Testagen 20mg

▎ ya Testagen Enzimba

▎ ku Testagen Okunoonyereza

Ensibuko y’okunoonyereza ku Testagen eri etya?

Nga tuli mu mbeera y’okutumbula tekinologiya ow’omulembe ow’ebiramu n’okunoonyereza ku by’obulamu, okunoonyereza ku peptides ezikola ku biramu kufuuse obulagirizi obw’amaanyi obw’okunoonyereza mu mulimu guno. Nga peptide ey’obutonde, Testagen erina amakulu ag’okunoonyereza ag’enjawulo olw’omugaso gwayo oguyinza okubaawo mu nkola z’obutoffaali, okuddamu okukola ebitundu by’omubiri, amakubo g’enkyukakyuka mu mubiri, n’enkola endala ez’omubiri n’ebiramu. Okubeera mu kiti kya peptides ezikola ebiramu, Testagen ekoleddwa

 wa ensengekera za amino asidi eziyinza okukwata ku nkolagana y’obutoffaali ne molekyu. Ensengekera yaayo ekoleddwa okukoppa oba okuwagira enkola z’ebiramu ez’omunda, bwe kityo n’eyanjula obusobozi ng’ekintu eky’okunoonyereza mu biology ya molekyu, biochemistry, n’okunoonyereza ku kuzzaawo.

Ekifaananyi 1. Enkola y’okulungamya ebiramu (bioregulation system) y’ekiramu ekirimu obutoffaali bungi. 

Ensibuko: MDPI ^{[1] .}

Enkola y’ebikolwa bya Testagen eri etya?

Okuyingira mu butoffaali: Okunoonyereza kulaga nti oluvannyuma lw’okufumbiza obutoffaali bwa HeLa ne Testagen eriko akabonero ka fluorescein isothiocyanate, okumasamasa okw’enjawulo kwalabiddwa mu cytoplasm, cell nucleus, ne nucleolus, ekiraga nti Testagen erina obusobozi okuyingira mu butoffaali bw’ebisolo ne nuclei zaabyo. Obusobozi bwayo okuyita mu buwuzi bw’obutoffaali n’obuwuzi bwa nyukiliya okuyingira munda mu butoffaali buyinza okuba nga bwekuusa ku puloteyina ezimu ezitambuza ku luwuzi lw’obutoffaali oba amazzi g’olususu. Olususu lw’obutoffaali si nsengekera etayitamu ddala; kirimu emikutu n’enkola z’entambula. Testagen eyinza okuyingira mu butoffaali nga ekwatagana ne puloteyina zino ez’entambula oba ng’eyita mu nkola eziringa endocytosis nga ekozesa amazzi g’olususu, n’eteekawo omusingi gw’ebikolwa byayo ebiddirira ^[2]..  

Enkolagana Entongole ne Nucleic Acids: Peptides ez’enjawulo ezitaliiko kamogo ez’ensibuko ziraga ebikolwa eby’enjawulo ku fluorescence ya 5,6-carboxyfluorescein-labeled deoxyoligonucleotides ne DNA-ethidium bromide complexes. Nga tupima Stern-Volmer constants, kyazuulibwa nti Testagen, bw’ogeraageranya ne peptides endala ennyimpi, ereeta diguli ez’enjawulo ez’okuzikiza kwa fluorescence mu deoxyoligonucleotides eziriko akabonero k’ekitangaala eky’omuguwa gumu n’ebiri, okusinziira ku nsengekera ya peptide enkulu. Kino kiraga enkolagana eyenjawulo wakati wa Testagen ne ensengekera za nucleic acid. Bwe yeegatta ku asidi za nyukiliya, Testagen esobola okwawula wakati w’ensengekera za nyukiliyotayidi ez’enjawulo n’atuuka n’okutegeera embeera yaabwe ey’okufuuka cytosine methylation. Okugeza, Testagen erabika ng’esinga kwesiba ku deoxyoligonucleotides ezirimu ensengekera za CAG. Okusiba okw’enjawulo ng’okwo kuyinza okutuukibwako okuyita mu nkolagana ezitali za covalent nga enkolagana ya haidrojeni n’enkolagana y’amasannyalaze wakati w’ebisigadde bya amino asidi ku molekyu ya Testagen ne base oba emigongo gya phosphate egya nucleic acids. Obutonde buno busobozesa Testagen okubeera mu kifo ekituufu mu bitundu bya nucleic acid ebitongole, bwe kityo n’ekwata ku nkola ng’okwolesebwa kw’obuzaale ^[2]..  

