|
1 pahu (10 Vials)
| Ka nui: | |
|---|---|
▎ Testagen Hoʻolālā
Puna: PepDraw |
Hui Molekala: C 22H 30N 6O6 Kaumaha Molekala: 474.53g/mol |
▎ Testagen Noiʻi
He aha ke kumu noiʻi o Testagen?
E kūʻē i ke kua o ka holomua biotechnology hou a me ka noiʻi biomedical, ua lilo ka ʻimi ʻana i nā peptides bioactive i alakaʻi noiʻi koʻikoʻi ma ke kula. Ma ke ʻano he peptide synthetic, paʻa ʻo Testagen i ka ʻimi noiʻi koʻikoʻi ma muli o kona waiwai kūpono i nā kaʻina cellular, ka hana hou ʻana o ka ʻiʻo, nā ala metabolic, a me nā ʻōnaehana physiological a me biochemical. No ka māhele o nā peptides bioactive, ua haku ʻia ʻo Testagen
o nā kaʻina amino acid i hiki ke hoʻololi i ka pilina o nā cell-molecular. Hoʻolālā ʻia kona ʻano e hoʻohālike a kākoʻo paha i nā kaʻina hana olaola endogenous, no laila e hōʻike ana i ka hiki ke kumu noiʻi i ka biology molecular, biochemistry, a me ka noiʻi regenerative.
Kiʻi 1. Pūnaehana bioregulation o kahi organism multicellular.
Puna: MDPI [1]
He aha ke ʻano o ka hana a Testagen?
ʻO ka hoʻopaʻa ʻana o ke kelepona: Ua hōʻike ʻia nā haʻawina ma hope o ka hoʻoulu ʻana i nā cell HeLa me ka fluorescein isothiocyanate-labeled Testagen, ʻike ʻia ka fluorescence ʻokoʻa i loko o ka cytoplasm, cell nucleus, a me ka nucleolus, e hōʻike ana he hiki i Testagen ke komo i nā pūnana holoholona a me kā lākou nuclei. ʻO kona hiki ke hele i nā membrane cell a me nā membrane nuklea i loko o ka hale o loko e pili paha i kekahi mau protein transport ma ka membrane cell a i ʻole ka membrane fluidity. ʻAʻole ʻo ka membrane cell kahi hale impermeable loa; aia nā ala a me nā mīkini lawe. Hiki i Testagen ke komo i nā pūnaewele ma o ka launa pū ʻana me kēia mau protein transport a i ʻole ma o nā ʻano endocytosis-like me ka hoʻohana ʻana i ka fluidity membrane, e kau ana i ke kumu no kāna mau hopena hope [2].
Nā Kūkākūkā Kūikawā me nā Nucleic Acids: Hōʻike nā peptides intact like ʻole i nā hopena like ʻole ma ka fluorescence o 5,6-carboxyfluorescein-labeled deoxyoligonucleotides a me DNA-ethidium bromide complexes. Ma ke ana ana o Stern-Volmer mau, ua ike ia Testagen, i hoohalikeia me na peptides pokole, e hooulu ana i na degere like ole o ka hoopau ana i ka fluorescence i ka deoxyoligonucleotides i hoailona ia me ka deoxyoligonucleotides, e pili ana i ke ano o ka peptide. Hōʻike kēia i nā pilina kikoʻī ma waena o Testagen a me nā hale nucleic acid. Ke hoʻopaʻa ʻia i nā waikawa nucleic, hiki iā Testagen ke hoʻokaʻawale i waena o nā kaʻina nucleotide like ʻole a ʻike pū i ko lākou kūlana cytosine methylation. No ka laʻana, ʻike ʻia ʻo Testagen e pili pono i nā deoxyoligonucleotides i loaʻa nā kaʻina CAG. Hiki ke hoʻokō ʻia kēlā paʻa kikoʻī ma o nā pilina non-covalent e like me nā paʻa hydrogen a me nā pilina electrostatic ma waena o nā koena amino acid ma ka mole Testagen a me nā kumu a i ʻole nā iwi hope phosphate o nā waikawa nucleic. Hāʻawi kēia kikoʻī iā Testagen e hoʻokaʻawale pololei i nā ʻāpana nucleic acid, a laila e hoʻohuli ai i nā kaʻina hana e like me ka hōʻike gene [2].
