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1kits （10Ibikoresho）
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Imiterere Ovagen ya
Inkomoko: PubChem |
Urukurikirane: EDL Inzira ya molekulari: C 15H 25N 3O.8 Uburemere bwa molekuline: 375.37 g / mol PubChem CID ： 444128 Synonyme: NH 2-Glu-Asp-Leu-COOH; glutamyl-aspartyl-leucine |
Research bwa Ovagen Ubushakashatsi
Ni ubuhe bushakashatsi bwakozwe na Ovagen?
Mu gihe imibereho igenda ihinduka - harimo uburozi bw’ibidukikije bwiyongera, gukoresha antibiotike ikabije, imiti myinshi ya chimiotherapie na radiotherapi, hamwe no gusaza kw’abaturage - indwara z’umwijima n’indwara zo mu nda ziyongereye cyane. Indwara nka hepatite idakira hamwe na cirrhose bigira ingaruka zikomeye kumibereho yabarwayi nubuzima. Ubuvuzi gakondo burwana no kugarura neza umwijima usanzwe nigikorwa cyigifu, kunanirwa gukumira byimazeyo no kuvura indwara ziterwa na etiologiya zitandukanye, kandi bikerekana imbaraga nke mukugabanya ibibazo biterwa na radiotherapi, chimiotherapie, ningaruka mbi za antibiotike. Ibi bishimangira ko byihutirwa uburyo bwo kuvura udushya.
Peptide, bitewe nuburyo butandukanye, irashobora gukorana na molekile nyinshi zidasanzwe, bigira ingaruka kumikorere ya selile nka metabolism, gukura, no gusana. Ibice by'ibanze bya Ovagen birimo peptide igizwe na aside amine yihariye, nka AC-3 ikorwa na acide glutamic, aside aspartic, na leucine. Iyi miterere igira uruhare muburyo bwo kugenzura imikorere yumwijima nigifu. Binyuze mu bushakashatsi bwakozwe kuri Ovagen, abahanga bakoze ubushakashatsi ku buryo bunoze bwo guhindura umwijima n’imikorere ya gastrointestinal kugira ngo babone imiti ivura no kwirinda indwara.
Ni ubuhe buryo bwa Ovagen bwo gukora?
Guhambira Kwakira Gutangiza Ibimenyetso
Guhambira kwakirwa neza: Imisemburo myinshi ya peptide ikora ingaruka zayo muguhuza reseptor yihariye yihariye, ari poroteyine zuzuye zizenguruka plasma membrane. Buri musemburo wa peptide ukorana na reseptor yabigenewe nkurufunguzo rukwiranye no gufunga ibimenyetso, byerekana neza kohereza ibimenyetso neza. Iyo uhambiriye, casade yibintu bya biohimiki ihuza ikibanza cyambere cyibikorwa bya hormone peptide - plasma membrane - nibisubizo bitandukanye byingirabuzimafatizo [1,2].
Gukora inzira yerekana ibimenyetso: Receptor-peptide guhuza ikora inzira yerekana ibimenyetso. Kurugero, imisemburo imwe ya peptide ihuza reseptors ikora cyclase ya adenylate, igateza imbere umusaruro wintumwa ya kabiri yintumwa ya cyclic AMP (cAMP). Nkintumwa yingenzi, cAMP ikora protein kinase, biganisha kuri fosifora ya substrate yihariye no kugenzura imikorere ya selile. Mu ngingo zimwe na zimwe zigamije, nk'umwijima na tipusi ya adipose, cAMP ikora nk'intumwa ya kabiri y'ibanze itera imisemburo yihariye ya biohimiki. Kurenga cAMP, izindi nzira zerekana ibimenyetso na molekile zintumwa zigira uruhare muburyo bwa peptide; nk'urugero, calcium ion igira uruhare runini mugutunganya ibisubizo bya selile mubice bimwe [2].
Igishushanyo 1 Igishushanyo cyinzira zigira uruhare mugutunganya steroidogenezi mumyanya ya gonadal hakoreshejwe imisemburo ya luteinizing [2].
Ni ubuhe butumwa bwa Ovagen?
