Ovagen 20 mg

▎ Ovagen Structure

▎ Ovagen Research

Dab tsi yog qhov kev tshawb fawb keeb kwm ntawm Ovagen?

Nyob nruab nrab ntawm kev hloov pauv hauv kev ua neej nyob - suav nrog kev nce ib puag ncig co toxins, kev siv tshuaj tua kab mob ntau dhau, kev siv tshuaj khomob thiab xov tooj cua, thiab cov neeg laus laus - qhov tshwm sim ntawm daim siab thiab kab mob plab tau nce siab. Cov xwm txheej zoo li mob siab mob siab mob siab thiab mob cirrhosis cuam tshuam rau cov neeg mob lub neej zoo thiab kev noj qab haus huv. Cov kev kho mob ib txwm muaj kev tawm tsam kom rov zoo li qub daim siab thiab plab hnyuv ua haujlwm, tsis ua tiav kev tiv thaiv thiab kho cov kab mob tshwm sim los ntawm ntau yam etiologies, thiab qhia tias tsis muaj txiaj ntsig hauv kev txo cov teeb meem los ntawm kev siv hluav taws xob, tshuaj kho mob, thiab kev mob tshwm sim ntawm cov tshuaj tua kab mob. Qhov no qhia txog qhov xav tau sai rau cov kev kho tshiab tshiab.

Peptides, vim lawv cov qauv sib txawv, tuaj yeem cuam tshuam nrog ntau lub cev hauv lub cev, cuam tshuam cov txheej txheem ntawm tes xws li cov metabolism, kev loj hlob, thiab kho. Ovagen cov khoom tseem ceeb suav nrog peptide complexes uas muaj cov amino acids tshwj xeeb, xws li AC-3 tsim los ntawm glutamic acid, aspartic acid, thiab leucine. Qhov kev sib xyaw no cuam tshuam rau nws cov txheej txheem tswj hwm ntawm daim siab thiab plab hnyuv ua haujlwm. Los ntawm kev tshawb fawb ntawm Ovagen, cov kws tshawb fawb tau tshawb nrhiav txoj hauv kev zoo dua rau kev hloov kho lub siab thiab lub plab zom mov kom ua tau raws li kev kho mob thiab kev tiv thaiv kab mob.

Ovagen's mechanism ntawm kev txiav txim yog dab tsi?

Receptor Binding Initiates Signal Transduction

Specific Receptor Binding : Ntau cov tshuaj peptide ua rau lawv cov teebmeem los ntawm kev khi rau cov receptors tshwj xeeb, uas yog cov proteins tseem ceeb hla lub plasma membrane. Txhua peptide hormone cuam tshuam nrog nws cov neeg txais kev xaiv zoo li tus yuam sij haum lub xauv, kom ntseeg tau tias cov teeb liab kis tau zoo. Raws li kev khi, ib qho cascade ntawm biochemical txheej xwm txuas rau qhov chaw pib ntawm peptide hormone kev txiav txim - lub plasma membrane - rau ntau lub hom phiaj ntawm tes teb ^[1,2].

Activating Signaling Pathways: Receptor-peptide binding activates intracellular signaling pathways. Piv txwv li, qee yam peptide cov tshuaj hormones khi rau cov receptors uas ua rau adenylate cyclase, txhawb kev tsim cov intracellular thib ob messenger cyclic AMP (cAMP). Raws li tus xa xov tseem ceeb, cAMP activates protein kinases, ua rau phosphorylation ntawm cov substrates tshwj xeeb thiab tswj lub hom phiaj ntawm tes ua haujlwm. Hauv qee lub hom phiaj cov ntaub so ntswg, xws li daim siab thiab cov ntaub so ntswg adipose, cAMP ua haujlwm ua tus xa xov thib ob uas ua rau cov tshuaj hormones tshwj xeeb biochemical teb. Tshaj li cAMP, lwm txoj hauv kev taw qhia thiab cov tub txib molecules koom nrog peptide mechanisms; Piv txwv li, calcium ions ua lub luag haujlwm tseem ceeb hauv kev tswj cov lus teb ntawm tes hauv qee cov ntaub so ntswg ^[2].

Daim duab 1 Daim duab ntawm txoj hauv kev koom nrog kev tswj hwm ntawm steroidogenesis hauv cov ntaub so ntswg gonadal los ntawm luteinizing hormone ^[2].

Lub luag haujlwm ntawm Ovagen yog dab tsi?

Ovagen txhawb kev loj hlob ntawm hepatocyte thiab tiv thaiv daim siab fibrosis thiab cirrhosis. Nws txhim kho daim siab ua haujlwm los ntawm kev tswj hwm hepatocyte DNA qauv thiab cov qauv hloov pauv. Ovagen kuj nthuav tawm cov teebmeem tiv thaiv kev laus, thim rov qab cov hnub nyoog ntsig txog DNA hloov kho kom rov ua kom cov hepatocytes rau lub xeev hluas dua. Ovagen txhim kho plab hnyuv mucosal barrier muaj nuj nqi, txo kev puas tsuaj rau lub plab zom mov tshwm sim los ntawm yam xws li tshuaj tua kab mob, ib puag ncig co toxins, kws khomob, thiab noj tsis txaus. Nws cov kev tswj xyuas kev ua haujlwm ntawm daim siab thiab plab hnyuv ua haujlwm thoob plaws ntau lub xeev inflammatory thiab kab mob muab cov ntawv thov dav dav. Nws tuaj yeem siv rau hauv kev saib xyuas tom qab phais, kev kho mob ntev ntev, kho mob qog noj ntshav, thiab tiv thaiv cov metabolism.