Epigenetic Regulation of Cellular Genetic Functions: Ma muli o kona hiki ke hoʻopaʻa paʻa pono i ka DNA, hiki i nā pilina kiko'ī o Testagen me DNA ke hoʻomalu i nā hana genetic cellular ma ka pae epigenetic. ʻAʻole hoʻololi ka hoʻoponopono Epigenetic i ke kaʻina kumu DNA akā hoʻololi i ka hōʻike gene ma o nā hoʻololi DNA (eg, methylation) a me nā hoʻololi histone. Hiki ke hoʻopaʻa ʻia ʻo Testagen i nā ʻāpana DNA kikoʻī, e pili ana i ka hoʻolālā chromatin ma ia mau wahi a i ʻole ke kiʻi ʻana i nā mea protein regulatory epigenetic e hoʻololi i ka hana transcriptional gene. He mea koʻikoʻi paha ia ʻano hoʻoponopono o ka hana gene i ka hoʻomaka ʻana o ke kumu o ke ola a me ka hoʻololi ʻana o ke ola, e kōkua ana i nā mea ola e hoʻoponopono pololei i ka hōʻike ʻana i nā ʻano like ʻole e hoʻololi i nā loli a hoʻopau i nā kaʻina ola [2].
Nā hopena i ka hana Endocrine i nā maʻi Prostatitis Non-Bacterial Chronic: Ma ka noiʻi olakino, ua ʻike nā haʻawina e pili ana i nā mea maʻi me ka prostatitis non-bacterial maʻi (IIIA) ma hope o hoʻokahi mahina o ka mālama conservative me kahi regimen me Testagen (α1-adrenergic blockers + rectal suppositories i loaʻa i nā lāʻau anti-inflammatory non-steroidal), hōʻemi nui i ka pae uroddynamic, testosterone. mahuahua. Hōʻike kēia e hiki iā Testagen ke hoʻoponopono i ke kaulike endocrine ma o kekahi mau hana. ʻO kahi hana kūpono ʻo Testagen ke hoʻoikaika i nā ala hōʻailona e pili ana i ka synthesis testosterone i nā pūnaewele Leydig. ʻO ka Testosterone synthesis kahi kaʻina hana paʻakikī e pili ana i nā enzymes a me nā molekala hōʻailona. Hiki i ka Testagen ke ho'āla a keʻakeʻa paha i nā ala hōʻailona pili ma o ka hoʻopaʻaʻana i nā mea hoʻokipa intracellular, a laila e hoʻoikaika i ka testosterone synthesis, hoʻomaikaʻi i ke kūlana endocrine o ka mea maʻi, a me ka hoʻohaʻahaʻaʻana i nā hōʻailona o ka prostatitis non-bacterial mau loa [3].
He aha nā mea hoʻohana o Testagen?
Lapaʻau ʻana i ka Prostatitis Non-Bacterial Chronic: ʻO ka prostatitis non-bacterial maʻi (IIIA), i hele pinepine ʻia me nā hōʻailona o ka ʻāpana mimi haʻahaʻa, hoʻopilikia maikaʻi i ka maikaʻi o ke ola o ka poʻe maʻi. He kuleana koʻikoʻi ko Testagen i ka mālama ʻana i ia mau maʻi [4] (Niu D, 2023). ʻO nā haʻawina e hoʻohana ana i kahi regimen mālama mālama conservative e hui pū ana i nā blockers α1-adrenergic, suppositories rectal me nā lāʻau anti-inflammatory non-steroidal, a ua loaʻa iā Testagen nā hopena kupaianaha ma hope o hoʻokahi mahina. Ua hoʻomaikaʻi maikaʻi ʻia nā ʻāpana Urodynamic, e hōʻike ana i ka hoʻonui ʻana i ka hana micturition a me ka hoʻomaha ʻana i nā hōʻailona obstruction o ka ʻāpana mimi haʻahaʻa. I kēia manawa, ua emi iho ka nui o ka mumū intraprostatic, e hōʻemi ana i ka pōʻino o ke kino. ʻO ka mea nui, ua hoʻonui ʻia ka nui o ka testosterone. He mea koʻikoʻi ka Testosterone no ka mālama ʻana i nā hana maʻamau o ka ʻōnaehana hānau kāne, ka hana wahine, a me ka metabolism holoʻokoʻa, a ʻo kona kiʻekiʻe e kōkua i ka hoʻomaikaʻi ʻana i nā maʻi endocrine i hoʻokumu ʻia e ka maʻi [3].