Epigenetic Regulation of Cellular Genetic Functions: Olw’obusobozi bwayo okwesiba mu ngeri ey’enjawulo ku DNA, enkolagana ya Testagen mu kifo ekimu ne DNA esobola okufuga emirimu gy’obuzaale bw’obutoffaali ku ddaala ly’obuzaale. Okulungamya epigenetic tekyusa nsengekera ya DNA base wabula kukwata ku gene expression okuyita mu nkyukakyuka za DNA (okugeza, methylation) n’okukyusa histone. Testagen eyinza okwesiba ku bitundu bya DNA ebitongole, okukosa ensengekera ya chromatin mu bitundu ebyo oba okuwandiika ensonga za puloteyina ezifuga epigenetic okukyusa emirimu gy’okuwandiika obuzaale. Okulungamya ng’okwo kw’emirimu gy’obuzaale kuyinza okuba nga kwakola kinene nnyo mu mitendera egy’olubereberye egy’ensibuko y’obulamu n’enkulaakulana y’ebiramu, okuyamba ebiramu okulungamya obulungi okwolesebwa kw’obuzaale mu mbeera ez’enjawulo okusobola okukyusakyusa n’enkola z’obulamu ezijjuvu ^[2]..  

Effects on Endocrine Function in Chronic Non-Bacterial Prostatitis Patients: Mu kunoonyereza kw’abasawo, okunoonyereza ku balwadde abalina obulwadde bw’ennywanto obutawona (IIIA) kuzudde nti oluvannyuma lw’omwezi gumu nga bajjanjabwa mu ngeri ey’obukuumi n’enkola omuli Testagen (α1-adrenergic blockers + rectal suppositories ezirimu eddagala eriziyiza okuzimba eritali lya steroid), urodynamic parameters significantly improved, emiwendo gy’okuzimba mu nseke gyakendeera, ate emiwendo gya serum total testosterone ne yeeyongera. Kino kiraga nti Testagen eyinza okulung’amya bbalansi y’endocrine ng’eyita mu nkola ezimu. Enkola entuufu eri nti Testagen ekwata ku makubo g’obubonero agakwatagana n’okusengejja testosterone mu butoffaali bwa Leydig. Okukola testosterone nkola nzibu erimu enziyiza eziwera ne molekyu eziraga obubonero. Testagen eyinza okukola oba okuziyiza amakubo g’obubonero agakwatagana nga yeesibye ku bikwata mu butoffaali, bwe kityo n’etumbula okukola kw’obusimu obuyitibwa testosterone, okulongoosa embeera y’omubiri gw’omulwadde, n’okukendeeza ku bubonero bw’obulwadde bw’ennywanto obutawona obutaba bwa bakitiriya ^[3]..  

Biki ebikozesebwa mu Testagen?  

Obujjanjabi bw’obulwadde bw’ennywanto obutawona: Obulwadde bw’ennywanto obutawona (IIIA), obutera okuwerekerwako obubonero bw’omusulo ogwa wansi, bukosa bubi omutindo gw’obulamu bw’abalwadde. Testagen ekola kinene mu kujjanjaba embeera ng’ezo ^[4] (Niu D, 2023). Okunoonyereza okwakolebwa nga bakozesa enkola y’obujjanjabi ey’okukuuma eddagala nga bagatta α1-adrenergic blockers, rectal suppositories n’eddagala eritali lya steroidal eriziyiza okuzimba, ne Testagen kwatuuka ku bivuddemu ebyewuunyisa oluvannyuma lw’omwezi gumu. Urodynamic parameters zalongooka nnyo, ekiraga nti enkola y’okufulumya omusulo eyongezeddwa n’okuwona obubonero bw’okuzibikira omusulo ogwa wansi. Mu kiseera kino, okuzimba mu nseke zakendeera, ne kikendeeza ku kwonooneka kw’ebitundu by’omubiri. Ekisinga obukulu, serum total testosterone levels yeeyongera. Testosterone kikulu nnyo mu kukuuma emirimu gya bulijjo egy’enkola y’okuzaala y’omusajja, enkola y’okwegatta, n’enkyukakyuka y’omubiri okutwalira awamu, era okulinnya kwayo kuyamba okulongoosa obuzibu bw’endwadde z’omubiri obuva ku bulwadde buno ^[3]..  

