Ovagen 20mg

▎ Ovagen Hoʻolālā

▎ Ovagen Research

He aha ke kumu noiʻi o Ovagen?

Ma waena o ka ulu ʻana o nā kūlana ola—me ka hoʻonui ʻana i nā toxins kaiapuni, ka hoʻohana nui ʻana i ka lāʻau antibiotic, ka laha ʻana o ka chemotherapy a me ka radiotherapy, a me ka ʻelemakule o ka lehulehu-ua piʻi nui ka maʻi o ka ate a me ka ʻōpū. ʻO nā kūlana e like me ka maʻi hepatitis mau loa a me ka cirrhosis e hoʻopilikia nui i ka maikaʻi o ke ola a me ke olakino. Paʻakikī nā lāʻau kuʻuna i ka hoʻihoʻi maikaʻi ʻana i ka hana maʻamau o ka ate a me ka ʻōpū, ʻaʻole hiki ke pale a mālama i nā maʻi i hoʻokumu ʻia e nā etiologies like ʻole, a hōʻike i ka palena palena i ka hoʻēmi ʻana i nā pilikia mai ka radiotherapy, chemotherapy, a me nā hopena ʻaoʻao o nā lāʻau antibiotic. Hōʻike kēia i ka pono wikiwiki o nā ala therapeutic hou.

Hiki i nā Peptides, ma muli o kā lākou mau ʻano like ʻole, hiki ke launa pū me nā molekole intracellular he nui, e hoʻohuli ana i nā kaʻina cellular e like me ka metabolism, ka ulu ʻana, a me ka hoʻoponopono. ʻO nā ʻāpana koʻikoʻi o Ovagen nā peptide complexes i haku ʻia me nā waikawa amino kikoʻī, e like me AC-3 i hana ʻia e ka glutamic acid, aspartic acid, a me ka leucine. Hoʻopili kēia haku mele i kāna mau hana hoʻoponopono i ka hana o ke ake a me ka gastrointestinal. Ma o ka noiʻi ʻana ma Ovagen, ua ʻimi nā kānaka ʻepekema i kahi ala ʻoi aku ka maikaʻi no ka hoʻololi ʻana i ka hana o ka ate a me ka ʻōpū e hoʻokō ai i ka mālama lapaʻau a me nā pono pale ʻana i nā maʻi.

He aha ke ʻano o ka hana a Ovagen?

Hoʻomaka ka Receptor Binding i ka hoʻololi ʻana i ka hōʻailona

ʻO ka hoʻopaʻa ʻana o ka mea hoʻopaʻa kikoʻī: ʻO ka nui o nā hormones peptide e hoʻokō i kā lākou hopena ma o ka hoʻopaʻa ʻana i nā mea loaʻa kiʻekiʻe-affinity kikoʻī, ʻo ia nā protein integral e pili ana i ka membrane plasma. Hoʻopili kēlā me kēia hormone peptide me kāna mea hoʻokipa i koho ʻia e like me ke kī i hoʻopaʻa ʻia i kahi laka, e hōʻoiaʻiʻo ana i ka lawe ʻana i ka hōʻailona pololei. Ma ka hoʻopaʻa ʻana, kahi cascade o nā hanana biochemical e hoʻopili i ka pūnaewele mua o ka hana peptide hormone-ʻo ka membrane plasma-i nā pane cell target like ʻole ^[1,2].

E ho'āla ana i nā ala hōʻailona: Hoʻopili ka Receptor-peptide i nā ala hōʻailona intracellular. No ka laʻana, hoʻopaʻa kekahi mau hormones peptide i nā mea loaʻa e hoʻāla i ka adenylate cyclase, e hoʻoikaika ana i ka hana ʻana o ka intracellular second messenger cyclic AMP (cAMP). Ma ke ʻano he ʻelele koʻikoʻi, hoʻāla ka cAMP i nā kinases protein, e alakaʻi ana i ka phosphorylation o nā substrates kikoʻī a me ka hoʻoponopono ʻana i nā hana cell target. I kekahi mau ʻiʻo i hoʻopaʻa ʻia, e like me ke ake a me ka ʻiʻo adipose, lawelawe ʻo cAMP ma ke ʻano he ʻelele lua mua e hoʻoulu i nā pane biochemical kikoʻī hormone. Ma waho aʻe o ka cAMP, komo nā ala hōʻailona ʻē aʻe a me nā molekele ʻelele i nā mīkini peptide; no ka laʻana, hana koʻikoʻi nā ion calcium i ka hoʻoponopono ʻana i nā pane kelepona i kekahi mau kiko ^[2].