ʻO ka hoʻopaʻa ʻana o ka Cell a me ka Nucleic Acid Interactions: Ma ke ʻano he peptide bioactive pōkole, hōʻike ʻo Testagen i nā waiwai kelepona kūʻokoʻa i hoʻokumu i ke kumu no kāna mau lāʻau lapaʻau [2] (Fedoreyeva LI, 2011). Ma nā hoʻokolohua cell HeLa, ua ʻike ʻia ka fluorescence nui i loko o ka cytoplasm, nucleus, a me ka nucleolus ma hope o ka incubation me ka fluorescein isothiocyanate-labeled Testagen, e hōʻike ana i kona hiki ke komo i nā pūnana holoholona a me ka nuclei. Hāʻawi kēia iā Testagen e komo i nā cell a launa pū me nā ʻāpana intracellular, e hiki ai i nā hana hoʻoponopono i loko o nā cell.
Ua ʻike nā haʻawina he ʻokoʻa nā hopena like ʻole o nā peptides bioactive pōkole i ka fluorescence o 5,6-carboxyfluorescein-labeled deoxyribooligonucleotides a me DNA-ethidium bromide complexes. ʻO nā pae hoʻoheheʻe fluorescence, ʻike ʻia e Stern-Volmer mau, ʻokoʻa i waena o nā peptides pōkole e like me Testagen ma muli o ko lākou ʻano kumu mua i ka wā e launa pū ai me nā deoxyribooligonucleotides i hoʻopaʻa inoa ʻia me ka deoxyribooligonucleotides, e hōʻike ana i nā pilina kikoʻī me nā hale nucleic acid. Hōʻike nā noiʻi hou aʻe e pili ana ʻo Testagen i nā deoxyribooligonucleotides i loaʻa nā kaʻina CAG. ʻO kēia hiki ke hoʻopaʻa i nā kaʻina waikona nucleic kikoʻī e hōʻike ana e hiki iā Testagen ke hoʻoponopono i nā hana genetic cellular ma ka pae epigenetic ma o nā pilina DNA kikoʻī kikoʻī, e pāʻani ana i kahi kuleana nui i ka hoʻoponopono hana gene. Loaʻa kēia i ka hiki ke hoʻomohala i nā lāʻau lapaʻau e pili ana i ka hoʻoponopono gene-no ka laʻana, i nā maʻi e pili ana i ka hōʻike ʻana o ke ʻano. ʻOiai ʻaʻole i hōʻike ʻia nā noi lapaʻau pololei, ʻike ʻia nā haʻawina mechanistic ma ka pae kelepona a me ka molecular i nā noi lapaʻau e hiki mai ana.
Ka hopena
I ka hōʻuluʻulu ʻana, ua hōʻike ʻo Testagen i ka hopena therapeutic i ka mālama ʻana i ka prostatitis non-bacterial maʻi, ʻoiai ʻo kāna mau waiwai o ke komo ʻana o ka cell a me ka pilina nucleic acid e hāʻawi i ka hiki no nā noi olakino ākea. Me ka noiʻi hou aku, ua manaʻo ʻia he hana koʻikoʻi i ka mālama ʻana i nā maʻi hou aʻe a me nā hana lapaʻau.
No ka mea kakau
ʻO nā mea i ʻōlelo ʻia ma luna nei ua noiʻi ʻia, hoʻoponopono ʻia a hōʻuluʻulu ʻia e Cocer Peptides.
Mea kākau moʻolelo ʻepekema
ʻO Niu, Dun he kanaka ʻepekema kaulana i ka ʻoihana lapaʻau a me ka ʻepekema ola. Hoʻopili ʻia me nā hui hanohano e like me Army Medical University a me University of South, ua kālele ʻo ia i kāna noiʻi ma Pharmacology & Pharmacy, Cell Biology, Immunology, a me Biochemistry & Molecular Biology. He mea koʻikoʻi kēia mau aʻo no ka wehe ʻana i nā mīkini maʻi, ka holomua ʻana i ka hoʻomohala lāʻau hou, a me ka hoʻonui ʻana i ke olakino kanaka. Eia kekahi, hana ʻo Niu, Dun i ka noiʻi ʻana i ka Cardiovascular System & Cardiology, e ʻimi ana i ka pathogenesis a me ka mālama ʻana i nā maʻi naʻau. Hāʻawi kāna hana i nā kumu aʻoaʻo koʻikoʻi a me ke alakaʻi kūpono no ka maʻi maʻi a me ka mālama ʻana i nā maʻi cardiovascular, e hōʻike ana i kona ʻike hohonu a me kona mana ākea i ka noiʻi olakino.
