Ovagen 20 MG

▎ Ovagen Tsarin

▎ Ovagen Binciken

Menene asalin binciken Ovagen?

Tsakanin sauye-sauyen yanayin rayuwa-ciki har da ƙara yawan gubobi na muhalli, yawan amfani da ƙwayoyin cuta, yaduwar chemotherapy da radiotherapy, da yawan tsufa—abun ciwon hanta da na ciki ya ƙaru sosai. Yanayi kamar ciwon hanta na yau da kullun da cirrhosis suna yin tasiri sosai ga ingancin rayuwa da lafiyar marasa lafiya. Jiyya na al'ada suna gwagwarmaya don dawo da aikin hanta na al'ada da aikin gastrointestinal yadda ya kamata, sun kasa yin rigakafi da kuma magance cututtukan da ke haifar da cututtuka daban-daban, kuma suna nuna iyakacin tasiri wajen rage rikitarwa daga radiotherapy, chemotherapy, da sakamako masu illa na maganin rigakafi. Wannan yana jaddada buƙatar gaggawa don sabbin hanyoyin warkewa.

Peptides, saboda tsarin su daban-daban, na iya yin hulɗa tare da ƙwayoyin intracellular da yawa, suna tasiri tsarin salon salula irin su metabolism, girma, da gyarawa. Abubuwan da ake buƙata na Ovagen sun haɗa da hadaddun peptide waɗanda suka ƙunshi takamaiman amino acid, irin su AC-3 wanda glutamic acid ya kirkira, aspartic acid, da leucine. Wannan abun da ke ciki yana rinjayar tsarin tsarin sa akan hanta da aikin gastrointestinal. Ta hanyar bincike kan Ovagen, masana kimiyya sun binciko hanyar da ta fi dacewa don daidaita aikin hanta da gastrointestinal don saduwa da magani na asibiti da bukatun rigakafin cututtuka.

Menene tsarin aikin Ovagen?

Daure Mai karɓa yana Ƙaddamar da Canja wurin Siginar

Ƙwararren Mai karɓa na Musamman: Yawancin peptide hormones suna yin tasirin su ta hanyar ɗaure ga takamaiman masu karɓa na haɗin gwiwa, waɗanda suke da haɗin gwiwar sunadaran da ke tattare da membrane na plasma. Kowane hormone peptide yana mu'amala da mai karɓar sa da aka keɓe kamar maɓalli mai dacewa da kulle, yana tabbatar da daidaitaccen watsa sigina. Bayan ɗaure, ɓarna na abubuwan da ke tattare da sinadarai suna haɗa rukunin farko na aikin hormone peptide - membrane plasma - zuwa nau'ikan martanin sel daban-daban ^[1,2].

Kunna Hanyoyin Sigina: Mai karɓa-peptide daure yana kunna hanyoyin siginar ciki. Misali, wasu hormones peptide suna ɗaure ga masu karɓa waɗanda ke kunna adenylate cyclase, suna haɓaka samar da manzo na biyu na cyclic AMP (cAMP). A matsayin manzo mai mahimmanci, cAMP yana kunna kinases sunadaran gina jiki, yana haifar da phosphorylation na takamaiman abubuwan da ke daidaita ayyukan tantanin halitta. A cikin wasu nau'ikan kyallen takarda, kamar hanta da nama mai adipose, cAMP yana aiki azaman manzo na farko na biyu yana haifar da takamaiman martanin kwayoyin halitta na hormone. Bayan cAMP, sauran hanyoyin sigina da ƙwayoyin manzo suna shiga cikin hanyoyin peptide; alal misali, ions calcium suna taka muhimmiyar rawa wajen daidaita martanin salula a wasu kyallen takarda ^[2].

Hoto 1 Hoto na hanyoyin da ke cikin tsarin tsarin steroidogenesis a cikin ƙwayar gonadal ta hanyar luteinizing hormone ^[2].

Menene aikin Ovagen?

Ovagen yana inganta haɓakar hanta kuma yana hana hanta fibrosis da cirrhosis. Yana inganta aikin hanta ta hanyar daidaita tsarin DNA na hepatocyte da tsarin rubutu. Ovagen kuma yana nuna tasirin tsufa, yana juyar da sauye-sauyen DNA masu alaƙa da shekaru don dawo da hanta zuwa yanayin ƙuruciya. Ovagen yana haɓaka aikin shinge na mucosal na gastrointestinal fili, yana rage lalacewa ga sashin gastrointestinal da ke haifar da abubuwa kamar maganin rigakafi, gubar muhalli, chemotherapy, da rashin abinci mai gina jiki. Ayyukansa na ka'idoji akan hanta da aikin gastrointestinal a fadin jihohi daban-daban masu kumburi da cututtuka suna ba da damar aikace-aikace masu yawa. Ana iya amfani da shi a cikin kulawa bayan tiyata, maganin rigakafi na dogon lokaci, rage tasirin maganin ciwon daji, da rigakafin metabolism.