Kiʻi 1 Diagram o nā ala i komo i ka hoʻoponopono ʻana i ka steroidogenesis i loko o ka ʻiʻo gonadal e ka luteinizing hormone ^[2].

He aha ka hana o Ovagen?

Hoʻoikaika ʻo Ovagen i ka ulu hepatocyte a pale i ka fibrosis ate a me ka cirrhosis. Hoʻomaikaʻi ia i ka hana o ka ate ma ka hoʻoponopono ʻana i ke ʻano hepatocyte DNA a me nā ʻano transcription. Hōʻike pū ʻo Ovagen i nā hopena anti-kahiko, hoʻohuli i nā hoʻololi DNA pili makahiki e hoʻihoʻi i nā hepatocytes i kahi kūlana ʻōpio. Hoʻonui ʻo Ovagen i ka hana pale mucosal gastrointestinal, hoʻēmi i ka pōʻino i ka ʻōpū o ka ʻōpū i hoʻokumu ʻia e nā kumu e like me ka lāʻau antibiotic, nā toxins kūlohelohe, chemotherapy, a me ka malnutrition. ʻO kāna mau hopena hoʻoponopono i ka hana o ka ate a me ka gastrointestinal ma waena o nā mokuʻāina inflammatory a me nā maʻi e hāʻawi i nā manaʻo noiʻi ākea. Hiki ke hoʻohana ʻia i ka mālama postoperative, ka lāʻau antibiotic lōʻihi, e hōʻoluʻolu i nā hopena ʻaoʻao o ka mālama ʻana i ka maʻi kanesa, a me ka pale ʻana i ka metabolism.

Ovagen a me HIV

Ua loaʻa ʻo Ovagen i ka nānā ʻana i ka noiʻi HIV ma muli o kona hōʻike ʻana i ka hopena pale i ka protease HIV-1. ʻO ka protease HIV-1 he enzyme koʻikoʻi no ke ola viral, kuleana no ka hoʻokaʻawale ʻana i nā protein viral i nā subunits hana. Ma ke ʻano he HIV-1 protease inhibitor, ʻo Ovagen kahi i waena o nā mea liʻiliʻi a ikaika loa i ʻike ʻia. Hiki ke kōkua i kēia hana pale i ka mālama ʻana i ka hoʻopiʻi hou ʻana o ka maʻi HIV, e wehe ana i nā ala hou no ka noiʻi ʻana i ka maʻi HIV.

ʻO ka noiʻi a Badaya A e hōʻike ana e hiki iā Ovagen ke kāohi i ka hana protease HIV-1 ^[3] . He enzyme koʻikoʻi ka protease HIV-1 i ka hoʻopiʻi viral, kuleana no ka ʻoki ʻana i nā polyproteins e oʻo a hōʻuluʻulu iā lākou i loko o nā ʻāpana viral infectious. Hoʻopilikia ka hana protease i ke kaʻina hana hoʻopiʻi viral ^[3] . Kāohi ʻo Ovagen i ka hana catalytic protease ma o ka hoʻopaʻa ʻana i kāna wahi hana a hoʻololi paha i kona conformation. Ma ka hoʻopaʻa ʻana i ka pūnaewele ikaika, pale ia i ke komo ʻana o ka substrate a me ka hopena cleavage ^[3].