Okuyingira kw’obutoffaali n’enkolagana ya Nucleic Acid: Nga peptide empya ekola ku bulamu, Testagen eraga eby’obutonde eby’enjawulo ebikola omusingi gw’okukozesebwa kwayo mu by’obujjanjabi ^[2] (Fedoreyeva LI, 2011). Mu kugezesa obutoffaali bwa HeLa, okumasamasa okw’amaanyi kwalabiddwa mu cytoplasm, nucleus, ne nucleolus oluvannyuma lw’okufumbirwa ne fluorescein isothiocyanate-labeled Testagen, ekiraga obusobozi bwayo okuyingira mu butoffaali bw’ebisolo ne nuclei. Kino kisobozesa Testagen okuyingira mu butoffaali n’okukwatagana n’ebitundu ebiri mu butoffaali, okusobozesa emirimu gy’okulungamya mu butoffaali.  

Okunoonyereza kuzudde nti peptides ez’enjawulo ennyimpi ezikola obulamu zikola ebikolwa eby’enjawulo ku fluorescence ya 5,6-carboxyfluorescein-labeled deoxyribooligonucleotides ne DNA-ethidium bromide complexes. Emitendera gy’okuzikiza ekitangaala, egyamanyibwa nga Stern-Volmer constants, gyawukana mu peptides ennyimpi nga Testagen okusinziira ku nsengekera yazo enkulu nga zikwatagana ne deoxyribooligonucleotides eziriko akabonero k’ekitangaala eky’omuguwa gumu n’ebiri, ekiraga enkolagana eyenjawulo n’ensengekera za nucleic acid. Okunoonyereza okulala kulaga nti Testagen esinga kwesiba ku deoxyribooligonucleotides ezirimu ensengekera za CAG. Obusobozi buno obw’okusiba ensengekera za nucleic acid ezenjawulo bulaga nti Testagen eyinza okulungamya emirimu gy’obuzaale bw’obutoffaali ku ddaala ly’obuzaale okuyita mu nkolagana ya DNA ey’ekifo, ng’ekola kinene mu kulungamya emirimu gy’obuzaale. Kino kirina obusobozi okukola obujjanjabi obwesigamye ku kulungamya obuzaale —okugeza, mu ndwadde ezikwatagana n’okwolesebwa kw’obuzaale okutali kwa bulijjo. Wadde ng’okukozesebwa obutereevu mu bujjanjabi tekunnaba kutegeezebwa, okunoonyereza okw’enkola ku mutendera gw’obutoffaali ne molekyu kulaga okukozesebwa mu by’obujjanjabi mu biseera eby’omu maaso.  

Mu bufunzi  

Mu bufunze, Testagen eraga obulungi bw’obujjanjabi mu kujjanjaba obulwadde bw’enseke obutawona obutali bwa bakitiriya, ate eby’obugagga byayo eby’okuyingira mu butoffaali n’okukwatagana kwa nucleic acid biwa obusobozi okukozesebwa mu by’obujjanjabi mu bugazi. Nga okwongera okunoonyereza, kisuubirwa okukola kinene mu kujjanjaba endwadde eziwera n’okuyingira mu nsonga z’abasawo.

Ebikwata ku Muwandiisi

Ebintu ebyogeddwako waggulu byonna binoonyerezeddwako, birongooseddwa era ne bikung’aanyizibwa kkampuni ya Cocer Peptides.