Ovagen da HIV

Ovagen ya ba da hankali a cikin bincike na HIV saboda tasirin da aka nuna akan cutar HIV-1. HIV-1 protease wani muhimmin enzyme ne don rayuwa ta hoto ko bidiyo mai zagaya yanar gizo da sauri, wanda ke da alhakin ƙwanƙwasa sunadaran hoto zuwa cikin sassan aiki. A matsayin mai hana cutar HIV-1, Ovagen ya kasance a cikin mafi ƙanƙanta kuma mafi yawan sanannun masu hana haɓakar protease. Wannan aikin hanawa na iya taimakawa wajen sarrafa kwafin cutar kanjamau, buɗe sabbin hanyoyin bincike na maganin cutar HIV.

Binciken da Badaya A ya yi ya nuna cewa Ovagen na iya hana cutar HIV-1 aikin protease ^[3] . HIV-1 protease wani muhimmin enzyme ne a cikin kwafin hoto, wanda ke da alhakin datse polyproteins don girma da kuma haɗa su cikin ƙwayoyin cuta masu kamuwa da cuta. Hana ayyukan protease yana rushe tsarin kwafi na kwayar cuta ^[3] . Ovagen yana hana aikin catalytic protease ta hanyar ɗaure wurin da yake aiki ko canza fasalin sa. Ta hanyar ɗaure ga rukunin yanar gizo mai aiki, yana hana shigarwar substrate da matakin tsagewa ^[3].

Kammalawa

Ovagen wani fili ne na tripeptide wanda ke nuna ayyukan halittu masu yawa, da farko yana daidaita ayyukan hanta da gastrointestinal. Yana haɓaka haɓakar hanta, yana hana fibrosis hanta da cirrhosis, yana haɓaka aikin hanta ta hanyar daidaita tsarin DNA da tsarin rubutu, kuma yana nuna yuwuwar rigakafin tsufa. Ovagen yana ƙarfafa aikin shinge na mucosal na ciki, yana rage lalacewa daga maganin rigakafi, gubar muhalli, chemotherapy, da rashin abinci mai gina jiki.

Ovagen wani fili ne na tripeptide tare da ayyukan nazarin halittu masu yawa, da farko yana daidaita aikin hanta da gastrointestinal. Yana haɓaka haɓakar hanta, yana hana fibrosis hanta da cirrhosis, yana haɓaka aikin hanta ta hanyar daidaita tsarin DNA da tsarin rubutu, kuma yana nuna yuwuwar rigakafin tsufa. Ovagen yana ƙarfafa aikin shinge na mucosal na ciki, yana rage lalacewar da maganin rigakafi ya haifar, gubobi na muhalli, chemotherapy, da rashin abinci mai gina jiki.

Game da Marubuci

Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.

Mawallafin Jaridar Kimiyya

Apoorva Badaya mai bincike ne wanda ya ƙware a ilimin lissafin halittu da kuma tsarin halittu. Ya yi karatun haɗin gwiwa tare da mai da hankali kan haɓakar ƙwayoyin ƙwayoyin cuta na HIV-1 protease, musamman dangane da ɗaure antibody da maye gurbi. Ayyukansa suna amfani da ingantattun fasahohin kwaikwaiyo don bincika ƙarfin furotin da sanar da dabarun warkewa. An jera Apoorva Badaya a cikin ambaton ambaton [3].

▎ Abubuwan da suka dace

[1] Barker S. Mechanism na aikin peptide hormones; 2020: 47-71.DOI: 10.1201/9781003076926-3.

[2] K., J., Kaf. BASIC RUKUNAN HANKALI NA AIKI NA PEPTIDE Hormones.; 2004. https://api.semanticscholar.org/CorpusID:250184627.

[3] Badaya A, Sasidhar YU. Hana ayyukan rigakafin cutar HIV-1 ta hanyar daurin antibody da maye gurbi da aka bincika ta hanyar simintin gyare-gyaren kwayoyin halitta. Rahoton Kimiyya 2020; 10 (1): 5501.DOI: 10.1038/s41598-020-62423-y.

DUKKANIN LABARI DA BAYANIN KYAUTATAWA DA AKE BAYAR A WANNAN SHAFIN KAWAI DOMIN WATSA BAYANI NE DA MANUFOFIN ILIMI.  

Kayayyakin da aka bayar akan wannan gidan yanar gizon an yi niyya ne kawai don binciken in vitro. Binciken in vitro (Latin: *a cikin gilashi*, ma'ana a cikin gilashin gilashi) ana gudanar da shi a wajen jikin mutum. Waɗannan samfuran ba magunguna ba ne, Hukumar Abinci da Magunguna ta Amurka (FDA) ba ta amince da su ba, kuma dole ne a yi amfani da su don hanawa, magani, ko warkar da kowane yanayi na likita, cuta, ko cuta. Doka ta haramta shigar da waɗannan samfuran cikin jikin mutum ko dabba ta kowace hanya.