Ka hopena

ʻO Ovagen kahi pūhui tripeptide e hōʻike ana i nā hana biological multifaceted, e hoʻoponopono mua i nā hana o ka ate a me ka gastrointestinal. Hoʻoikaika ia i ka ulu ʻana o ka hepatocyte, pale i ka fibrosis ate a me ka cirrhosis, hoʻonui i ka hana o ka ate ma o ka hoʻololi ʻana i ka hoʻolālā DNA a me nā ʻano transcriptional, a hōʻike i ka hiki ke kū i ka wā kahiko. Hoʻoikaika ʻo Ovagen i ka hana pale mucosal gastrointestinal, e hoʻēmi ana i ka pōʻino mai nā lāʻau antibiotic, nā toxins kūlohelohe, ka chemotherapy, a me ka malnutrition.

ʻO Ovagen kahi pūhui tripeptide me nā hana biological multifaceted, e hoʻoponopono mua i ka hana o ka ate a me ka gastrointestinal. Hoʻoikaika ia i ka ulu ʻana o ka hepatocyte, pale i ka fibrosis ate a me ka cirrhosis, hoʻonui i ka hana o ka ate ma o ka hoʻololi ʻana i ka hoʻolālā DNA a me nā ʻano transcriptional, a hōʻike i ka hiki ke kū i ka wā kahiko. Hoʻoikaika ʻo Ovagen i ka hana pale mucosal gastrointestinal, hoʻemi i ka pōʻino i hoʻokumu ʻia e nā lāʻau antibiotic, nā toxins kūlohelohe, chemotherapy, a me ka malnutrition.

No ka mea kakau

ʻO nā mea i ʻōlelo ʻia ma luna nei ua noiʻi ʻia, hoʻoponopono ʻia a hōʻuluʻulu ʻia e Cocer Peptides.

Mea kākau moʻolelo ʻepekema

He mea noiʻi ʻo Apoorva Badaya i ka helu ʻana i ka biophysics a me ka bioinformatics structural. Ua kākau pū ʻo ia i nā haʻawina e pili ana i ka molecular dynamics o ka HIV-1 protease, e pili ana i ka hoʻopaʻa ʻana i ka antibody a me nā mutations. Hoʻohana kāna hana i nā ʻenehana simulation kiʻekiʻe e ʻimi i ka dinamika protein a hoʻomaopopo i nā hoʻolālā therapeutic. Ua helu ʻia ʻo Apoorva Badaya ma ka ʻōlelo kuhikuhi [3].

▎ Nā ʻōlelo pili

[1] ʻO Barker S. Mechanism o ka hana o nā hormones peptide; 2020: 47-71.DOI: 10.1201/9781003076926-3.

[2] K., J., Catf. NA MANAO KUMU O KA MECHANISM OF HANA O PEPTIDE HORMONES.; 2004. https://api.semanticscholar.org/CorpusID:250184627.

[3] Badaya A, Sasidhar YU. Ka pale ʻana i ka hana o ka protease HIV-1 ma o ka hoʻopaʻa ʻana i ka antibody a me nā mutations i ʻimi ʻia e nā simulation molecular dynamics. Nā Hōʻike ʻepekema 2020; 10(1): 5501.DOI: 10.1038/s41598-020-62423-y.

ʻO nā ʻatikala a me nā ʻike huahana i hāʻawi ʻia ma kēia pūnaewele pūnaewele wale nō no ka hoʻolaha ʻana i ka ʻike a me nā kumu hoʻonaʻauao.  

ʻO nā huahana i hāʻawi ʻia ma kēia pūnaewele i manaʻo wale ʻia no ka noiʻi in vitro. Hana ʻia ka noiʻi in vitro (Latin: *i ke aniani*, ʻo ia hoʻi i ka ipu aniani) ma waho o ke kino kanaka. ʻAʻole kēia mau huahana he lāʻau lapaʻau, ʻaʻole i ʻae ʻia e ka US Food and Drug Administration (FDA), a ʻaʻole pono e hoʻohana ʻia no ka pale ʻana, mālama, a hoʻōla paha i kekahi maʻi olakino, maʻi, a maʻi paha. Ua pāpā loa ʻia e ke kānāwai ke hoʻokomo i kēia mau huahana i loko o ke kino kanaka a holoholona paha ma kekahi ʻano.