ƒe akpa siwo xɔa dɔlékuiwo me. Protease ƒe dɔwɔwɔ nu tsitsi gblẽa dɔlékui ƒe dzidziɖedzi ƒe ɖoɖoa me [3] . Ovagen xea mɔ na protease ƒe dɔwɔwɔ to eƒe kadodo ɖe eƒe dɔwɔwɔ ƒe teƒe alo eƒe nɔnɔme tɔtrɔ me. To kadodo ɖe teƒe si le dɔ wɔm ŋu me la, exea mɔ na substrate ƒe gege ɖe eme kple cleavage reaction [3]..
Nyanuwuwuw
Ovagen nye tripeptide ƒe atike si ɖea nugbagbeŋusẽ ƒe dɔwɔwɔ vovovowo fiana, eye wòɖɔa aklã kple dɔgbo ƒe dɔwɔwɔ ɖo koŋ. Edoa aklãmenugbagbeviwo ƒe tsitsi ɖe ŋgɔ, xea mɔ na aklã ƒe fibrosis kple cirrhosis, enaa aklã ƒe dɔwɔwɔ nyona ɖe edzi to asitɔtrɔ le DNA ƒe wɔwɔme kple nuŋɔŋlɔ ƒe ɖoɖowo ŋu me, eye wòɖea ŋutete si tsi tre ɖe tsitsi ŋu fiana. Ovagen doa ŋusẽ dɔgbo ƒe ʋukawo ƒe mɔxenu ƒe dɔwɔwɔ, si ɖea nusiwo dɔlékuiwutikewo, aɖi siwo le nutoa me, atikewɔmɔnu, kple nunyuimakpɔɖu gblẽna le ame ŋu dzi kpɔtɔna.
Ovagen nye peptide etɔ̃ si me nugbagbeviwo ƒe dɔwɔwɔ le mɔ vovovowo nu le, eye koŋue wòɖɔa aklã kple dɔgbo ƒe dɔwɔwɔ ɖo. Edoa aklãmenugbagbeviwo ƒe tsitsi ɖe ŋgɔ, xea mɔ na aklã ƒe fibrosis kple cirrhosis, enaa aklã ƒe dɔwɔwɔ nyona ɖe edzi to asitɔtrɔ le DNA ƒe wɔwɔme kple nuŋɔŋlɔ ƒe ɖoɖowo ŋu me, eye wòɖea ŋutete si tsi tre ɖe tsitsi ŋu fiana. Ovagen doa ŋusẽ dɔgbo ƒe lãkusi ƒe mɔxenu ƒe dɔwɔwɔ, si ɖea nusiwo dɔlékuiwutikewo, aɖi siwo le nutoa me, atikewɔmɔnu, kple nunyuimakpɔɖu gblẽna le ame ŋu dzi kpɔtɔna.
Le Agbalẽŋlɔla La Ŋu
Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.
Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla
Apoorva Badaya nye numekula si bi ɖe akɔntabubu ƒe nugbagbeŋutinunya kple xɔtuɖaŋu ŋuti nyatakakawo me. Ewɔ ɖeka kple agbalẽŋlɔlawo ƒe numekuku siwo ku ɖe HIV-1 protease ƒe molecule ƒe dɔwɔwɔ ŋu, vevietɔ le dɔlékuiwutikewo ƒe kadodo kple woƒe tɔtrɔwo gome. Eƒe dɔa zãa aɖaŋu deŋgɔ siwo wotsɔ wɔa nɔnɔmetatawoe tsɔ kua protein ƒe ŋusẽkpɔɖeamedzi me eye wònana nyanya atikewɔwɔmɔnu. Woŋlɔ Apoorva Badaya ŋkɔ ɖe nyayɔyɔ ƒe nyatakaka me [3].