Ovagen thiab HIV

Ovagen tau txais kev saib xyuas hauv kev tshawb fawb HIV vim nws pom tias inhibitory nyhuv ntawm HIV-1 protease. HIV-1 protease yog ib qho tseem ceeb enzyme rau cov kab mob ciaj sia, lub luag hauj lwm rau cleaving viral proteins mus rau hauv lub functional subunits. Raws li HIV-1 protease inhibitor, Ovagen nyob rau ntawm qhov tsawg tshaj plaws thiab muaj peev xwm paub txog cov tshuaj tiv thaiv protease. Qhov kev tiv thaiv no tuaj yeem pab tswj hwm tus kab mob HIV, qhib txoj hauv kev tshiab rau kev tshawb fawb txog kev kho mob HIV.

Kev tshawb fawb los ntawm Badaya A qhia tias Ovagen tuaj yeem cuam tshuam HIV-1 protease kev ua haujlwm ^[3] . HIV-1 protease yog ib qho tseem ceeb enzyme nyob rau hauv cov kab mob replication, lub luag hauj lwm rau cleaving polyproteins kom loj hlob thiab sib sau ua ke rau hauv kis kab mob. Inhibiting protease kev ua cuam tshuam cuam tshuam cov txheej txheem rov ua dua tshiab ^[3] . Ovagen inhibits protease catalytic muaj nuj nqi los ntawm kev khi rau nws qhov chaw nquag lossis hloov nws qhov kev sib haum xeeb. Los ntawm kev khi rau qhov chaw nquag, nws tiv thaiv substrate nkag thiab cov tshuaj tiv thaiv cleavage ^[3].

Xaus

Ovagen yog ib qho tripeptide compound uas nthuav tawm ntau yam kev ua haujlwm lom neeg, feem ntau tswj lub siab thiab plab hnyuv ua haujlwm. Nws txhawb kev loj hlob ntawm hepatocyte, tiv thaiv daim siab fibrosis thiab cirrhosis, txhim kho daim siab ua haujlwm los ntawm kev hloov kho DNA qauv thiab cov qauv hloov pauv, thiab ua kom pom kev tiv thaiv kev laus. Ovagen ntxiv dag zog rau lub plab hnyuv mucosal barrier muaj nuj nqi, txo kev puas tsuaj los ntawm cov tshuaj tua kab mob, ib puag ncig co toxins, chemotherapy, thiab noj tsis txaus.

Ovagen yog ib qho tripeptide compound nrog ntau yam kev ua haujlwm lom neeg, feem ntau tswj lub siab thiab plab hnyuv ua haujlwm. Nws txhawb kev loj hlob ntawm hepatocyte, tiv thaiv daim siab fibrosis thiab cirrhosis, txhim kho daim siab ua haujlwm los ntawm kev hloov kho DNA qauv thiab cov qauv kev hloov pauv, thiab muaj peev xwm tiv thaiv kev laus. Ovagen ntxiv dag zog rau lub plab hnyuv mucosal barrier muaj nuj nqi, txo kev puas tsuaj los ntawm cov tshuaj tua kab mob, ib puag ncig co toxins, chemotherapy, thiab noj tsis txaus.

Hais Txog Tus Sau

Cov ntaub ntawv hais saum toj no yog txhua yam tshawb fawb, kho thiab sau los ntawm Cocer Peptides.

Scientific Journal Author

Apoorva Badaya yog tus kws tshawb fawb tshwj xeeb hauv kev suav biophysics thiab cov txheej txheem bioinformatics. Nws tau koom nrog cov kev tshawb fawb tsom mus rau lub molecular dynamics ntawm HIV-1 protease, tshwj xeeb tshaj yog nyob rau hauv kev sib raug zoo nrog antibody khi thiab kev hloov. Nws txoj haujlwm siv cov txheej txheem simulation siab heev los tshawb nrhiav cov protein ntau thiab qhia cov tswv yim kho mob. Apoorva Badaya tau teev nyob rau hauv qhov kev siv ntawm cov ntaub ntawv pov thawj [3].

▎ Cov Lus Qhia Tseem Ceeb

[1] Barker S. Mechanism ntawm kev txiav txim ntawm cov tshuaj hormones peptide; 2020: 47-71.DOI: 10.1201/9781003076926-3.

[2] K., J., Cab. IB QHOV CHAW UA HAUJ LWM NTAWM CHAW UA HAUJ LWM NTAWM PEPTIDE HORMONES.; 2004. https://api.semanticscholar.org/CorpusID:250184627.

[3] Badaya A, Sasidhar YU. Inhibition ntawm kev ua ntawm HIV-1 protease los ntawm cov tshuaj tiv thaiv kab mob khi thiab kev hloov pauv tau soj ntsuam los ntawm kev sim molecular dynamics simulations. Kev Tshaj Tawm Txog Kev Tshawb Fawb 2020; 10(1): 5501.DOI: 10.1038/s41598-020-62423-y.

Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.  

Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.