Omuwandiisi wa Scientific Journal

Niu, Dun mukenkufu mututumufu mu by’obusawo ne ssaayansi w’obulamu. Yeegattira mu matendekero ag’ettutumu nga Army Medical University ne University of South , okunoonyereza kwe assa ku Pharmacology & Pharmacy, Cell Biology, Immunology, ne Biochemistry & Molecular Biology. Emisomo gino gikulu nnyo mu kuzuula enkola z’endwadde, okutumbula okukola eddagala eppya, n’okutumbula obulamu bw’abantu. Okugatta ku ekyo, Niu, Dun akola okunoonyereza mu Cardiovascular System & Cardiology, ng’anoonyereza ku ntandikwa y’endwadde n’obujjanjabi bw’endwadde z’omutima. Omulimu gwe guwa emisingi emikulu egy’enzikiriziganya n’obulagirizi obw’omugaso mu kuzuula n’okujjanjaba endwadde z’emisuwa mu bujjanjabi, nga kiraga obukugu bwe obw’amaanyi n’obuyinza bwe obw’amaanyi mu kunoonyereza ku by’obusawo.. Niu, Dun is listed in the reference of citation [4].

▎ Ebiwandiiko Ebikwatagana

[1] Khavinson VK, Popovich IGE, Linkova N. S., n’abalala. Okulungamya peptide mu kwolesebwa kw’obuzaale: Okuddamu okwetegereza okutegekeddwa[J]. Molekyulu, 2021,26 (22},https://www.mdpi.com/1420-3049/26/22/7053

EKITUNDU-ENNAMBA = {7053).DOI:10.3390/molekyulu26227053.

[2] Fedoreyeva L. I., Kireev II, Khavinson V, n’abalala. Okuyingira kwa peptides ennyimpi eziwandiikiddwa mu fluorescence mu nucleus mu butoffaali bwa HeLa n’enkolagana ey’enjawulo mu vitro eya peptides ne deoxy ribooligonucleotides ne DNA[J]. Ebiramu-Moscow, 2011, 76 (11): 1210-1219.DOI: 10.1134 / S0006297911110022.

[3] Rossikhin V, Hoshchenko Y, Osipov P. Obulung'amu bw'okukozesa testosterone synthesis inductor 'testagen' mu bbula lya androgenic mu balwadde abalina obulwadde bwa abacterial prostatitis obutawona[J]. Ebizibu by’endwadde z’omu lubuto, 2011,36:17-22.DOI:10.21856/j-PEP.2011.2.03.

[4] Niu D, Wu Y, Lian J. Eddagala lya RNA eryekulungirivu mu kuziyiza n’okujjanjaba endwadde[J]. Okukyusa obubonero n’obujjanjabi obugendereddwamu, 2023,8. https://api.semanticscholar.org/CorpusID:261662530. Enkola y’okukuuma obutonde bw’ensi.

EBINTU BYONNNA N’AMAWULIRE GW’EBINTU EBIweereddwa KU MUTINDO GUNO BIKOZESEBWA KU KUSASANYA AMAWULIRE N’EBIKOLWA BY’OKUSOMESA BYOKKA.  

Ebintu ebiweereddwa ku mukutu guno bigendereddwamu kunoonyereza mu kisenge (in vitro research) byokka. Okunoonyereza mu kisenge (in vitro research) (Olulattini: *mu ndabirwamu*, ekitegeeza mu bikozesebwa mu ndabirwamu) kukolebwa ebweru w’omubiri gw’omuntu. Ebintu bino si bya ddagala, tebikkiriziddwa kitongole kya Amerika ekivunaanyizibwa ku by’emmere n’eddagala (FDA), era tebirina kukozesebwa kuziyiza, kujjanjaba oba kuwonya mbeera yonna ya bujjanjabi, bulwadde oba bulwadde. Kikugirwa nnyo mu mateeka okuyingiza ebintu bino mu mubiri gw’omuntu oba ebisolo mu ngeri yonna.