Ovagen itera gukura kwa hepatocyte kandi ikarinda fibrosis yumwijima na cirrhose. Itezimbere imikorere yumwijima muguhindura imiterere ya ADN ya hepatocyte nuburyo bwo kwandukura. Ovagen yerekana kandi ingaruka zo kurwanya gusaza, ihindura ADN ihindura imyaka kugirango igarure hepatocytes mu rubyiruko. Ovagen yongera imikorere ya barrière gastrointestinal mucosal barrière, igabanya ibyangiritse kumitsi yigifu iterwa nibintu nka therapy antibiotique, uburozi bwibidukikije, chimiotherapie, nimirire mibi. Ingaruka zayo zigenga umwijima na gastrointestinal mumikorere itandukanye yindwara nindwara zitanga ibyifuzo byinshi. Irashobora gukoreshwa mubuvuzi nyuma yubuvuzi, kuvura antibiotique igihe kirekire, kugabanya ingaruka zo kuvura kanseri, no kwirinda diyabete.
Ovagen na VIH
Ovagen yitabiriwe cyane n’ubushakashatsi bwa virusi itera sida kubera ingaruka zayo zibuza protease ya VIH-1. Virusi ya VIH-1 ni enzyme ikomeye yo kubaho kwa virusi, ishinzwe guhuza poroteyine za virusi mu mikorere ikora. Nka virusi ya virusi ya VIH-1, Ovagen iri mu ruto ruto kandi rukomeye ruzwi cyane. Iki gikorwa cyo kubuza gishobora gufasha mukurwanya kwandura virusi itera sida, gufungura inzira nshya zubushakashatsi bwo kuvura virusi itera sida.
Ubushakashatsi bwakozwe na Badaya A bwerekana ko Ovagen ishobora guhagarika ibikorwa bya poroteyine ya VIH-1 [3] . Virusi ya VIH-1 ni enzyme ikomeye mu kwigana virusi, ishinzwe gukuramo polyproteine kugira ngo ikure kandi ikusanyirize hamwe mu bice byanduye virusi. Guhagarika ibikorwa bya protease bihagarika inzira yo kwigana virusi [3] . Ovagen ibuza protease catalitike imikorere ihuza urubuga rwayo cyangwa guhindura ihinduka ryayo. Muguhuza urubuga rukora, birinda substrate kwinjira hamwe na reaction ya clavage [3].
Umwanzuro
Ovagen ni uruganda rwa tripeptide rugaragaza ibikorwa byibinyabuzima byinshi, cyane cyane bigenga imikorere yumwijima nigifu. Itera imikurire ya hepatocyte, irinda fibrosis yumwijima na cirrhose, yongera imikorere yumwijima ihindura imiterere ya ADN nuburyo bwo kwandukura, kandi ikerekana ubushobozi bwo kurwanya gusaza. Ovagen ishimangira imikorere ya gastrointestinal mucosal barrière, kugabanya ibyangiritse biterwa na antibiotike, uburozi bwibidukikije, chimiotherapie, nimirire mibi.
Ovagen ni uruganda rwa tripeptide hamwe nibikorwa byinshi byibinyabuzima, cyane cyane bigenga umwijima nigikorwa cya gastrointestinal. Itera imikurire ya hepatocyte, irinda fibrosis yumwijima na cirrhose, yongera imikorere yumwijima ihindura imiterere ya ADN nuburyo bwo kwandukura, kandi ikerekana ubushobozi bwo kurwanya gusaza. Ovagen ishimangira imikorere ya gastrointestinal mucosal barrière, kugabanya ibyangiritse biterwa na antibiotike, uburozi bwibidukikije, chimiotherapie, nimirire mibi.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Apoorva Badaya numushakashatsi winzobere mu kubara ibinyabuzima na bioinformatics. Yanditse ubushakashatsi yibanda ku mikorere ya molekile ya poroteyine ya VIH-1, cyane cyane ibijyanye no guhuza antibody no guhinduka. Igikorwa cye gikoresha tekinoroji yo kwigana igamije gushakisha imbaraga za poroteyine no kumenyesha ingamba zo kuvura. Apoorva Badaya yanditse murutonde rwerekana [3].
